JP2005515225A5 - - Google Patents
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- JP2005515225A5 JP2005515225A5 JP2003559525A JP2003559525A JP2005515225A5 JP 2005515225 A5 JP2005515225 A5 JP 2005515225A5 JP 2003559525 A JP2003559525 A JP 2003559525A JP 2003559525 A JP2003559525 A JP 2003559525A JP 2005515225 A5 JP2005515225 A5 JP 2005515225A5
- Authority
- JP
- Japan
- Prior art keywords
- blood substitute
- hemoglobin
- substitute product
- pao
- product according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003633 blood substitute Substances 0.000 claims 22
- 108010054147 Hemoglobins Proteins 0.000 claims 18
- 102000001554 Hemoglobins Human genes 0.000 claims 18
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 7
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 7
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 108010061951 Methemoglobin Proteins 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000001706 oxygenating effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 108010001708 stroma free hemoglobin Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34774102P | 2002-01-11 | 2002-01-11 | |
| US60/347,741 | 2002-01-11 | ||
| US10/114,400 | 2002-04-01 | ||
| US10/114,400 US20030153491A1 (en) | 2002-01-11 | 2002-04-01 | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| PCT/US2003/000696 WO2003059363A1 (en) | 2002-01-11 | 2003-01-10 | Methods and compositions for oxygen transport comprising a high oyzgen affinity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010052387A Division JP2010138197A (ja) | 2002-01-11 | 2010-03-09 | 高酸素親和性改変ヘモグロビンを含む、酸素輸送のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005515225A JP2005515225A (ja) | 2005-05-26 |
| JP2005515225A5 true JP2005515225A5 (enExample) | 2005-12-22 |
| JP5149480B2 JP5149480B2 (ja) | 2013-02-20 |
Family
ID=26812138
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003559525A Expired - Fee Related JP5149480B2 (ja) | 2002-01-11 | 2003-01-10 | 高酸素親和性改変ヘモグロビンを含む、酸素輸送のための方法および組成物 |
| JP2010052387A Pending JP2010138197A (ja) | 2002-01-11 | 2010-03-09 | 高酸素親和性改変ヘモグロビンを含む、酸素輸送のための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010052387A Pending JP2010138197A (ja) | 2002-01-11 | 2010-03-09 | 高酸素親和性改変ヘモグロビンを含む、酸素輸送のための方法および組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20030153491A1 (enExample) |
| EP (1) | EP1465643B1 (enExample) |
| JP (2) | JP5149480B2 (enExample) |
| KR (1) | KR100964604B1 (enExample) |
| CN (2) | CN103203013A (enExample) |
| AT (1) | ATE382358T1 (enExample) |
| AU (1) | AU2003207504B2 (enExample) |
| BR (1) | BR0306846A (enExample) |
| CA (1) | CA2473662C (enExample) |
| DE (1) | DE60318388T2 (enExample) |
| DK (1) | DK1465643T3 (enExample) |
| ES (1) | ES2299686T3 (enExample) |
| MX (1) | MXPA04006733A (enExample) |
| PT (1) | PT1465643E (enExample) |
| WO (1) | WO2003059363A1 (enExample) |
Families Citing this family (53)
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| DE60329627D1 (de) | 2002-12-31 | 2009-11-19 | Nektar Therapeutics Al Corp | Hydrolysestabile maleimidendgruppen-enthaltende polymere |
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| US8455437B2 (en) * | 2005-02-04 | 2013-06-04 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Method to predict and prevent oxygen-induced inflammatory tissue injury |
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| WO2007050121A2 (en) * | 2005-05-11 | 2007-05-03 | Albert Einstein College Of Medicine Of Yeshiva University | Site specific pegylated hemoglobin, method of preparing same, and uses thereof |
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| AU2006269845B2 (en) * | 2005-07-19 | 2012-03-22 | Nektar Therapeutics | Method for preparing polymer maleimides |
| US8404632B2 (en) | 2006-05-22 | 2013-03-26 | The Regents Of The University Of California | Compositions and methods for the delivery of nitric oxide |
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| US20130052232A1 (en) | 2011-08-31 | 2013-02-28 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking |
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| CN105497894B (zh) * | 2015-12-21 | 2019-01-04 | 中国科学院深圳先进技术研究院 | 用于肿瘤光动力治疗的血红蛋白-光敏剂试剂及其应用 |
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| ES2865481T3 (es) | 2016-04-29 | 2021-10-15 | Poseida Therapeutics Inc | Micelas basadas en poli(histidina) para la complejación y el aporte de proteínas y ácidos nucleicos |
| WO2018008729A1 (ja) | 2016-07-06 | 2018-01-11 | 学校法人 中央大学 | 虚血性疾患の治療剤 |
| ES2651717B1 (es) * | 2016-07-26 | 2018-11-16 | Lara OLLER DUQUE | Solución acuosa cristaloide isotónica |
| US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
| AU2019264885B2 (en) * | 2018-05-11 | 2025-02-20 | Spectronix Inc. | Abnormal blood oxygenation level monitoring system and method, and self-monitoring oxygenation system and method |
| EP3836911A1 (en) | 2018-08-15 | 2021-06-23 | Omniox, Inc. | H-nox proteins for treating cardiovascular and pulmonary conditions |
| CN111499732B (zh) * | 2020-04-22 | 2022-05-13 | 中国科学院过程工程研究所 | 一种基于双重化学修饰的血红蛋白氧载体及其制备方法和应用 |
| WO2021261712A1 (en) * | 2020-06-26 | 2021-12-30 | Sunbio, Inc. | Hemoglobin derivative co-conjugated with fatty acid-linked peg and alkoxy peg as a blood substitute |
| CN114617957B (zh) * | 2022-03-10 | 2024-01-16 | 中国人民解放军军事科学院军事医学研究院 | 羟乙基淀粉血红蛋白偶联物及其制备方法与应用 |
| WO2024112490A2 (en) * | 2022-10-27 | 2024-05-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Nitrosyl-heme formulations for the treatment cardiovascular conditions, hemolysis, and the stabilization of cell-free heme molecules |
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-
2002
- 2002-04-01 US US10/114,400 patent/US20030153491A1/en not_active Abandoned
-
2003
- 2003-01-10 JP JP2003559525A patent/JP5149480B2/ja not_active Expired - Fee Related
- 2003-01-10 US US10/340,141 patent/US6844317B2/en not_active Expired - Lifetime
- 2003-01-10 ES ES03705713T patent/ES2299686T3/es not_active Expired - Lifetime
- 2003-01-10 DK DK03705713T patent/DK1465643T3/da active
- 2003-01-10 MX MXPA04006733A patent/MXPA04006733A/es active IP Right Grant
- 2003-01-10 CN CN2013100910214A patent/CN103203013A/zh active Pending
- 2003-01-10 WO PCT/US2003/000696 patent/WO2003059363A1/en not_active Ceased
- 2003-01-10 KR KR1020047010847A patent/KR100964604B1/ko not_active Expired - Fee Related
- 2003-01-10 PT PT03705713T patent/PT1465643E/pt unknown
- 2003-01-10 AT AT03705713T patent/ATE382358T1/de active
- 2003-01-10 BR BR0306846-3A patent/BR0306846A/pt not_active Application Discontinuation
- 2003-01-10 CN CN038036487A patent/CN1630527B/zh not_active Expired - Fee Related
- 2003-01-10 DE DE60318388T patent/DE60318388T2/de not_active Expired - Lifetime
- 2003-01-10 CA CA002473662A patent/CA2473662C/en not_active Expired - Lifetime
- 2003-01-10 EP EP03705713A patent/EP1465643B1/en not_active Expired - Lifetime
- 2003-01-10 AU AU2003207504A patent/AU2003207504B2/en not_active Ceased
-
2004
- 2004-08-24 US US10/925,067 patent/US6974795B2/en not_active Expired - Lifetime
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2010
- 2010-03-09 JP JP2010052387A patent/JP2010138197A/ja active Pending
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