JP2005519044A5 - - Google Patents
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- Publication number
- JP2005519044A5 JP2005519044A5 JP2003554229A JP2003554229A JP2005519044A5 JP 2005519044 A5 JP2005519044 A5 JP 2005519044A5 JP 2003554229 A JP2003554229 A JP 2003554229A JP 2003554229 A JP2003554229 A JP 2003554229A JP 2005519044 A5 JP2005519044 A5 JP 2005519044A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acids
- conjugate
- antibody
- methacryloylated
- units
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010038807 Oligopeptides Proteins 0.000 claims 8
- 102000015636 Oligopeptides Human genes 0.000 claims 8
- 235000008206 alpha-amino acids Nutrition 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 5
- -1 aromatic amino acids Chemical class 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- WEZDRVHTDXTVLT-GJZGRUSLSA-N 2-[[(2s)-2-[[(2s)-2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CN)CC1=CC=CC=C1 WEZDRVHTDXTVLT-GJZGRUSLSA-N 0.000 claims 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- CCBIBMKQNXHNIN-ZETCQYMHSA-N Gly-Leu-Gly Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O CCBIBMKQNXHNIN-ZETCQYMHSA-N 0.000 claims 2
- IGOYNRWLWHWAQO-JTQLQIEISA-N Gly-Phe-Gly Chemical compound OC(=O)CNC(=O)[C@@H](NC(=O)CN)CC1=CC=CC=C1 IGOYNRWLWHWAQO-JTQLQIEISA-N 0.000 claims 2
- 108010009504 Gly-Phe-Leu-Gly Proteins 0.000 claims 2
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 2
- 150000001371 alpha-amino acids Chemical class 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
- 108010074605 gamma-Globulins Proteins 0.000 claims 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 2
- 108010077435 glycyl-phenylalanyl-glycine Proteins 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000003068 static effect Effects 0.000 claims 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims 1
- 101150044980 Akap1 gene Proteins 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 125000000998 L-alanino group Chemical group [H]N([*])[C@](C([H])([H])[H])([H])C(=O)O[H] 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000005263 alkylenediamine group Chemical group 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 229960004050 aminobenzoic acid Drugs 0.000 claims 1
- 229960002684 aminocaproic acid Drugs 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940000635 beta-alanine Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims 1
- 125000005597 hydrazone group Chemical group 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical group CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20014653A CZ293787B6 (cs) | 2001-12-20 | 2001-12-20 | pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii |
| CZPV4653-01 | 2001-12-20 | ||
| PCT/CZ2002/000070 WO2003053473A2 (en) | 2001-12-20 | 2002-12-20 | Ph-sensitive polymeric conjugates of an anthracycline drug |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005519044A JP2005519044A (ja) | 2005-06-30 |
| JP2005519044A5 true JP2005519044A5 (enExample) | 2006-01-05 |
| JP4718117B2 JP4718117B2 (ja) | 2011-07-06 |
Family
ID=5473644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003554229A Expired - Lifetime JP4718117B2 (ja) | 2001-12-20 | 2002-12-20 | ターゲット療法用アントラサイクリン系制癌薬のｐＨ感受性重合体コンジュゲート |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7919076B2 (enExample) |
| EP (2) | EP1782833A3 (enExample) |
| JP (1) | JP4718117B2 (enExample) |
| KR (1) | KR20040076874A (enExample) |
| AT (1) | ATE439864T1 (enExample) |
| AU (1) | AU2002366715A1 (enExample) |
| CA (1) | CA2470976A1 (enExample) |
| CZ (1) | CZ293787B6 (enExample) |
| DE (1) | DE60233434D1 (enExample) |
| DK (1) | DK1463529T5 (enExample) |
| EA (1) | EA007353B1 (enExample) |
| ES (1) | ES2331303T3 (enExample) |
| HU (1) | HUP0500541A3 (enExample) |
| PL (1) | PL216518B1 (enExample) |
| PT (1) | PT1463529E (enExample) |
| SI (1) | SI1463529T1 (enExample) |
| SK (1) | SK2912004A3 (enExample) |
| WO (1) | WO2003053473A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ294996B6 (cs) * | 2003-07-16 | 2005-04-13 | Ústav Makromolekulární Chemie Av Čr | Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů |
| US8614228B2 (en) | 2004-08-11 | 2013-12-24 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
| US7812051B2 (en) | 2004-08-11 | 2010-10-12 | Arqule, Inc. | Pharmaceutical compositions of β-lapachone and β-lapachone analogs with improved tumor targeting potential |
| CZ2005558A3 (cs) * | 2005-09-05 | 2007-04-04 | Zentiva, A. S. | Zpusob prípravy polymerních konjugátu doxorubicinu s pH-rízeným uvolnováním léciva |
| CZ2006207A3 (cs) * | 2006-03-28 | 2008-01-16 | Zentiva, A. S. | Micelární nosiče léčiv s protinádorovou aktivitou |
| CZ2006505A3 (cs) * | 2006-08-09 | 2008-04-09 | Zentiva, A. S. | Polymerní konjugáty doxorubicinu s pH-rízeným uvolnováním léciva a zpusob jejich prípravy |
| EP2518495A3 (en) * | 2006-08-09 | 2013-11-27 | Sumitomo Bakelite Company, Ltd. | Sugar chain-capturing substance and use thereof |
| CZ298945B6 (cs) * | 2006-09-18 | 2008-03-19 | Zentiva, A. S. | Polymerní lécivo a zpusob jeho výroby |
| DK2152686T3 (en) | 2007-04-30 | 2015-01-12 | Arqule Inc | HYDROXYSULFONAT OF quinone compounds AND THEIR USES |
| CZ301288B6 (cs) * | 2008-10-23 | 2009-12-30 | Zentiva, A. S | Polymerní prípravek se synergickým úcinkem pri lécbe nádorových onemocnení |
| CZ302830B6 (cs) * | 2009-12-15 | 2011-11-30 | Ústav makromolekulární chemie AV CR, v.v.i. | Vysokomolekulární polymerní nosice léciv odvozené od dendrimeru a jejich konjugáty s lécivy pro lécbu zejména pevných nádoru |
| EP3069715A1 (en) | 2015-03-20 | 2016-09-21 | Salmon Pharma GmbH | Immediate release dosage forms of Atomoxetine |
| WO2018071767A1 (en) | 2016-10-14 | 2018-04-19 | University Of Utah Research Foundation | Antibody-polymer-drug conjugates |
| WO2020214858A1 (en) * | 2019-04-17 | 2020-10-22 | Avidea Technologies, Inc. | Compositions and methods of manufacturing star polymers for ligand display and/or drug delivery |
| CZ309828B6 (cs) * | 2019-10-09 | 2023-11-15 | I.T.A.-Intertact S.R.O. | Fluorescenční polymer, fluorescenční sonda a konjugační sada pro pokročilé funkční analýzy buněk v hematologii, imunologii a mikrobiologii, způsob jejich přípravy a jejich použití |
| KR20220092565A (ko) * | 2019-10-30 | 2022-07-01 | 씨아이에스 파르마 에이쥐 | 활성제를 전달하기 위한 생체 적합성 중합체 약물 담체 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8500209D0 (en) | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
-
2001
- 2001-12-20 CZ CZ20014653A patent/CZ293787B6/cs not_active IP Right Cessation
-
2002
- 2002-12-20 SI SI200230855T patent/SI1463529T1/sl unknown
- 2002-12-20 SK SK291-2004A patent/SK2912004A3/sk not_active Application Discontinuation
- 2002-12-20 DE DE60233434T patent/DE60233434D1/de not_active Expired - Lifetime
- 2002-12-20 AU AU2002366715A patent/AU2002366715A1/en not_active Abandoned
- 2002-12-20 EA EA200400802A patent/EA007353B1/ru not_active IP Right Cessation
- 2002-12-20 CA CA002470976A patent/CA2470976A1/en not_active Abandoned
- 2002-12-20 WO PCT/CZ2002/000070 patent/WO2003053473A2/en not_active Ceased
- 2002-12-20 ES ES02805243T patent/ES2331303T3/es not_active Expired - Lifetime
- 2002-12-20 KR KR10-2004-7009872A patent/KR20040076874A/ko not_active Withdrawn
- 2002-12-20 PL PL370719A patent/PL216518B1/pl not_active IP Right Cessation
- 2002-12-20 AT AT02805243T patent/ATE439864T1/de active
- 2002-12-20 US US10/499,422 patent/US7919076B2/en active Active
- 2002-12-20 EP EP06025316A patent/EP1782833A3/en not_active Withdrawn
- 2002-12-20 PT PT02805243T patent/PT1463529E/pt unknown
- 2002-12-20 EP EP02805243A patent/EP1463529B9/en not_active Expired - Lifetime
- 2002-12-20 DK DK02805243.9T patent/DK1463529T5/da active
- 2002-12-20 HU HU0500541A patent/HUP0500541A3/hu unknown
- 2002-12-20 JP JP2003554229A patent/JP4718117B2/ja not_active Expired - Lifetime
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