JP2005521389A5 - - Google Patents
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- JP2005521389A5 JP2005521389A5 JP2003567383A JP2003567383A JP2005521389A5 JP 2005521389 A5 JP2005521389 A5 JP 2005521389A5 JP 2003567383 A JP2003567383 A JP 2003567383A JP 2003567383 A JP2003567383 A JP 2003567383A JP 2005521389 A5 JP2005521389 A5 JP 2005521389A5
- Authority
- JP
- Japan
- Prior art keywords
- hla
- restricted antigen
- moiety
- molecule
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims description 68
- 108091007433 antigens Proteins 0.000 claims description 68
- 102000036639 antigens Human genes 0.000 claims description 68
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims description 34
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 30
- 108091054437 MHC class I family Proteins 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims description 16
- 230000001225 therapeutic effect Effects 0.000 claims description 16
- 230000001363 autoimmune Effects 0.000 claims description 11
- 230000003612 virological effect Effects 0.000 claims description 11
- 102000043129 MHC class I family Human genes 0.000 claims description 9
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims description 8
- 208000036142 Viral infection Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 230000009385 viral infection Effects 0.000 claims description 6
- 208000023275 Autoimmune disease Diseases 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims 19
- 102000040430 polynucleotide Human genes 0.000 claims 19
- 239000002157 polynucleotide Substances 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 10
- 108010026122 HLA-A*33 antigen Proteins 0.000 claims 8
- 108010035452 HLA-A1 Antigen Proteins 0.000 claims 8
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 8
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 8
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims 8
- 108010029526 HLA-A28 antigen Proteins 0.000 claims 8
- 108010086377 HLA-A3 Antigen Proteins 0.000 claims 8
- 108010018475 HLA-A31 antigen Proteins 0.000 claims 8
- -1 HLA-A34 Proteins 0.000 claims 8
- 108010028938 HLA-B45 antigen Proteins 0.000 claims 8
- 108010091938 HLA-B7 Antigen Proteins 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 7
- 102000004127 Cytokines Human genes 0.000 claims 6
- 108090000695 Cytokines Proteins 0.000 claims 6
- 231100000433 cytotoxic Toxicity 0.000 claims 6
- 230000001472 cytotoxic effect Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 231100000331 toxic Toxicity 0.000 claims 6
- 230000002588 toxic effect Effects 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000034287 fluorescent proteins Human genes 0.000 claims 3
- 108091006047 fluorescent proteins Proteins 0.000 claims 3
- 230000002637 immunotoxin Effects 0.000 claims 3
- 239000002596 immunotoxin Substances 0.000 claims 3
- 231100000608 immunotoxin Toxicity 0.000 claims 3
- 229940051026 immunotoxin Drugs 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000002823 phage display Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims 1
- 210000000628 antibody-producing cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000047279 human B2M Human genes 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/073,301 US6992176B2 (en) | 2002-02-13 | 2002-02-13 | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| PCT/IL2003/000105 WO2003068201A2 (en) | 2002-02-13 | 2003-02-11 | High affinity antibody having a tcr-like specificity and use in detection and treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005521389A JP2005521389A (ja) | 2005-07-21 |
| JP2005521389A5 true JP2005521389A5 (enExample) | 2006-02-09 |
| JP4272535B2 JP4272535B2 (ja) | 2009-06-03 |
Family
ID=27732335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003567383A Expired - Fee Related JP4272535B2 (ja) | 2002-02-13 | 2003-02-11 | Ｔ細胞受容体様特異性を有し、さらに高親和性の抗体ならびに癌、ウイルス感染、および自己免疫疾患の検出および治療でのその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6992176B2 (enExample) |
| EP (3) | EP2072045B1 (enExample) |
| JP (1) | JP4272535B2 (enExample) |
| AT (1) | ATE446745T1 (enExample) |
| AU (3) | AU2003208582C1 (enExample) |
| CA (1) | CA2474782C (enExample) |
| DE (1) | DE60329823D1 (enExample) |
| ES (2) | ES2425539T3 (enExample) |
| IL (1) | IL193376A (enExample) |
| WO (1) | WO2003068201A2 (enExample) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004527449A (ja) * | 2000-02-15 | 2004-09-09 | リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | テロメラーゼ逆転写酵素を用いる癌を治療するための万能ワクチンと方法 |
| US20040191260A1 (en) * | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
| US6992176B2 (en) * | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| CA2476625A1 (en) * | 2002-02-20 | 2003-08-28 | Dyax Corp. | Mhc-peptide complex binding ligands |
| US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
| AU2005251563B2 (en) * | 2004-06-09 | 2011-08-04 | Technion Research & Development Foundation Ltd. | Antibodies for selective apoptosis of cells |
| EP2332971B1 (en) * | 2004-06-17 | 2016-02-17 | MannKind Corporation | Epitope analogs |
| ES2549128T3 (es) * | 2006-05-19 | 2015-10-23 | Technion Research And Development Foundation Ltd. | Proteínas de fusión, usos de las mismas y procesos para producir las mismas |
| WO2008120203A2 (en) * | 2007-03-29 | 2008-10-09 | Technion Research & Development Foundation Ltd. | Antibodies and their uses for diagnosis and treatment of cytomegalovirus infection and associated diseases |
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| WO2009125394A1 (en) * | 2008-04-09 | 2009-10-15 | Technion Research & Development Foundation Ltd. | Anti human immunodeficiency antibodies and uses thereof |
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| PT2119726E (pt) | 2008-05-14 | 2015-03-30 | Immatics Biotechnologies Gmbh | Novos e poderosos peptídeos para mhc classe ii derivados de survinina e neurocano |
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| JPWO2015050259A1 (ja) * | 2013-10-03 | 2017-03-09 | 大日本住友製薬株式会社 | 腫瘍抗原ペプチド |
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| HRP20211754T1 (hr) | 2014-12-23 | 2022-03-04 | Immatics Biotechnologies Gmbh | Novi peptidi i kombinacije peptida za upotrebu u imunoterapiji protiv hepatocelularnog karcinoma (hcc) i drugih rakova |
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2005
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2008
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2010
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