JP2005514456A - ＰＰＡＲα活性化に応答する疾患の治療に有用なα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の誘導体 - Google Patents

ＰＰＡＲα活性化に応答する疾患の治療に有用なα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の誘導体 Download PDF

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JP2005514456A
JP2005514456A JP2003559979A JP2003559979A JP2005514456A JP 2005514456 A JP2005514456 A JP 2005514456A JP 2003559979 A JP2003559979 A JP 2003559979A JP 2003559979 A JP2003559979 A JP 2003559979A JP 2005514456 A JP2005514456 A JP 2005514456A
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mmol
halogen
alkyl
silica gel
eluent
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JP2005514456A5 (enExample
Inventor
ファビオ・ジャンネッシ
ナタリナ・デッルオーモ
エマヌエラ・タッソーニ
マリア・オルネッラ・ティンティ
アンナ・フロリアナ・シャローニ
モニカ・バンデラ
ポンペオ・ペッソット
アルドゥイーノ・アルドゥイーニ
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Publication of JP2005514456A publication Critical patent/JP2005514456A/ja
Publication of JP2005514456A5 publication Critical patent/JP2005514456A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
JP2003559979A 2002-01-15 2003-01-15 ＰＰＡＲα活性化に応答する疾患の治療に有用なα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の誘導体 Pending JP2005514456A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002RM000014A ITRM20020014A1 (it) 2002-01-15 2002-01-15 Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del
PCT/IT2003/000011 WO2003059875A2 (en) 2002-01-15 2003-01-15 DERIVATIVES OF α-PHENYLTHIOCARBOXYLIC AND α-PHENYLOXY-CARBOXYLIC ACIDS USEFUL FOR THE TREATMENT OF DISEASES RESPONDING TO PPARα ACTIVATION

Publications (2)

Publication Number Publication Date
JP2005514456A true JP2005514456A (ja) 2005-05-19
JP2005514456A5 JP2005514456A5 (enExample) 2006-07-13

Family

ID=11455954

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JP2003559979A Pending JP2005514456A (ja) 2002-01-15 2003-01-15 ＰＰＡＲα活性化に応答する疾患の治療に有用なα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の誘導体

Country Status (16)

Country Link
US (2) US20050054671A1 (enExample)
EP (1) EP1474387B1 (enExample)
JP (1) JP2005514456A (enExample)
KR (1) KR100975961B1 (enExample)
CN (1) CN100522940C (enExample)
AR (1) AR038146A1 (enExample)
AT (1) ATE489361T1 (enExample)
AU (1) AU2003209679B2 (enExample)
BR (1) BR0306824A (enExample)
CA (1) CA2472223A1 (enExample)
DE (1) DE60335083D1 (enExample)
IT (1) ITRM20020014A1 (enExample)
MX (1) MXPA04006803A (enExample)
PL (1) PL372666A1 (enExample)
TW (1) TW200305410A (enExample)
WO (1) WO2003059875A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006512362A (ja) * 2002-12-19 2006-04-13 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 血清グルコース低下および血清脂質低下活性を有するα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の使用
JP2008513374A (ja) * 2004-09-15 2008-05-01 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ４−（（フェノキシアルキル）チオ）−フェノキシ酢酸および類似物
JP2010088497A (ja) * 2008-10-03 2010-04-22 Canon Inc 生体情報取得装置
JP2013176706A (ja) * 2013-06-27 2013-09-09 Canon Inc 生体情報取得装置

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US7553867B2 (en) 2002-09-06 2009-06-30 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
DK1667964T3 (da) 2003-09-19 2009-10-26 Janssen Pharmaceutica Nv 4-((Phenoxyalkyl)thio)-phenoxyeddikesyrer og analoger
CN1867546A (zh) * 2003-10-28 2006-11-22 雷迪实验室有限公司 新颖化合物及其在药物中的用途、其制备方法以及含有它们的药物组合物
US7902367B2 (en) 2004-08-11 2011-03-08 Kyorin Pharmaceutical Co., Ltd. Cyclic amino benzoic acid derivative
FR2880886B1 (fr) * 2005-01-14 2007-04-06 Merck Sante Soc Par Actions Si Derives de l'acide 6-phenylhex-5-enoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
WO2006082495A1 (en) * 2005-02-02 2006-08-10 Ranbaxy Laboratories Limited Peroxisome proliferator activated receptor modulators
FR2882359A1 (fr) * 2005-02-24 2006-08-25 Negma Lerads Soc Par Actions S Derives activateurs de ppar, procede de preparation et application en therapeutique
WO2006101108A1 (ja) * 2005-03-23 2006-09-28 Kyorin Pharmaceutical Co., Ltd. 新規環状アミノフェニルアルカン酸誘導体
JO3006B1 (ar) 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
PE20080188A1 (es) 2006-04-18 2008-03-10 Janssen Pharmaceutica Nv Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol
WO2008014430A1 (en) 2006-07-27 2008-01-31 Emisphere Technologies, Inc. Arylsulfanyl compounds and compositions for delivering active agents
CN106179111B (zh) * 2016-07-16 2018-08-14 江南大学 一种由羧酸盐阴离子表面活性剂和二聚季铵盐形成的粘弹溶液

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US3652646A (en) * 1966-03-31 1972-03-28 Ici Ltd Carboxylic acid derivatives
JPS51125228A (en) * 1974-09-30 1976-11-01 Lafon Labor Preparation of diaryl compounds
JPS5416447A (en) * 1977-07-07 1979-02-07 Ciba Geigy Ag Phenoxyphenylsulfinyll and phenjxypenylsulfonyllcarboxylate derivative process for preparing same and herbicidal and plant growth controlling agent containing same
JPH0311045A (ja) * 1989-06-08 1991-01-18 Hodogaya Chem Co Ltd ベンズアミド誘導体
JPH06234732A (ja) * 1992-09-10 1994-08-23 Banyu Pharmaceut Co Ltd 置換アセトアミド誘導体
JPH09160167A (ja) * 1995-12-04 1997-06-20 Fuji Photo Film Co Ltd ハロゲン化銀感光材料
WO1997027857A1 (en) * 1996-02-02 1997-08-07 Merck & Co., Inc. Antidiabetic agents
WO1999067255A1 (en) * 1998-06-22 1999-12-29 F. Hoffmann-La Roche Ag Propenyl cephalosporin derivatives
US6197791B1 (en) * 1997-02-27 2001-03-06 American Cyanamid Company N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6294573B1 (en) * 1997-08-06 2001-09-25 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
WO2001092201A1 (fr) * 2000-05-29 2001-12-06 Kyorin Pharmaceutical Co., Ltd. Derives substitues d'acide phenylpropionique
JP2003520839A (ja) * 2000-01-28 2003-07-08 ノボ ノルディスク アクティーゼルスカブ 新規化合物、それらの製造及び使用
JP2004501076A (ja) * 2000-04-17 2004-01-15 ノボ　ノルディスク　アクティーゼルスカブ 新規化合物、それらの製造及び使用
JP2004503464A (ja) * 1999-11-08 2004-02-05 カリックス　セラピューティックス　インコーポレイテッド 糖尿病および関連する状態を治療するための新規化合物
JP2004509084A (ja) * 2000-08-23 2004-03-25 イーライ・リリー・アンド・カンパニー オキサゾリル−アリールオキシ酢酸誘導体およびそのｐｐａｒアゴニストとしての使用
JP2004534035A (ja) * 2001-05-11 2004-11-11 グラクソ　グループ　リミテッド ヒト・ペルオキシソーム増殖因子活性化受容体を活性化するフランおよびチオフェン誘導体

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US3965093A (en) * 1971-09-24 1976-06-22 E. R. Squibb & Sons, Inc. 6-Arylthio penicillanic acid and derivatives thereof
GB1422679A (en) * 1972-11-16 1976-01-28 Funai Pharmaceutical Ind Ltd Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same
FR2700166B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
AU4050797A (en) 1996-08-02 1998-02-25 Ligand Pharmaceuticals Incorporated Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators
JP4618845B2 (ja) * 1999-06-09 2011-01-26 杏林製薬株式会社 ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体
DE19940415A1 (de) * 1999-08-26 2001-03-08 Friedrich Spener Verzweigtkettige Fettsäuren als fettabbauende Wirkstoffe

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652646A (en) * 1966-03-31 1972-03-28 Ici Ltd Carboxylic acid derivatives
JPS51125228A (en) * 1974-09-30 1976-11-01 Lafon Labor Preparation of diaryl compounds
JPS5416447A (en) * 1977-07-07 1979-02-07 Ciba Geigy Ag Phenoxyphenylsulfinyll and phenjxypenylsulfonyllcarboxylate derivative process for preparing same and herbicidal and plant growth controlling agent containing same
JPH0311045A (ja) * 1989-06-08 1991-01-18 Hodogaya Chem Co Ltd ベンズアミド誘導体
JPH06234732A (ja) * 1992-09-10 1994-08-23 Banyu Pharmaceut Co Ltd 置換アセトアミド誘導体
JPH09160167A (ja) * 1995-12-04 1997-06-20 Fuji Photo Film Co Ltd ハロゲン化銀感光材料
WO1997027857A1 (en) * 1996-02-02 1997-08-07 Merck & Co., Inc. Antidiabetic agents
US6197791B1 (en) * 1997-02-27 2001-03-06 American Cyanamid Company N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6294573B1 (en) * 1997-08-06 2001-09-25 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
WO1999067255A1 (en) * 1998-06-22 1999-12-29 F. Hoffmann-La Roche Ag Propenyl cephalosporin derivatives
JP2004503464A (ja) * 1999-11-08 2004-02-05 カリックス　セラピューティックス　インコーポレイテッド 糖尿病および関連する状態を治療するための新規化合物
JP2003520839A (ja) * 2000-01-28 2003-07-08 ノボ ノルディスク アクティーゼルスカブ 新規化合物、それらの製造及び使用
JP2004501076A (ja) * 2000-04-17 2004-01-15 ノボ　ノルディスク　アクティーゼルスカブ 新規化合物、それらの製造及び使用
WO2001092201A1 (fr) * 2000-05-29 2001-12-06 Kyorin Pharmaceutical Co., Ltd. Derives substitues d'acide phenylpropionique
JP2004509084A (ja) * 2000-08-23 2004-03-25 イーライ・リリー・アンド・カンパニー オキサゾリル−アリールオキシ酢酸誘導体およびそのｐｐａｒアゴニストとしての使用
JP2004534035A (ja) * 2001-05-11 2004-11-11 グラクソ　グループ　リミテッド ヒト・ペルオキシソーム増殖因子活性化受容体を活性化するフランおよびチオフェン誘導体

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006512362A (ja) * 2002-12-19 2006-04-13 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 血清グルコース低下および血清脂質低下活性を有するα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の使用
JP2008513374A (ja) * 2004-09-15 2008-05-01 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ４−（（フェノキシアルキル）チオ）−フェノキシ酢酸および類似物
JP2010088497A (ja) * 2008-10-03 2010-04-22 Canon Inc 生体情報取得装置
JP2013176706A (ja) * 2013-06-27 2013-09-09 Canon Inc 生体情報取得装置

Also Published As

Publication number Publication date
DE60335083D1 (de) 2011-01-05
CN1620429A (zh) 2005-05-25
US20080027098A1 (en) 2008-01-31
KR100975961B1 (ko) 2010-08-16
AR038146A1 (es) 2004-12-29
ATE489361T1 (de) 2010-12-15
EP1474387A2 (en) 2004-11-10
TW200305410A (en) 2003-11-01
WO2003059875A3 (en) 2003-12-04
AU2003209679A1 (en) 2003-07-30
EP1474387B1 (en) 2010-11-24
BR0306824A (pt) 2004-12-21
KR20040068996A (ko) 2004-08-02
ITRM20020014A1 (it) 2003-07-15
US20050054671A1 (en) 2005-03-10
WO2003059875A2 (en) 2003-07-24
AU2003209679B2 (en) 2009-02-19
PL372666A1 (en) 2005-07-25
ITRM20020014A0 (it) 2002-01-15
CA2472223A1 (en) 2003-07-24
MXPA04006803A (es) 2004-10-11
CN100522940C (zh) 2009-08-05
HK1076625A1 (zh) 2006-01-20

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