CN103601806B - Il-6结合分子 - Google Patents

Il-6结合分子 Download PDF

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Publication number
CN103601806B
CN103601806B CN201310193693.6A CN201310193693A CN103601806B CN 103601806 B CN103601806 B CN 103601806B CN 201310193693 A CN201310193693 A CN 201310193693A CN 103601806 B CN103601806 B CN 103601806B
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seq
amino acid
domain
antibody
acid sequence
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Chinese (zh)
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CN103601806A (zh
Inventor
C.布兰切托特
J.德哈德
T.德赖尔
N.A.德琼格
S.P.范德沃宁
N.G.H.翁奇内
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Yagenkes Co ltd
Yagenks Corp
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Yagn -X Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201310193693.6A 2012-05-23 2013-05-23 Il-6结合分子 Active CN103601806B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261650883P 2012-05-23 2012-05-23
US61/650,883 2012-05-23
US201261720102P 2012-10-30 2012-10-30
US61/720,102 2012-10-30
PCT/IB2012/056424 WO2013175276A1 (en) 2012-05-23 2012-11-14 Il-6 binding molecules
IBPCT/IB2012/056424 2012-11-14

Publications (2)

Publication Number Publication Date
CN103601806A CN103601806A (zh) 2014-02-26
CN103601806B true CN103601806B (zh) 2019-01-18

Family

ID=47559582

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310193693.6A Active CN103601806B (zh) 2012-05-23 2013-05-23 Il-6结合分子

Country Status (17)

Country Link
US (4) US10183995B2 (https=)
EP (1) EP2852616A1 (https=)
JP (1) JP6410712B2 (https=)
KR (1) KR20150063311A (https=)
CN (1) CN103601806B (https=)
AU (1) AU2013264779B2 (https=)
BR (1) BR112014029219B1 (https=)
CA (1) CA2871148C (https=)
CL (1) CL2014003167A1 (https=)
CO (1) CO7240362A2 (https=)
EC (1) ECSP14029713A (https=)
IL (1) IL235134B (https=)
MX (1) MX360163B (https=)
NZ (1) NZ701370A (https=)
PE (1) PE20150335A1 (https=)
RU (1) RU2676078C2 (https=)
WO (2) WO2013175276A1 (https=)

Families Citing this family (12)

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CN108026582A (zh) 2015-07-31 2018-05-11 米迪缪尼有限公司 用于治疗海帕西啶介导的病症的方法
CN105194655A (zh) * 2015-10-21 2015-12-30 胶州市人民中医医院 一种新生儿细菌感染性脑炎的治疗方法
GB201611123D0 (en) * 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
KR20200012823A (ko) 2017-02-01 2020-02-05 예일 유니버시티 이뇨제 내성의 치료
CA3087699A1 (en) 2018-01-05 2019-07-11 Corvidia Therapeutics, Inc. Methods for treating il-6 mediated inflammation without immunosuppression
US12594286B2 (en) 2018-07-02 2026-04-07 Ayuvis Research, Inc. Immunodulating small molecules
CN111153998B (zh) * 2020-01-16 2022-06-24 佛山汉腾生物科技有限公司 抗ctla-4纳米抗体及其应用
US20230236199A1 (en) * 2020-04-23 2023-07-27 Eli Lilly And Company Subcutaneous absorption and bioavailability of antibodies
CN113150140B (zh) * 2021-01-25 2022-11-04 山西农业大学 一种sox6二价纳米抗体及其应用
CA3257177A1 (en) * 2022-05-25 2023-11-30 Ayuvis Research, Inc. NEW SMALL IMMUNOMOLATORY MOLECULES
CN117186222A (zh) * 2022-05-31 2023-12-08 北京天广实生物技术股份有限公司 Pd-l1结合分子及其用途
CN119331091B (zh) * 2024-11-06 2025-05-13 重庆探生科技有限公司 一种抗人白介素6的单克隆抗体及其应用

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CA2871148A1 (en) 2013-11-28
US20240158492A1 (en) 2024-05-16
WO2013175276A1 (en) 2013-11-28
CN103601806A (zh) 2014-02-26
BR112014029219A8 (pt) 2019-05-14
US10183995B2 (en) 2019-01-22
MX360163B (es) 2018-10-09
CA2871148C (en) 2020-07-14
US11117959B2 (en) 2021-09-14
NZ701370A (en) 2016-11-25
JP6410712B2 (ja) 2018-10-24
CO7240362A2 (es) 2015-04-17
US20220073604A1 (en) 2022-03-10
IL235134B (en) 2019-12-31
KR20150063311A (ko) 2015-06-09
US20190233509A1 (en) 2019-08-01
AU2013264779A1 (en) 2014-10-30
RU2014152006A (ru) 2016-07-20
EP2852616A1 (en) 2015-04-01
WO2013175427A1 (en) 2013-11-28
US11827701B2 (en) 2023-11-28
IL235134A0 (en) 2014-12-31
BR112014029219B1 (pt) 2022-04-19
PE20150335A1 (es) 2015-03-20
CL2014003167A1 (es) 2015-06-12
US20150140011A1 (en) 2015-05-21
BR112014029219A2 (https=) 2017-08-15
ECSP14029713A (es) 2015-09-30
RU2676078C2 (ru) 2018-12-26
MX2014014218A (es) 2015-11-23
AU2013264779B2 (en) 2018-03-22
JP2015518857A (ja) 2015-07-06

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