JP2009525764A5 - - Google Patents
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- Publication number
- JP2009525764A5 JP2009525764A5 JP2008554523A JP2008554523A JP2009525764A5 JP 2009525764 A5 JP2009525764 A5 JP 2009525764A5 JP 2008554523 A JP2008554523 A JP 2008554523A JP 2008554523 A JP2008554523 A JP 2008554523A JP 2009525764 A5 JP2009525764 A5 JP 2009525764A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- composition
- cancer
- fgf19
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77231006P | 2006-02-10 | 2006-02-10 | |
| US60/772,310 | 2006-02-10 | ||
| US78060806P | 2006-03-09 | 2006-03-09 | |
| US60/780,608 | 2006-03-09 | ||
| US88586607P | 2007-01-19 | 2007-01-19 | |
| US60/885,866 | 2007-01-19 | ||
| PCT/US2007/061936 WO2007136893A2 (en) | 2006-02-10 | 2007-02-09 | Anti-fgf19 antibodies and methods using same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009525764A JP2009525764A (ja) | 2009-07-16 |
| JP2009525764A5 true JP2009525764A5 (https=) | 2010-03-18 |
| JP5209505B2 JP5209505B2 (ja) | 2013-06-12 |
Family
ID=38723925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554523A Expired - Fee Related JP5209505B2 (ja) | 2006-02-10 | 2007-02-09 | 抗fgf19抗体およびその使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US7678373B2 (https=) |
| EP (1) | EP1989230B1 (https=) |
| JP (1) | JP5209505B2 (https=) |
| AR (1) | AR059432A1 (https=) |
| AU (1) | AU2007254005B2 (https=) |
| CA (1) | CA2637988A1 (https=) |
| ES (1) | ES2582652T3 (https=) |
| NZ (1) | NZ569957A (https=) |
| TW (1) | TWI388568B (https=) |
| WO (1) | WO2007136893A2 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| EP1910542B1 (en) | 2005-07-22 | 2009-12-02 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with fgfr fusion proteins |
| EP1989230B1 (en) | 2006-02-10 | 2016-06-01 | Genentech, Inc. | Anti-fgf19 antibodies and methods using same |
| US20100267145A1 (en) * | 2006-06-05 | 2010-10-21 | Hiroshima University | Immunocompetent cell having anti-cd38 antibody on its cell surface |
| EP1918376A1 (en) * | 2006-11-03 | 2008-05-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs |
| SI2550972T1 (en) * | 2007-04-02 | 2018-05-31 | Genentech, Inc. | A Klotho-beta agonist antibody for use in the treatment of diabetes mellitus or insulin resistance |
| NZ582619A (en) | 2007-08-03 | 2012-08-31 | Genentech Inc | Humanized anti-fgf19 antagonists and methods using same |
| US20090309617A1 (en) * | 2007-08-24 | 2009-12-17 | Ye Fang | Biosensor antibody functional mapping |
| US20090226459A1 (en) * | 2008-01-29 | 2009-09-10 | Cold Spring Harbor Laboratory | Role of fgf-19 in cancer diagnosis and treatment |
| CN102056939A (zh) * | 2008-04-30 | 2011-05-11 | 温特研究公司 | 雌激素受体-α的活性的恢复 |
| WO2010008726A1 (en) | 2008-06-16 | 2010-01-21 | Immunogen Inc. | Novel synergistic effects |
| FR2933702A1 (fr) * | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Antagonistes specifiques du recepteur fgf-r4 |
| WO2010006214A1 (en) * | 2008-07-09 | 2010-01-14 | Ambrx, Inc. | Fgf-21 neutralizing antibodies and their uses |
| CN102171343B (zh) | 2008-08-04 | 2017-07-14 | 戊瑞治疗有限公司 | Fgfr细胞外结构域酸性区突变蛋白 |
| US20100092470A1 (en) * | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
| US20100136584A1 (en) * | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
| WO2011034940A1 (en) | 2009-09-15 | 2011-03-24 | Five Prime Therapeutics, Inc. | Hair growth methods using fgfr4 extracellular domains |
| MX368790B (es) * | 2009-10-15 | 2019-10-16 | Genentech Inc | Factores de crecimiento de fibroblasto quimericos con especificidad de receptor alterada. |
| AU2010319327B2 (en) | 2009-11-13 | 2015-08-13 | Five Prime Therapeutics, Inc. | Use of FGFR1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in FGFR2 |
| EP2507381A4 (en) * | 2009-12-04 | 2016-07-20 | Hoffmann La Roche | MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS AND METHODS |
| EP2512501A4 (en) | 2009-12-17 | 2014-01-01 | Five Prime Therapeutics Inc | METHODS FOR PROMOTING HAIR GROWTH USING FGFR3 EXTRACELLULAR DOMAINS |
| JP4881428B2 (ja) * | 2009-12-25 | 2012-02-22 | 株式会社東芝 | 電子機器 |
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| US8951972B2 (en) | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
| KR20190107761A (ko) | 2011-03-09 | 2019-09-20 | 셀 시그널링 테크놀러지, 인크. | 모노클로날 항체를 생성하는 방법 및 시약 |
| WO2012177481A2 (en) * | 2011-06-24 | 2012-12-27 | University Of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| JP2015505818A (ja) | 2011-11-14 | 2015-02-26 | ファイブ プライム セラピューティックス インコーポレイテッド | 癌を治療する方法 |
| US10112987B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide |
| US10112988B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide |
| US20130183294A1 (en) * | 2012-01-18 | 2013-07-18 | Genentech, Inc. | Methods of using fgf19 modulators |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| LT3495387T (lt) | 2012-07-13 | 2021-11-25 | Roche Glycart Ag | Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti |
| WO2014075788A1 (en) | 2012-11-13 | 2014-05-22 | Biontech Ag | Agents for treatment of claudin expressing cancer diseases |
| CN105683188B (zh) | 2013-10-25 | 2018-02-09 | 诺华股份有限公司 | 作为fgfr4抑制剂的稠环二环吡啶基衍生物 |
| WO2015092021A1 (en) * | 2013-12-20 | 2015-06-25 | Spingotec Therapeutics Gmbh | Adrenomedullin binder for use in therapy of cancer |
| TWI728373B (zh) | 2013-12-23 | 2021-05-21 | 美商建南德克公司 | 抗體及使用方法 |
| JP6585167B2 (ja) | 2014-10-03 | 2019-10-02 | ノバルティス アーゲー | Fgfr4阻害剤としての縮環二環式ピリジル誘導体の使用 |
| CN114129709A (zh) * | 2014-10-23 | 2022-03-04 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
| RU2017134379A (ru) | 2015-03-25 | 2019-04-03 | Новартис Аг | Формилированные n-гетероциклические производные в качестве ингибиторов fgfr4 |
| ES2972458T3 (es) * | 2016-02-10 | 2024-06-12 | Bioinvent Int Ab | Combinación de anticuerpo humano anti-FGFR4 y sorafenib |
| EP3453392B1 (en) * | 2016-05-17 | 2025-10-22 | Japanese Foundation For Cancer Research | Therapeutic agent for lung cancer that has acquired egfr-tki resistance |
| WO2018055503A1 (en) | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
| SG11201903911UA (en) | 2016-11-02 | 2019-05-30 | Novartis Ag | Combinations of fgfr4 inhibitors and bile acid sequestrants |
| US20190218285A1 (en) * | 2018-01-18 | 2019-07-18 | Molecular Cloning Laboratories (MCLAB) LLC | Long-Acting Therapeutic Fusion Proteins |
| CN109251983B (zh) * | 2018-08-15 | 2022-03-25 | 深圳市罗湖区人民医院 | Frs2基因的拷贝数扩增及其应用、检测拷贝数扩增的特异性引物对 |
| EP3873519A1 (en) | 2018-10-29 | 2021-09-08 | F. Hoffmann-La Roche AG | Antibody formulation |
| JP7643727B2 (ja) * | 2019-02-02 | 2025-03-11 | 華輝安健(北京)生物科技有限公司 | 抗-fgf19抗体 |
| FI3865155T3 (fi) * | 2020-02-13 | 2023-01-13 | Menetelmä vasta-aineen kohdespesifiseksi modifioimiseksi | |
| CN116726005B (zh) * | 2022-03-03 | 2026-02-13 | 上海市第六人民医院 | 一种治疗运动损伤的药物及筛选方法和应用 |
| JP2025517398A (ja) | 2022-05-19 | 2025-06-05 | タイラ・バイオサイエンシーズ・インコーポレイテッド | Pparアゴニスト及びfgfr4阻害剤による治療 |
| EP4509142A1 (en) | 2023-08-16 | 2025-02-19 | Ona Therapeutics S.L. | Fgfr4 as target in cancer treatment |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US20020042367A1 (en) | 1997-11-25 | 2002-04-11 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
| US20020012961A1 (en) | 1999-04-15 | 2002-01-31 | Genentech, Inc. | Fibroblast growth factor- 19 |
| EP1032668B1 (en) | 1997-11-25 | 2008-05-28 | Genentech, Inc. | Fibroblast growth factor-19 |
| US20050026832A1 (en) | 1997-11-25 | 2005-02-03 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
| US20020155543A1 (en) | 1997-11-25 | 2002-10-24 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
| US20040126852A1 (en) | 1997-11-25 | 2004-07-01 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| CN1560249A (zh) | 1999-09-08 | 2005-01-05 | 杰南技术公司 | 成纤维细胞生长因子-19(fgf-19)的核酸和多肽以及用于治疗肥胖的方法 |
| US7348162B2 (en) | 2000-03-22 | 2008-03-25 | Amgen Inc. | Nucleic acids encoding fibroblast growth factor receptor-like proteins and uses thereof |
| US20030143539A1 (en) | 2000-12-08 | 2003-07-31 | Francois Bertucci | Gene expression profiling of primary breast carcinomas using arrays of candidate genes |
| CA2459219A1 (en) | 2001-09-17 | 2003-03-27 | Protein Design Labs, Inc. | Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer |
| US20030157082A1 (en) | 2002-01-31 | 2003-08-21 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer using 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480,20893, 33230,1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 or 66428 molecules |
| MXPA04012243A (es) | 2002-06-07 | 2005-02-25 | Genentech Inc | Composiciones y metodos para l diagnostico y tratamiento de tumores. |
| US20050198642A1 (en) * | 2004-03-04 | 2005-09-08 | International Business Machines Corporation | Mechanism for assigning home nodes to newly created threads |
| US7837626B2 (en) * | 2005-08-05 | 2010-11-23 | Siemens Medical Solutions Usa, Inc. | Contrast agent manipulation with medical ultrasound imaging |
| EP1989230B1 (en) * | 2006-02-10 | 2016-06-01 | Genentech, Inc. | Anti-fgf19 antibodies and methods using same |
-
2007
- 2007-02-09 EP EP07797128.1A patent/EP1989230B1/en active Active
- 2007-02-09 NZ NZ569957A patent/NZ569957A/en not_active IP Right Cessation
- 2007-02-09 TW TW096104900A patent/TWI388568B/zh not_active IP Right Cessation
- 2007-02-09 AU AU2007254005A patent/AU2007254005B2/en not_active Ceased
- 2007-02-09 AR ARP070100563A patent/AR059432A1/es not_active Application Discontinuation
- 2007-02-09 CA CA002637988A patent/CA2637988A1/en not_active Abandoned
- 2007-02-09 ES ES07797128.1T patent/ES2582652T3/es active Active
- 2007-02-09 JP JP2008554523A patent/JP5209505B2/ja not_active Expired - Fee Related
- 2007-02-09 US US11/673,411 patent/US7678373B2/en not_active Expired - Fee Related
- 2007-02-09 WO PCT/US2007/061936 patent/WO2007136893A2/en not_active Ceased
-
2010
- 2010-01-22 US US12/692,468 patent/US7846691B2/en not_active Expired - Fee Related
- 2010-10-27 US US12/913,660 patent/US8241633B2/en not_active Expired - Fee Related
-
2011
- 2011-12-08 US US13/315,220 patent/US8293241B2/en not_active Expired - Fee Related
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