JP2008524338A5 - - Google Patents

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Publication number
JP2008524338A5
JP2008524338A5 JP2007548599A JP2007548599A JP2008524338A5 JP 2008524338 A5 JP2008524338 A5 JP 2008524338A5 JP 2007548599 A JP2007548599 A JP 2007548599A JP 2007548599 A JP2007548599 A JP 2007548599A JP 2008524338 A5 JP2008524338 A5 JP 2008524338A5
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JP
Japan
Prior art keywords
reagent
hydrogen
poly
carbon atoms
lower alkyl
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JP2007548599A
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English (en)
Japanese (ja)
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JP5243041B2 (ja
JP2008524338A (ja
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Priority claimed from PCT/US2005/047337 external-priority patent/WO2006069388A2/en
Publication of JP2008524338A publication Critical patent/JP2008524338A/ja
Publication of JP2008524338A5 publication Critical patent/JP2008524338A5/ja
Application granted granted Critical
Publication of JP5243041B2 publication Critical patent/JP5243041B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2007548599A 2004-12-21 2005-12-21 安定化ポリマーチオール試薬 Expired - Fee Related JP5243041B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63982304P 2004-12-21 2004-12-21
US60/639,823 2004-12-21
US70596805P 2005-08-04 2005-08-04
US60/705,968 2005-08-04
PCT/US2005/047337 WO2006069388A2 (en) 2004-12-21 2005-12-21 Stabilized polymeric thiol reagents

Publications (3)

Publication Number Publication Date
JP2008524338A JP2008524338A (ja) 2008-07-10
JP2008524338A5 true JP2008524338A5 (enExample) 2009-01-29
JP5243041B2 JP5243041B2 (ja) 2013-07-24

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Family Applications (1)

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JP2007548599A Expired - Fee Related JP5243041B2 (ja) 2004-12-21 2005-12-21 安定化ポリマーチオール試薬

Country Status (12)

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US (5) US7851565B2 (enExample)
EP (1) EP1827501B2 (enExample)
JP (1) JP5243041B2 (enExample)
KR (1) KR101320936B1 (enExample)
CN (1) CN101111267B (enExample)
AT (1) ATE494012T1 (enExample)
AU (1) AU2005318984B2 (enExample)
CA (1) CA2591233C (enExample)
DE (1) DE602005025805D1 (enExample)
ES (1) ES2357089T5 (enExample)
MX (1) MX2007007471A (enExample)
WO (1) WO2006069388A2 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947261B2 (en) 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
EP1586334A1 (en) * 2004-04-15 2005-10-19 TRASTEC scpa G-CSF conjugates with peg
JP5243041B2 (ja) * 2004-12-21 2013-07-24 ネクター セラピューティックス 安定化ポリマーチオール試薬
BRPI0614257A2 (pt) * 2005-08-04 2011-03-15 Nektar Therapeutics Al Corp conjugados de uma porção de g-csf e um polìmero
CN101291658B (zh) 2005-08-31 2014-04-16 阿布拉科斯生物科学有限公司 用于制备稳定性增加的水难溶性药物的组合物和方法
US7771751B2 (en) 2005-08-31 2010-08-10 Abraxis Bioscience, Llc Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
KR100819064B1 (ko) 2006-12-19 2008-04-04 (재)대구경북과학기술연구원 생분자 고정화 링커
EP2014256A1 (en) 2007-07-12 2009-01-14 Straumann Holding AG Composite bone repair material
BRPI0721948A2 (pt) * 2007-08-20 2014-04-08 Enzon Pharmaceuticals Inc Ligantes poliméricos contendo frações dissulfeto de piridila
WO2009052148A1 (en) 2007-10-15 2009-04-23 California Institute Of Technology Functionalized polymers using protected thiols
WO2009103199A1 (zh) * 2008-02-18 2009-08-27 江苏恒瑞医药股份有限公司 水溶性聚合物修饰的g-csf偶联物
WO2009143412A2 (en) * 2008-05-23 2009-11-26 Enzon Pharmaceuticals, Inc. Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides
US20120128587A1 (en) * 2009-07-31 2012-05-24 Endocyte, Inc. Folate-targeted diagnostics and treatment
CA2796729C (en) 2010-04-20 2020-06-23 Octapharma Ag Melezitose for stabilizing human blood plasma proteins
JP2019043961A (ja) * 2010-04-20 2019-03-22 オクタファルマ・アーゲー 医薬タンパク質の新規な安定化剤
CN101885841B (zh) * 2010-07-02 2012-05-16 清华大学 一种可与巯基发生加成反应且成键水解稳定的高分子
WO2012021791A2 (en) * 2010-08-13 2012-02-16 Scidose Llc Aqueous formulation with improved stability
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
HUE035803T2 (en) 2012-12-21 2018-05-28 Sanofi Sa Dual GLP1 / GIP or trigonal GLP1 / GIP / glucagon agonists
EP3574924B1 (en) 2013-11-19 2021-01-06 Purdue Research Foundation Patient selection method for inflammation
TW201609797A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重glp-1/升糖素受體促效劑
EP3080154B1 (en) 2013-12-13 2018-02-07 Sanofi Dual glp-1/gip receptor agonists
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自exendin-4之雙重glp-1/升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物
WO2019040507A1 (en) * 2017-08-21 2019-02-28 Prevail Therapeutics, Inc. MODIFIED LYSOSOMIAL ENZYMES
AU2019305215B2 (en) * 2018-07-20 2026-01-22 Hercules Llc Water soluble or dispersible composition
EP4007787A4 (en) 2019-08-01 2023-09-20 Hercules LLC Synthetic thickeners incorporating non-reactive diluents
CN115785473B (zh) * 2022-12-20 2023-08-18 上海赛翠克环保科技有限公司 端异硫脲基三羟甲基丙烷芯树枝状聚合物及其制备方法和缓蚀应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1365481A (en) † 1968-07-15 1974-09-04 Ciba Geigy Uk Ltd Process for keratinous fabric
DE2138448A1 (de) † 1968-07-15 1972-02-17 IWS Nominee Co Ltd , London, Ciba Geigy AG, Basel (Schweiz) Behandlung von keratinhaltigen Materialien
GB1379203A (en) † 1970-12-14 1975-01-02 Ciba Geigy Ag Textile finishing
DE2238940A1 (de) 1972-08-08 1974-02-21 Bayer Ag Permanent antistatische acrylnitrilpolymerisate
GB1435085A (en) † 1972-09-01 1976-05-12 Ciba Geigy Ag Keratinous textiles and fibres
US3948820A (en) † 1972-11-02 1976-04-06 Horizons Incorporated Curable polyphosphazene copolymers and terpolymers
CH565275A (enExample) † 1973-06-21 1975-08-15
ES2087069T3 (es) † 1988-11-23 1996-07-16 Ciba Geigy Ag Mezclas de resinas epoxi reticulables que contienen polioxialquilenditioles y poliaminas.
DE59008799D1 (de) 1989-11-21 1995-05-04 Ciba Geigy Ag Härtbare Epoxidharz-Stoffgemische enthaltend einen latenten Härter, ein Amin und ein Thiol.
US5516703A (en) 1993-08-20 1996-05-14 The University Of Utah Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5580923A (en) 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US6306584B1 (en) 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
JPH1138544A (ja) * 1997-07-16 1999-02-12 Konica Corp ハロゲン化銀写真感光材料及びその処理方法
DE69936409T2 (de) * 1998-04-28 2008-04-17 Laboratoires Serono S.A., Coinsins Verfahren zur schrittweise Bindung von Polyethylenglykol (PEG) an Polypeptide
TW593427B (en) 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
US7053150B2 (en) 2000-12-18 2006-05-30 Nektar Therapeutics Al, Corporation Segmented polymers and their conjugates
PT3025726T (pt) 2002-01-18 2020-01-09 Biogen Ma Inc Compostos do polímero polialquileno e utilizações dos mesmos
CN1511861A (zh) 2002-12-26 2004-07-14 北京键凯科技有限公司 聚乙二醇-脂肪酸衍生物及其药物结合物
ATE444984T1 (de) 2002-12-31 2009-10-15 Nektar Therapeutics Al Corp Hydrolysestabile maleimidendgruppen-enthaltende polymere
KR101031206B1 (ko) 2002-12-31 2011-04-27 넥타르 테라퓨틱스 말레암산 중합체 유도체 및 이의 바이오컨쥬게이트
US7910661B2 (en) 2003-01-06 2011-03-22 Nektar Therapeutics Thiol-selective water-soluble polymer derivatives
JP4109559B2 (ja) † 2003-02-19 2008-07-02 独立行政法人科学技術振興機構 オリゴヌクレオチドとポリエチレンオキシドのコンジュゲート
DE602004011660T2 (de) 2004-06-16 2009-01-29 Straumann Holding Ag Abdeckmembran
JP5243041B2 (ja) 2004-12-21 2013-07-24 ネクター セラピューティックス 安定化ポリマーチオール試薬
BRPI0614257A2 (pt) † 2005-08-04 2011-03-15 Nektar Therapeutics Al Corp conjugados de uma porção de g-csf e um polìmero
WO2007075534A2 (en) † 2005-12-16 2007-07-05 Nektar Therapeutics Al, Corporation Polymer conjugates of glp-1
US20100223106A1 (en) 2009-02-27 2010-09-02 Hallowell Zachary E Wholesale Virtual Inventory and Retail Lead Generation

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