JP2015518857A5 - - Google Patents
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- Publication number
- JP2015518857A5 JP2015518857A5 JP2015513338A JP2015513338A JP2015518857A5 JP 2015518857 A5 JP2015518857 A5 JP 2015518857A5 JP 2015513338 A JP2015513338 A JP 2015513338A JP 2015513338 A JP2015513338 A JP 2015513338A JP 2015518857 A5 JP2015518857 A5 JP 2015518857A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- amino acid
- antigen
- domain
- binding fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 47
- 108090001005 Interleukin-6 Proteins 0.000 claims description 38
- 102000004889 Interleukin-6 Human genes 0.000 claims description 38
- 239000000427 antigen Substances 0.000 claims description 34
- 102000036639 antigens Human genes 0.000 claims description 34
- 108091007433 antigens Proteins 0.000 claims description 34
- 239000012634 fragment Substances 0.000 claims description 33
- 235000001014 amino acid Nutrition 0.000 claims description 15
- 239000011800 void material Substances 0.000 claims description 10
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims description 5
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims description 5
- 125000000539 amino acid group Chemical group 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 5
- 239000013604 expression vector Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 238000003259 recombinant expression Methods 0.000 claims description 5
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 4
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
- 241000282567 Macaca fascicularis Species 0.000 claims description 2
- 101100286715 Macaca fascicularis IL6 gene Proteins 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- 230000009824 affinity maturation Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 235000013922 glutamic acid Nutrition 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 2
- 102000052611 human IL6 Human genes 0.000 claims description 2
- 210000004408 hybridoma Anatomy 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 2
- 230000010474 transient expression Effects 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 2
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 claims 2
- 235000017274 Diospyros sandwicensis Nutrition 0.000 claims 1
- 101100029932 Drosophila melanogaster lama gene Proteins 0.000 claims 1
- 241000282838 Lama Species 0.000 claims 1
- 101100127662 Mus musculus Lama1 gene Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 241000282842 Lama glama Species 0.000 description 3
- 210000004602 germ cell Anatomy 0.000 description 2
- 235000002198 Annona diversifolia Nutrition 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650883P | 2012-05-23 | 2012-05-23 | |
| US61/650,883 | 2012-05-23 | ||
| US201261720102P | 2012-10-30 | 2012-10-30 | |
| US61/720,102 | 2012-10-30 | ||
| PCT/IB2012/056424 WO2013175276A1 (en) | 2012-05-23 | 2012-11-14 | Il-6 binding molecules |
| IBPCT/IB2012/056424 | 2012-11-14 | ||
| PCT/IB2013/054271 WO2013175427A1 (en) | 2012-05-23 | 2013-05-23 | Il-6 binding molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518857A JP2015518857A (ja) | 2015-07-06 |
| JP2015518857A5 true JP2015518857A5 (https=) | 2016-07-07 |
| JP6410712B2 JP6410712B2 (ja) | 2018-10-24 |
Family
ID=47559582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015513338A Active JP6410712B2 (ja) | 2012-05-23 | 2013-05-23 | Ｉｌ−６結合分子 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10183995B2 (https=) |
| EP (1) | EP2852616A1 (https=) |
| JP (1) | JP6410712B2 (https=) |
| KR (1) | KR20150063311A (https=) |
| CN (1) | CN103601806B (https=) |
| AU (1) | AU2013264779B2 (https=) |
| BR (1) | BR112014029219B1 (https=) |
| CA (1) | CA2871148C (https=) |
| CL (1) | CL2014003167A1 (https=) |
| CO (1) | CO7240362A2 (https=) |
| EC (1) | ECSP14029713A (https=) |
| IL (1) | IL235134B (https=) |
| MX (1) | MX360163B (https=) |
| NZ (1) | NZ701370A (https=) |
| PE (1) | PE20150335A1 (https=) |
| RU (1) | RU2676078C2 (https=) |
| WO (2) | WO2013175276A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2991637C (en) | 2015-07-31 | 2022-07-05 | Medimmune Limited | Methods for treating hepcidin-mediated disorders |
| CN105194655A (zh) * | 2015-10-21 | 2015-12-30 | 胶州市人民中医医院 | 一种新生儿细菌感染性脑炎的治疗方法 |
| GB201611123D0 (en) * | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
| KR20200012823A (ko) | 2017-02-01 | 2020-02-05 | 예일 유니버시티 | 이뇨제 내성의 치료 |
| EP3735421A4 (en) | 2018-01-05 | 2021-09-22 | Corvidia Therapeutics, Inc. | METHOD OF TREATMENT OF IL-6 MEDIATED INFLAMMATION WITHOUT IMMUNSUPPRESSION |
| US12594286B2 (en) | 2018-07-02 | 2026-04-07 | Ayuvis Research, Inc. | Immunodulating small molecules |
| CN111153998B (zh) * | 2020-01-16 | 2022-06-24 | 佛山汉腾生物科技有限公司 | 抗ctla-4纳米抗体及其应用 |
| CN115443147A (zh) * | 2020-04-23 | 2022-12-06 | 伊莱利利公司 | 抗体的皮下吸收和生物利用度 |
| CN113150140B (zh) * | 2021-01-25 | 2022-11-04 | 山西农业大学 | 一种sox6二价纳米抗体及其应用 |
| EP4531867A1 (en) * | 2022-05-25 | 2025-04-09 | Ayuvis Research, Inc. | Novel immunodulating small molecules |
| CN117186222A (zh) * | 2022-05-31 | 2023-12-08 | 北京天广实生物技术股份有限公司 | Pd-l1结合分子及其用途 |
| CN119331091B (zh) * | 2024-11-06 | 2025-05-13 | 重庆探生科技有限公司 | 一种抗人白介素6的单克隆抗体及其应用 |
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-
2012
- 2012-11-14 WO PCT/IB2012/056424 patent/WO2013175276A1/en not_active Ceased
-
2013
- 2013-05-23 BR BR112014029219-1A patent/BR112014029219B1/pt active IP Right Grant
- 2013-05-23 JP JP2015513338A patent/JP6410712B2/ja active Active
- 2013-05-23 WO PCT/IB2013/054271 patent/WO2013175427A1/en not_active Ceased
- 2013-05-23 MX MX2014014218A patent/MX360163B/es active IP Right Grant
- 2013-05-23 CN CN201310193693.6A patent/CN103601806B/zh active Active
- 2013-05-23 US US14/403,135 patent/US10183995B2/en active Active
- 2013-05-23 KR KR1020147031922A patent/KR20150063311A/ko not_active Ceased
- 2013-05-23 CA CA2871148A patent/CA2871148C/en active Active
- 2013-05-23 PE PE2014001913A patent/PE20150335A1/es not_active Application Discontinuation
- 2013-05-23 AU AU2013264779A patent/AU2013264779B2/en active Active
- 2013-05-23 RU RU2014152006A patent/RU2676078C2/ru active
- 2013-05-23 NZ NZ701370A patent/NZ701370A/en unknown
- 2013-05-23 EP EP13734185.5A patent/EP2852616A1/en not_active Withdrawn
-
2014
- 2014-10-19 IL IL235134A patent/IL235134B/en active IP Right Grant
- 2014-11-21 CL CL2014003167A patent/CL2014003167A1/es unknown
- 2014-11-24 CO CO14258229A patent/CO7240362A2/es unknown
- 2014-12-03 EC ECIEPI201429713A patent/ECSP14029713A/es unknown
-
2019
- 2019-01-03 US US16/239,321 patent/US11117959B2/en active Active
-
2021
- 2021-08-10 US US17/398,080 patent/US11827701B2/en active Active
-
2023
- 2023-10-23 US US18/492,526 patent/US20240158492A1/en active Pending
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