ATE382358T1 - Verfahren und zusammensetzungen zum sauerstofftransport mit hoher sauerstoffaffinität - Google Patents
Verfahren und zusammensetzungen zum sauerstofftransport mit hoher sauerstoffaffinitätInfo
- Publication number
- ATE382358T1 ATE382358T1 AT03705713T AT03705713T ATE382358T1 AT E382358 T1 ATE382358 T1 AT E382358T1 AT 03705713 T AT03705713 T AT 03705713T AT 03705713 T AT03705713 T AT 03705713T AT E382358 T1 ATE382358 T1 AT E382358T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- oxygen
- affinity
- transport
- present
- Prior art date
Links
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 229910052760 oxygen Inorganic materials 0.000 title abstract 4
- 239000001301 oxygen Substances 0.000 title abstract 4
- 102000001554 Hemoglobins Human genes 0.000 abstract 1
- 108010054147 Hemoglobins Proteins 0.000 abstract 1
- 239000010836 blood and blood product Substances 0.000 abstract 1
- 229940125691 blood product Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34774102P | 2002-01-11 | 2002-01-11 | |
US10/114,400 US20030153491A1 (en) | 2002-01-11 | 2002-04-01 | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE382358T1 true ATE382358T1 (de) | 2008-01-15 |
Family
ID=26812138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03705713T ATE382358T1 (de) | 2002-01-11 | 2003-01-10 | Verfahren und zusammensetzungen zum sauerstofftransport mit hoher sauerstoffaffinität |
Country Status (15)
Country | Link |
---|---|
US (3) | US20030153491A1 (de) |
EP (1) | EP1465643B1 (de) |
JP (2) | JP5149480B2 (de) |
KR (1) | KR100964604B1 (de) |
CN (2) | CN103203013A (de) |
AT (1) | ATE382358T1 (de) |
AU (1) | AU2003207504B2 (de) |
BR (1) | BR0306846A (de) |
CA (1) | CA2473662C (de) |
DE (1) | DE60318388T2 (de) |
DK (1) | DK1465643T3 (de) |
ES (1) | ES2299686T3 (de) |
MX (1) | MXPA04006733A (de) |
PT (1) | PT1465643E (de) |
WO (1) | WO2003059363A1 (de) |
Families Citing this family (50)
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US20050164915A1 (en) * | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
AU2003299700B2 (en) * | 2002-12-23 | 2009-03-26 | Albert Einstein College Of Medicine Of Yeshiva University | Modified hemoglobin and methods of making same |
US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
DE60329627D1 (de) * | 2002-12-31 | 2009-11-19 | Nektar Therapeutics Al Corp | Hydrolysestabile maleimidendgruppen-enthaltende polymere |
US7790835B2 (en) | 2003-12-03 | 2010-09-07 | Nektar Therapeutics | Method of preparing maleimide functionalized polymers |
ES2347805T3 (es) * | 2004-08-31 | 2010-11-04 | Sangart, Inc. | Metodos para aumentar la estabilidad hemodinamica usando composiciones que transportan oxigeno. |
US8455437B2 (en) * | 2005-02-04 | 2013-06-04 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Method to predict and prevent oxygen-induced inflammatory tissue injury |
CA2600927C (en) | 2005-03-07 | 2017-04-18 | Sangart, Inc. | Compositions and methods for delivering carbon monoxide (co) and nitric oxide (no) to tissue using heme proteins as carriers |
US20090215670A1 (en) * | 2005-05-11 | 2009-08-27 | Acharya Seetharama A | Site specific pegylated hemoglobin, method of preparing same, and uses thereof |
WO2007058678A2 (en) * | 2005-06-10 | 2007-05-24 | Albert Einstein College Of Medicine Of Yeshiva University | Uses of pegylated albumin |
WO2006135740A1 (en) * | 2005-06-10 | 2006-12-21 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated hemoglobin and albumin and uses thereof |
MX2008000867A (es) * | 2005-07-19 | 2008-04-04 | Nektar Therapeutics Al Corp | Metodo para preparar polimeros de maleimidas. |
BRPI0711901A2 (pt) | 2006-05-22 | 2012-03-06 | The Regents Of The University Of California | Composições e métodos para a liberação de oxigênio |
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WO2009043031A2 (en) * | 2007-09-27 | 2009-04-02 | Children's Medical Center Corporation | Microbubbles and methods for oxygen delivery |
NO2440239T3 (de) | 2009-06-09 | 2018-02-10 | ||
US10172950B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
US10172949B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
US9114109B2 (en) * | 2009-06-16 | 2015-08-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | Five-coordinate neuroglobin and use thereof as a blood substitute |
US8273857B2 (en) * | 2009-09-22 | 2012-09-25 | Jen-Chang Hsia | Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine |
US20130041134A1 (en) * | 2009-11-05 | 2013-02-14 | Sangart ,Inc. | Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material |
US9493616B2 (en) | 2010-02-25 | 2016-11-15 | Sangart, Inc. | Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios |
US7989593B1 (en) | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
US7932356B1 (en) | 2010-06-23 | 2011-04-26 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition |
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PT2661275T (pt) * | 2011-01-07 | 2019-04-24 | Poseida Therapeutics Inc | Composições e métodos para a entrega a tumores de agentes ligantes de elevada afinidade para o oxigénio |
US20120196270A1 (en) * | 2011-02-02 | 2012-08-02 | Sangart, Inc. | Methods for preserving an organ for transplantation using a hemoglobin-carbon monoxide complex |
EP2682407B1 (de) | 2011-03-01 | 2016-09-14 | Chuo University | Hämoglobin-albumin-komplex sowie künstlicher plasmaexpander und künstlicher sauerstoffträger damit |
US8084581B1 (en) | 2011-04-29 | 2011-12-27 | Bing Lou Wong | Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus |
US20130052232A1 (en) | 2011-08-31 | 2013-02-28 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking |
JP6389125B2 (ja) * | 2011-11-07 | 2018-09-12 | ザ ジェネラル ホスピタル コーポレイション | 赤血球の処理法 |
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US20150094267A1 (en) | 2012-04-03 | 2015-04-02 | Kim D. Vandegriff | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins |
WO2013151682A1 (en) | 2012-04-06 | 2013-10-10 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
CN105408354B (zh) | 2013-01-07 | 2020-09-18 | 欧姆尼奥克斯公司 | H-nox蛋白的多聚形式 |
JP6657070B2 (ja) * | 2013-03-15 | 2020-03-04 | ウィリアム・シンドラーWilliam Schindler | ポリアルキレンオキシド吉草酸ヘモグロビン接合体 |
US10577554B2 (en) | 2013-03-15 | 2020-03-03 | Children's Medical Center Corporation | Gas-filled stabilized particles and methods of use |
US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
CN105497894B (zh) * | 2015-12-21 | 2019-01-04 | 中国科学院深圳先进技术研究院 | 用于肿瘤光动力治疗的血红蛋白-光敏剂试剂及其应用 |
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US20190328892A1 (en) | 2016-07-06 | 2019-10-31 | Chuo University | Therapeutic agent for ischemic disease |
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WO2018160752A1 (en) | 2017-02-28 | 2018-09-07 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
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CN111499732B (zh) * | 2020-04-22 | 2022-05-13 | 中国科学院过程工程研究所 | 一种基于双重化学修饰的血红蛋白氧载体及其制备方法和应用 |
WO2021261712A1 (en) * | 2020-06-26 | 2021-12-30 | Sunbio, Inc. | Hemoglobin derivative co-conjugated with fatty acid-linked peg and alkoxy peg as a blood substitute |
CN114617957B (zh) * | 2022-03-10 | 2024-01-16 | 中国人民解放军军事科学院军事医学研究院 | 羟乙基淀粉血红蛋白偶联物及其制备方法与应用 |
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-
2002
- 2002-04-01 US US10/114,400 patent/US20030153491A1/en not_active Abandoned
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2003
- 2003-01-10 JP JP2003559525A patent/JP5149480B2/ja not_active Expired - Fee Related
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- 2003-01-10 CA CA002473662A patent/CA2473662C/en not_active Expired - Lifetime
- 2003-01-10 ES ES03705713T patent/ES2299686T3/es not_active Expired - Lifetime
- 2003-01-10 CN CN2013100910214A patent/CN103203013A/zh active Pending
- 2003-01-10 BR BR0306846-3A patent/BR0306846A/pt not_active Application Discontinuation
- 2003-01-10 KR KR1020047010847A patent/KR100964604B1/ko active IP Right Grant
- 2003-01-10 AU AU2003207504A patent/AU2003207504B2/en not_active Ceased
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- 2003-01-10 EP EP03705713A patent/EP1465643B1/de not_active Expired - Lifetime
- 2003-01-10 AT AT03705713T patent/ATE382358T1/de active
- 2003-01-10 DK DK03705713T patent/DK1465643T3/da active
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Also Published As
Publication number | Publication date |
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BR0306846A (pt) | 2004-12-07 |
US6974795B2 (en) | 2005-12-13 |
WO2003059363A1 (en) | 2003-07-24 |
CN1630527B (zh) | 2013-04-24 |
DK1465643T3 (da) | 2008-05-13 |
ES2299686T3 (es) | 2008-06-01 |
JP2005515225A (ja) | 2005-05-26 |
CA2473662A1 (en) | 2003-07-24 |
AU2003207504B2 (en) | 2007-05-24 |
JP5149480B2 (ja) | 2013-02-20 |
US20030153491A1 (en) | 2003-08-14 |
US20050026816A1 (en) | 2005-02-03 |
DE60318388D1 (de) | 2008-02-14 |
JP2010138197A (ja) | 2010-06-24 |
KR20040081451A (ko) | 2004-09-21 |
CN103203013A (zh) | 2013-07-17 |
PT1465643E (pt) | 2008-03-27 |
CA2473662C (en) | 2009-12-22 |
EP1465643A4 (de) | 2004-10-20 |
US6844317B2 (en) | 2005-01-18 |
CN1630527A (zh) | 2005-06-22 |
KR100964604B1 (ko) | 2010-06-21 |
MXPA04006733A (es) | 2005-12-05 |
EP1465643B1 (de) | 2008-01-02 |
DE60318388T2 (de) | 2008-12-24 |
US20030162693A1 (en) | 2003-08-28 |
AU2003207504A1 (en) | 2003-07-30 |
EP1465643A1 (de) | 2004-10-13 |
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