JP2005515225A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005515225A5 JP2005515225A5 JP2003559525A JP2003559525A JP2005515225A5 JP 2005515225 A5 JP2005515225 A5 JP 2005515225A5 JP 2003559525 A JP2003559525 A JP 2003559525A JP 2003559525 A JP2003559525 A JP 2003559525A JP 2005515225 A5 JP2005515225 A5 JP 2005515225A5
- Authority
- JP
- Japan
- Prior art keywords
- blood substitute
- hemoglobin
- substitute product
- pao
- product according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003633 blood substitute Substances 0.000 claims 22
- 108010054147 Hemoglobins Proteins 0.000 claims 18
- 102000001554 Hemoglobins Human genes 0.000 claims 18
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 7
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 7
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 108010061951 Methemoglobin Proteins 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000001706 oxygenating effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 108010001708 stroma free hemoglobin Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34774102P | 2002-01-11 | 2002-01-11 | |
| US60/347,741 | 2002-01-11 | ||
| US10/114,400 | 2002-04-01 | ||
| US10/114,400 US20030153491A1 (en) | 2002-01-11 | 2002-04-01 | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| PCT/US2003/000696 WO2003059363A1 (en) | 2002-01-11 | 2003-01-10 | Methods and compositions for oxygen transport comprising a high oyzgen affinity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010052387A Division JP2010138197A (ja) | 2002-01-11 | 2010-03-09 | 高酸素親和性改変ヘモグロビンを含む、酸素輸送のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005515225A JP2005515225A (ja) | 2005-05-26 |
| JP2005515225A5 true JP2005515225A5 (enExample) | 2005-12-22 |
| JP5149480B2 JP5149480B2 (ja) | 2013-02-20 |
Family
ID=26812138
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003559525A Expired - Fee Related JP5149480B2 (ja) | 2002-01-11 | 2003-01-10 | 高酸素親和性改変ヘモグロビンを含む、酸素輸送のための方法および組成物 |
| JP2010052387A Pending JP2010138197A (ja) | 2002-01-11 | 2010-03-09 | 高酸素親和性改変ヘモグロビンを含む、酸素輸送のための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010052387A Pending JP2010138197A (ja) | 2002-01-11 | 2010-03-09 | 高酸素親和性改変ヘモグロビンを含む、酸素輸送のための方法および組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20030153491A1 (enExample) |
| EP (1) | EP1465643B1 (enExample) |
| JP (2) | JP5149480B2 (enExample) |
| KR (1) | KR100964604B1 (enExample) |
| CN (2) | CN1630527B (enExample) |
| AT (1) | ATE382358T1 (enExample) |
| AU (1) | AU2003207504B2 (enExample) |
| BR (1) | BR0306846A (enExample) |
| CA (1) | CA2473662C (enExample) |
| DE (1) | DE60318388T2 (enExample) |
| DK (1) | DK1465643T3 (enExample) |
| ES (1) | ES2299686T3 (enExample) |
| MX (1) | MXPA04006733A (enExample) |
| PT (1) | PT1465643E (enExample) |
| WO (1) | WO2003059363A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6602498B2 (en) | 2000-02-22 | 2003-08-05 | Shearwater Corporation | N-maleimidyl polymer derivatives |
| US20050164915A1 (en) * | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| AU2003299700B2 (en) * | 2002-12-23 | 2009-03-26 | Albert Einstein College Of Medicine Of Yeshiva University | Modified hemoglobin and methods of making same |
| US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| ATE444984T1 (de) | 2002-12-31 | 2009-10-15 | Nektar Therapeutics Al Corp | Hydrolysestabile maleimidendgruppen-enthaltende polymere |
| US7790835B2 (en) | 2003-12-03 | 2010-09-07 | Nektar Therapeutics | Method of preparing maleimide functionalized polymers |
| DE602005023191D1 (de) * | 2004-08-31 | 2010-10-07 | Sangart Inc | Verfahren zur verbesserung der hämodynamischen stabilität mit sauerstoff-tragenden zusammensetzungen |
| US8455437B2 (en) * | 2005-02-04 | 2013-06-04 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Method to predict and prevent oxygen-induced inflammatory tissue injury |
| EP1863503B1 (en) * | 2005-03-07 | 2019-05-22 | Sangart, Inc. | Composition for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers |
| WO2007050121A2 (en) * | 2005-05-11 | 2007-05-03 | Albert Einstein College Of Medicine Of Yeshiva University | Site specific pegylated hemoglobin, method of preparing same, and uses thereof |
| WO2007058678A2 (en) * | 2005-06-10 | 2007-05-24 | Albert Einstein College Of Medicine Of Yeshiva University | Uses of pegylated albumin |
| WO2006135740A1 (en) * | 2005-06-10 | 2006-12-21 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated hemoglobin and albumin and uses thereof |
| CA2614987C (en) * | 2005-07-19 | 2013-10-08 | Nektar Therapeutics Al, Corporation | Method for preparing polymer maleimides |
| EP2463295A1 (en) | 2006-05-22 | 2012-06-13 | The Regents of The University of California | Compositions and methods for the delivery of oxygen |
| US7504377B2 (en) * | 2006-10-23 | 2009-03-17 | Ikor, Inc. | Nitric oxide-blocked cross-linked tetrameric hemoglobin |
| CN101158676B (zh) * | 2006-12-31 | 2011-12-14 | 重庆大学 | 一种评价血液及其代用品携氧、释氧功能的分析方法及装置 |
| EP2200652B1 (en) | 2007-09-27 | 2018-03-21 | Children's Medical Center Corporation | Microbubbles and methods for oxygen delivery |
| US10172950B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| DK3266463T3 (da) | 2009-06-09 | 2024-01-08 | Prolong Pharmaceuticals Llc | Hæmoglobinsammensætninger |
| US10172949B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| US9114109B2 (en) * | 2009-06-16 | 2015-08-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | Five-coordinate neuroglobin and use thereof as a blood substitute |
| US8273857B2 (en) * | 2009-09-22 | 2012-09-25 | Jen-Chang Hsia | Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine |
| US20130041134A1 (en) * | 2009-11-05 | 2013-02-14 | Sangart ,Inc. | Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material |
| WO2011106396A1 (en) * | 2010-02-25 | 2011-09-01 | Sangart, Inc. | Methods for preparing peg-hemoglobin conjugates using reduced reactant ratios |
| US7989593B1 (en) | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
| US7932356B1 (en) | 2010-06-23 | 2011-04-26 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition |
| US8048856B1 (en) | 2010-06-23 | 2011-11-01 | Billion King, Ltd. | Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition |
| WO2012094679A2 (en) * | 2011-01-07 | 2012-07-12 | Vindico NanoBio Technology Inc. | Compositions and methods for delivery of high-affinity oxygen binding agents to tumors |
| US20120196270A1 (en) * | 2011-02-02 | 2012-08-02 | Sangart, Inc. | Methods for preserving an organ for transplantation using a hemoglobin-carbon monoxide complex |
| US8889830B2 (en) | 2011-03-01 | 2014-11-18 | Chuo University | Hemoglobin-albumin complex, and artificial plasma expander and artificial oxygen carrier containing the complex |
| US8084581B1 (en) | 2011-04-29 | 2011-12-27 | Bing Lou Wong | Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus |
| US20130052232A1 (en) | 2011-08-31 | 2013-02-28 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking |
| JP6389125B2 (ja) * | 2011-11-07 | 2018-09-12 | ザ ジェネラル ホスピタル コーポレイション | 赤血球の処理法 |
| CN109731098A (zh) | 2012-03-29 | 2019-05-10 | 桑加特公司 | 双阿司匹林交联聚乙二醇化血红蛋白 |
| WO2013151776A1 (en) | 2012-04-03 | 2013-10-10 | Sangart, Inc. | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins |
| WO2013151682A1 (en) | 2012-04-06 | 2013-10-10 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
| EP3922643A1 (en) | 2013-01-07 | 2021-12-15 | Omniox, Inc. | Polymeric forms of h-nox proteins |
| US10577554B2 (en) | 2013-03-15 | 2020-03-03 | Children's Medical Center Corporation | Gas-filled stabilized particles and methods of use |
| EP2968597B1 (en) * | 2013-03-15 | 2021-08-18 | Schindler, William | Polyalkylene oxide valerate hemoglobin conjugates |
| WO2016149562A2 (en) | 2015-03-17 | 2016-09-22 | Omniox, Inc. | Modulation of tumor immunity by protein-mediated 02 delivery |
| US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
| CN105497894B (zh) * | 2015-12-21 | 2019-01-04 | 中国科学院深圳先进技术研究院 | 用于肿瘤光动力治疗的血红蛋白-光敏剂试剂及其应用 |
| EP3416673B1 (en) | 2016-02-16 | 2022-11-02 | Omniox, Inc. | Modulation of hypoxia associated with stroke |
| EP3449004B1 (en) | 2016-04-29 | 2021-02-24 | Poseida Therapeutics, Inc. | Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids |
| EP3508214A4 (en) | 2016-07-06 | 2020-05-13 | Chuo University | Therapeutic agent for ischemic diseases |
| ES2651717B1 (es) * | 2016-07-26 | 2018-11-16 | Lara OLLER DUQUE | Solución acuosa cristaloide isotónica |
| WO2018160752A1 (en) | 2017-02-28 | 2018-09-07 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
| EP3790467B1 (en) * | 2018-05-11 | 2023-12-06 | Spectronix Inc. | Abnormal blood oxygenation level monitoring system and self-monitoring oxygenation system |
| WO2020037052A1 (en) | 2018-08-15 | 2020-02-20 | Omniox, Inc. | H-nox proteins for treating cardiovascular and pulmonary conditions |
| CN111499732B (zh) * | 2020-04-22 | 2022-05-13 | 中国科学院过程工程研究所 | 一种基于双重化学修饰的血红蛋白氧载体及其制备方法和应用 |
| WO2021261712A1 (en) * | 2020-06-26 | 2021-12-30 | Sunbio, Inc. | Hemoglobin derivative co-conjugated with fatty acid-linked peg and alkoxy peg as a blood substitute |
| WO2022082322A1 (en) | 2020-10-24 | 2022-04-28 | Spectronix Inc. | System and method for adaptive user experience cycle profiling under anomalous environmental respiratory conditions |
| CN114617957B (zh) * | 2022-03-10 | 2024-01-16 | 中国人民解放军军事科学院军事医学研究院 | 羟乙基淀粉血红蛋白偶联物及其制备方法与应用 |
| WO2024112490A2 (en) * | 2022-10-27 | 2024-05-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Nitrosyl-heme formulations for the treatment cardiovascular conditions, hemolysis, and the stabilization of cell-free heme molecules |
| CN119462905B (zh) * | 2024-11-11 | 2026-08-11 | 广东龙康方承医疗器械有限公司 | 一种携氧蛋白分子及其制备方法与应用 |
Family Cites Families (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507146A (en) | 1968-02-09 | 1970-04-21 | Webb James E | Method and system for respiration analysis |
| US3956259A (en) | 1973-01-30 | 1976-05-11 | Baxter Laboratories, Inc. | Fractionation of blood using block copolymer of ethylene oxide and polyoxypropylene polymer to recover fraction suitable for organ perfusate |
| US3925344A (en) * | 1973-04-11 | 1975-12-09 | Community Blood Council | Plasma protein substitute |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| DE2430898A1 (de) | 1974-06-27 | 1976-01-08 | Clevert Hans Dietmar | Doppelkapillar-oxygenator |
| DE2449885C3 (de) | 1974-10-21 | 1980-04-30 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat |
| US4001200A (en) | 1975-02-27 | 1977-01-04 | Alza Corporation | Novel polymerized, cross-linked, stromal-free hemoglobin |
| US4001401A (en) * | 1975-02-02 | 1977-01-04 | Alza Corporation | Blood substitute and blood plasma expander comprising polyhemoglobin |
| US4061736A (en) * | 1975-02-02 | 1977-12-06 | Alza Corporation | Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin |
| US4053590A (en) | 1975-02-27 | 1977-10-11 | Alza Corporation | Compositions of matter comprising macromolecular hemoglobin |
| CA1055932A (en) | 1975-10-22 | 1979-06-05 | Hematech Inc. | Blood substitute based on hemoglobin |
| GB1578776A (en) | 1976-06-10 | 1980-11-12 | Univ Illinois | Hemoglobin liposome and method of making the same |
| JPS5329908A (en) | 1976-08-27 | 1978-03-20 | Green Cross Corp:The | Immobilized haptoglobin preparation |
| US4209300A (en) | 1978-09-25 | 1980-06-24 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Hemoglobin-oxygen equilibrium curve analyzer |
| JPS6023084B2 (ja) * | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| JPS5716815A (en) | 1980-07-02 | 1982-01-28 | Ajinomoto Co Inc | Oxygen transporting agent for artificial blood |
| US4401652A (en) | 1980-12-31 | 1983-08-30 | Allied Corporation | Process for the preparation of stroma-free hemoglobin solutions |
| JPS57206622A (en) | 1981-06-10 | 1982-12-18 | Ajinomoto Co Inc | Blood substitute |
| US4532130A (en) | 1981-07-06 | 1985-07-30 | Rush-Presbyterian-St. Luke's Medical Center | Preparation of synthetic frythrocytes |
| DE3130770C2 (de) | 1981-08-04 | 1986-06-19 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Gewinnung von hepatitissicheren, sterilen, pyrogenfreien und stromafreien Hämoglobinlösungen |
| US4473496A (en) * | 1981-09-14 | 1984-09-25 | The United States Of America As Represented By The Secretary Of The Army | Intramolecularly crosslinked hemoglobin |
| DE3144705C2 (de) | 1981-11-11 | 1983-12-08 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat |
| CH650647A5 (de) * | 1982-12-10 | 1985-08-15 | Knorr Naehrmittel Ag | Lagerfaehiges, zu einer dessert-mousse aufschlagbares produkt und verfahren zu dessen herstellung. |
| US4529719A (en) * | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| US4473494A (en) | 1983-05-04 | 1984-09-25 | The United States Of America As Represented By The Secretary Of The Army | Preparation of stroma-free, non-heme protein-free hemoglobin |
| GB8328917D0 (en) | 1983-10-28 | 1983-11-30 | Fisons Plc | Blood substitute |
| US4831012A (en) | 1984-03-23 | 1989-05-16 | Baxter International Inc. | Purified hemoglobin solutions and method for making same |
| US5281579A (en) | 1984-03-23 | 1994-01-25 | Baxter International Inc. | Purified virus-free hemoglobin solutions and method for making same |
| DE3412144A1 (de) | 1984-03-31 | 1985-10-10 | Biotest Pharma GmbH, 6000 Frankfurt | Verfahren zur herstellung hochgereinigter, stromafreier, hepatitissicherer human- und tierhaemoglobinloesungen |
| US4738952A (en) | 1984-04-27 | 1988-04-19 | Synthetic Blood Corporation | Substitute for human blood and a method of making the same |
| US4600531A (en) * | 1984-06-27 | 1986-07-15 | University Of Iowa Research Foundation | Production of alpha-alpha cross-linked hemoglobins in high yield |
| US4598064A (en) | 1984-06-27 | 1986-07-01 | University Of Iowa Research Foundation | Alpha-alpha cross-linked hemoglobins |
| US4584130A (en) | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US5080885A (en) | 1986-01-14 | 1992-01-14 | Alliance Pharmaceutical Corp. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
| US5077036A (en) | 1986-01-14 | 1991-12-31 | Alliance Pharmaceutical Corp. | Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid |
| US4987154A (en) | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
| US5684050A (en) | 1986-01-24 | 1997-11-04 | Hemagen/Pfc | Stable emulsions of highly fluorinated organic compounds |
| US4826811A (en) | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5464814A (en) | 1986-06-20 | 1995-11-07 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5194590A (en) * | 1986-06-20 | 1993-03-16 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| DE3620873A1 (de) | 1986-06-21 | 1987-12-23 | Rau Guenter | Vorrichtung zur bestimmung des partialdruckes von in einem fluid geloesten gasen und gasgemischen |
| US4911929A (en) | 1986-08-29 | 1990-03-27 | The United States Of America As Represented By The Secretary Of The Navy | Blood substitute comprising liposome-encapsulated hemoglobin |
| DE3636590A1 (de) | 1986-10-28 | 1988-05-26 | Braun Melsungen Ag | Blutersatzmittel |
| CA1312009C (en) | 1986-11-10 | 1992-12-29 | Carl W. Rausch | Extra pure semi-synthetic blood substitute |
| US5084558A (en) | 1987-10-13 | 1992-01-28 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
| GB8710598D0 (en) * | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
| US5449759A (en) | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
| GB8711614D0 (en) * | 1987-05-16 | 1987-06-24 | Medical Res Council | Proteins |
| US4861867A (en) | 1988-02-03 | 1989-08-29 | Baxter International, Inc. | Purified hemoglobin solutions and method for making same |
| US4901727A (en) | 1988-05-05 | 1990-02-20 | The Boc Group, Inc. | Micro-probe for gas sampling |
| US4900780A (en) | 1988-05-25 | 1990-02-13 | Masonic Medical Research Laboratory | Acellular resuscitative fluid |
| JPH07113599B2 (ja) | 1988-07-29 | 1995-12-06 | 三菱石油株式会社 | 流動液体中の気泡含有量の動的定量装置 |
| CA1338244C (en) | 1988-08-17 | 1996-04-09 | Xiang-Fu Wu | Purification of hemoglobin and methemoglobin by bioselective elution |
| US5061688A (en) | 1988-08-19 | 1991-10-29 | Illinois Institute Of Technology | Hemoglobin multiple emulsion |
| IL87707A (en) | 1988-09-08 | 1994-06-24 | Technion Inst For Research And | Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof |
| US5128452A (en) | 1989-04-19 | 1992-07-07 | Baxter International Inc. | Process for the production of crosslinked hemoglobin in the presence of sodium tripolyphosphate |
| US5545727A (en) * | 1989-05-10 | 1996-08-13 | Somatogen, Inc. | DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin |
| US5599907A (en) | 1989-05-10 | 1997-02-04 | Somatogen, Inc. | Production and use of multimeric hemoglobins |
| NL8901174A (nl) | 1989-05-10 | 1990-12-03 | Het Hoofd Van De Afdeling Mili | Hemoglobine-preparaat en gebruik daarvan. |
| US5478806A (en) | 1989-11-22 | 1995-12-26 | Enzon, Inc. | Enhancement of antitumor therapy with hemoglobin-based conjugates |
| US5650388A (en) | 1989-11-22 | 1997-07-22 | Enzon, Inc. | Fractionated polyalkylene oxide-conjugated hemoglobin solutions |
| US5312808A (en) | 1989-11-22 | 1994-05-17 | Enzon, Inc. | Fractionation of polyalkylene oxide-conjugated hemoglobin solutions |
| US5234903A (en) | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
| US5386014A (en) | 1989-11-22 | 1995-01-31 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute |
| US5041615A (en) | 1989-12-05 | 1991-08-20 | Baxter International Inc. | Preparation of bis(salicyl) diesters |
| US5239061A (en) | 1990-06-20 | 1993-08-24 | Research Corporation Technologies, Inc. | Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin |
| US5352773A (en) | 1990-08-06 | 1994-10-04 | Baxter International Inc. | Stable hemoglobin based composition and method to store same |
| US5248766A (en) | 1990-08-17 | 1993-09-28 | Baxter International Inc. | Oxirane-modified hemoglobin based composition |
| IT1244609B (it) | 1990-09-14 | 1994-08-08 | Instrumentation Lab Spa | Procedimento ed apparecchiatura per la determinazione elettrochimica di specie gassose o volatili con particolare riferimento ad emogsanalizzatori. |
| US5114932A (en) | 1990-11-30 | 1992-05-19 | Runge Thomas M | Hyperosmolar oxyreplete hemosubstitute |
| US5234555A (en) * | 1991-02-05 | 1993-08-10 | Ibbott Jack Kenneth | Method and apparatus for ionizing fluids utilizing a capacitive effect |
| CA2066374C (en) | 1991-04-19 | 2002-01-29 | Paul E. Segall | Solution for perfusing primates |
| US5295944A (en) | 1991-05-14 | 1994-03-22 | Dana-Farber Cancer Institute | Method for treating a tumor with ionizing radiation |
| US5250665A (en) * | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
| US5334705A (en) | 1991-08-15 | 1994-08-02 | Duke University | Benzenetricarboxylate derivative-crosslinked low oxygen affinity hemoglobin |
| US5349054A (en) | 1991-08-15 | 1994-09-20 | Duke University | Activated benzenepentacarboxylate-crosslinked low oxygen affinity hemoglobin |
| US5334706A (en) | 1992-01-30 | 1994-08-02 | Baxter International | Administration of low dose hemoglobin to increase perfusion |
| US5200323A (en) | 1992-01-31 | 1993-04-06 | Mcgill University | In vitro method to determine the safety of modified hemoglobin blood substitutes for human prior to clinical use |
| US5296466A (en) | 1992-02-19 | 1994-03-22 | Board Of Regents, The University Of Texas System | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein |
| US5344393A (en) | 1992-02-28 | 1994-09-06 | Alliance Pharmaceutical Corp. | Use of synthetic oxygen carriers to facilitate oxygen delivery |
| US5264555A (en) | 1992-07-14 | 1993-11-23 | Enzon, Inc. | Process for hemoglobin extraction and purification |
| US5628930A (en) | 1992-10-27 | 1997-05-13 | Alliance Pharmaceutical Corp. | Stabilization of fluorocarbon emulsions |
| US5558855A (en) | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| US5635538A (en) | 1993-03-16 | 1997-06-03 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions with reduced pulmonary gas-trapping properties |
| KR100306000B1 (ko) | 1993-03-16 | 2001-12-01 | 메그닌 안토니에이. | 산화되고고리열린당화물에의한헤모글로빈의선택적인가교결합 |
| US5612310A (en) * | 1993-05-24 | 1997-03-18 | Duke University | Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders |
| US5554638A (en) | 1993-05-24 | 1996-09-10 | Duke University | Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders |
| PT701455E (pt) | 1993-06-04 | 2001-09-27 | Biotime Inc | Solucao semelhante a plasma |
| US5407428A (en) | 1993-06-04 | 1995-04-18 | Biotime, Inc. | Solutions for use as plasma expanders and substitutes |
| US5578564A (en) | 1993-07-23 | 1996-11-26 | Somatogen, Inc. | Nickel-free hemoglobin and methods for producing such hemoglobin |
| TW381022B (en) | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
| US5545328A (en) | 1993-09-21 | 1996-08-13 | Hemosol Inc. | Purification of hemoglobin by displacement chromatography |
| CA2106612C (en) | 1993-09-21 | 2001-02-06 | Diana Pliura | Displacement chromatography process |
| US5631219A (en) | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
| US5585484A (en) * | 1995-04-19 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hemoglobin crosslinkers |
| US5525630A (en) | 1995-06-01 | 1996-06-11 | Allos Therapeutics, Inc. | Treatment for carbon monoxide poisoning |
| US6054427A (en) * | 1997-02-28 | 2000-04-25 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
| US5814601A (en) * | 1997-02-28 | 1998-09-29 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
| EP1046033B1 (en) | 1997-10-17 | 2004-06-30 | The Regents of the University of California | System and method to characterize gas transport properties |
| US5985825A (en) | 1998-02-28 | 1999-11-16 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
| CA2233725A1 (en) * | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| EP1469811A4 (en) * | 2002-01-11 | 2006-01-04 | Sangart Inc | METHOD AND COMPOSITIONS FOR OXYGEN TRANSPORT WITH MODIFIED HEMOGLOBIN IN PLASMA |
| US20050119161A1 (en) * | 2002-01-11 | 2005-06-02 | Winslow Robert M. | Methods and compositions for oxygen transport comprising an oxygen carrier and a crystalloid in hypertonic solution |
| AU2003299700B2 (en) * | 2002-12-23 | 2009-03-26 | Albert Einstein College Of Medicine Of Yeshiva University | Modified hemoglobin and methods of making same |
-
2002
- 2002-04-01 US US10/114,400 patent/US20030153491A1/en not_active Abandoned
-
2003
- 2003-01-10 US US10/340,141 patent/US6844317B2/en not_active Expired - Lifetime
- 2003-01-10 BR BR0306846-3A patent/BR0306846A/pt not_active Application Discontinuation
- 2003-01-10 DE DE60318388T patent/DE60318388T2/de not_active Expired - Lifetime
- 2003-01-10 KR KR1020047010847A patent/KR100964604B1/ko not_active Expired - Fee Related
- 2003-01-10 CA CA002473662A patent/CA2473662C/en not_active Expired - Lifetime
- 2003-01-10 JP JP2003559525A patent/JP5149480B2/ja not_active Expired - Fee Related
- 2003-01-10 DK DK03705713T patent/DK1465643T3/da active
- 2003-01-10 WO PCT/US2003/000696 patent/WO2003059363A1/en not_active Ceased
- 2003-01-10 MX MXPA04006733A patent/MXPA04006733A/es active IP Right Grant
- 2003-01-10 ES ES03705713T patent/ES2299686T3/es not_active Expired - Lifetime
- 2003-01-10 EP EP03705713A patent/EP1465643B1/en not_active Expired - Lifetime
- 2003-01-10 PT PT03705713T patent/PT1465643E/pt unknown
- 2003-01-10 AU AU2003207504A patent/AU2003207504B2/en not_active Ceased
- 2003-01-10 AT AT03705713T patent/ATE382358T1/de active
- 2003-01-10 CN CN038036487A patent/CN1630527B/zh not_active Expired - Fee Related
- 2003-01-10 CN CN2013100910214A patent/CN103203013A/zh active Pending
-
2004
- 2004-08-24 US US10/925,067 patent/US6974795B2/en not_active Expired - Lifetime
-
2010
- 2010-03-09 JP JP2010052387A patent/JP2010138197A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5919455A (en) | Non-antigenic branched polymer conjugates | |
| JP5112203B2 (ja) | ポリアルキレングリコール酸添加剤 | |
| Spahn et al. | Artificial O2 carriers: status in 2005 | |
| JP2010530014A5 (enExample) | ||
| JP2021502120A5 (enExample) | ||
| CA2473662A1 (en) | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin | |
| CA2481365A1 (en) | Occlusive composition comprising a poly (2-cyanoacrylate) monomer | |
| JP2006505634A5 (enExample) | ||
| JP2002508400A5 (enExample) | ||
| RU2005139404A (ru) | Каучуковые смеси | |
| JP2004197077A (ja) | 修飾された生体関連物質、その製造方法および中間体 | |
| JP4709465B2 (ja) | アルギニンデイミナーゼの新規突然変異体 | |
| ATE333261T1 (de) | Klebstoffzusammensetzung und verfahren zu ihrer herstellung | |
| JP2008540565A5 (enExample) | ||
| AU2001274853A1 (en) | Methods for refolding proteins containing free cysteine residues | |
| JP2008500275A5 (enExample) | ||
| CN109641034A (zh) | 聚乙二醇化的猪干扰素及其使用方法 | |
| MX2014011944A (es) | Compuestos de nitroxilo activados con succinimida y metodos para el uso de los mismos para nitroxilacion de proteinas. | |
| JP2005535606A5 (enExample) | ||
| JP2007508427A (ja) | アジドまたはアセチレン末端水溶性ポリマー | |
| JP2011528654A5 (enExample) | ||
| EP2827887A1 (en) | Method of enhancing efficacy of blood transfusions | |
| CN110101898B (zh) | 双组分原位注射型聚天冬酰胺仿生组织粘合剂及其制备方法 | |
| JP2013525414A5 (enExample) | ||
| JP2011507913A5 (enExample) |