JP2005538932A5 - - Google Patents
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- Publication number
- JP2005538932A5 JP2005538932A5 JP2003566175A JP2003566175A JP2005538932A5 JP 2005538932 A5 JP2005538932 A5 JP 2005538932A5 JP 2003566175 A JP2003566175 A JP 2003566175A JP 2003566175 A JP2003566175 A JP 2003566175A JP 2005538932 A5 JP2005538932 A5 JP 2005538932A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- variant
- albumin
- fusion protein
- albumin fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000009027 Albumins Human genes 0.000 claims 47
- 108010088751 Albumins Proteins 0.000 claims 47
- 239000012634 fragment Substances 0.000 claims 47
- 108020001507 fusion proteins Proteins 0.000 claims 27
- 102000037865 fusion proteins Human genes 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 238000001727 in vivo Methods 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 230000004071 biological effect Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 230000002950 deficient Effects 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010019860 Hereditary angioedema Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 102000012479 Serine Proteases Human genes 0.000 claims 2
- 108010022999 Serine Proteases Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 108010088842 Fibrinolysin Proteins 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 claims 1
- 102000001399 Kallikrein Human genes 0.000 claims 1
- 108060005987 Kallikrein Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 208000034158 bleeding Diseases 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 102000052502 human ELANE Human genes 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004962 physiological condition Effects 0.000 claims 1
- 229940012957 plasmin Drugs 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35554702P | 2002-02-07 | 2002-02-07 | |
| PCT/US2003/003616 WO2003066824A2 (en) | 2002-02-07 | 2003-02-07 | Albumin-fused kunitz domain peptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009239593A Division JP2010046076A (ja) | 2002-02-07 | 2009-10-16 | アルブミン融合クニッツドメインペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005538932A JP2005538932A (ja) | 2005-12-22 |
| JP2005538932A5 true JP2005538932A5 (https=) | 2006-03-16 |
Family
ID=27734531
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003566175A Pending JP2005538932A (ja) | 2002-02-07 | 2003-02-07 | アルブミン融合クニッツドメインペプチド |
| JP2003565501A Pending JP2005516607A (ja) | 2002-02-07 | 2003-02-07 | Ｈｉｖ阻害タンパク質 |
| JP2003565508A Pending JP2005530484A (ja) | 2002-02-07 | 2003-02-07 | アルブミン融合抗血管形成ペプチド |
| JP2009239593A Pending JP2010046076A (ja) | 2002-02-07 | 2009-10-16 | アルブミン融合クニッツドメインペプチド |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003565501A Pending JP2005516607A (ja) | 2002-02-07 | 2003-02-07 | Ｈｉｖ阻害タンパク質 |
| JP2003565508A Pending JP2005530484A (ja) | 2002-02-07 | 2003-02-07 | アルブミン融合抗血管形成ペプチド |
| JP2009239593A Pending JP2010046076A (ja) | 2002-02-07 | 2009-10-16 | アルブミン融合クニッツドメインペプチド |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20060122374A1 (https=) |
| EP (4) | EP1471928A1 (https=) |
| JP (4) | JP2005538932A (https=) |
| KR (4) | KR20040089608A (https=) |
| CN (3) | CN1642567A (https=) |
| AU (5) | AU2003244515A1 (https=) |
| CA (3) | CA2485064A1 (https=) |
| NZ (3) | NZ534492A (https=) |
| WO (3) | WO2003066824A2 (https=) |
| ZA (3) | ZA200406124B (https=) |
Families Citing this family (85)
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|---|---|---|---|---|
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| EP2386310B1 (en) * | 2002-08-28 | 2018-11-07 | Dyax Corp. | Methods for preserving organs and tissues |
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| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| US7524811B2 (en) * | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
| DE602004015142D1 (de) * | 2003-08-29 | 2008-08-28 | Childrens Medical Center | Antiangiogene peptide zur behandlung oder vorbeugung von endometriose |
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| US9057061B2 (en) | 2003-12-23 | 2015-06-16 | Novozymes Biopharma Dk A/S | Gene expression technique |
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| ES2325344B1 (es) * | 2004-11-02 | 2010-06-09 | Univ Madrid Autonoma | Inhibidores de angiogenesis multifuncionales y multivalentes. |
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| SMT201800552T1 (it) | 2010-01-06 | 2018-11-09 | Dyax Corp | Proteine che legano la callicreina plasmatica |
| CN101875693B (zh) * | 2010-01-22 | 2012-07-18 | 成都正能生物技术有限责任公司 | 具备抗血管生成活性的白蛋白变异体及其制备方法 |
| EP2556087A1 (en) * | 2010-04-09 | 2013-02-13 | Novozymes Biopharma DK A/S | Albumin derivatives and variants |
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| US20130225496A1 (en) | 2010-11-01 | 2013-08-29 | Novozymes Biopharma Dk A/S | Albumin Variants |
| KR102320178B1 (ko) | 2011-01-06 | 2021-11-02 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
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| CN110105453A (zh) * | 2011-08-17 | 2019-08-09 | 科罗拉多大学董事会法人团体 | 运铁蛋白-肿瘤抑素融合蛋白质及其生成和使用方法 |
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| US10428158B2 (en) | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
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-
2003
- 2003-02-07 WO PCT/US2003/003616 patent/WO2003066824A2/en not_active Ceased
- 2003-02-07 AU AU2003244515A patent/AU2003244515A1/en not_active Abandoned
- 2003-02-07 AU AU2003210885A patent/AU2003210885B2/en not_active Ceased
- 2003-02-07 JP JP2003566175A patent/JP2005538932A/ja active Pending
- 2003-02-07 EP EP03737417A patent/EP1471928A1/en not_active Ceased
- 2003-02-07 EP EP03737416A patent/EP1471933A1/en not_active Withdrawn
- 2003-02-07 CN CNA038069687A patent/CN1642567A/zh active Pending
- 2003-02-07 CA CA002485064A patent/CA2485064A1/en not_active Abandoned
- 2003-02-07 ZA ZA200406124A patent/ZA200406124B/xx unknown
- 2003-02-07 NZ NZ534492A patent/NZ534492A/en not_active IP Right Cessation
- 2003-02-07 KR KR10-2004-7012254A patent/KR20040089608A/ko not_active Ceased
- 2003-02-07 US US10/503,836 patent/US20060122374A1/en not_active Abandoned
- 2003-02-07 EP EP09004575A patent/EP2090589A1/en not_active Withdrawn
- 2003-02-07 KR KR1020107028953A patent/KR20110014661A/ko not_active Ceased
- 2003-02-07 KR KR10-2004-7012255A patent/KR20040095217A/ko not_active Ceased
- 2003-02-07 NZ NZ534310A patent/NZ534310A/en not_active IP Right Cessation
- 2003-02-07 CN CN038076411A patent/CN1646154B/zh not_active Expired - Fee Related
- 2003-02-07 WO PCT/IB2003/000433 patent/WO2003066085A1/en not_active Ceased
- 2003-02-07 EP EP03737682A patent/EP1572930A4/en not_active Withdrawn
- 2003-02-07 AU AU2003244516A patent/AU2003244516A1/en not_active Abandoned
- 2003-02-07 NZ NZ579419A patent/NZ579419A/en not_active IP Right Cessation
- 2003-02-07 KR KR10-2004-7012256A patent/KR20050002823A/ko not_active Ceased
- 2003-02-07 CN CNA038075164A patent/CN101166762A/zh active Pending
- 2003-02-07 JP JP2003565501A patent/JP2005516607A/ja active Pending
- 2003-02-07 JP JP2003565508A patent/JP2005530484A/ja active Pending
- 2003-02-07 CA CA002475539A patent/CA2475539A1/en not_active Abandoned
- 2003-02-07 CA CA002475382A patent/CA2475382A1/en not_active Abandoned
- 2003-02-07 WO PCT/IB2003/000434 patent/WO2003066078A1/en not_active Ceased
-
2004
- 2004-07-21 ZA ZA200405813A patent/ZA200405813B/en unknown
- 2004-07-21 ZA ZA200405811A patent/ZA200405811B/en unknown
-
2008
- 2008-12-23 AU AU2008264153A patent/AU2008264153A1/en not_active Abandoned
-
2009
- 2009-01-23 US US12/358,815 patent/US20090175893A1/en not_active Abandoned
- 2009-08-27 AU AU2009212820A patent/AU2009212820B2/en not_active Expired - Fee Related
- 2009-10-16 JP JP2009239593A patent/JP2010046076A/ja active Pending
-
2011
- 2011-10-31 US US13/285,727 patent/US20120263747A1/en not_active Abandoned
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2013
- 2013-07-18 US US13/945,314 patent/US20140017273A1/en not_active Abandoned
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