JP2005514418A5 - - Google Patents
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- Publication number
- JP2005514418A5 JP2005514418A5 JP2003557981A JP2003557981A JP2005514418A5 JP 2005514418 A5 JP2005514418 A5 JP 2005514418A5 JP 2003557981 A JP2003557981 A JP 2003557981A JP 2003557981 A JP2003557981 A JP 2003557981A JP 2005514418 A5 JP2005514418 A5 JP 2005514418A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- group
- hydroxy
- optionally
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 35
- 229910052757 nitrogen Inorganic materials 0.000 claims 31
- 125000000623 heterocyclic group Chemical group 0.000 claims 23
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000005843 halogen group Chemical group 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 15
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 11
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 11
- 125000004043 oxo group Chemical group O=* 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 9
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 7
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 6
- 150000001204 N-oxides Chemical group 0.000 claims 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 6
- 125000004423 acyloxy group Chemical group 0.000 claims 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- NAHBIQPRNOVXRC-UHFFFAOYSA-N 1-[(3-pyridin-3-yl-5,6-dihydro-2h-1,2,4-oxadiazin-5-yl)methyl]piperidin-2-one Chemical compound O=C1CCCCN1CC1NC(C=2C=NC=CC=2)=NOC1 NAHBIQPRNOVXRC-UHFFFAOYSA-N 0.000 claims 1
- MMFLOJBJOZUABV-UHFFFAOYSA-N 1-[(3-pyridin-3-yl-5,6-dihydro-2h-1,2,4-oxadiazin-5-yl)methyl]piperidin-4-ol Chemical compound C1CC(O)CCN1CC1NC(C=2C=NC=CC=2)=NOC1 MMFLOJBJOZUABV-UHFFFAOYSA-N 0.000 claims 1
- FCAHAMLBLDTJDZ-UHFFFAOYSA-N 5-[(4-benzylpiperidin-1-yl)methyl]-3-pyridin-3-yl-5,6-dihydro-2h-1,2,4-oxadiazine Chemical compound C1CC(CC=2C=CC=CC=2)CCN1CC(N1)CON=C1C1=CC=CN=C1 FCAHAMLBLDTJDZ-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0200109A HUP0200109D0 (en) | 2002-01-11 | 2002-01-11 | Compounds having pharmaceutical activity |
| HU0204362A HUP0204362D0 (en) | 2002-12-17 | 2002-12-17 | Compounds having pharmaceutical activity |
| PCT/HU2003/000003 WO2003057664A1 (en) | 2002-01-11 | 2003-01-10 | Carboxamidine derivatives and their use in the treatment of vascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514418A JP2005514418A (ja) | 2005-05-19 |
| JP2005514418A5 true JP2005514418A5 (enExample) | 2006-03-02 |
Family
ID=90001534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003557981A Pending JP2005514418A (ja) | 2002-01-11 | 2003-01-10 | カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US7384936B2 (enExample) |
| EP (1) | EP1492763A1 (enExample) |
| JP (1) | JP2005514418A (enExample) |
| KR (1) | KR20040089102A (enExample) |
| CN (1) | CN1615296A (enExample) |
| AU (1) | AU2003202104B8 (enExample) |
| BR (1) | BR0306778A (enExample) |
| CA (1) | CA2471752A1 (enExample) |
| HR (1) | HRP20040558A2 (enExample) |
| IL (1) | IL162941A0 (enExample) |
| MX (1) | MXPA04006716A (enExample) |
| NO (1) | NO20043029L (enExample) |
| NZ (1) | NZ533795A (enExample) |
| PL (1) | PL371251A1 (enExample) |
| RS (1) | RS60604A (enExample) |
| RU (1) | RU2320330C2 (enExample) |
| WO (1) | WO2003057664A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057664A1 (en) * | 2002-01-11 | 2003-07-17 | Biorex Kutató És Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| JP5616336B2 (ja) | 2008-06-26 | 2014-10-29 | オルファザイム エーピーエスＯｒｐｈａｚｙｍｅ Ａｐｓ | 酵素活性の調節因子としてのＨｓｐ７０の使用 |
| US9662375B2 (en) | 2010-11-30 | 2017-05-30 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
| DK2892540T3 (en) * | 2012-09-06 | 2018-11-19 | Mcpharma Biotech Inc | TREATMENT OF DIARRES AND DRAWN DIARRES WITH RESISTANT POTATO STARCH |
| US10709700B2 (en) | 2014-09-15 | 2020-07-14 | Orphazyme A/S | Arimoclomol formulation |
| CN109069298B (zh) | 2016-04-01 | 2021-08-10 | 3M创新有限公司 | 听力保护装置及形成其的方法 |
| WO2017178029A1 (en) | 2016-04-13 | 2017-10-19 | Orphazyme Aps | Heat shock proteins and cholesterol homeostasis |
| ES2831764T3 (es) | 2016-04-29 | 2021-06-09 | Orphazyme As | Arimoclomol para el tratamiento de trastornos asociados a glucocerebrosidasa |
| EP4247792A1 (en) | 2020-11-19 | 2023-09-27 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177578B (en) | 1976-08-27 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
| DE2651083A1 (de) | 1976-11-09 | 1978-05-18 | Hoechst Ag | Neue o-alkylierte hydroxylamine, verfahren zu ihrer herstellung und ihre verwendung |
| IT1110460B (it) | 1977-03-02 | 1985-12-23 | Ciba Geigy Ag | Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego |
| US4187220A (en) | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| HU207988B (en) | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| EP0369944A1 (de) | 1988-11-18 | 1990-05-23 | Ciba-Geigy Ag | Substituierte Oxadiaminobutane |
| HUT54347A (en) | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
| GB9017351D0 (en) | 1990-08-08 | 1990-09-19 | Wellcome Found | Medicaments for treatment of atherosclerosis |
| EP0495750A3 (en) | 1991-01-14 | 1992-09-16 | Ciba-Geigy Ag | Heterocyclic hydroxylamine |
| US5334600A (en) | 1991-07-30 | 1994-08-02 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
| BR9407933A (pt) * | 1993-11-01 | 1996-11-26 | Japat Ltd | Antagonistas de receptores de endotelina |
| CN1079789C (zh) * | 1994-05-06 | 2002-02-27 | 拜奥列克斯研究发展公司 | 新的羟肟酸衍生物,包含它们的药物组合物及其制法 |
| HU218480B (hu) | 1995-06-15 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények |
| HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
| HU220971B1 (hu) | 1997-04-03 | 2002-07-29 | BIOREX Kutató és Fejlesztő Rt. | Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására |
| HUP9702365A3 (en) * | 1997-04-22 | 1999-09-28 | Biorex Kutato Fejlesztoe Kft | Application of hydroxilamin-derivatives, as well as process and composition for increase of weather extreme resistent by cultivated plants |
| HU226617B1 (en) | 1998-12-14 | 2009-04-28 | Cytrx Corp | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| HUP9900475D0 (en) | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| WO2003057664A1 (en) * | 2002-01-11 | 2003-07-17 | Biorex Kutató És Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
-
2003
- 2003-01-10 WO PCT/HU2003/000003 patent/WO2003057664A1/en not_active Ceased
- 2003-01-10 CN CNA03802151XA patent/CN1615296A/zh active Pending
- 2003-01-10 AU AU2003202104A patent/AU2003202104B8/en not_active Ceased
- 2003-01-10 PL PL03371251A patent/PL371251A1/xx unknown
- 2003-01-10 IL IL16294103A patent/IL162941A0/xx unknown
- 2003-01-10 KR KR10-2004-7010650A patent/KR20040089102A/ko not_active Ceased
- 2003-01-10 CA CA002471752A patent/CA2471752A1/en not_active Abandoned
- 2003-01-10 US US10/501,029 patent/US7384936B2/en not_active Expired - Fee Related
- 2003-01-10 EP EP03700962A patent/EP1492763A1/en not_active Withdrawn
- 2003-01-10 BR BR0306778-5A patent/BR0306778A/pt not_active IP Right Cessation
- 2003-01-10 RS YU60604A patent/RS60604A/sr unknown
- 2003-01-10 JP JP2003557981A patent/JP2005514418A/ja active Pending
- 2003-01-10 RU RU2004124378/15A patent/RU2320330C2/ru not_active IP Right Cessation
- 2003-01-10 HR HR20040558A patent/HRP20040558A2/hr not_active Application Discontinuation
- 2003-01-10 NZ NZ533795A patent/NZ533795A/xx not_active IP Right Cessation
- 2003-01-10 MX MXPA04006716A patent/MXPA04006716A/es active IP Right Grant
-
2004
- 2004-07-12 US US10/889,966 patent/US7361655B2/en not_active Expired - Fee Related
- 2004-07-13 NO NO20043029A patent/NO20043029L/no not_active Application Discontinuation
-
2007
- 2007-10-30 US US11/981,376 patent/US7691849B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/981,422 patent/US7550457B2/en not_active Expired - Fee Related
-
2009
- 2009-06-18 US US12/487,151 patent/US20090253690A1/en not_active Abandoned
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