JP2005527625A5 - - Google Patents

Download PDF

Info

Publication number
JP2005527625A5
JP2005527625A5 JP2004507434A JP2004507434A JP2005527625A5 JP 2005527625 A5 JP2005527625 A5 JP 2005527625A5 JP 2004507434 A JP2004507434 A JP 2004507434A JP 2004507434 A JP2004507434 A JP 2004507434A JP 2005527625 A5 JP2005527625 A5 JP 2005527625A5
Authority
JP
Japan
Prior art keywords
group
phenyl
methyl
methyloxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004507434A
Other languages
English (en)
Japanese (ja)
Other versions
JP4486882B2 (ja
JP2005527625A (ja
Filing date
Publication date
Priority claimed from US10/444,946 external-priority patent/US6908935B2/en
Application filed filed Critical
Publication of JP2005527625A publication Critical patent/JP2005527625A/ja
Publication of JP2005527625A5 publication Critical patent/JP2005527625A5/ja
Application granted granted Critical
Publication of JP4486882B2 publication Critical patent/JP4486882B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2004507434A 2002-05-23 2003-05-23 カルシウム受容体調節アリールアルキルアミン Expired - Fee Related JP4486882B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38305002P 2002-05-23 2002-05-23
US44106503P 2003-01-17 2003-01-17
US10/444,946 US6908935B2 (en) 2002-05-23 2003-05-22 Calcium receptor modulating agents
PCT/US2003/016401 WO2003099776A1 (en) 2002-05-23 2003-05-23 Calcium receptor modulating arylalkylamines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010027494A Division JP2010150268A (ja) 2002-05-23 2010-02-10 カルシウム受容体調節剤

Publications (3)

Publication Number Publication Date
JP2005527625A JP2005527625A (ja) 2005-09-15
JP2005527625A5 true JP2005527625A5 (enExample) 2006-07-06
JP4486882B2 JP4486882B2 (ja) 2010-06-23

Family

ID=29587692

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004507434A Expired - Fee Related JP4486882B2 (ja) 2002-05-23 2003-05-23 カルシウム受容体調節アリールアルキルアミン
JP2010027494A Pending JP2010150268A (ja) 2002-05-23 2010-02-10 カルシウム受容体調節剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010027494A Pending JP2010150268A (ja) 2002-05-23 2010-02-10 カルシウム受容体調節剤

Country Status (8)

Country Link
US (3) US6908935B2 (enExample)
EP (1) EP1509497A1 (enExample)
JP (2) JP4486882B2 (enExample)
AU (1) AU2003233671B2 (enExample)
CA (1) CA2486399C (enExample)
MX (1) MXPA04011471A (enExample)
PL (1) PL376438A1 (enExample)
WO (1) WO2003099776A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908935B2 (en) * 2002-05-23 2005-06-21 Amgen Inc. Calcium receptor modulating agents
EP2295433A3 (en) * 2003-03-06 2011-07-06 Eisai R&D Management Co., Ltd. JNK inhibitors
KR101020350B1 (ko) * 2003-03-13 2011-03-08 이데미쓰 고산 가부시키가이샤 신규한 질소 함유 헤테로환 유도체 및 이를 이용한 유기 전기발광 소자
WO2005065050A2 (ja) * 2003-12-25 2005-07-21 Asahi Kasei Pharma Corporation ２環化合物
GB0400781D0 (en) * 2004-01-14 2004-02-18 Novartis Ag Organic compounds
KR101182690B1 (ko) * 2004-03-02 2012-09-14 아벤티스 파마슈티칼스 인크. 트립타제 억제제의 제조방법
ES2561111T3 (es) * 2004-05-28 2016-02-24 Mitsubishi Tanabe Pharma Corporation Arilalquilaminas y procedimiento para la producción de las mismas
US7361789B1 (en) 2004-07-28 2008-04-22 Amgen Inc. Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
MX2007011153A (es) * 2005-03-17 2007-12-12 Amgen Inc Metodos para reducir la calcificacion.
CA2608957C (en) * 2005-05-19 2013-12-10 Astellas Pharma Inc. Pyrrolidine derivative or salt thereof
JP5388574B2 (ja) * 2005-05-31 2014-01-15 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なヘテロ環式類
AU2006295340B2 (en) 2005-08-05 2010-11-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
WO2007027548A2 (en) * 2005-09-02 2007-03-08 Amgen Inc. Methods of modulating intestinal fluid balance
EP1948220A2 (en) * 2005-10-21 2008-07-30 Amgen Inc. Methods of decreasing vascular calcification using il-1 inhibitors
JP2009528273A (ja) * 2006-01-25 2009-08-06 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連使用用の置換ビアリール化合物
CA2645494C (en) * 2006-03-23 2016-01-12 Amgen Inc. Methods and compositions for making and using polymorphs of cinacalcet
EP2010150A2 (en) * 2006-04-20 2009-01-07 Amgen Inc. Stable emulsion formulations
GB0614579D0 (en) * 2006-07-21 2006-08-30 Black James Foundation Pyrimidine derivatives
EP2049481A2 (en) * 2006-08-09 2009-04-22 SmithKline Beecham Corporation Novel compounds as antagonists or inverse agonists for opioid receptors
TW200821276A (en) * 2006-08-18 2008-05-16 Leo Pharma As Substituted acetylenic compounds useful for the treatment of diseases
CA2672956C (en) * 2006-10-26 2015-02-10 Amgen Inc. Calcium receptor modulating agents
JP2010509392A (ja) * 2006-11-13 2010-03-25 ファイザー・プロダクツ・インク ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
US8093299B2 (en) 2007-03-30 2012-01-10 Amgen Inc. Methods of treating bowel disorders
WO2009051718A2 (en) * 2007-10-15 2009-04-23 Amgen Inc. Calcium receptor modulating agents
EP2278961A2 (en) * 2008-03-28 2011-02-02 Amgen, Inc Calcimimetic compound for use in the treatment of epithelial injury
WO2010042642A1 (en) * 2008-10-08 2010-04-15 Amgen Inc. Calcium receptor modulating agents
WO2010052448A2 (en) * 2008-11-05 2010-05-14 Ucb Pharma S.A. Fused pyrazine derivatives as kinase inhibitors
WO2010104882A1 (en) 2009-03-10 2010-09-16 Amgen Inc. Methods of modulating sperm motility
DE102009015697A1 (de) 2009-03-31 2010-10-07 Markus Dr. Heinrich Verfahren zur Arylierung von ringsubstituierten Phenolen und Phenylethern
EP2435400A2 (en) 2009-05-27 2012-04-04 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
EP2435404A1 (en) 2009-05-27 2012-04-04 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
RU2599788C2 (ru) 2010-06-30 2016-10-20 Лео Фарма А/С Новая полиморфная форма кальцимиметического соединения
RU2599789C2 (ru) 2010-06-30 2016-10-20 Лео Фарма А/С Новая полиморфная форма кальцимиметического соединения
EP2643298A1 (en) 2010-11-26 2013-10-02 Leo Pharma A/S Substituted cyclopentyl - azines as casr- active compounds
RU2013128973A (ru) 2010-11-26 2015-01-10 Лео Фарма А/С Соединения, активные в отношении кальций-чувствительных рецепторов
JP2014508104A (ja) 2010-11-26 2014-04-03 レオ ファーマ アクティーゼルスカブ カルシウム感知受容体活性化合物
WO2012069419A1 (en) 2010-11-26 2012-05-31 Leo Pharma A/S Calcium-sensing receptor-active compounds
WO2012127385A1 (en) * 2011-03-18 2012-09-27 Lupin Limited Benzo [b] [1, 4] oxazin derivatives as calcium sensing receptor modulators
CA2882039A1 (en) * 2012-08-27 2014-03-06 Lupin Limited Arylalkylamine compounds as calcium sensing receptor modulators
GB201217330D0 (en) 2012-09-28 2012-11-14 Univ Cardiff Therapeutic for treating inflammatory lung disorders
CN104292157A (zh) * 2014-09-15 2015-01-21 湖南华腾制药有限公司 一种1-(喹啉-4-基)乙胺的制备方法
WO2017037616A1 (en) * 2015-08-31 2017-03-09 Lupin Limited Arylalkylamine compounds as calcium sensing receptor modulators
DE102015011861B4 (de) 2015-09-10 2018-03-01 Rudolf Schindler Neue cyclische Carboxamide als NMDA NR2B Rezeptor Inhibitoren

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
US6011068A (en) 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
ES2256370T3 (es) 1991-08-23 2006-07-16 Nps Pharmaceuticals, Inc. Moleculas activas para el receptor de calcio.
US6031003A (en) 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
DK0724561T3 (da) 1991-08-23 2004-06-28 Nps Pharma Inc Calciumreceptoraktive arylalkylaminer
DE69333527T2 (de) 1993-02-23 2005-06-16 Brigham & Women's Hospital, Inc., Boston Calciumrezeptoraktive moleküle
AU3414295A (en) 1994-08-19 1996-03-14 Nps Pharmaceuticals, Inc. Methods and compounds active at metabotropic glutamate receptors useful for treatment of neurological disorders and diseases
WO1996009818A1 (en) 1994-09-27 1996-04-04 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis
CN1147459C (zh) 1994-10-21 2004-04-28 Nps药物有限公司 钙受体活性化合物
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
JPH10507934A (ja) 1995-07-26 1998-08-04 エヌピーエス・ファーマシウティカルズ・インコーポレイテッド 代謝指向型グルタミン酸受容体に活性を示す化合物を同定するためのキメラ受容体および方法、ならびに神経学的障害および疾患の治療におけるそのような化合物の使用
AU726659B2 (en) 1996-04-09 2000-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
ATE430123T1 (de) 1996-05-01 2009-05-15 Nps Pharma Inc Inorganische am ionen-rezeptor aktive verbindungen
ES2364179T3 (es) 1996-07-08 2011-08-26 Kyowa Hakko Kirin Co., Ltd. Compuestos con actividad receptora de calcio.
HU228509B1 (en) 1997-02-21 2013-03-28 Bayer Ip Gmbh Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases
UY24949A1 (es) 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos
US6103737A (en) 1997-07-03 2000-08-15 Dupont Pharmaceuticals Company Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists
JP2002507603A (ja) * 1998-03-25 2002-03-12 ブリストル−マイヤーズ スクイブ カンパニー イミダゾロン食欲抑制薬：ｉ．非環式誘導体
US6335338B1 (en) 1998-08-12 2002-01-01 Smithkline Beecham Corporation Calcilytic compounds
CA2347092A1 (en) 1998-10-14 2000-04-20 Ortho-Mcneil Pharmaceutical, Inc. 1,2-disubstituted cyclopropanes
CN1134417C (zh) 1999-02-24 2004-01-14 弗·哈夫曼-拉罗切有限公司 3-苯基吡啶衍生物及其作为nk-1受体拮抗剂的应用
CN1131212C (zh) 1999-02-24 2003-12-17 弗·哈夫曼-拉罗切有限公司 苯基－和吡啶基衍生物
EP1074539B1 (en) 1999-08-04 2007-10-17 Sumitomo Chemical Company, Limited Process for producing optically active 3,3,3,-trifluoro-2-hydroxy-2-methylpropionic acid, and salt thereof
DE10028575A1 (de) 2000-06-14 2002-03-14 Basf Ag Integrinliganden
FR2800735B1 (fr) 1999-11-09 2002-02-01 Centre Nat Rech Scient Nouvelles aralkyle-1,2-diamines possedant une activite calcimimetique et leur mode de preparation
EP1116711B1 (de) 1999-12-18 2005-12-14 Wella Aktiengesellschaft 2-Aminoalkyl-1,4-diaminobenzol-Derivate und diese Verbindungen enthaltende Färbemittel
FR2809396B1 (fr) 2000-05-24 2005-10-14 Centre Nat Rech Scient Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation
DE10028402A1 (de) 2000-06-13 2001-12-20 Merck Patent Gmbh Pyridin-2-yl-aminoalkycarbonylglycyl-beta-alanin und Derivate
WO2001096307A2 (en) 2000-06-15 2001-12-20 Pharmacia Corporation Cycloalkyl alkanoic acids as integrin receptor antagonists
WO2003020723A1 (en) 2001-08-30 2003-03-13 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINE DERIVATIVE
US6908935B2 (en) * 2002-05-23 2005-06-21 Amgen Inc. Calcium receptor modulating agents
US7176322B2 (en) 2002-05-23 2007-02-13 Amgen Inc. Calcium receptor modulating agents

Similar Documents

Publication Publication Date Title
JP2005527625A5 (enExample)
CA2486399A1 (en) Calcium receptor modulating agents
RU2439068C2 (ru) Модуляторы mglur5
RU2447060C2 (ru) Ингибиторы сфингозинкиназы
KR101200175B1 (ko) 향대사성 글루타메이트 수용체의 조정자로서의 신규한알키닐 유도체
US7495018B2 (en) Substituted 1,3-thiazole compounds, their production and use
NZ609955A (en) Sgc stimulators
RU2342383C2 (ru) ПРОИЗВОДНЫЕ ИМИДАЗОЛ-4-ИЛЭТИНИЛПИРИДИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ (ВАРИАНТЫ) И ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНКСИОЛИТИКА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ НАРУШЕНИЙ, ОПОСРЕДУЕМЫХ РЕЦЕПТОРОМ mGLuR5
JP2006514942A5 (enExample)
JP3162721B2 (ja) 新規チアゾリジンジオン及びそれを含有する医薬製剤
JP2020516671A5 (enExample)
JP2002529532A5 (enExample)
CA2396824A1 (en) Heteroaromatic carboxamide derivatives and their use as inhibitors of the enzyme ikk-2
JP2004534035A5 (enExample)
JP2010506825A5 (enExample)
RU2006101890A (ru) Производные тиазолилпиперидина в качестве ингибиторов мпб
JP2002534519A5 (enExample)
JP2009525960A5 (enExample)
JP2008509982A5 (enExample)
JP2007519695A5 (enExample)
JP2017519818A5 (enExample)
RU2015132105A (ru) Азоловые производные бензола
JP2011500679A5 (enExample)
JP2009504791A5 (enExample)
RU2019117958A (ru) Производные индола, полезные в качестве ингибиторов диацилглицерид-о-ацилтрансферазы 2