JP2008527989A5 - - Google Patents
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- Publication number
- JP2008527989A5 JP2008527989A5 JP2007551754A JP2007551754A JP2008527989A5 JP 2008527989 A5 JP2008527989 A5 JP 2008527989A5 JP 2007551754 A JP2007551754 A JP 2007551754A JP 2007551754 A JP2007551754 A JP 2007551754A JP 2008527989 A5 JP2008527989 A5 JP 2008527989A5
- Authority
- JP
- Japan
- Prior art keywords
- specific binding
- binding member
- amino acid
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000009870 specific binding Effects 0.000 claims 38
- 125000003275 alpha amino acid group Chemical group 0.000 claims 29
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 8
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 8
- 229940053128 nerve growth factor Drugs 0.000 claims 8
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 claims 7
- 102000046917 human NGF Human genes 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 230000027455 binding Effects 0.000 claims 6
- 210000004602 germ cell Anatomy 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000003472 neutralizing effect Effects 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 101100404651 Mus musculus Ngf gene Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 101100404655 Rattus norvegicus Ngf gene Proteins 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 102000015533 trkA Receptor Human genes 0.000 claims 1
- 108010064884 trkA Receptor Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64558705P | 2005-01-24 | 2005-01-24 | |
| US60/645,587 | 2005-01-24 | ||
| PCT/GB2006/000238 WO2006077441A1 (en) | 2005-01-24 | 2006-01-24 | Specific binding members for ngf |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008527989A JP2008527989A (ja) | 2008-07-31 |
| JP2008527989A5 true JP2008527989A5 (https=) | 2009-03-05 |
| JP5096167B2 JP5096167B2 (ja) | 2012-12-12 |
Family
ID=36088563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551754A Expired - Fee Related JP5096167B2 (ja) | 2005-01-24 | 2006-01-24 | Ｎｇｆに対する特異的結合メンバー |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9315571B2 (https=) |
| EP (2) | EP2298345A3 (https=) |
| JP (1) | JP5096167B2 (https=) |
| KR (1) | KR101298383B1 (https=) |
| CN (1) | CN101107268B (https=) |
| AU (1) | AU2006207338B2 (https=) |
| BR (1) | BRPI0606933B8 (https=) |
| CA (1) | CA2595800C (https=) |
| ES (1) | ES2435691T3 (https=) |
| IL (1) | IL183752A (https=) |
| MX (1) | MX2007008722A (https=) |
| NO (1) | NO343064B1 (https=) |
| NZ (1) | NZ556157A (https=) |
| PT (1) | PT1846451E (https=) |
| RU (1) | RU2406728C2 (https=) |
| WO (1) | WO2006077441A1 (https=) |
| ZA (1) | ZA200705754B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200502612B (en) | 2002-10-08 | 2007-07-25 | Rinat Neuroscience Corp | Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same |
| US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| DK2270048T3 (en) | 2002-12-24 | 2016-01-18 | Rinat Neuroscience Corp | Anti-NGF antibodies and methods for their use |
| BRPI0407375A (pt) | 2003-02-19 | 2006-02-07 | Rinat Neuroscience Corp | Métodos para tratar dor por meio da administração de um antagonista do fator de crescimento neural e u nsaid e composições contendo os mesmos |
| AR045056A1 (es) | 2003-07-15 | 2005-10-12 | Amgen Inc | Anticuerpos anti-ngf humanos neutralizantes como inhibidores selectivos de la via de ngf |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| EP3372614B1 (en) | 2004-04-07 | 2022-06-08 | Rinat Neuroscience Corp. | Methods for treating bone cancer pain by administering a nerve growth factor antagonist |
| ME00226B (me) | 2004-07-15 | 2011-02-10 | Medarex Llc | Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade |
| ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| US7488630B2 (en) | 2007-03-06 | 2009-02-10 | International Business Machines Corporation | Method for preparing 2-dimensional semiconductor devices for integration in a third dimension |
| US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
| MX2010001395A (es) * | 2007-08-10 | 2010-03-10 | Regeneron Pharma | Anticuerpos humanos de alta afinidad de factor de crecimiento de nervio humano. |
| MX2010006610A (es) * | 2007-12-20 | 2010-09-30 | Cytos Biotechnology Ag | Conjugados de factor de crecimiento de nervios y usos de los mismos. |
| TW201034684A (en) * | 2009-02-18 | 2010-10-01 | Genentech Inc | Method for inhibiting neurodegeneration |
| SG175436A1 (en) | 2009-05-04 | 2011-12-29 | Abbott Res Bv | Antibodies against nerve growth factor (ngf) with enhanced in vivo stability |
| EP2431463A4 (en) * | 2009-05-13 | 2012-12-26 | Shionogi & Co | TESTS FOR VISCERAL ADIPOSITAS AND ITS USE |
| AU2011227335B2 (en) | 2010-03-17 | 2014-11-06 | Abbott Research B.V. | Anti-nerve growth factor (NGF) antibody compositions |
| WO2012024650A2 (en) | 2010-08-19 | 2012-02-23 | Abbott Laboratories | Anti-ngf antibodies and their use |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| EP2646468B1 (en) | 2010-12-01 | 2018-07-25 | AlderBio Holdings LLC | Anti-ngf compositions and use thereof |
| SI2743348T1 (en) | 2011-08-11 | 2018-04-30 | Astellas Pharma Inc. | Novel anti-human ngf antibody |
| CA2875783C (en) | 2012-06-06 | 2018-12-11 | Zoetis Llc | Caninized anti-ngf antibodies and methods thereof |
| US9127055B2 (en) | 2013-02-08 | 2015-09-08 | Astellas Pharma Inc. | Method of treating pain with anti-human NGF antibody |
| LT3099713T (lt) | 2014-02-02 | 2020-07-10 | Medimmune Limited | Chimerinis baltymas, sudarytas iš ngf antagonistinio domeno ir tnfa antagonistinio domeno |
| WO2016190263A1 (ja) | 2015-05-22 | 2016-12-01 | アステラス製薬株式会社 | 新規抗ヒトＮＧＦ抗体Ｆａｂフラグメント |
| US9862760B2 (en) | 2015-09-16 | 2018-01-09 | Novartis Ag | Polyomavirus neutralizing antibodies |
| EP3368039A1 (en) | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| BR112020017701A2 (pt) | 2018-03-12 | 2020-12-29 | Zoetis Services Llc | Anticorpos anti-ngf e métodos dos mesmos |
| EP3795176A4 (en) | 2018-05-15 | 2022-01-12 | Astellas Pharma Inc. | Pharmaceutical composition for suppressing atrial fibrillation having as active ingredient anti-human ngf antibody or antigen-binding fragment thereof |
| WO2020248942A1 (zh) * | 2019-06-10 | 2020-12-17 | 山东博安生物技术有限公司 | 抗β-NGF纳米抗体及其应用 |
| CN117186219B (zh) * | 2020-04-17 | 2024-07-12 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| CN113527483B (zh) * | 2020-04-17 | 2023-09-22 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| KR20230084199A (ko) | 2020-09-28 | 2023-06-12 | 메디뮨 리미티드 | 통증 치료를 위한 화합물 및 방법 |
| CN121410259B (zh) * | 2025-12-30 | 2026-03-20 | 北京索莱宝科技有限公司 | 用于检测人β-NGF含量的双抗夹心ELISA试剂盒 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0559834A1 (en) | 1990-11-30 | 1993-09-15 | Abbott Laboratories | Immunoassay and monoclonal antibodies useful for detecting truncated nerve growth factor receptor |
| IT1306704B1 (it) * | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| WO2001027279A1 (en) * | 1999-10-12 | 2001-04-19 | Cambridge Antibody Technology | Human anti-adipocyte monoclonal antibodies and their use |
| WO2001044300A2 (en) * | 1999-12-13 | 2001-06-21 | Cambridge Antibody Technology Limited | Brain specific binding members |
| US6548062B2 (en) | 2000-02-29 | 2003-04-15 | Cephalon, Inc. | Method of treating cancer with anti-neurotrophin agents |
| FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
| CA2975521A1 (en) * | 2001-05-30 | 2002-12-05 | Genentech, Inc. | Anti-ngf antibodies for the treatment of various disorders |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| AU2003240822A1 (en) * | 2002-05-30 | 2003-12-19 | Human Genome Sciences, Inc. | Antibodies that specifically bind to neurokinin b |
| CA2500901A1 (en) | 2002-10-04 | 2004-04-22 | Rinat Neuroscience Corp. | Methods for treating cardiac arrhythmia and preventing death due to cardiac arrhythmia using ngf antagonists |
| ZA200502612B (en) | 2002-10-08 | 2007-07-25 | Rinat Neuroscience Corp | Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same |
| US7285269B2 (en) * | 2002-12-02 | 2007-10-23 | Amgen Fremont, Inc. | Antibodies directed to tumor necrosis factor |
| DK2270048T3 (en) * | 2002-12-24 | 2016-01-18 | Rinat Neuroscience Corp | Anti-NGF antibodies and methods for their use |
| AR045056A1 (es) * | 2003-07-15 | 2005-10-12 | Amgen Inc | Anticuerpos anti-ngf humanos neutralizantes como inhibidores selectivos de la via de ngf |
-
2006
- 2006-01-24 EP EP10008629A patent/EP2298345A3/en not_active Withdrawn
- 2006-01-24 RU RU2007132020/10A patent/RU2406728C2/ru active
- 2006-01-24 PT PT67010991T patent/PT1846451E/pt unknown
- 2006-01-24 JP JP2007551754A patent/JP5096167B2/ja not_active Expired - Fee Related
- 2006-01-24 ES ES06701099T patent/ES2435691T3/es not_active Expired - Lifetime
- 2006-01-24 CN CN2006800024090A patent/CN101107268B/zh not_active Expired - Lifetime
- 2006-01-24 NZ NZ556157A patent/NZ556157A/en unknown
- 2006-01-24 EP EP06701099.1A patent/EP1846451B1/en not_active Expired - Lifetime
- 2006-01-24 CA CA2595800A patent/CA2595800C/en not_active Expired - Lifetime
- 2006-01-24 BR BRPI0606933A patent/BRPI0606933B8/pt active IP Right Grant
- 2006-01-24 WO PCT/GB2006/000238 patent/WO2006077441A1/en not_active Ceased
- 2006-01-24 MX MX2007008722A patent/MX2007008722A/es active IP Right Grant
- 2006-01-24 US US11/814,668 patent/US9315571B2/en active Active
- 2006-01-24 KR KR1020077017099A patent/KR101298383B1/ko not_active Expired - Lifetime
- 2006-01-24 AU AU2006207338A patent/AU2006207338B2/en not_active Expired
-
2007
- 2007-06-07 IL IL183752A patent/IL183752A/en active IP Right Grant
- 2007-07-12 ZA ZA200705754A patent/ZA200705754B/xx unknown
- 2007-08-21 NO NO20074266A patent/NO343064B1/no unknown
-
2016
- 2016-04-18 US US15/131,825 patent/US9701746B2/en not_active Expired - Lifetime
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