JP2005529840A - Ｃｎｓ標的モジュレータを使用するｃｎｓ障害の治療 - Google Patents

Ｃｎｓ標的モジュレータを使用するｃｎｓ障害の治療 Download PDF

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JP2005529840A
JP2005529840A JP2003535718A JP2003535718A JP2005529840A JP 2005529840 A JP2005529840 A JP 2005529840A JP 2003535718 A JP2003535718 A JP 2003535718A JP 2003535718 A JP2003535718 A JP 2003535718A JP 2005529840 A JP2005529840 A JP 2005529840A
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compound
cns
therapeutic compound
disorder
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JP2005529840A5 (fr
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デール エム． エドガー，
デービッド ジー． ハンガウアー，
ハリー ジェファーソン レイトン，
エマニュエル ジェイ． エム． ミグノット，
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ヒプニオン， インコーポレイテッド
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Heart & Thoracic Surgery (AREA)
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  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2003535718A 2001-10-16 2002-10-16 Ｃｎｓ標的モジュレータを使用するｃｎｓ障害の治療 Pending JP2005529840A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32970101P 2001-10-16 2001-10-16
US38150702P 2002-05-17 2002-05-17
US41424302P 2002-09-27 2002-09-27
PCT/US2002/032970 WO2003032912A2 (fr) 2001-10-16 2002-10-16 Traitement de troubles du systeme nerveux central (snc) a l'aide de modulateurs de cible snc

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JP2005529840A true JP2005529840A (ja) 2005-10-06
JP2005529840A5 JP2005529840A5 (fr) 2006-01-05

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US (2) US20050009730A1 (fr)
EP (1) EP1443929A4 (fr)
JP (1) JP2005529840A (fr)
AU (1) AU2002347906A2 (fr)
CA (1) CA2463579A1 (fr)
WO (1) WO2003032912A2 (fr)

Cited By (4)

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JP2004051600A (ja) * 2002-07-24 2004-02-19 Iyaku Bunshi Sekkei Kenkyusho:Kk 造血器型プロスタグランジンｄ２合成酵素阻害剤
JP2005505626A (ja) * 2001-10-16 2005-02-24 エスティーシー ナラ カンパニー リミテッド ピペリジン誘導体、これの製造方法及びこれを含む痴呆治療用薬学的組成物
JP2007516175A (ja) * 2003-06-27 2007-06-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式デルタオピオイド調節剤
JP2014224146A (ja) * 2007-12-12 2014-12-04 アムジエン・インコーポレーテツド グリシン輸送体−１阻害薬

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US7411069B2 (en) 2003-12-10 2008-08-12 Hypnion, Inc. Doxepin analogs and methods of use thereof
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WO2005102335A2 (fr) 2004-04-23 2005-11-03 Hypnion, Inc. Methodes de traitement de troubles du sommeil
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EP2041088B1 (fr) * 2006-06-28 2014-01-08 Amgen Inc. Inhibiteurs du transporteur 1 de la glycine
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PT2257315T (pt) * 2008-02-29 2020-01-27 Lantheus Medical Imaging Inc Agentes de contraste para aplicações incluindo imagiologia de perfusão
PT2419096T (pt) 2009-04-15 2020-02-19 Lantheus Medical Imaging Inc Estabilização de composições radiofarmacêuticas utilizando ácido ascórbico
CN101838234B (zh) * 2009-06-17 2012-02-08 重庆华邦制药股份有限公司 阿法乙酯衍生物的合成方法
PT2534136T (pt) 2010-02-08 2017-12-15 Lantheus Medical Imaging Inc Métodos para sintetizar agentes de imagiologia, e seus intermediários
CN102311381A (zh) * 2010-07-06 2012-01-11 重庆华邦胜凯制药有限公司 阿伐乙酯衍生物的合成方法
CN107929743B (zh) 2012-01-18 2023-09-01 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN104447516B (zh) * 2014-12-15 2017-05-31 重庆华邦制药有限公司 一种阿伐斯丁的制备方法
CA2980162C (fr) 2015-03-26 2024-06-18 Jacqueline M. Iversen Procedes et compositions pour inhiber les symptomes associes a la veisalgie
PL3280414T3 (pl) 2016-04-15 2024-06-24 Oxford University Innovation Limited Modulatory receptora adenozyny w leczeniu schorzeń rytmu okołodobowego
EP3391886A1 (fr) 2017-04-19 2018-10-24 Novartis AG Utilisation d'un agoniste inverse h3r pour le traitement de trouble du travail par équipes
CN108558860B (zh) * 2018-06-04 2020-12-25 成都伊诺达博医药科技有限公司 一种合成芜地溴铵的方法
CN110903182A (zh) * 2018-09-14 2020-03-24 北京艾德旺科技发展有限公司 简单环保的4-氟-2-甲基苯甲酸的化学合成方法
WO2021080997A1 (fr) 2019-10-21 2021-04-29 Alairion, Inc. Dérivés de l'acide 3-(4-(11h-dibenzo[b,e][1,4]azépin-6-yl)pipérazin-1-yl)- et 3-(4-(dibenzo[b,f][1,4]oxazépin/thiazépin/diazépin-11-yl)pipérazin-1-yl)-propanoïque utilisés comme modulateurs des récepteurs h1 et 5-ht2a pour le traitement des troubles du sommeil

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JP2005505626A (ja) * 2001-10-16 2005-02-24 エスティーシー ナラ カンパニー リミテッド ピペリジン誘導体、これの製造方法及びこれを含む痴呆治療用薬学的組成物
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JP2014224146A (ja) * 2007-12-12 2014-12-04 アムジエン・インコーポレーテツド グリシン輸送体−１阻害薬

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US20040142972A1 (en) 2004-07-22
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US7317026B2 (en) 2008-01-08
EP1443929A4 (fr) 2008-02-06
US20050009730A1 (en) 2005-01-13
WO2003032912A8 (fr) 2004-08-19
WO2003032912A3 (fr) 2003-12-11
AU2002347906A2 (en) 2003-04-28
CA2463579A1 (fr) 2003-04-24

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