JP2005504797A - 眼周囲または結膜下投与のための眼用デポー製剤 - Google Patents

眼周囲または結膜下投与のための眼用デポー製剤 Download PDF

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Publication number
JP2005504797A
JP2005504797A JP2003528517A JP2003528517A JP2005504797A JP 2005504797 A JP2005504797 A JP 2005504797A JP 2003528517 A JP2003528517 A JP 2003528517A JP 2003528517 A JP2003528517 A JP 2003528517A JP 2005504797 A JP2005504797 A JP 2005504797A
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Prior art keywords
active agent
formulation
polymer
depot
microparticles
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Japanese (ja)
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JP2005504797A5 (https=
Inventor
マルクス・アールハイム
ミヒャエル・アウスボルン
ダフィト・ボドマー
クリスティアン・ショッホ
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ノバルティス アクチエンゲゼルシャフト
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Publication of JP2005504797A publication Critical patent/JP2005504797A/ja
Publication of JP2005504797A5 publication Critical patent/JP2005504797A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2003528517A 2001-09-14 2002-09-13 眼周囲または結膜下投与のための眼用デポー製剤 Withdrawn JP2005504797A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0122318.9A GB0122318D0 (en) 2001-09-14 2001-09-14 Organic compounds
PCT/EP2002/010314 WO2003024420A1 (en) 2001-09-14 2002-09-13 Ophthalmic depot formulations for periocular or subconjunctival administration

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010224231A Division JP2011026338A (ja) 2001-09-14 2010-10-01 眼周囲または結膜下投与のための眼用デポー製剤

Publications (2)

Publication Number Publication Date
JP2005504797A true JP2005504797A (ja) 2005-02-17
JP2005504797A5 JP2005504797A5 (https=) 2006-01-05

Family

ID=9922147

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003528517A Withdrawn JP2005504797A (ja) 2001-09-14 2002-09-13 眼周囲または結膜下投与のための眼用デポー製剤
JP2010224231A Withdrawn JP2011026338A (ja) 2001-09-14 2010-10-01 眼周囲または結膜下投与のための眼用デポー製剤
JP2013099024A Pending JP2013147516A (ja) 2001-09-14 2013-05-09 眼周囲または結膜下投与のための眼用デポー製剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2010224231A Withdrawn JP2011026338A (ja) 2001-09-14 2010-10-01 眼周囲または結膜下投与のための眼用デポー製剤
JP2013099024A Pending JP2013147516A (ja) 2001-09-14 2013-05-09 眼周囲または結膜下投与のための眼用デポー製剤

Country Status (24)

Country Link
US (4) US20040234611A1 (https=)
EP (1) EP1429725B1 (https=)
JP (3) JP2005504797A (https=)
KR (1) KR20040030869A (https=)
CN (2) CN102008428A (https=)
AT (1) ATE389385T1 (https=)
AU (1) AU2002342694B2 (https=)
BR (1) BR0212475A (https=)
CA (1) CA2455680C (https=)
CO (1) CO5560548A2 (https=)
DE (1) DE60225701T2 (https=)
EC (1) ECSP044967A (https=)
ES (1) ES2302849T3 (https=)
GB (1) GB0122318D0 (https=)
HU (1) HU229453B1 (https=)
IL (2) IL160027A0 (https=)
MX (1) MXPA04002421A (https=)
NO (1) NO333825B1 (https=)
NZ (1) NZ531481A (https=)
PL (1) PL203949B1 (https=)
PT (1) PT1429725E (https=)
RU (1) RU2316315C2 (https=)
WO (1) WO2003024420A1 (https=)
ZA (1) ZA200400524B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009545516A (ja) * 2006-05-02 2009-12-24 メディバス エルエルシー 眼の外部または内部への眼科用薬剤の送達法
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof

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