JP2005506527A5 - - Google Patents
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- JP2005506527A5 JP2005506527A5 JP2003534911A JP2003534911A JP2005506527A5 JP 2005506527 A5 JP2005506527 A5 JP 2005506527A5 JP 2003534911 A JP2003534911 A JP 2003534911A JP 2003534911 A JP2003534911 A JP 2003534911A JP 2005506527 A5 JP2005506527 A5 JP 2005506527A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- probe
- support
- microparticles
- array
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000011859 microparticle Substances 0.000 claims description 55
- 239000000523 sample Substances 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 40
- 239000000463 material Substances 0.000 claims description 28
- -1 aryl ketone Chemical class 0.000 claims description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 22
- 102000004169 proteins and genes Human genes 0.000 claims description 22
- 150000001875 compounds Chemical class 0.000 claims description 11
- 125000003277 amino group Chemical group 0.000 claims description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 8
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 8
- 239000010419 fine particle Substances 0.000 claims description 6
- 108010090804 Streptavidin Proteins 0.000 claims description 5
- 125000003172 aldehyde group Chemical group 0.000 claims description 4
- 229960002685 biotin Drugs 0.000 claims description 4
- 235000020958 biotin Nutrition 0.000 claims description 4
- 239000011616 biotin Substances 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 4
- 125000003700 epoxy group Chemical group 0.000 claims description 4
- 239000003550 marker Substances 0.000 claims 25
- 229920013730 reactive polymer Polymers 0.000 claims 21
- 239000002245 particle Substances 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 4
- 239000002853 nucleic acid probe Substances 0.000 claims 4
- KKGFAULLJCULTN-UHFFFAOYSA-N 4-benzoyl-n-[3-(2-methylprop-2-enoylamino)propyl]benzamide Chemical compound C1=CC(C(=O)NCCCNC(=O)C(=C)C)=CC=C1C(=O)C1=CC=CC=C1 KKGFAULLJCULTN-UHFFFAOYSA-N 0.000 claims 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 3
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 3
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 3
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 3
- 102000004856 Lectins Human genes 0.000 claims 3
- 108090001090 Lectins Proteins 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 3
- 229920002125 Sokalan® Polymers 0.000 claims 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- XXTZHYXQVWRADW-UHFFFAOYSA-N diazomethanone Chemical compound [N]N=C=O XXTZHYXQVWRADW-UHFFFAOYSA-N 0.000 claims 3
- CCGKOQOJPYTBIH-UHFFFAOYSA-N ethenone Chemical compound C=C=O CCGKOQOJPYTBIH-UHFFFAOYSA-N 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 230000003100 immobilizing effect Effects 0.000 claims 3
- 239000002523 lectin Substances 0.000 claims 3
- 239000006249 magnetic particle Substances 0.000 claims 3
- CPGRMGOILBSUQC-UHFFFAOYSA-N phosphoryl azide Chemical compound [N-]=[N+]=NP(=O)(N=[N+]=[N-])N=[N+]=[N-] CPGRMGOILBSUQC-UHFFFAOYSA-N 0.000 claims 3
- 229920002401 polyacrylamide Polymers 0.000 claims 3
- 239000004584 polyacrylic acid Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000002096 quantum dot Substances 0.000 claims 3
- HSVFKFNNMLUVEY-UHFFFAOYSA-N sulfuryl diazide Chemical compound [N-]=[N+]=NS(=O)(=O)N=[N+]=[N-] HSVFKFNNMLUVEY-UHFFFAOYSA-N 0.000 claims 3
- BXEFQPCKQSTMKA-UHFFFAOYSA-N OC(=O)C=[N+]=[N-] Chemical compound OC(=O)C=[N+]=[N-] BXEFQPCKQSTMKA-UHFFFAOYSA-N 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 238000000059 patterning Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 5
- 239000003431 cross linking reagent Substances 0.000 description 5
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 239000004971 Cross linker Substances 0.000 description 3
- 239000003068 molecular probe Substances 0.000 description 3
- 108090001008 Avidin Proteins 0.000 description 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 230000001588 bifunctional effect Effects 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 150000001735 carboxylic acids Chemical group 0.000 description 2
- 239000005090 green fluorescent protein Substances 0.000 description 2
- 150000002540 isothiocyanates Chemical class 0.000 description 2
- UUVBVONAGUSCCH-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4',5'-dichloro-3',6'-dihydroxy-2',7'-dimethoxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-carboxylate Chemical compound ClC1=C(O)C(OC)=CC2=C1OC1=C(Cl)C(O)=C(OC)C=C1C2(C1=C2)OC(=O)C1=CC=C2C(=O)ON1C(=O)CCC1=O UUVBVONAGUSCCH-UHFFFAOYSA-N 0.000 description 1
- RBAFCMJBDZWZIV-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-azido-2-hydroxybenzoate Chemical compound OC1=CC(N=[N+]=[N-])=CC=C1C(=O)ON1C(=O)CCC1=O RBAFCMJBDZWZIV-UHFFFAOYSA-N 0.000 description 1
- WXXSHAKLDCERGU-UHFFFAOYSA-N 1-[4-(2,5-dioxopyrrol-1-yl)butyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1CCCCN1C(=O)C=CC1=O WXXSHAKLDCERGU-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- IHDBZCJYSHDCKF-UHFFFAOYSA-N 4,6-dichlorotriazine Chemical class ClC1=CC(Cl)=NN=N1 IHDBZCJYSHDCKF-UHFFFAOYSA-N 0.000 description 1
- 239000012099 Alexa Fluor family Substances 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 239000004158 L-cystine Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 150000001502 aryl halides Chemical class 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012954 diazonium Substances 0.000 description 1
- ZWIBGKZDAWNIFC-UHFFFAOYSA-N disuccinimidyl suberate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCCC(=O)ON1C(=O)CCC1=O ZWIBGKZDAWNIFC-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 108091006047 fluorescent proteins Proteins 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000000269 nucleophilic effect Effects 0.000 description 1
- 150000003009 phosphonic acids Chemical group 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical group 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical group 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/972,687 US7195913B2 (en) | 2001-10-05 | 2001-10-05 | Randomly ordered arrays and methods of making and using |
| PCT/US2002/031740 WO2003031979A1 (en) | 2001-10-05 | 2002-10-04 | Randomly ordered arrays and methods of making and using |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005506527A JP2005506527A (ja) | 2005-03-03 |
| JP2005506527A5 true JP2005506527A5 (enExample) | 2006-01-05 |
| JP4464132B2 JP4464132B2 (ja) | 2010-05-19 |
Family
ID=25520000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003534911A Expired - Fee Related JP4464132B2 (ja) | 2001-10-05 | 2002-10-04 | ランダムに配置されたアレイ群、ならびにその製造方法と使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7195913B2 (enExample) |
| EP (1) | EP1432989B1 (enExample) |
| JP (1) | JP4464132B2 (enExample) |
| AT (1) | ATE450795T1 (enExample) |
| CA (1) | CA2462736A1 (enExample) |
| DE (1) | DE60234614D1 (enExample) |
| MX (1) | MXPA04003184A (enExample) |
| WO (1) | WO2003031979A1 (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997040385A1 (en) | 1996-04-25 | 1997-10-30 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
| US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
| JP4744778B2 (ja) | 2000-06-21 | 2011-08-10 | バイオアレイ ソルーションズ リミテッド | 特定のランダム粒子アレイを適用した複数の被検体分子の分析方法 |
| US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
| EP1434571B1 (en) * | 2001-10-05 | 2005-05-11 | SurModics, Inc. | Particle immobilized coatings and uses thereof |
| IL161391A0 (en) | 2001-10-15 | 2004-09-27 | Bioarray Solutions Ltd | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
| US7108891B2 (en) * | 2002-03-07 | 2006-09-19 | Eastman Kodak Company | Random array of microspheres |
| US7526114B2 (en) | 2002-11-15 | 2009-04-28 | Bioarray Solutions Ltd. | Analysis, secure access to, and transmission of array images |
| CN1514243A (zh) * | 2003-04-30 | 2004-07-21 | 成都夸常科技有限公司 | 对目标物进行定性和/或定量分析的方法、装置和标记物及检测试剂盒 |
| DE10319155B4 (de) | 2003-04-29 | 2008-02-14 | Bruker Daltonik Gmbh | Elektrisch auslesbare Bindungen von Analytmolekülen an immobilisierten Sondenmolekülen |
| US20050019745A1 (en) * | 2003-07-23 | 2005-01-27 | Eastman Kodak Company | Random array of microspheres |
| JP4363935B2 (ja) * | 2003-09-17 | 2009-11-11 | 株式会社豊田中央研究所 | 生体物質の光固定化・回収方法及び表面プラズモン共鳴センサー |
| US7927796B2 (en) | 2003-09-18 | 2011-04-19 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
| NZ546072A (en) | 2003-09-22 | 2009-08-28 | Bioarray Solutions Ltd | Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules |
| NZ547492A (en) | 2003-10-28 | 2009-12-24 | Bioarray Solutions Ltd | Optimization of gene expression analysis using immobilized capture probes of different lengths and densities |
| WO2005045060A2 (en) | 2003-10-29 | 2005-05-19 | Bioarray Solutions, Ltd. | Multiplexed nucleic acid analysis by fragmentation of double-stranded dna |
| EP1731909A1 (en) * | 2004-03-31 | 2006-12-13 | Universal Bio Research Co., Ltd. | Immobilization vehicle, method of treating vehicle and continuous vehicle treating apparatus |
| US20050239112A1 (en) * | 2004-04-01 | 2005-10-27 | Migenix, Inc. | Methods and processes for attaching compounds to matrices |
| US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
| KR20070073905A (ko) | 2004-10-12 | 2007-07-10 | 루미넥스 코포레이션 | 염색된 마이크로스피어 및 염색된 마이크로스피어의개체군의 형성 방법 |
| JP2006118920A (ja) * | 2004-10-20 | 2006-05-11 | Institute Of Physical & Chemical Research | 相互作用観察方法 |
| US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
| US20070161124A1 (en) * | 2006-01-09 | 2007-07-12 | Sigma-Aldrich Co. | Compositions for separation of a plurality of distinct targets from a sample |
| US20070161121A1 (en) * | 2006-01-09 | 2007-07-12 | Sigma Aldrich | Compositions for separation of a plurality of distinct targets from a sample |
| CA2571904A1 (en) * | 2006-02-15 | 2007-08-15 | Fio Corporation | System and method of detecting pathogens |
| DE102006029032A1 (de) * | 2006-02-17 | 2007-08-23 | Poly-An Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH | Vorrichtung, Verfahren und Kit zum Nachweis von Analyten in einer Probe |
| US8460878B2 (en) | 2006-02-21 | 2013-06-11 | The Trustees Of Tufts College | Methods and arrays for detecting cells and cellular components in small defined volumes |
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| AT503573B1 (de) * | 2006-04-13 | 2007-11-15 | Arc Seibersdorf Res Gmbh | Vorrichtung zur steigerung der reaktions-, insbesondere der anbindungseffizienz zwischen molekülen bzw. molekülteilen |
| DE102006056949B4 (de) * | 2006-11-30 | 2011-12-22 | Ruprecht-Karls-Universität Heidelberg | Verfahren und Vorrichtung zur Detektion mindestens einer Eigenschaft von mindestens einem Objekt mit einem Mikrochip |
| CA2580589C (en) * | 2006-12-19 | 2016-08-09 | Fio Corporation | Microfluidic detection system |
| WO2008119184A1 (en) | 2007-04-02 | 2008-10-09 | Fio Corporation | System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology |
| US8597729B2 (en) | 2007-06-22 | 2013-12-03 | Fio Corporation | Systems and methods for manufacturing quantum dot-doped polymer microbeads |
| JP5507454B2 (ja) * | 2007-07-09 | 2014-05-28 | フィオ コーポレイション | 試験サンプル中の標的分子の蛍光検出の向上のためのシステムおよび方法 |
| CA2761176C (en) * | 2007-07-23 | 2012-07-31 | Fio Corporation | A method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects |
| US8551763B2 (en) * | 2007-10-12 | 2013-10-08 | Fio Corporation | Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto |
| WO2009155704A1 (en) | 2008-06-25 | 2009-12-30 | Fio Corporation | Bio-threat alert system |
| US9459200B2 (en) | 2008-08-29 | 2016-10-04 | Fio Corporation | Single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples |
| KR101065078B1 (ko) * | 2008-11-05 | 2011-09-15 | 삼성전자주식회사 | 바이오칩용 기판 및 그 제조 방법 |
| RU2578023C2 (ru) | 2009-01-13 | 2016-03-20 | Эф-Ай-Оу Корпорейшн | Портативный диагностический прибор и способ его применения с электронным устройством и диагностическим картриджем при диагностическом экспресс-исследовании |
| US8574835B2 (en) | 2009-05-29 | 2013-11-05 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| GB0913258D0 (en) | 2009-07-29 | 2009-09-02 | Dynex Technologies Inc | Reagent dispenser |
| US9523701B2 (en) | 2009-07-29 | 2016-12-20 | Dynex Technologies, Inc. | Sample plate systems and methods |
| US20110105990A1 (en) * | 2009-11-04 | 2011-05-05 | Silvestrini Thomas A | Zonal drug delivery device and method |
| US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
| WO2011109379A1 (en) | 2010-03-01 | 2011-09-09 | Quanterix Corporation | Methods and systems for extending dynamic range in assays for the detection of molecules or particles |
| US8236574B2 (en) | 2010-03-01 | 2012-08-07 | Quanterix Corporation | Ultra-sensitive detection of molecules or particles using beads or other capture objects |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| US8541498B2 (en) | 2010-09-08 | 2013-09-24 | Biointeractions Ltd. | Lubricious coatings for medical devices |
| US9952237B2 (en) | 2011-01-28 | 2018-04-24 | Quanterix Corporation | Systems, devices, and methods for ultra-sensitive detection of molecules or particles |
| WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| US9512397B2 (en) | 2012-03-21 | 2016-12-06 | Shengyuan Yang | Micro and nano scale structures disposed in a material so as to present micrometer and nanometer scale curvature and stiffness patterns for use in cell and tissue culturing and in other surface and interface applications |
| US20130252337A1 (en) * | 2012-03-21 | 2013-09-26 | Shengyuan Yang | Substrates with micrometer and nanometer scale stiffness patterns for use in cell and tissue culturing and a method for making same |
| WO2014007034A1 (ja) * | 2012-07-06 | 2014-01-09 | 株式会社 日立ハイテクノロジーズ | 分析装置及び分析方法 |
| US9910008B2 (en) | 2012-07-06 | 2018-03-06 | Robert Bosch Gmbh | Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions |
| US9874538B2 (en) | 2012-07-06 | 2018-01-23 | Robert Bosch Gmbh | Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions |
| US9810688B2 (en) * | 2013-03-15 | 2017-11-07 | Robert Bosch Gmbh | Smart glass slide for microarrays |
| GB201212902D0 (en) | 2012-07-20 | 2012-09-05 | Univ Singapore | Combinatoric encoding methods for microarrays |
| JP6037701B2 (ja) * | 2012-08-03 | 2016-12-07 | 株式会社日立ハイテクノロジーズ | 免疫分析装置 |
| EP2909337B1 (en) | 2012-10-17 | 2019-01-09 | Spatial Transcriptomics AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| WO2014210223A1 (en) | 2013-06-25 | 2014-12-31 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
| EP3105572B1 (en) | 2014-02-13 | 2019-04-10 | Robert Bosch GmbH | Capacitive bubble detection |
| WO2016015037A1 (en) * | 2014-07-25 | 2016-01-28 | Microscale Devices Llc | Apparatus and methods for detecting multiple labelled biopolymers |
| WO2016115256A1 (en) * | 2015-01-13 | 2016-07-21 | Quanterix Corporation | Methods relating to improving accuracy of capture object-based assays |
| ES2955488T3 (es) | 2015-04-10 | 2023-12-01 | Spatial Transcriptomics Ab | Análisis multiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos |
| US11867660B2 (en) | 2015-07-06 | 2024-01-09 | Robert Bosch Gmbh | Electronic control of the pH of a solution close to an electrode surface |
| US10011549B2 (en) | 2015-07-06 | 2018-07-03 | Robert Bosch Gmbh | Electrochemically active agents for pH modulation in biological buffers |
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| JP7130919B2 (ja) * | 2016-03-11 | 2022-09-06 | 三菱瓦斯化学株式会社 | 生体物質固定化方法 |
| US10667923B2 (en) | 2016-10-31 | 2020-06-02 | Warsaw Orthopedic, Inc. | Sacro-iliac joint implant system and method |
| WO2018176262A1 (zh) * | 2017-03-27 | 2018-10-04 | 武汉优视科技有限公司 | 一种免疫印迹的自动检测系统 |
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| CN106932596A (zh) * | 2017-03-27 | 2017-07-07 | 武汉优视科技有限公司 | 一种免疫印迹薄膜及其制备方法 |
| US10871435B2 (en) | 2017-07-18 | 2020-12-22 | Shengyuan Yang | Methods and kits for cell sorting |
| DE102018115391A1 (de) * | 2018-06-26 | 2020-01-02 | Brandenburgische Technische Universität Cottbus-Senftenberg | Assay, Verfahren zu seiner Herstellung sowie seine Verwendung |
| WO2020123318A1 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Resolving spatial arrays using deconvolution |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| GB201905181D0 (en) * | 2019-04-11 | 2019-05-29 | Arrayjet Ltd | Method and apparatus for substrate handling and printing |
| US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| CN115375604B (zh) * | 2021-05-18 | 2024-07-26 | 南京大学 | 一种基于量子化自编码器的无监督缺陷检测方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
| EP0745689A3 (en) | 1990-05-11 | 1996-12-11 | Microprobe Corporation | A dipstick for a nucleic acid hybridization assay |
| US5993935A (en) | 1991-10-11 | 1999-11-30 | 3M Innovative Properties Company | Covalently reactive particles incorporated in a continous porous matrix |
| WO1993016176A1 (en) * | 1992-02-13 | 1993-08-19 | Bio-Metric Systems, Inc. | Immobilization of chemical species in crosslinked matrices |
| US5900921A (en) * | 1994-07-06 | 1999-05-04 | Jong-Deok Park | Lens for diplopia and amblyopia and glasses using the same |
| CA2202511A1 (en) * | 1994-10-12 | 1996-04-25 | Laurence A. Roth | Targeted delivery via biodegradable polymers |
| US5736257A (en) | 1995-04-25 | 1998-04-07 | Us Navy | Photoactivatable polymers for producing patterned biomolecular assemblies |
| US5714360A (en) | 1995-11-03 | 1998-02-03 | Bsi Corporation | Photoactivatable water soluble cross-linking agents containing an onium group |
| US5700921A (en) * | 1995-11-27 | 1997-12-23 | Vector Laboratories | Labeling nucleic acids |
| US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| US7115884B1 (en) | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
| DE19823660C1 (de) | 1998-05-20 | 1999-10-07 | Nanomont Ges Fuer Nanotechnolo | Verfahren und Vorrichtung zur Fixierung fester Mikro- und/oder Nanoobjekte |
| JP3662850B2 (ja) | 1998-06-24 | 2005-06-22 | イルミナ インコーポレイテッド | 微小球を有するアレイセンサーのデコード |
| US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
| EP1151302B1 (en) | 1999-02-09 | 2010-03-31 | Illumina, Inc. | Intrabead screening methods and compositions |
| US6503556B2 (en) * | 2000-12-28 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Methods of forming a coating for a prosthesis |
| US20020039728A1 (en) | 2000-02-10 | 2002-04-04 | Robert Kain | Alternative substrates and formats for bead-based array of arrays |
| US6673385B1 (en) * | 2000-05-31 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Methods for polymeric coatings stents |
| US6669980B2 (en) * | 2001-09-18 | 2003-12-30 | Scimed Life Systems, Inc. | Method for spray-coating medical devices |
-
2001
- 2001-10-05 US US09/972,687 patent/US7195913B2/en not_active Expired - Fee Related
-
2002
- 2002-10-04 MX MXPA04003184A patent/MXPA04003184A/es unknown
- 2002-10-04 DE DE60234614T patent/DE60234614D1/de not_active Expired - Lifetime
- 2002-10-04 EP EP02800906A patent/EP1432989B1/en not_active Expired - Lifetime
- 2002-10-04 AT AT02800906T patent/ATE450795T1/de not_active IP Right Cessation
- 2002-10-04 JP JP2003534911A patent/JP4464132B2/ja not_active Expired - Fee Related
- 2002-10-04 WO PCT/US2002/031740 patent/WO2003031979A1/en not_active Ceased
- 2002-10-04 CA CA002462736A patent/CA2462736A1/en not_active Abandoned
-
2007
- 2007-03-06 US US11/682,526 patent/US20080039343A1/en not_active Abandoned
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