JP2005505499A5 - - Google Patents
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- Publication number
- JP2005505499A5 JP2005505499A5 JP2002584819A JP2002584819A JP2005505499A5 JP 2005505499 A5 JP2005505499 A5 JP 2005505499A5 JP 2002584819 A JP2002584819 A JP 2002584819A JP 2002584819 A JP2002584819 A JP 2002584819A JP 2005505499 A5 JP2005505499 A5 JP 2005505499A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- alkyl
- compound
- pharmaceutically acceptable
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 48
- 239000008194 pharmaceutical composition Substances 0.000 claims 44
- 150000001875 compounds Chemical class 0.000 claims 33
- 239000003814 drug Substances 0.000 claims 26
- 125000003342 alkenyl group Chemical group 0.000 claims 24
- 125000000304 alkynyl group Chemical group 0.000 claims 24
- 229940124597 therapeutic agent Drugs 0.000 claims 24
- 125000003545 alkoxy group Chemical group 0.000 claims 22
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 20
- 229940002612 prodrug Drugs 0.000 claims 19
- 239000000651 prodrug Substances 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 19
- 150000008064 anhydrides Chemical class 0.000 claims 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 8
- -1 phenalkyl Chemical group 0.000 claims 8
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 208000036142 Viral infection Diseases 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 239000003443 antiviral agent Substances 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 241001529453 unidentified herpesvirus Species 0.000 claims 4
- 241000725303 Human immunodeficiency virus Species 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 claims 2
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 2
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 2
- 241000282414 Homo sapiens Species 0.000 claims 2
- 229960002756 azacitidine Drugs 0.000 claims 2
- 229960002436 cladribine Drugs 0.000 claims 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960001428 mercaptopurine Drugs 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 2
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 2
- 230000029812 viral genome replication Effects 0.000 claims 2
- 208000014644 Brain disease Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 241000531123 GB virus C Species 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- 208000005331 Hepatitis D Diseases 0.000 claims 1
- 241000724675 Hepatitis E virus Species 0.000 claims 1
- 241000724709 Hepatitis delta virus Species 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000701041 Human betaherpesvirus 7 Species 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 241000701027 Human herpesvirus 6 Species 0.000 claims 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 claims 1
- 208000018501 Lymphatic disease Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 208000005252 hepatitis A Diseases 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 201000010284 hepatitis E Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 208000018555 lymphatic system disease Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000004498 neuroglial cell Anatomy 0.000 claims 1
- 208000017443 reproductive system disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/844,201 | 2001-04-27 | ||
| US09/844,201 US7026469B2 (en) | 2000-10-19 | 2001-04-27 | Compositions and methods of double-targeting virus infections and cancer cells |
| PCT/US2002/013338 WO2002087465A2 (en) | 2001-04-27 | 2002-04-26 | Compositions and methods of double-targeting virus infections and cancer cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005505499A JP2005505499A (ja) | 2005-02-24 |
| JP2005505499A5 true JP2005505499A5 (enExample) | 2006-01-05 |
| JP4782365B2 JP4782365B2 (ja) | 2011-09-28 |
Family
ID=25292094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002584819A Expired - Fee Related JP4782365B2 (ja) | 2001-04-27 | 2002-04-26 | ウイルス感染症と癌細胞を二重ターゲッティングする組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7026469B2 (enExample) |
| EP (1) | EP1389970A4 (enExample) |
| JP (1) | JP4782365B2 (enExample) |
| AU (1) | AU2002252731A1 (enExample) |
| CA (1) | CA2445565C (enExample) |
| WO (1) | WO2002087465A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1460082A1 (en) * | 2003-03-19 | 2004-09-22 | Heidelberg Pharma Holding GmbH | Phospholipid esters of clofarabine derivatives |
| US20050187191A1 (en) * | 2004-02-20 | 2005-08-25 | Kucera Louis S. | Methods and compositions for the treatment of respiratory syncytial virus |
| US20050187192A1 (en) * | 2004-02-20 | 2005-08-25 | Kucera Pharmaceutical Company | Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses |
| CN1984663A (zh) | 2004-03-29 | 2007-06-20 | 南佛罗里达大学 | 用曲西瑞宾和相关化合物有效治疗肿瘤和癌症 |
| US8101745B2 (en) | 2004-12-16 | 2012-01-24 | The Regents Of The University Of California | Lung-targeted drugs |
| WO2006110655A2 (en) | 2005-04-08 | 2006-10-19 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
| JP2008538354A (ja) * | 2005-04-08 | 2008-10-23 | キメリクス，インコーポレイテッド | ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法 |
| ES2600792T3 (es) * | 2006-05-03 | 2017-02-10 | Chimerix, Inc. | Alcoxialquilésteres metabólicamente estables de fosfonatos, fosfonatos nucleosídicos y fosfatos nucleosídicos antivirales o antiproliferativos |
| WO2008118879A2 (en) * | 2007-03-23 | 2008-10-02 | Ardea Biosciences, Inc. | Antiviral compositions comprising 2 compounds |
| US9446150B2 (en) | 2007-10-09 | 2016-09-20 | Washington University | Particles for imaging |
| WO2009049089A1 (en) | 2007-10-09 | 2009-04-16 | Washington University In St. Louis | Ligand directed toroidal nanoparticles for therapy and diagnostic imaging |
| CN105055432A (zh) * | 2008-01-25 | 2015-11-18 | 奇默里克斯公司 | 治疗病毒感染的方法 |
| US8999960B2 (en) | 2008-10-08 | 2015-04-07 | Vascular Biogenics Ltd. | Oxidized thiophospholipid compounds and uses thereof |
| KR20110095288A (ko) * | 2008-11-06 | 2011-08-24 | 바스큘라 바이오제닉스 리미티드 | 산화된 지질 화합물 및 이의 용도 |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| US9764043B2 (en) | 2009-12-17 | 2017-09-19 | Washington University | Antithrombotic nanoparticle |
| US9808500B2 (en) | 2009-12-17 | 2017-11-07 | Washington University | Antithrombotic nanoparticle |
| CA2789443C (en) | 2010-02-12 | 2016-09-13 | Chimerix, Inc. | Nucleoside phosphonate salts |
| EP2558072B1 (en) | 2010-04-15 | 2018-09-26 | The Washington University | Prodrug compositions, prodrug nanoparticles, and methods of use thereof |
| EP2563367A4 (en) | 2010-04-26 | 2013-12-04 | Chimerix Inc | Methods of treating retroviral infections and related dosage regimes |
| US9192680B2 (en) * | 2010-06-01 | 2015-11-24 | Aposense Ltd. | Pharmaceutical compounds |
| US8530444B2 (en) * | 2010-06-01 | 2013-09-10 | Aposense Ltd. | Pharmaceutical compounds |
| KR20150130355A (ko) | 2013-03-15 | 2015-11-23 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 비환식 뉴클레오사이드 포스포네이트 디에스테르 |
| MX377983B (es) | 2014-09-15 | 2025-03-04 | Univ California | Análogos de nucleótidos. |
| CN106999506A (zh) | 2014-11-26 | 2017-08-01 | 脉管生物生长有限公司 | 氧化脂质以及纤维化的治疗或预防 |
| US9771385B2 (en) | 2014-11-26 | 2017-09-26 | Vascular Biogenics Ltd. | Oxidized lipids |
| EP3875462A1 (en) | 2015-09-15 | 2021-09-08 | The Regents of The University of California | Nucleotide analogs |
| KR20250052378A (ko) | 2022-07-21 | 2025-04-18 | 안티바 바이오사이언시즈, 인크. | Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태 |
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| GB9806815D0 (en) | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
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-
2001
- 2001-04-27 US US09/844,201 patent/US7026469B2/en not_active Expired - Lifetime
-
2002
- 2002-04-26 EP EP02721822A patent/EP1389970A4/en not_active Withdrawn
- 2002-04-26 AU AU2002252731A patent/AU2002252731A1/en not_active Abandoned
- 2002-04-26 CA CA2445565A patent/CA2445565C/en not_active Expired - Fee Related
- 2002-04-26 WO PCT/US2002/013338 patent/WO2002087465A2/en not_active Ceased
- 2002-04-26 JP JP2002584819A patent/JP4782365B2/ja not_active Expired - Fee Related
-
2006
- 2006-04-06 US US11/398,529 patent/US7638528B2/en not_active Expired - Fee Related
-
2009
- 2009-12-02 US US12/629,387 patent/US8138200B2/en not_active Expired - Fee Related
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