ATE489361T1 - Derivate von alpha-phenylthiocarbon- und alpha- phenyloxycarbonsäuren, die für die behandlung von auf die aktivierung von ppar alpha ansprechende krankheiten geeignet sind - Google Patents
Derivate von alpha-phenylthiocarbon- und alpha- phenyloxycarbonsäuren, die für die behandlung von auf die aktivierung von ppar alpha ansprechende krankheiten geeignet sindInfo
- Publication number
- ATE489361T1 ATE489361T1 AT03729547T AT03729547T ATE489361T1 AT E489361 T1 ATE489361 T1 AT E489361T1 AT 03729547 T AT03729547 T AT 03729547T AT 03729547 T AT03729547 T AT 03729547T AT E489361 T1 ATE489361 T1 AT E489361T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- phenylthiocarbone
- phenyloxycarbonic
- activation
- derivatives
- Prior art date
Links
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 230000004913 activation Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000014A ITRM20020014A1 (it) | 2002-01-15 | 2002-01-15 | Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del |
| PCT/IT2003/000011 WO2003059875A2 (en) | 2002-01-15 | 2003-01-15 | DERIVATIVES OF α-PHENYLTHIOCARBOXYLIC AND α-PHENYLOXY-CARBOXYLIC ACIDS USEFUL FOR THE TREATMENT OF DISEASES RESPONDING TO PPARα ACTIVATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE489361T1 true ATE489361T1 (de) | 2010-12-15 |
Family
ID=11455954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03729547T ATE489361T1 (de) | 2002-01-15 | 2003-01-15 | Derivate von alpha-phenylthiocarbon- und alpha- phenyloxycarbonsäuren, die für die behandlung von auf die aktivierung von ppar alpha ansprechende krankheiten geeignet sind |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20050054671A1 (enExample) |
| EP (1) | EP1474387B1 (enExample) |
| JP (1) | JP2005514456A (enExample) |
| KR (1) | KR100975961B1 (enExample) |
| CN (1) | CN100522940C (enExample) |
| AR (1) | AR038146A1 (enExample) |
| AT (1) | ATE489361T1 (enExample) |
| AU (1) | AU2003209679B2 (enExample) |
| BR (1) | BR0306824A (enExample) |
| CA (1) | CA2472223A1 (enExample) |
| DE (1) | DE60335083D1 (enExample) |
| IT (1) | ITRM20020014A1 (enExample) |
| MX (1) | MXPA04006803A (enExample) |
| PL (1) | PL372666A1 (enExample) |
| TW (1) | TW200305410A (enExample) |
| WO (1) | WO2003059875A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7553867B2 (en) | 2002-09-06 | 2009-06-30 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| ITRM20020629A1 (it) * | 2002-12-19 | 2004-06-20 | Sigma Tau Ind Farmaceuti | Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante. |
| DK1667964T3 (da) | 2003-09-19 | 2009-10-26 | Janssen Pharmaceutica Nv | 4-((Phenoxyalkyl)thio)-phenoxyeddikesyrer og analoger |
| CN1867546A (zh) * | 2003-10-28 | 2006-11-22 | 雷迪实验室有限公司 | 新颖化合物及其在药物中的用途、其制备方法以及含有它们的药物组合物 |
| US7902367B2 (en) | 2004-08-11 | 2011-03-08 | Kyorin Pharmaceutical Co., Ltd. | Cyclic amino benzoic acid derivative |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| FR2880886B1 (fr) * | 2005-01-14 | 2007-04-06 | Merck Sante Soc Par Actions Si | Derives de l'acide 6-phenylhex-5-enoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique |
| WO2006082495A1 (en) * | 2005-02-02 | 2006-08-10 | Ranbaxy Laboratories Limited | Peroxisome proliferator activated receptor modulators |
| FR2882359A1 (fr) * | 2005-02-24 | 2006-08-25 | Negma Lerads Soc Par Actions S | Derives activateurs de ppar, procede de preparation et application en therapeutique |
| WO2006101108A1 (ja) * | 2005-03-23 | 2006-09-28 | Kyorin Pharmaceutical Co., Ltd. | 新規環状アミノフェニルアルカン酸誘導体 |
| JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| PE20080188A1 (es) | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
| WO2008014430A1 (en) | 2006-07-27 | 2008-01-31 | Emisphere Technologies, Inc. | Arylsulfanyl compounds and compositions for delivering active agents |
| JP5305818B2 (ja) * | 2008-10-03 | 2013-10-02 | キヤノン株式会社 | 生体情報取得装置 |
| JP5669889B2 (ja) * | 2013-06-27 | 2015-02-18 | キヤノン株式会社 | 生体情報取得装置 |
| CN106179111B (zh) * | 2016-07-16 | 2018-08-14 | 江南大学 | 一种由羧酸盐阴离子表面活性剂和二聚季铵盐形成的粘弹溶液 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1121722A (en) * | 1966-03-31 | 1968-07-31 | Ici Ltd | New carboxylic acid derivatives |
| US3663540A (en) * | 1970-06-19 | 1972-05-16 | R & L Molecular Research Ltd | 7 - (p-aminomethylphenylthio)acetamido-3 -(pyridiniummethyl)ceph - 3 - em - 4-carboxylate |
| US3965093A (en) * | 1971-09-24 | 1976-06-22 | E. R. Squibb & Sons, Inc. | 6-Arylthio penicillanic acid and derivatives thereof |
| GB1422679A (en) * | 1972-11-16 | 1976-01-28 | Funai Pharmaceutical Ind Ltd | Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same |
| FR2285867A1 (fr) * | 1974-09-30 | 1976-04-23 | Lafon Labor | Derives du diphenylsulfoxyde |
| DE2861187D1 (en) * | 1977-07-07 | 1981-12-24 | Ciba Geigy Ag | Phenoxy-phenylsulfinyl-and-sulfonylalkanecarboxylic acid derivatives, method for their preparation and their use as herbicides and plant growth regulators. |
| JPH0311045A (ja) * | 1989-06-08 | 1991-01-18 | Hodogaya Chem Co Ltd | ベンズアミド誘導体 |
| JPH06234732A (ja) * | 1992-09-10 | 1994-08-23 | Banyu Pharmaceut Co Ltd | 置換アセトアミド誘導体 |
| FR2700166B1 (fr) * | 1993-01-07 | 1995-02-17 | Rhone Poulenc Rorer Sa | Dérivés de pyrrolidine, leur préparation et les médicaments les contenant. |
| JP3583529B2 (ja) * | 1995-12-04 | 2004-11-04 | 富士写真フイルム株式会社 | ハロゲン化銀感光材料 |
| EP0904079B1 (en) * | 1996-02-02 | 2004-03-24 | Merck & Co., Inc. | Antidiabetic agents |
| AU4050797A (en) | 1996-08-02 | 1998-02-25 | Ligand Pharmaceuticals Incorporated | Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators |
| US6197791B1 (en) * | 1997-02-27 | 2001-03-06 | American Cyanamid Company | N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| US6294573B1 (en) * | 1997-08-06 | 2001-09-25 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
| CA2335288A1 (en) * | 1998-06-22 | 1999-12-29 | F. Hoffmann-La Roche Ag | Propenyl cephalosporin derivatives |
| JP4618845B2 (ja) * | 1999-06-09 | 2011-01-26 | 杏林製薬株式会社 | ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体 |
| DE19940415A1 (de) * | 1999-08-26 | 2001-03-08 | Friedrich Spener | Verzweigtkettige Fettsäuren als fettabbauende Wirkstoffe |
| US6525093B1 (en) * | 1999-11-08 | 2003-02-25 | Calyx Therapeutics Inc. | Compounds to treat diabetes and associated conditions |
| KR20020090211A (ko) * | 2000-01-28 | 2002-11-30 | 노보 노르디스크 에이/에스 | 알키닐 치환된 프로피온산 유도체 및 당뇨병 및 비만에대한 그것의 사용 |
| WO2001079150A1 (en) * | 2000-04-17 | 2001-10-25 | Novo Nordisk A/S | New compounds, their preparation and use |
| PT1285908E (pt) * | 2000-05-29 | 2008-12-04 | Kyorin Seiyaku Kk | Derivados do ácido fenilpropiónico substituídos |
| CA2420178A1 (en) * | 2000-08-23 | 2002-03-07 | Eli Lilly And Company | Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists |
| GB0111523D0 (en) * | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
-
2002
- 2002-01-15 IT IT2002RM000014A patent/ITRM20020014A1/it unknown
-
2003
- 2003-01-15 KR KR1020047010634A patent/KR100975961B1/ko not_active Expired - Fee Related
- 2003-01-15 MX MXPA04006803A patent/MXPA04006803A/es active IP Right Grant
- 2003-01-15 BR BR0306824-2A patent/BR0306824A/pt not_active IP Right Cessation
- 2003-01-15 JP JP2003559979A patent/JP2005514456A/ja active Pending
- 2003-01-15 AU AU2003209679A patent/AU2003209679B2/en not_active Ceased
- 2003-01-15 EP EP03729547A patent/EP1474387B1/en not_active Expired - Lifetime
- 2003-01-15 DE DE60335083T patent/DE60335083D1/de not_active Expired - Lifetime
- 2003-01-15 AR ARP030100103A patent/AR038146A1/es unknown
- 2003-01-15 CN CNB038022893A patent/CN100522940C/zh not_active Expired - Fee Related
- 2003-01-15 TW TW092101061A patent/TW200305410A/zh unknown
- 2003-01-15 WO PCT/IT2003/000011 patent/WO2003059875A2/en not_active Ceased
- 2003-01-15 US US10/501,472 patent/US20050054671A1/en not_active Abandoned
- 2003-01-15 PL PL03372666A patent/PL372666A1/xx unknown
- 2003-01-15 AT AT03729547T patent/ATE489361T1/de not_active IP Right Cessation
- 2003-01-15 CA CA002472223A patent/CA2472223A1/en not_active Abandoned
-
2007
- 2007-08-17 US US11/889,930 patent/US20080027098A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60335083D1 (de) | 2011-01-05 |
| CN1620429A (zh) | 2005-05-25 |
| US20080027098A1 (en) | 2008-01-31 |
| KR100975961B1 (ko) | 2010-08-16 |
| AR038146A1 (es) | 2004-12-29 |
| EP1474387A2 (en) | 2004-11-10 |
| TW200305410A (en) | 2003-11-01 |
| WO2003059875A3 (en) | 2003-12-04 |
| AU2003209679A1 (en) | 2003-07-30 |
| EP1474387B1 (en) | 2010-11-24 |
| BR0306824A (pt) | 2004-12-21 |
| KR20040068996A (ko) | 2004-08-02 |
| ITRM20020014A1 (it) | 2003-07-15 |
| US20050054671A1 (en) | 2005-03-10 |
| WO2003059875A2 (en) | 2003-07-24 |
| JP2005514456A (ja) | 2005-05-19 |
| AU2003209679B2 (en) | 2009-02-19 |
| PL372666A1 (en) | 2005-07-25 |
| ITRM20020014A0 (it) | 2002-01-15 |
| CA2472223A1 (en) | 2003-07-24 |
| MXPA04006803A (es) | 2004-10-11 |
| CN100522940C (zh) | 2009-08-05 |
| HK1076625A1 (zh) | 2006-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |