JP2005507000A - 下部胃腸管において制限された薬物放出性を有する胃保持性経口投薬形態 - Google Patents
下部胃腸管において制限された薬物放出性を有する胃保持性経口投薬形態 Download PDFInfo
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- JP2005507000A JP2005507000A JP2003537608A JP2003537608A JP2005507000A JP 2005507000 A JP2005507000 A JP 2005507000A JP 2003537608 A JP2003537608 A JP 2003537608A JP 2003537608 A JP2003537608 A JP 2003537608A JP 2005507000 A JP2005507000 A JP 2005507000A
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
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Applications Claiming Priority (3)
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| US4581601A | 2001-10-25 | 2001-10-25 | |
| US10/024,932 US20030104052A1 (en) | 2001-10-25 | 2001-12-18 | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| PCT/US2002/034297 WO2003035041A1 (en) | 2001-10-25 | 2002-10-25 | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
Publications (2)
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| JP2005507000A true JP2005507000A (ja) | 2005-03-10 |
| JP2005507000A5 JP2005507000A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
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| JP2003537608A Pending JP2005507000A (ja) | 2001-10-25 | 2002-10-25 | 下部胃腸管において制限された薬物放出性を有する胃保持性経口投薬形態 |
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| EP (1) | EP1439826A1 (cg-RX-API-DMAC7.html) |
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| CA (1) | CA2409552A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003035041A1 (cg-RX-API-DMAC7.html) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008528636A (ja) * | 2005-02-01 | 2008-07-31 | エミスフェアー・テクノロジーズ・インク | 胃内滞留および制御放出型送達系 |
| JP2011503073A (ja) * | 2007-11-13 | 2011-01-27 | メリテイジ ファーマ,インク. | コルチコステロイド組成物 |
| JP2012500221A (ja) * | 2008-08-15 | 2012-01-05 | ディポメド,インコーポレイティド | Cns障害の処理及び予防のための胃保持性医薬組成物 |
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| US8865692B2 (en) | 2007-11-13 | 2014-10-21 | Meritage Pharma, Inc | Compositions for the treatment of gastrointestinal inflammation |
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| US11413296B2 (en) | 2005-11-12 | 2022-08-16 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| JP2023548216A (ja) * | 2020-10-30 | 2023-11-15 | トリアステック インコーポレイテッド | 胃保持のための薬物剤形 |
Families Citing this family (189)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110092677A1 (en) * | 2001-08-30 | 2011-04-21 | Biorexis Technology, Inc. | Modified transferin-antibody fusion proteins |
| US7612112B2 (en) | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
| TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| US20030091630A1 (en) * | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
| US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| EP1558081A4 (en) | 2003-01-13 | 2006-06-14 | Dynogen Pharmaceuticals Inc | METHOD FOR THE TREATMENT OF FUNCTIONAL ENDURANCE DISEASES |
| EP2529730A1 (en) * | 2003-06-16 | 2012-12-05 | ANDRX Pharmaceuticals LLC. | Oral sustained-release composition |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| JP2005132803A (ja) * | 2003-10-31 | 2005-05-26 | Ono Pharmaceut Co Ltd | 胃内滞留固形剤 |
| US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
| US20050169991A1 (en) * | 2003-12-12 | 2005-08-04 | Penwest Pharmaceuticals Co. | Sustained release torsemide dosage forms |
| CA2550983C (en) * | 2003-12-24 | 2013-09-17 | Advancis Pharmaceutical Corporation | Enhanced absorption of modified release dosage forms |
| EP1731139A4 (en) * | 2004-03-31 | 2008-12-03 | Aspion Co Ltd | PHARMACEUTICAL PREPARATION OF THE S / O TYPE AND MANUFACTURING METHOD THEREFOR |
| MXPA06011820A (es) * | 2004-04-16 | 2006-12-15 | Santarus Inc | Combinacion de inhibidor de bomba de proton, agente regulador del ph y agente procinetico. |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| EP1690540A1 (en) * | 2005-02-15 | 2006-08-16 | Neuro3D | Composition comprising ocaperidone |
| JP2008531605A (ja) * | 2005-03-04 | 2008-08-14 | インテルジェネクス コーポレイション | 遅延放出性医薬品経口剤、及びその作製方法 |
| US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
| US20080242642A1 (en) | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
| US8252776B2 (en) * | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
| DK1919466T3 (da) | 2005-07-11 | 2012-07-02 | Cortria Corp | Formuleringer til behandling af lipoprotein-abnormiteter omfattende et statin og et methylnicotinamidderivat |
| US20090176882A1 (en) * | 2008-12-09 | 2009-07-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| PE20080907A1 (es) * | 2006-08-31 | 2008-08-22 | Novartis Ag | Sistema de suministro de farmaco oral gastro-retentivo de liberacion extendida para valsartan |
| US20080139655A1 (en) * | 2006-09-08 | 2008-06-12 | Drugtech Corporation | Sustained-release composition and method of use thereof |
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| GB0707127D0 (en) * | 2007-04-13 | 2007-05-23 | Zysis Ltd | Pharmaceutical compositions |
| ES2559319T3 (es) | 2007-06-04 | 2016-02-11 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| TW200914006A (en) * | 2007-07-12 | 2009-04-01 | Takeda Pharmaceutical | Coated preparation |
| US20090028941A1 (en) * | 2007-07-27 | 2009-01-29 | Depomed, Inc. | Pulsatile gastric retentive dosage forms |
| NZ586792A (en) | 2008-01-25 | 2012-09-28 | Gruenenthal Chemie | Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces |
| US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| TWI524904B (zh) | 2008-05-09 | 2016-03-11 | 歌林達股份有限公司 | 製備醫藥用固體劑型,尤指錠劑之方法,及製備固體劑型,尤指錠劑之前驅物之方法 |
| EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2010017310A1 (en) | 2008-08-06 | 2010-02-11 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
| AU2009301994B2 (en) * | 2008-10-08 | 2016-10-20 | Bioplus Life Sciences Pvt. Ltd. | Sustained release drug delivery system |
| US8822610B2 (en) | 2008-12-22 | 2014-09-02 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| US8815971B2 (en) | 2008-12-22 | 2014-08-26 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| EP2210585A1 (en) | 2009-01-16 | 2010-07-28 | Exelgyn | SPRM pharmaceutical compositions methods of treatment using them |
| US8569421B2 (en) | 2009-04-23 | 2013-10-29 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
| US8173750B2 (en) | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
| US9783628B2 (en) | 2009-04-23 | 2017-10-10 | ATRP Solutions, Inc. | Dual-mechanism thickening agents for hydraulic fracturing fluids |
| EP3195896A1 (en) | 2009-05-05 | 2017-07-26 | Board of Regents, The University of Texas System | Novel formulations of volatile anesthetics and methods of use for reducing inflammation |
| RU2555531C2 (ru) | 2009-07-22 | 2015-07-10 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма для чувствительных к окислению опиоидов |
| EP2456427B1 (en) | 2009-07-22 | 2015-03-04 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
| US9211377B2 (en) | 2009-07-30 | 2015-12-15 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
| WO2011027346A1 (en) * | 2009-09-03 | 2011-03-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A gastroretentive dosage form for oral treatment of domestic animals |
| ES2569925T3 (es) | 2009-09-30 | 2016-05-13 | Acura Pharmaceuticals, Inc. | Métodos y composiciones de disuasión del abuso |
| US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| US20110150989A1 (en) * | 2009-12-22 | 2011-06-23 | Mallinkckrodt Inc. | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
| US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| EP2531176B1 (en) | 2010-02-03 | 2016-09-07 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of an extruder |
| WO2012021629A2 (en) | 2010-08-11 | 2012-02-16 | Philadelphia Health & Education Corporation | Novel d3 dopamine receptor agonists to treat dyskinesia in parkinson's disease |
| NZ608865A (en) | 2010-09-02 | 2015-03-27 | Gruenenthal Chemie | Tamper resistant dosage form comprising an anionic polymer |
| PE20131102A1 (es) | 2010-09-02 | 2013-10-12 | Gruenenthal Chemie | Forma de dosificacion resistente a manipulacion que comprende una sal inorganica |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| JP6076913B2 (ja) | 2010-12-07 | 2017-02-08 | ドレクセル ユニバーシティ | 癌からの転移を阻害する方法 |
| US9587064B2 (en) | 2010-12-08 | 2017-03-07 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
| US8476221B2 (en) | 2011-03-18 | 2013-07-02 | Halimed Pharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders |
| US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
| US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
| US9050335B1 (en) | 2011-05-17 | 2015-06-09 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
| US9119793B1 (en) | 2011-06-28 | 2015-09-01 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for doxycycline |
| US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
| NO2736495T3 (cg-RX-API-DMAC7.html) | 2011-07-29 | 2018-01-20 | ||
| CN103857386A (zh) | 2011-07-29 | 2014-06-11 | 格吕伦塔尔有限公司 | 提供药物立即释放的抗破碎片剂 |
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| WO2013096744A1 (en) | 2011-12-21 | 2013-06-27 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
| BR112014019988A8 (pt) | 2012-02-28 | 2017-07-11 | Gruenenthal Gmbh | Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico |
| CN102579344B (zh) * | 2012-03-02 | 2014-02-26 | 海南美兰史克制药有限公司 | 氯沙坦钾脂质体固体制剂 |
| AR090695A1 (es) | 2012-04-18 | 2014-12-03 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
| CA2877774C (en) | 2012-07-12 | 2017-07-18 | Mallinckrodt Llc | Extended release, abuse deterrent pharmaceutical compositions |
| WO2014015157A2 (en) | 2012-07-19 | 2014-01-23 | Philadelphia Health & Education Corporation | Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same |
| EP3158995B1 (en) | 2012-08-09 | 2018-05-23 | Dynamis Therapeutics, Inc. | Meglumine for reducing high triglyceride levels |
| CA2882832C (en) | 2012-08-30 | 2021-08-24 | ATRP Solutions, Inc. | Dual mechanism thickening agents for hydraulic fracturing fluids |
| NZ705372A (en) | 2012-09-18 | 2018-07-27 | Auspex Pharmaceuticals Inc | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| WO2014085599A1 (en) | 2012-11-30 | 2014-06-05 | Acura Pharmaceuticals, Inc. | Self-regulated release of active pharmaceutical ingredient |
| US20160000721A1 (en) * | 2012-12-21 | 2016-01-07 | Merck Sharp & Dohme Corp. | Gastro-retentive formulations |
| RS61101B1 (sr) | 2013-01-07 | 2020-12-31 | Univ Pennsylvania | Preparati i postupci za lečenje kožnog limfoma t-ćelija |
| EP2951220B1 (en) | 2013-02-04 | 2020-11-25 | Pilot Polymer Technologies, Inc. | Salt-tolerant star macromolecules |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| US10201656B2 (en) | 2013-03-13 | 2019-02-12 | Tandem Diabetes Care, Inc. | Simplified insulin pump for type II diabetics |
| US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
| US10842802B2 (en) | 2013-03-15 | 2020-11-24 | Medicis Pharmaceutical Corporation | Controlled release pharmaceutical dosage forms |
| US9492608B2 (en) | 2013-03-15 | 2016-11-15 | Tandem Diabetes Care, Inc. | Method and device utilizing insulin delivery protocols |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| AR096439A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido que contiene una o más partículas |
| WO2014191397A1 (en) | 2013-05-29 | 2014-12-04 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
| US10166207B2 (en) | 2013-06-05 | 2019-01-01 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| EP3017054B1 (en) | 2013-07-02 | 2019-11-13 | EcoPlanet Environmental LLC | Volatile organic compound formulations having antimicrobial activity |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CA2917136C (en) | 2013-07-12 | 2022-05-31 | Grunenthal Gmbh | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| US20160220630A1 (en) | 2013-10-10 | 2016-08-04 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of opioid induced dysfunctions |
| ES2806027T3 (es) | 2013-11-26 | 2021-02-16 | Univ Yale | Nuevas composiciones penetrantes de células y métodos de uso de las mismas |
| JP6480936B2 (ja) | 2013-11-26 | 2019-03-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | クライオミリングによる粉末状医薬組成物の調製 |
| CA2930744A1 (en) | 2013-12-03 | 2015-06-11 | Auspex Pharmaceuticals, Inc. | Methods of manufacturing benzoquinoline compounds |
| US10258615B2 (en) | 2013-12-09 | 2019-04-16 | Thomas Jefferson University | Methods of treating a neurodegenerative disease in a mammal in need thereof |
| CA2982270C (en) | 2014-04-07 | 2023-01-10 | Women & Infants Hospital Of Rhode Island | Novel 7-dehydrocholesterol derivatives and methods using same |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| JP2017518980A (ja) | 2014-05-12 | 2017-07-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールを含む、改変防止即時放出カプセル製剤 |
| US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
| CN106535878B (zh) | 2014-06-02 | 2022-11-01 | 科莱西奥生物科技有限公司 | 可张开的胃内滞留剂型 |
| CN106573999A (zh) * | 2014-06-11 | 2017-04-19 | 麻省理工学院 | 驻留结构及相关方法 |
| JP6689210B2 (ja) | 2014-07-03 | 2020-04-28 | パイロット ポリマー テクノロジーズ, インク. | 界面活性剤相溶性星形高分子 |
| ES2971639T3 (es) | 2014-08-20 | 2024-06-06 | Univ Yale | Composiciones y métodos novedosos útiles para tratar o prevenir enfermedades o trastornos hepáticos y favorecer la pérdida de peso |
| CN114796209A (zh) | 2015-03-06 | 2022-07-29 | 奥斯拜客斯制药有限公司 | 氘代丁苯那嗪或包含氘代丁苯那嗪的组合物 |
| BR112017021475A2 (pt) | 2015-04-24 | 2018-07-10 | Gruenenthal Gmbh | forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente |
| WO2016182968A1 (en) | 2015-05-08 | 2016-11-17 | Brown University | Novel syringolin analogues and methods of making and using same |
| CA3176123A1 (en) | 2015-05-19 | 2016-11-24 | Yale University | Compositions for treating pathological calcification conditions, and methods using same |
| EP3302442B1 (en) | 2015-06-03 | 2024-10-16 | Triastek, Inc. | Dosage forms and use thereof |
| WO2016201288A1 (en) | 2015-06-12 | 2016-12-15 | Brown University | Novel antibacterial compounds and methods of making and using same |
| RU2734506C2 (ru) | 2015-06-30 | 2020-10-19 | Нейрад Лтд. | Новые модулирующие регуляцию дыхания соединения и способы их получения и применения |
| US11090354B2 (en) | 2015-08-06 | 2021-08-17 | The Johns Hopkins University | Composition and method for treatment of metabolic disorders |
| WO2017040607A1 (en) | 2015-08-31 | 2017-03-09 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
| US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| WO2017075145A1 (en) | 2015-10-28 | 2017-05-04 | Yale University | Quinoline amides and methods of using same |
| JP2018537093A (ja) | 2015-11-20 | 2018-12-20 | イエール ユニバーシティ | 異所性石灰化障害を治療するための組成物およびそれを使用する方法 |
| EP3402804A1 (en) | 2016-01-11 | 2018-11-21 | Synergy Pharmaceuticals Inc. | Formulations and methods for treating ulcerative colitis |
| US20190119364A1 (en) | 2016-04-29 | 2019-04-25 | The Regents Of The University Of Colorado, A Body Corporate | Compounds and compositions useful for treating metabolic syndrome, and methods using same |
| WO2018026764A1 (en) | 2016-08-01 | 2018-02-08 | University Of Rochester | Nanoparticles for controlled release of anti-biofilm agents and methods of use |
| BR112019002355A2 (pt) | 2016-08-05 | 2019-07-16 | Yale University | composições e métodos para prevenção de acidente vascular cerebral em pacientes pediátricos com anemia falciforme |
| AU2017321791B2 (en) | 2016-09-01 | 2022-03-24 | Mebias Discovery, Inc. | Substituted ureas and methods of making and using same |
| US10821103B2 (en) | 2016-11-07 | 2020-11-03 | Arbutus Biopharma Corporation | Substituted pyridinone-containing trycyclic compounds, and methods using same |
| CN110035718B (zh) | 2016-12-02 | 2021-04-06 | 克雷西奥生物科技有限公司 | 胃内滞留系统 |
| US10941126B2 (en) | 2017-01-19 | 2021-03-09 | Temple University-Of The Commonwealth System Of Higher Education | Bridged bicycloalkyl-substituted aminothiazoles and their methods of use |
| EP3601216B1 (en) | 2017-03-21 | 2023-10-25 | Arbutus Biopharma Corporation | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same for the treatment of hepatitis b virus infection |
| IL270070B2 (en) | 2017-04-17 | 2023-09-01 | Univ Yale | Compounds, compositions and methods for treating or preventing acute lung injury |
| US10987311B2 (en) | 2017-06-16 | 2021-04-27 | Kashiv Specialty Pharmaceuticals, Llc | Extended release compositions comprising pyridostigmine |
| US10588863B2 (en) | 2017-06-16 | 2020-03-17 | Kashiv Biosciences, Llc | Extended release compositions comprising pyridostigmine |
| WO2018232413A1 (en) | 2017-06-16 | 2018-12-20 | Kashiv Pharma Llc | Gastroretentive dosage forms for sustained drug delivery |
| CA3071345A1 (en) | 2017-07-28 | 2019-01-31 | Yale University | Anticancer drugs and methods of making and using same |
| JP2020533298A (ja) | 2017-09-08 | 2020-11-19 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | Her誘発性薬剤耐性がんの治療又は予防のための化合物、組成物及び方法 |
| US20200323895A1 (en) | 2017-11-27 | 2020-10-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Compounds, Compositions, and Methods for Treating And/Or Preventing Periodontal Disease |
| US11547839B2 (en) | 2017-12-04 | 2023-01-10 | Clexio Biosciences Ltd. | Long acting gastric residence system |
| IL275444B2 (en) | 2017-12-18 | 2025-01-01 | Tris Pharma Inc | Modified release drug powder formulation containing gastric-retaining raft-forming systems with pulsed drug release |
| WO2019126214A1 (en) | 2017-12-18 | 2019-06-27 | Tris Pharma, Inc. | Pharmaceutical composition comprising ghb gastro-retentive raft forming systems having trigger pulse drug release |
| US11666546B2 (en) | 2017-12-18 | 2023-06-06 | Tris Pharma, Inc | GHB pharmaceutical compositions comprising a floating interpenetrating polymer network forming system |
| WO2019125184A1 (en) | 2017-12-19 | 2019-06-27 | Auckland Uniservices Limited | Use of biomarker in cancer therapy |
| AU2018390826B2 (en) | 2017-12-20 | 2024-09-12 | Purdue Pharma L.P. | Abuse deterrent morphine sulfate dosage forms |
| SG11202006994XA (en) | 2018-01-24 | 2020-08-28 | Univ Rockefeller | Antibacterial compounds, compositions thereof, and methods using same |
| EP3746058B1 (en) | 2018-01-29 | 2023-06-07 | Duke University | Compositions and methods of enhancing 5-hydroxytryptophan bioavailability |
| CA3101680A1 (en) | 2018-05-25 | 2019-11-28 | Temple University-Of The Commonwealth System Of Higher Education | Eradication of bacterial biofilm using anti-amyloid monoclonal antibodies |
| WO2019231739A1 (en) | 2018-05-29 | 2019-12-05 | Cersci Therapeutics, Inc. | Compounds for pain treatment, compositions comprising same, and methods of using same |
| CA3061382C (en) | 2018-06-18 | 2020-12-15 | Kashiv Biosciences, Llc | Extended release compositions comprising pyridostigmine |
| TWI826492B (zh) | 2018-07-27 | 2023-12-21 | 加拿大商愛彼特生物製藥公司 | 經取代四氫環戊[c]吡咯、經取代二氫吡咯,其類似物及使用其之方法 |
| CA3109798A1 (en) | 2018-08-17 | 2020-02-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of acute lung injury |
| CN112839661A (zh) | 2018-10-11 | 2021-05-25 | 萨尼菲特治疗有限公司 | 用于治疗异位钙化的肌醇磷酸酯类 |
| US12458601B2 (en) | 2018-10-19 | 2025-11-04 | Temple University-Of The Commonwealth System Of Higher Education | Tamper-resistant drug dosage forms and methods of making and use thereof |
| TW202415643A (zh) | 2018-12-12 | 2024-04-16 | 加拿大商愛彼特生物製藥公司 | 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法 |
| EP3917535A1 (en) | 2019-01-30 | 2021-12-08 | Sanifit Therapeutics S.A. | Inositol phosphate compounds for use in increasing tissular perfusion |
| US20200246316A1 (en) | 2019-02-01 | 2020-08-06 | Cersci Therapeutics, Inc. | Methods of treating post-surgical pain with a thiazoline anti-hyperalgesic agent |
| WO2020159588A1 (en) | 2019-02-01 | 2020-08-06 | Cersci Therapeutics, Inc. | Methods of treating diabetic neuropathy with a thiazoline anti-hyperalgesic agent |
| US11471508B2 (en) | 2019-05-09 | 2022-10-18 | The Feinstein Institutes For Medical Research | HMGB1 antagonist treatment of diabetic peripheral neuropathy |
| EP3983391A4 (en) | 2019-06-12 | 2023-06-28 | The Wistar Institute | Acetyl-coa synthetase 2 (acss2) inhibitors and methods using same |
| US11555010B2 (en) | 2019-07-25 | 2023-01-17 | Brown University | Diamide antimicrobial agents |
| EP3818983A1 (en) | 2019-11-11 | 2021-05-12 | Sanifit Therapeutics S.A. | Inositol phosphate compounds for use in treating, inhibiting the progression, or preventing cardiovascular calcification |
| WO2021127456A1 (en) | 2019-12-19 | 2021-06-24 | Rain Therapeutics Inc. | Methods of inhibiting epidermal growth factor receptor proteins |
| EP4162036A1 (en) | 2020-06-09 | 2023-04-12 | Inozyme Pharma, Inc. | Soluble enpp1 or enpp3 proteins and uses thereof |
| EP4015494A1 (en) | 2020-12-15 | 2022-06-22 | Sanifit Therapeutics S.A. | Processes for the preparation of soluble salts of inositol phosphates |
| EP4036097A1 (en) | 2021-01-29 | 2022-08-03 | Sanifit Therapeutics S.A. | Ip4-4,6 substituted derivative compounds |
| CA3226223A1 (en) | 2021-07-30 | 2023-02-02 | Jacob Pade Ramsoe Jacobsen | 5-hydroxytryptophan gastroretentive dosage forms |
| US12409163B2 (en) | 2021-07-30 | 2025-09-09 | Evecxia Therapeutics, Inc. | Method of enhancing 5-hydroxytryptophan (5-HTP) exposure |
| US11779567B2 (en) | 2021-10-14 | 2023-10-10 | Evecxia Therapeutics, Inc. | Method for optimizing 5-hydroxytryptamine function in the brain for therapeutic purposes |
| JP2025525092A (ja) | 2022-07-29 | 2025-08-01 | サニフィット・セラピューティクス・ソシエダッド・アノニマ | 異所性石灰化の治療、進行の阻害、および予防に使用するためのip4-4,6置換誘導体化合物 |
| TW202412815A (zh) | 2022-07-29 | 2024-04-01 | 西班牙商薩尼菲特治療公司 | Ip5經取代化合物 |
| CN115184371B (zh) * | 2022-08-05 | 2023-04-25 | 深圳市俱进纸品包装有限公司 | 一种礼盒印刷的瑕疵视觉检测装置 |
| EP4583858A1 (en) | 2022-09-06 | 2025-07-16 | Hadasit Medical Research Services&Development Ltd. | Combinations comprising psychedelics for the treatment of schizophrenia and other neuropsychiatric and neurologic disorders |
| KR20240108663A (ko) * | 2023-01-02 | 2024-07-09 | 일양약품주식회사 | 베타네콜을 함유하는 안정한 방출 제어형 약제학적 조성물 및 이의 제조방법 |
| US20250057848A1 (en) | 2023-08-14 | 2025-02-20 | Neurim Pharmaceuticals (1991) Ltd. | Gal475 compositions and methods of use thereof |
| WO2025162971A1 (en) | 2024-01-31 | 2025-08-07 | Sanifit Therapeutics, S.A. | Substituted ip5 compounds for use in the treatment, inhibition of progression, and prevention of ectopic calcification |
| WO2025217096A1 (en) | 2024-04-08 | 2025-10-16 | University Of Rochester | Inhibitors of leucine-rich repeat kinase 2 (lrrk2) and medical uses thereof |
| WO2025217094A1 (en) | 2024-04-08 | 2025-10-16 | University Of Rochester | Interleukin receptor-associated kinase (irak) protac degraders and medical use thereof |
| WO2025217379A1 (en) | 2024-04-10 | 2025-10-16 | University Of Rochester | Drug treatment for macular degeneration |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA722664B (en) | 1971-05-18 | 1973-01-31 | Smith Kline French Lab | Lyered bolus for animal husbandry providing for immediate and sustained release of medicament |
| US4670444B1 (en) | 1980-09-03 | 1999-02-09 | Bayer Ag | and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds |
| US4434153A (en) * | 1982-03-22 | 1984-02-28 | Alza Corporation | Drug delivery system comprising a reservoir containing a plurality of tiny pills |
| HU187215B (en) * | 1983-01-26 | 1985-11-28 | Egyt Gyogyszervegyeszeti Gyar | Method for producing pharmaceutical product of high actor content and prolonged effect |
| US4690824A (en) * | 1983-07-07 | 1987-09-01 | Redi-Rowell, Inc. | Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion: expanded range |
| JPS6124516A (ja) * | 1984-07-12 | 1986-02-03 | Fujisawa Pharmaceut Co Ltd | 持続性錠剤 |
| US4753801A (en) * | 1985-10-25 | 1988-06-28 | Eli Lilly And Company | Sustained release tablets |
| IL77186A0 (en) * | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
| IT1188212B (it) * | 1985-12-20 | 1988-01-07 | Paolo Colombo | Sistema per il rilascio a velocita' controllata di sostanze attive |
| IT1201136B (it) * | 1987-01-13 | 1989-01-27 | Resa Farma | Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive |
| US4851232A (en) * | 1987-02-13 | 1989-07-25 | Alza Corporation | Drug delivery system with means for obtaining desirable in vivo release rate pattern |
| US4786503A (en) * | 1987-04-06 | 1988-11-22 | Alza Corporation | Dosage form comprising parallel lamine |
| US5002772A (en) * | 1988-05-31 | 1991-03-26 | Pfizer Inc. | Gastric retention system for controlled drug release |
| US5007790A (en) * | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| US5085865A (en) * | 1989-04-12 | 1992-02-04 | Warner-Lambert Company | Sustained release pharmaceutical preparations containing an analgesic and a decongestant |
| DK469989D0 (da) * | 1989-09-22 | 1989-09-22 | Bukh Meditec | Farmaceutisk praeparat |
| US5064656A (en) * | 1989-11-14 | 1991-11-12 | Dr. Gergely & Co. | Uncoated pharmaceutical reaction tablet |
| IT1237904B (it) * | 1989-12-14 | 1993-06-18 | Ubaldo Conte | Compresse a rilascio a velocita' controllata delle sostanze attive |
| US5232704A (en) * | 1990-12-19 | 1993-08-03 | G. D. Searle & Co. | Sustained release, bilayer buoyant dosage form |
| DE69222006T2 (de) * | 1991-10-30 | 1998-01-22 | Glaxo Group Ltd | Mehrschichtzusammensetzungen enthaltend Histamin- oder Serotonin- Antagonisten |
| DE4209160A1 (de) * | 1992-03-20 | 1993-09-30 | Bauer Kurt Heinz Prof Dr | Vernetzte Polysaccharide, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US5582837A (en) * | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
| US5260068A (en) * | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
| IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| IT1256393B (it) | 1992-11-17 | 1995-12-04 | Inverni Della Beffa Spa | Forme matriciali multistrato per il rilascio controllato di principi attivi |
| US5260069A (en) * | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| US5358502A (en) * | 1993-02-25 | 1994-10-25 | Pfizer Inc | PH-triggered osmotic bursting delivery devices |
| US5382435A (en) * | 1993-03-24 | 1995-01-17 | Southwest Research Institute | Microparticulate pharmaceutical delivery system |
| IT1264517B1 (it) | 1993-05-31 | 1996-09-24 | Ekita Investments Nv | Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati |
| IT1264696B1 (it) * | 1993-07-09 | 1996-10-04 | Applied Pharma Res | Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata |
| IT1265240B1 (it) * | 1993-11-30 | 1996-10-31 | Ekita Investments Nv | Compressa farmaceutica a rilascio controllato, di forma lenticolare |
| US5393765A (en) * | 1993-12-13 | 1995-02-28 | Hoffmann-La Roche Inc. | Pharmaceutical compositions with constant erosion volume for zero order controlled release |
| GB9326267D0 (en) * | 1993-12-23 | 1994-02-23 | Scherer Corp R P | Expulsion of material |
| DE4406424A1 (de) * | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
| US5458887A (en) | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
| US5458888A (en) * | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
| US20030056896A1 (en) * | 1995-05-12 | 2003-03-27 | Frank Jao | Effective therapy for epilepsies |
| US5464633A (en) * | 1994-05-24 | 1995-11-07 | Jagotec Ag | Pharmaceutical tablets releasing the active substance after a definite period of time |
| US5945125A (en) * | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
| US5695781A (en) * | 1995-03-01 | 1997-12-09 | Hallmark Pharmaceuticals, Inc. | Sustained release formulation containing three different types of polymers |
| AU5652796A (en) | 1995-04-14 | 1996-10-30 | Pharma Pass Llc | Solid compositions containing polyethyleneoxide and a non-am orphous active principle |
| US5736159A (en) * | 1995-04-28 | 1998-04-07 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water insoluble drugs in which a passageway is formed in situ |
| US5811126A (en) * | 1995-10-02 | 1998-09-22 | Euro-Celtique, S.A. | Controlled release matrix for pharmaceuticals |
| JP3220373B2 (ja) * | 1995-11-28 | 2001-10-22 | バイエル薬品株式会社 | 持続性ニフエジピン製剤 |
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| US5783212A (en) * | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
| IT1282650B1 (it) * | 1996-02-19 | 1998-03-31 | Jagotec Ag | Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici |
| US6048547A (en) | 1996-04-15 | 2000-04-11 | Seth; Pawan | Process for manufacturing solid compositions containing polyethylene oxide and an active ingredient |
| WO1998001117A1 (en) * | 1996-07-08 | 1998-01-15 | Edward Mendell Co., Inc. | Sustained release matrix for high-dose insoluble drugs |
| US5972389A (en) * | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
| IT1289160B1 (it) * | 1997-01-08 | 1998-09-29 | Jagotec Ag | Compressa farmaceutica completamente rivestita per il rilascio controllato di principi attivi che presentano problemi di |
| EP0951279A1 (en) * | 1997-01-10 | 1999-10-27 | Abbott Laboratories | Tablet for the controlled release of active agents |
| US5891474A (en) * | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| US5837379A (en) * | 1997-01-31 | 1998-11-17 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
| US5840329A (en) * | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| GB9710699D0 (en) * | 1997-05-24 | 1997-07-16 | Danbiosyst Uk | Gastro-retentive controlled release system |
| WO1998055107A1 (en) * | 1997-06-06 | 1998-12-10 | Depomed, Inc. | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
| US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
| DE69828289T2 (de) * | 1997-08-11 | 2005-06-02 | Alza Corp., Mountain View | Dosierungsform für verzögerte Freisetzung eines Wirkstoffs |
| IT1294760B1 (it) * | 1997-09-03 | 1999-04-12 | Jagotec Ag | Procedimento per la preparazione di compresse farmaceutiche in grado di cedere,secondo schemi predeterminabili, principi attivi poco |
| IN186245B (cg-RX-API-DMAC7.html) * | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| US5916595A (en) * | 1997-12-12 | 1999-06-29 | Andrx Pharmaceutials, Inc. | HMG co-reductase inhibitor |
| TW357614U (en) | 1998-03-12 | 1999-05-01 | Wen-Neng Liu | Retractable safety syringe needle for hypodermic injection |
| FR2781152B1 (fr) * | 1998-07-20 | 2001-07-06 | Permatec Tech Ag | Utilisation d'un polymere de type acrylique en tant qu'agent de desagregation |
| FR2784583B1 (fr) | 1998-10-16 | 2002-01-25 | Synthelabo | Composition pharmaceutique a residence gastrique et a liberation controlee |
| WO2000038650A1 (en) * | 1998-12-23 | 2000-07-06 | Alza Corporation | Gastric retention dosage form having multiple layers |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6562375B1 (en) * | 1999-08-04 | 2003-05-13 | Yamanouchi Pharmaceuticals, Co., Ltd. | Stable pharmaceutical composition for oral use |
| MXPA02004413A (es) | 1999-11-02 | 2002-09-02 | Depomed Inc | Induccion farmacologica del modo de alimentacion, para la administracion aumentada de drogas al estomago. |
| AU767812B2 (en) | 2000-02-04 | 2003-11-27 | Depomed, Inc. | Shell-and-core dosage form approaching zero-order drug release |
| US6368628B1 (en) * | 2000-05-26 | 2002-04-09 | Pharma Pass Llc | Sustained release pharmaceutical composition free of food effect |
| US6488962B1 (en) * | 2000-06-20 | 2002-12-03 | Depomed, Inc. | Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms |
| US6451808B1 (en) * | 2000-10-17 | 2002-09-17 | Depomed, Inc. | Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists |
| TWI259836B (en) | 2001-04-12 | 2006-08-11 | Astrazeneca Ab | Modified release formulation suitable for antiarrhythmic compounds |
| JP2004532259A (ja) | 2001-05-29 | 2004-10-21 | デポメッド ディベロップメント リミティド | 胃食道逆流症及び夜間に胃酸分泌が回復する現象の治療方法 |
| US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
| US20030091630A1 (en) * | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
-
2002
- 2002-10-23 CA CA002409552A patent/CA2409552A1/en not_active Abandoned
- 2002-10-25 JP JP2003537608A patent/JP2005507000A/ja active Pending
- 2002-10-25 WO PCT/US2002/034297 patent/WO2003035041A1/en not_active Ceased
- 2002-10-25 EP EP02786524A patent/EP1439826A1/en not_active Withdrawn
-
2004
- 2004-01-29 US US10/769,574 patent/US7976870B2/en not_active Expired - Fee Related
-
2011
- 2011-06-03 US US13/153,211 patent/US9980903B2/en not_active Expired - Fee Related
-
2012
- 2012-11-21 US US13/684,155 patent/US20130149379A1/en not_active Abandoned
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| JP2008528636A (ja) * | 2005-02-01 | 2008-07-31 | エミスフェアー・テクノロジーズ・インク | 胃内滞留および制御放出型送達系 |
| US11413296B2 (en) | 2005-11-12 | 2022-08-16 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| JP2011503073A (ja) * | 2007-11-13 | 2011-01-27 | メリテイジ ファーマ,インク. | コルチコステロイド組成物 |
| US11357859B2 (en) | 2007-11-13 | 2022-06-14 | Viropharma Biologics Llc | Compositions for the treatment of gastrointestinal inflammation |
| US8865692B2 (en) | 2007-11-13 | 2014-10-21 | Meritage Pharma, Inc | Compositions for the treatment of gastrointestinal inflammation |
| US10293052B2 (en) | 2007-11-13 | 2019-05-21 | Meritage Pharma, Inc. | Compositions for the treatment of gastrointestinal inflammation |
| US9937142B2 (en) | 2008-08-15 | 2018-04-10 | Depomed, Inc. | Gastric retentive pharmaceutical compositions for treatment and prevention of CNS disorders |
| US9161911B2 (en) | 2008-08-15 | 2015-10-20 | Depomed, Inc. | Gastric retentive pharmaceutical compositions for treatment and prevention of CNS disorders |
| JP2012500221A (ja) * | 2008-08-15 | 2012-01-05 | ディポメド,インコーポレイティド | Cns障害の処理及び予防のための胃保持性医薬組成物 |
| JP2013501762A (ja) * | 2009-08-12 | 2013-01-17 | デブルジャ・ゼ・タソシエ・ファルマ | 浮遊微粒剤 |
| JP2021502352A (ja) * | 2017-11-07 | 2021-01-28 | ラニ セラピューティクス, エルエルシー | 嚥下可能薬物送達デバイスを使用する腸管組織への送達のための凝固因子調製物 |
| JP7370974B2 (ja) | 2017-11-07 | 2023-10-30 | ラニ セラピューティクス, エルエルシー | 嚥下可能薬物送達デバイスを使用する腸管組織への送達のための凝固因子調製物 |
| US11826464B2 (en) | 2017-11-07 | 2023-11-28 | Rani Therapeutics, Llc | Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device |
| US12201721B2 (en) | 2017-11-07 | 2025-01-21 | Rani Therapeutics, Llc | Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device |
| JP2023548216A (ja) * | 2020-10-30 | 2023-11-15 | トリアステック インコーポレイテッド | 胃保持のための薬物剤形 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1439826A1 (en) | 2004-07-28 |
| US7976870B2 (en) | 2011-07-12 |
| US9980903B2 (en) | 2018-05-29 |
| WO2003035041A1 (en) | 2003-05-01 |
| CA2409552A1 (en) | 2003-04-25 |
| US20130149379A1 (en) | 2013-06-13 |
| US20040185105A1 (en) | 2004-09-23 |
| US20110301129A1 (en) | 2011-12-08 |
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