JP2005530484A5 - - Google Patents
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- Publication number
- JP2005530484A5 JP2005530484A5 JP2003565508A JP2003565508A JP2005530484A5 JP 2005530484 A5 JP2005530484 A5 JP 2005530484A5 JP 2003565508 A JP2003565508 A JP 2003565508A JP 2003565508 A JP2003565508 A JP 2003565508A JP 2005530484 A5 JP2005530484 A5 JP 2005530484A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- angiogenesis
- albumin fusion
- albumin
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000009027 Albumins Human genes 0.000 claims 75
- 108010088751 Albumins Proteins 0.000 claims 75
- 108020001507 fusion proteins Proteins 0.000 claims 57
- 102000037865 fusion proteins Human genes 0.000 claims 57
- 230000033115 angiogenesis Effects 0.000 claims 45
- 239000012634 fragment Substances 0.000 claims 41
- 108090000765 processed proteins & peptides Proteins 0.000 claims 39
- 230000002401 inhibitory effect Effects 0.000 claims 28
- 238000000034 method Methods 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 16
- 241000124008 Mammalia Species 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 230000001419 dependent effect Effects 0.000 claims 11
- 238000001727 in vivo Methods 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 230000004927 fusion Effects 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 4
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 4
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 4
- 230000001772 anti-angiogenic effect Effects 0.000 claims 4
- 230000004071 biological effect Effects 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 230000002950 deficient Effects 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 206010000050 Abdominal adhesions Diseases 0.000 claims 1
- 102400000068 Angiostatin Human genes 0.000 claims 1
- 108010079709 Angiostatins Proteins 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000003732 Cat-scratch disease Diseases 0.000 claims 1
- 102400001047 Endostatin Human genes 0.000 claims 1
- 108010079505 Endostatins Proteins 0.000 claims 1
- 241000590002 Helicobacter pylori Species 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 206010043189 Telangiectasia Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 230000003527 anti-angiogenesis Effects 0.000 claims 1
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 claims 1
- 230000002380 cytological effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 206010016629 fibroma Diseases 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 229940037467 helicobacter pylori Drugs 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000023597 hemostasis Effects 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 claims 1
- 230000002390 hyperplastic effect Effects 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000005457 optimization Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 208000009056 telangiectasis Diseases 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35554702P | 2002-02-07 | 2002-02-07 | |
| PCT/IB2003/000433 WO2003066085A1 (en) | 2002-02-07 | 2003-02-07 | Albumin-fused anti-angiogenesis peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530484A JP2005530484A (ja) | 2005-10-13 |
| JP2005530484A5 true JP2005530484A5 (https=) | 2005-12-22 |
Family
ID=27734531
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003566175A Pending JP2005538932A (ja) | 2002-02-07 | 2003-02-07 | アルブミン融合クニッツドメインペプチド |
| JP2003565501A Pending JP2005516607A (ja) | 2002-02-07 | 2003-02-07 | Ｈｉｖ阻害タンパク質 |
| JP2003565508A Pending JP2005530484A (ja) | 2002-02-07 | 2003-02-07 | アルブミン融合抗血管形成ペプチド |
| JP2009239593A Pending JP2010046076A (ja) | 2002-02-07 | 2009-10-16 | アルブミン融合クニッツドメインペプチド |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003566175A Pending JP2005538932A (ja) | 2002-02-07 | 2003-02-07 | アルブミン融合クニッツドメインペプチド |
| JP2003565501A Pending JP2005516607A (ja) | 2002-02-07 | 2003-02-07 | Ｈｉｖ阻害タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009239593A Pending JP2010046076A (ja) | 2002-02-07 | 2009-10-16 | アルブミン融合クニッツドメインペプチド |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20060122374A1 (https=) |
| EP (4) | EP1471928A1 (https=) |
| JP (4) | JP2005538932A (https=) |
| KR (4) | KR20040089608A (https=) |
| CN (3) | CN1642567A (https=) |
| AU (5) | AU2003244515A1 (https=) |
| CA (3) | CA2485064A1 (https=) |
| NZ (3) | NZ534492A (https=) |
| WO (3) | WO2003066824A2 (https=) |
| ZA (3) | ZA200406124B (https=) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| ATE277081T1 (de) | 1994-01-11 | 2004-10-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| WO2005003296A2 (en) * | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| ES2348230T3 (es) * | 2002-06-07 | 2010-12-01 | Dyax Corp. | Prevención y reducción de la isquemia. |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| GB0217033D0 (en) * | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| EP2386310B1 (en) * | 2002-08-28 | 2018-11-07 | Dyax Corp. | Methods for preserving organs and tissues |
| WO2004056852A2 (en) | 2002-12-19 | 2004-07-08 | Nektar Therapeutics Al, Corp. | Cyanovirin variant-polymer conjugates |
| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| US7524811B2 (en) * | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
| DE602004015142D1 (de) * | 2003-08-29 | 2008-08-28 | Childrens Medical Center | Antiangiogene peptide zur behandlung oder vorbeugung von endometriose |
| GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
| GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
| US9057061B2 (en) | 2003-12-23 | 2015-06-16 | Novozymes Biopharma Dk A/S | Gene expression technique |
| WO2006067511A1 (en) | 2004-12-23 | 2006-06-29 | Novozymes Delta Limited | Gene expression technique |
| WO2005063282A1 (en) * | 2003-12-23 | 2005-07-14 | Centocor, Inc. | Anti-retroviral agents, compositions, methods and uses |
| TW200607523A (en) | 2004-06-01 | 2006-03-01 | Domantis Ltd | Drug compositions, fusions and conjugates |
| AU2011218732B2 (en) * | 2004-09-27 | 2013-07-04 | Takeda Pharmaceutical Company Limited | Kallikrein Inhibitors and Uses Thereof |
| US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| ES2325344B1 (es) * | 2004-11-02 | 2010-06-09 | Univ Madrid Autonoma | Inhibidores de angiogenesis multifuncionales y multivalentes. |
| EP1835926A4 (en) * | 2004-11-22 | 2009-04-01 | Dyax Corp | PLASMINE-INHIBITING THERAPIES |
| PL1981519T3 (pl) * | 2005-12-29 | 2018-07-31 | Dyax Corp. | Hamowanie proteaz |
| CN100475270C (zh) * | 2006-01-20 | 2009-04-08 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
| EP1816201A1 (en) * | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| WO2007104541A2 (en) | 2006-03-16 | 2007-09-20 | Dyax Corp. | Compositions and methods using serine protease inhibiting peptides for treating ophthalmic disorders |
| EP2450368A1 (en) | 2007-01-30 | 2012-05-09 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
| CL2008002092A1 (es) * | 2007-07-20 | 2009-05-29 | Hoffmann La Roche | Conjugado que contiene dos o mas peptidos antifusogenicos y un anticuerpo anti-cd-4; metodo de produccion; composicion farmaceutica que lo comprende; polipeptidos antifusogenicos y uso del conjugado para tratar infecciones viricas. |
| WO2009019314A1 (en) | 2007-08-08 | 2009-02-12 | Novozymes A/S | Transferrin variants and conjugates |
| WO2009026539A1 (en) * | 2007-08-23 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| US9025330B2 (en) | 2007-09-30 | 2015-05-05 | Alcatel Lucent | Recirculating gas rack cooling architecture |
| EP2353010B1 (en) | 2008-10-28 | 2015-07-08 | Uladzimir A. Murauski | Methods for detection of toxemia |
| US8637454B2 (en) | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| KR101722961B1 (ko) | 2009-02-11 | 2017-04-04 | 알부메딕스 에이/에스 | 알부민 변이체 및 접합체 |
| DK2427486T3 (en) | 2009-05-07 | 2015-05-26 | Novozymes Biopharma Dk As | A process for purifying albumin |
| EP2493921B1 (en) | 2009-10-30 | 2018-09-26 | Albumedix Ltd | Albumin variants |
| SMT201800552T1 (it) | 2010-01-06 | 2018-11-09 | Dyax Corp | Proteine che legano la callicreina plasmatica |
| CN101875693B (zh) * | 2010-01-22 | 2012-07-18 | 成都正能生物技术有限责任公司 | 具备抗血管生成活性的白蛋白变异体及其制备方法 |
| EP2556087A1 (en) * | 2010-04-09 | 2013-02-13 | Novozymes Biopharma DK A/S | Albumin derivatives and variants |
| MX2013002556A (es) * | 2010-09-14 | 2013-05-28 | Hoffmann La Roche | Polipeptido de fusion de dedo de serpina. |
| CN102453097A (zh) * | 2010-10-27 | 2012-05-16 | 上海科新生物技术股份有限公司 | 抑制血管新生的融合蛋白vf及药物组合物和应用 |
| US20130225496A1 (en) | 2010-11-01 | 2013-08-29 | Novozymes Biopharma Dk A/S | Albumin Variants |
| KR102320178B1 (ko) | 2011-01-06 | 2021-11-02 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
| CA2830660A1 (en) | 2011-05-05 | 2012-11-08 | Novozymes Biopharma Dk A/S | Albumin variants |
| CN110105453A (zh) * | 2011-08-17 | 2019-08-09 | 科罗拉多大学董事会法人团体 | 运铁蛋白-肿瘤抑素融合蛋白质及其生成和使用方法 |
| CN102532326B (zh) * | 2011-11-18 | 2017-06-09 | 南京大学 | 一种肿瘤靶向的人纤溶酶原Kringle5变体及其应用 |
| EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
| US9528992B2 (en) | 2012-02-20 | 2016-12-27 | Uladzimir A. Murauski | Methods and kits for detection of active malignancy |
| DK2825556T3 (en) | 2012-03-16 | 2018-04-16 | Albumedix As | albumin Variants |
| EP2890389A1 (en) * | 2012-08-28 | 2015-07-08 | Novartis AG | Use of a vegf antagonist in treating ocular vascular proliferative diseases |
| MX2015005363A (es) | 2012-11-08 | 2015-11-06 | Novozymes Biopharma Dk As | Variantes de albumina. |
| US10690670B2 (en) | 2013-01-20 | 2020-06-23 | Dyax Corp. | Assays for determining levels of plasma protease C1 inhibitor |
| US20160033523A1 (en) | 2013-02-16 | 2016-02-04 | Novozymes Biopharma Dk A/S | Pharmacokinetic animal model |
| WO2014182684A2 (en) * | 2013-05-06 | 2014-11-13 | Cell Machines, Inc. | Methods and compositions related to large scale production of proteins |
| CN103333255A (zh) * | 2013-06-28 | 2013-10-02 | 复旦大学 | 一种长效hiv‐1膜融合抑制剂 |
| US10428158B2 (en) | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| DE102014112212A1 (de) | 2014-08-26 | 2016-03-03 | Akesion Gmbh | Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen |
| CN105440138A (zh) * | 2014-09-30 | 2016-03-30 | 复旦大学 | 一种长效内皮抑素融合蛋白的制备方法和用途 |
| WO2016196233A1 (en) * | 2015-05-30 | 2016-12-08 | Genomatica, Inc. | Vinylisomerase-dehydratases, alkenol dehydratases, linalool dehydratases and/ crotyl alcohol dehydratases and methods for making and using them |
| CN104926946B (zh) * | 2015-07-13 | 2021-09-17 | 中国科学院广州生物医药与健康研究院 | 具有延长体内半衰期的adamts13-mdtcs融合蛋白及其应用 |
| JP7007261B2 (ja) | 2015-08-20 | 2022-01-24 | アルブミディクス リミティド | アルブミン変異体及びコンジュゲート |
| CA3183289A1 (en) | 2015-09-08 | 2017-03-16 | Jcr Pharmaceuticals Co., Ltd. | Novel human serum albumin mutant |
| CN110498851B (zh) * | 2015-11-10 | 2022-10-11 | 孙嘉琳 | 一种抗肿瘤蛋白内皮抑素的衍生物及应用 |
| EP3387018A1 (en) | 2015-12-11 | 2018-10-17 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| JP7146637B2 (ja) | 2015-12-22 | 2022-10-04 | アルブミディクス リミティド | 改善されたタンパク質発現株 |
| EP3394243A1 (en) | 2015-12-22 | 2018-10-31 | Albumedix Ltd. | Improved protein expression strains |
| CN105646717B (zh) * | 2016-01-26 | 2020-06-09 | 复旦大学 | 一种长效hiv融合抑制剂及其应用 |
| US11130979B2 (en) | 2017-06-20 | 2021-09-28 | Albumedix Ltd | Protein expression strains |
| WO2019032472A1 (en) * | 2017-08-08 | 2019-02-14 | The Board Of Trustees Of The Leland Stanford Junior University | HIGH AFFINITY MODIFIED MATRIX INHIBITOR |
| SG11202001595SA (en) * | 2017-08-31 | 2020-03-30 | Singapore Health Serv Pte Ltd | Angio-3 for treatment of retinal angiogenic diseases |
| JP7799945B2 (ja) | 2017-09-22 | 2026-01-16 | サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック | 変異型ウイルスタンパク質 |
| WO2019060695A1 (en) * | 2017-09-22 | 2019-03-28 | Kite Pharma, Inc. | CHIMERIC POLYPEPTIDES AND USES THEREOF |
| CN109879969B (zh) * | 2017-12-06 | 2024-04-09 | 天士力生物医药股份有限公司 | 一种hm-3融合蛋白及其应用 |
| CA3117961A1 (en) | 2018-10-29 | 2020-05-07 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
| DE102019000490A1 (de) * | 2019-01-23 | 2020-07-23 | HAEMES Verwaltungsgesellschaft mbH | Verwendung von Oligonukleotiden für die Behandlung von Tumoren |
| WO2020214638A1 (en) | 2019-04-16 | 2020-10-22 | Dyax Corp. | Methods for quantitation of functional c1 esterase inhibitor (fc1-inh) |
| CN111995686B (zh) * | 2019-05-27 | 2022-06-14 | 兰州大学 | 一种具有抗血管生成活性的药物及其制备方法 |
| EP4090427A1 (en) | 2020-01-13 | 2022-11-23 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
| CN111494604B (zh) * | 2020-05-11 | 2022-05-06 | 中国药科大学 | 蓝藻抗病毒蛋白n在制备抗炎药物中的应用 |
| CN111560049B (zh) * | 2020-05-17 | 2022-05-17 | 浙江大学 | 两性离子多肽及其衍生物以及以其为基础的纳米药物 |
| WO2022007885A1 (zh) * | 2020-07-08 | 2022-01-13 | 南京师范大学 | 融合多肽和多肽二聚体及其用途 |
| US20250179209A1 (en) * | 2022-03-09 | 2025-06-05 | Immunofyx | Anti-cancer n-terminal fc conjugated immunotherapeutics |
| AU2024247601A1 (en) * | 2023-03-28 | 2025-10-23 | Nb Health Laboratory Co., Ltd. | Antibody, nucleic acid, cell and drug |
| EP4442251A1 (en) | 2023-04-05 | 2024-10-09 | Albumedix Ltd | Formulations and uses thereof |
| AU2024353718A1 (en) | 2023-09-25 | 2026-04-09 | Kelonia Therapeutics, Inc. | Compositions for treating cancer |
| CN117924430B (zh) * | 2024-03-22 | 2024-06-28 | 中国人民解放军军事科学院军事医学研究院 | 促进血小板生成的tpor结合肽 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US355547A (en) | 1887-01-04 | mebcee | ||
| CA91311A (en) | 1904-11-15 | 1905-01-31 | The Canadian Westinghouse Company, Limited | Single phase alternating current motors |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| EP0216846B2 (en) | 1985-04-01 | 1995-04-26 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| GB8510219D0 (en) | 1985-04-22 | 1985-05-30 | Bass Plc | Isolation of fermentation products |
| JPS6296086A (ja) | 1985-10-21 | 1987-05-02 | Agency Of Ind Science & Technol | 複合プラスミド |
| US5576195A (en) | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| GB8615701D0 (en) | 1986-06-27 | 1986-08-06 | Delta Biotechnology Ltd | Stable gene integration vector |
| US4857467A (en) | 1986-07-23 | 1989-08-15 | Phillips Petroleum Company | Carbon and energy source markers for transformation of strains of the genes Pichia |
| GB8620926D0 (en) | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
| JP2873012B2 (ja) | 1987-04-09 | 1999-03-24 | デルタ バイオテクノロジー リミテッド | 酵母ベクター |
| WO1989000103A1 (en) | 1987-07-08 | 1989-01-12 | Primtec | Hold-pressure control and clamping in stacked multi-parting molding system having desynchronized injection periods |
| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| EP0387319B1 (en) | 1988-07-23 | 1996-03-06 | Delta Biotechnology Limited | Secretory leader sequences |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5766883A (en) * | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
| GB8924021D0 (en) | 1989-10-25 | 1989-12-13 | Celltech Ltd | Recombinant dna method and vectors for the use therein |
| US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US5602307A (en) | 1992-08-12 | 1997-02-11 | Baylor College Of Medicine | Non-human animal having predefined allele of a cellular adhesion gene |
| DE4244915C2 (de) | 1992-08-14 | 1998-12-03 | Widmar Prof Dr Tanner | DNA-Moleküle codierend Proteine, die an der O-Glykosylierung von Proteinen beteiligt sind |
| TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| US5489743A (en) | 1993-01-19 | 1996-02-06 | Amgen Inc. | Transgenic animal models for thrombocytopenia |
| US5464933A (en) * | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| WO1995021601A2 (en) * | 1994-01-11 | 1995-08-17 | Protein Engineering Corporation | Kallikrein-inhibiting 'kunitz domain' proteins and analogues thereof |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| ATE277081T1 (de) * | 1994-01-11 | 2004-10-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| GB9404270D0 (en) | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
| ATE355379T1 (de) * | 1994-04-26 | 2006-03-15 | Childrens Medical Center | Angiostatin und verfahren zu seiner nutzung zur vermeidung der angiogenese |
| GB9411356D0 (en) | 1994-06-07 | 1994-07-27 | Delta Biotechnology Ltd | Yeast strains |
| US5854205A (en) * | 1995-10-23 | 1998-12-29 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
| US5854221A (en) * | 1996-12-12 | 1998-12-29 | The Children's Medical Center Corporation | Endothelial cell proliferation inhibitor and method of use |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| US6797488B1 (en) * | 1997-12-08 | 2004-09-28 | Beth Israel Deaconess Medical Center | Methods of producing anti-angiogenic proteins |
| US6258782B1 (en) * | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| US20030012792A1 (en) * | 1998-05-22 | 2003-01-16 | Holaday John W. | Compositions and methods for inhibiting endothelial cell proliferation and regulating angiogenesis using cancer markers |
| US6087473A (en) | 1999-05-26 | 2000-07-11 | Zymogenetics, Inc. | Kunitz domain polypeptide and materials and methods for making it |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| US20020048571A1 (en) * | 1999-07-19 | 2002-04-25 | Jeno Gyuris | Chimeric polypeptides of serum albumin and uses related thereto |
| US20010056075A1 (en) * | 1999-07-19 | 2001-12-27 | Jeno Gyuris | Chimeric polypeptides of serum albumin and uses related thereto |
| WO2001047958A2 (en) * | 1999-12-29 | 2001-07-05 | Zymogenetics, Inc. | Kunitz domain polypeptide zkun10 |
| WO2001074980A2 (en) | 2000-04-03 | 2001-10-11 | Novozymes A/S | Enzyme tablets for cleaning improvement |
| US6946134B1 (en) * | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP2213743A1 (en) * | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1197550A3 (en) * | 2000-08-25 | 2002-11-20 | Pfizer Products Inc. | Methods and compositions for diagnosing and treating disorders involving angiogenesis |
| US20020159992A1 (en) * | 2000-09-29 | 2002-10-31 | Jack Henkin | Antiangiogenic polypeptides and methods for inhibiting angiogenesis |
| AU2002364586A1 (en) * | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| GB0329722D0 (en) * | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
| US9057061B2 (en) * | 2003-12-23 | 2015-06-16 | Novozymes Biopharma Dk A/S | Gene expression technique |
| GB0329681D0 (en) * | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
| EP2556087A1 (en) * | 2010-04-09 | 2013-02-13 | Novozymes Biopharma DK A/S | Albumin derivatives and variants |
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2003
- 2003-02-07 WO PCT/US2003/003616 patent/WO2003066824A2/en not_active Ceased
- 2003-02-07 AU AU2003244515A patent/AU2003244515A1/en not_active Abandoned
- 2003-02-07 AU AU2003210885A patent/AU2003210885B2/en not_active Ceased
- 2003-02-07 JP JP2003566175A patent/JP2005538932A/ja active Pending
- 2003-02-07 EP EP03737417A patent/EP1471928A1/en not_active Ceased
- 2003-02-07 EP EP03737416A patent/EP1471933A1/en not_active Withdrawn
- 2003-02-07 CN CNA038069687A patent/CN1642567A/zh active Pending
- 2003-02-07 CA CA002485064A patent/CA2485064A1/en not_active Abandoned
- 2003-02-07 ZA ZA200406124A patent/ZA200406124B/xx unknown
- 2003-02-07 NZ NZ534492A patent/NZ534492A/en not_active IP Right Cessation
- 2003-02-07 KR KR10-2004-7012254A patent/KR20040089608A/ko not_active Ceased
- 2003-02-07 US US10/503,836 patent/US20060122374A1/en not_active Abandoned
- 2003-02-07 EP EP09004575A patent/EP2090589A1/en not_active Withdrawn
- 2003-02-07 KR KR1020107028953A patent/KR20110014661A/ko not_active Ceased
- 2003-02-07 KR KR10-2004-7012255A patent/KR20040095217A/ko not_active Ceased
- 2003-02-07 NZ NZ534310A patent/NZ534310A/en not_active IP Right Cessation
- 2003-02-07 CN CN038076411A patent/CN1646154B/zh not_active Expired - Fee Related
- 2003-02-07 WO PCT/IB2003/000433 patent/WO2003066085A1/en not_active Ceased
- 2003-02-07 EP EP03737682A patent/EP1572930A4/en not_active Withdrawn
- 2003-02-07 AU AU2003244516A patent/AU2003244516A1/en not_active Abandoned
- 2003-02-07 NZ NZ579419A patent/NZ579419A/en not_active IP Right Cessation
- 2003-02-07 KR KR10-2004-7012256A patent/KR20050002823A/ko not_active Ceased
- 2003-02-07 CN CNA038075164A patent/CN101166762A/zh active Pending
- 2003-02-07 JP JP2003565501A patent/JP2005516607A/ja active Pending
- 2003-02-07 JP JP2003565508A patent/JP2005530484A/ja active Pending
- 2003-02-07 CA CA002475539A patent/CA2475539A1/en not_active Abandoned
- 2003-02-07 CA CA002475382A patent/CA2475382A1/en not_active Abandoned
- 2003-02-07 WO PCT/IB2003/000434 patent/WO2003066078A1/en not_active Ceased
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2004
- 2004-07-21 ZA ZA200405813A patent/ZA200405813B/en unknown
- 2004-07-21 ZA ZA200405811A patent/ZA200405811B/en unknown
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2008
- 2008-12-23 AU AU2008264153A patent/AU2008264153A1/en not_active Abandoned
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2009
- 2009-01-23 US US12/358,815 patent/US20090175893A1/en not_active Abandoned
- 2009-08-27 AU AU2009212820A patent/AU2009212820B2/en not_active Expired - Fee Related
- 2009-10-16 JP JP2009239593A patent/JP2010046076A/ja active Pending
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2011
- 2011-10-31 US US13/285,727 patent/US20120263747A1/en not_active Abandoned
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2013
- 2013-07-18 US US13/945,314 patent/US20140017273A1/en not_active Abandoned
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