JP2005519028A5 - - Google Patents
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- Publication number
- JP2005519028A5 JP2005519028A5 JP2003543594A JP2003543594A JP2005519028A5 JP 2005519028 A5 JP2005519028 A5 JP 2005519028A5 JP 2003543594 A JP2003543594 A JP 2003543594A JP 2003543594 A JP2003543594 A JP 2003543594A JP 2005519028 A5 JP2005519028 A5 JP 2005519028A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- adamantylmethyl
- chloro
- propyl
- isonicotinamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c1cnc(*)c(*)c1* Chemical compound *c1cnc(*)c(*)c1* 0.000 description 5
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0103836A SE0103836D0 (sv) | 2001-11-16 | 2001-11-16 | Novel compounds |
| PCT/SE2002/002057 WO2003041707A1 (en) | 2001-11-16 | 2002-11-12 | N-adamantylmethyl derivates and intermediates as pharmaceutical compositions and processes for their preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005519028A JP2005519028A (ja) | 2005-06-30 |
| JP2005519028A5 true JP2005519028A5 (https=) | 2009-12-24 |
| JP4559077B2 JP4559077B2 (ja) | 2010-10-06 |
Family
ID=20286020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003543594A Expired - Fee Related JP4559077B2 (ja) | 2001-11-16 | 2002-11-12 | 医薬組成物としてのｎ−アダマンチルメチル誘導体および中間体、ならびにそれらの製造方法 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7129246B2 (https=) |
| EP (1) | EP1448195B1 (https=) |
| JP (1) | JP4559077B2 (https=) |
| KR (1) | KR20040058290A (https=) |
| CN (1) | CN1585640B (https=) |
| AR (1) | AR037534A1 (https=) |
| AT (1) | ATE344034T1 (https=) |
| AU (1) | AU2002347741B2 (https=) |
| BR (1) | BR0214142A (https=) |
| CA (1) | CA2464863A1 (https=) |
| CO (1) | CO5580747A2 (https=) |
| DE (1) | DE60215851T2 (https=) |
| DK (1) | DK1448195T3 (https=) |
| ES (1) | ES2274110T3 (https=) |
| HU (1) | HUP0402560A3 (https=) |
| IL (1) | IL161693A0 (https=) |
| IS (1) | IS7261A (https=) |
| MX (1) | MXPA04004498A (https=) |
| MY (1) | MY136430A (https=) |
| NO (1) | NO20042155L (https=) |
| NZ (1) | NZ532755A (https=) |
| PL (1) | PL370855A1 (https=) |
| PT (1) | PT1448195E (https=) |
| RU (1) | RU2300525C2 (https=) |
| SE (1) | SE0103836D0 (https=) |
| TW (1) | TW200407297A (https=) |
| UA (1) | UA77978C2 (https=) |
| WO (1) | WO2003041707A1 (https=) |
| ZA (1) | ZA200403682B (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
| GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
| SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
| SE0300480D0 (sv) * | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
| WO2004105797A1 (en) * | 2003-05-29 | 2004-12-09 | Astrazeneca Ab | A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine |
| MXPA05012705A (es) * | 2003-05-29 | 2006-02-08 | Astrazeneca Ab | Una composicion farmaceutica que comprende un antagonista del receptor p2x7 y un factor alfa de necrosis tumoral. |
| US20070281931A1 (en) * | 2003-05-29 | 2007-12-06 | Nigel Boughton-Smith | Pharmaceutical Composition Containing a P2x7 Receptor Antagonist and Methotrexate |
| GB0312609D0 (en) * | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| KR100554155B1 (ko) * | 2003-06-09 | 2006-02-22 | 학교법인 포항공과대학교 | 금속/반도체 나노막대 이종구조를 이용한 전극 구조물 및그 제조 방법 |
| SE0302139D0 (sv) * | 2003-07-28 | 2003-07-28 | Astrazeneca Ab | Novel compounds |
| SE0302192D0 (sv) * | 2003-08-08 | 2003-08-08 | Astrazeneca Ab | Novel compounds |
| SE0302488D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | New combination |
| SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
| SE0402925D0 (sv) * | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
| EP2591675A1 (en) | 2006-11-27 | 2013-05-15 | H. Lundbeck A/S | Heteroaryl amide derivatives |
| CA2680761A1 (en) * | 2007-03-22 | 2008-09-25 | Astrazeneca Ab | Quinoline derivatives for the treatment of inflammatory diseases |
| WO2008124153A1 (en) | 2007-04-10 | 2008-10-16 | H. Lundbeck A/S | Heteroaryl amide analogues as p2x7 antagonists |
| PE20091036A1 (es) | 2007-11-30 | 2009-08-15 | Astrazeneca Ab | Derivado de quinolina como antagonista del receptor p2x7 |
| BRPI0910034B1 (pt) | 2008-03-25 | 2022-02-08 | Affectis Pharmaceuticals Ag | Antagonistas do p2x7r e composições farmacêuticas que os compreendem |
| AU2010237302A1 (en) | 2009-04-14 | 2011-12-01 | Affectis Pharmaceuticals Ag | Novel P2X7R antagonists and their use |
| SG185400A1 (en) | 2010-05-14 | 2012-12-28 | Affectis Pharmaceuticals Ag | Novel methods for the preparation of p2x7r antagonists |
| WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| CN103687860B (zh) | 2011-07-22 | 2016-06-08 | 埃科特莱茵药品有限公司 | 作为p2x7受体拮抗剂的杂环酰胺衍生物 |
| US9409917B2 (en) | 2012-01-20 | 2016-08-09 | Actelion Pharmaceuticals Ltd. | Heterocyclic amide derivatives as P2X7 receptor antagonists |
| KR101576235B1 (ko) | 2012-11-30 | 2015-12-11 | 한국생명공학연구원 | 신규한 이치환 아다만틸 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 전이 억제용 약학적 조성물 |
| WO2014091415A1 (en) | 2012-12-12 | 2014-06-19 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
| KR102232744B1 (ko) | 2012-12-18 | 2021-03-26 | 이도르시아 파마슈티컬스 리미티드 | Ｐ２ｘ７ 수용체 길항제로서의 인돌 카르복사미드 유도체 |
| ES2616883T3 (es) | 2013-01-22 | 2017-06-14 | Actelion Pharmaceuticals Ltd. | Derivados amida heterocíclicos como antagonistas del receptor P2X7 |
| CA2896790C (en) | 2013-01-22 | 2022-05-10 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
| CN104163795B (zh) * | 2014-08-19 | 2016-02-03 | 四川大学 | 盐酸烟酰美金刚胺溶剂合物、其制备方法和用途 |
| CN104693084B (zh) * | 2015-02-12 | 2016-03-16 | 佛山市赛维斯医药科技有限公司 | 含腈基苯基的n-金刚烷酰胺类化合物、其制备方法及用途 |
| CN104628615B (zh) * | 2015-02-12 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 含卤代苯的n-金刚烷酰胺类化合物、其制备方法及其用途 |
| CN104628616B (zh) * | 2015-02-12 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 含对硝基苯基的n-金刚烷酰胺类化合物、其制备方法及用途 |
| CN104628617B (zh) * | 2015-02-12 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | N-金刚烷酰胺类葡萄糖激酶活化剂、制备方法及其用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3352912A (en) | 1963-07-24 | 1967-11-14 | Du Pont | Adamantanes and tricyclo[4. 3. 1. 1 3.8] undecanes |
| US3471491A (en) * | 1967-08-28 | 1969-10-07 | Squibb & Sons Inc | Adamantyl-s-triazines |
| US3464998A (en) * | 1968-03-04 | 1969-09-02 | Searle & Co | Adamantyl esters and amides of pyridinecarboxylic acids |
| GB1274652A (en) | 1968-08-27 | 1972-05-17 | Lilly Industries Ltd | Adamantanyl-alkylamine derivatives and their preparation |
| US4027035A (en) * | 1968-08-27 | 1977-05-31 | Eli Lilly And Company | Therapeutic uses of adamantanealkylamine compounds |
| IL53441A0 (en) | 1977-11-22 | 1978-01-31 | Teva Pharma | Methyladamantyl hydrazines their preparation and pharmaceutical compositions containing them |
| US4751292A (en) * | 1985-07-02 | 1988-06-14 | The Plant Cell Research Institute, Inc. | Adamantyl purines |
| WO1990010622A1 (fr) * | 1989-03-10 | 1990-09-20 | Idemitsu Kosan Co. Ltd. | Derives de pyridine et leurs sels, et agent insecticide/acaricide les contenant en tant qu'ingredient actif |
| CA2167154A1 (en) | 1993-08-10 | 1995-02-16 | Sarkis Barret Kalindjian | Gastrin and cck receptor ligands |
| US6034136A (en) * | 1997-03-20 | 2000-03-07 | Novartis Ag | Certain cyclic thio substituted acylaminoacid amide derivatives |
| FR2761358B1 (fr) | 1997-03-27 | 1999-05-07 | Adir | Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| SE9704545D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| SE9704544D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| CZ20013608A3 (cs) | 1999-04-09 | 2002-05-15 | Astrazeneca Ab | Adamantanové deriváty |
| GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
| SE0200920D0 (sv) | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
-
2001
- 2001-11-16 SE SE0103836A patent/SE0103836D0/xx unknown
-
2002
- 2002-11-07 TW TW091132764A patent/TW200407297A/zh unknown
- 2002-11-12 PT PT02783941T patent/PT1448195E/pt unknown
- 2002-11-12 CA CA002464863A patent/CA2464863A1/en not_active Abandoned
- 2002-11-12 US US10/495,711 patent/US7129246B2/en not_active Expired - Fee Related
- 2002-11-12 DE DE60215851T patent/DE60215851T2/de not_active Expired - Lifetime
- 2002-11-12 RU RU2004112780/04A patent/RU2300525C2/ru not_active IP Right Cessation
- 2002-11-12 MX MXPA04004498A patent/MXPA04004498A/es active IP Right Grant
- 2002-11-12 CN CN028225171A patent/CN1585640B/zh not_active Expired - Fee Related
- 2002-11-12 IL IL16169302A patent/IL161693A0/xx unknown
- 2002-11-12 ES ES02783941T patent/ES2274110T3/es not_active Expired - Lifetime
- 2002-11-12 KR KR10-2004-7007397A patent/KR20040058290A/ko not_active Ceased
- 2002-11-12 DK DK02783941T patent/DK1448195T3/da active
- 2002-11-12 NZ NZ532755A patent/NZ532755A/en unknown
- 2002-11-12 WO PCT/SE2002/002057 patent/WO2003041707A1/en not_active Ceased
- 2002-11-12 AT AT02783941T patent/ATE344034T1/de not_active IP Right Cessation
- 2002-11-12 AU AU2002347741A patent/AU2002347741B2/en not_active Ceased
- 2002-11-12 EP EP02783941A patent/EP1448195B1/en not_active Expired - Lifetime
- 2002-11-12 BR BR0214142-6A patent/BR0214142A/pt not_active IP Right Cessation
- 2002-11-12 JP JP2003543594A patent/JP4559077B2/ja not_active Expired - Fee Related
- 2002-11-12 PL PL02370855A patent/PL370855A1/xx not_active Application Discontinuation
- 2002-11-12 HU HU0402560A patent/HUP0402560A3/hu unknown
- 2002-11-14 MY MYPI20024270A patent/MY136430A/en unknown
- 2002-11-15 AR ARP020104406A patent/AR037534A1/es unknown
- 2002-12-11 UA UA20040503316A patent/UA77978C2/uk unknown
-
2004
- 2004-05-11 CO CO04043373A patent/CO5580747A2/es not_active Application Discontinuation
- 2004-05-13 ZA ZA200403682A patent/ZA200403682B/xx unknown
- 2004-05-13 IS IS7261A patent/IS7261A/is unknown
- 2004-05-25 NO NO20042155A patent/NO20042155L/no not_active Application Discontinuation
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