JP2005502357A5 - - Google Patents
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- Publication number
- JP2005502357A5 JP2005502357A5 JP2003527090A JP2003527090A JP2005502357A5 JP 2005502357 A5 JP2005502357 A5 JP 2005502357A5 JP 2003527090 A JP2003527090 A JP 2003527090A JP 2003527090 A JP2003527090 A JP 2003527090A JP 2005502357 A5 JP2005502357 A5 JP 2005502357A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- cells
- medium
- culture
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 42
- 241000700605 Viruses Species 0.000 claims 28
- 208000015181 infectious disease Diseases 0.000 claims 10
- 239000002609 medium Substances 0.000 claims 10
- 230000012010 growth Effects 0.000 claims 7
- 238000004113 cell culture Methods 0.000 claims 6
- 239000012141 concentrate Substances 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 239000001963 growth medium Substances 0.000 claims 4
- 239000012092 media component Substances 0.000 claims 4
- 239000012737 fresh medium Substances 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- 241001529453 unidentified herpesvirus Species 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 241000702263 Reovirus sp. Species 0.000 claims 2
- 238000004115 adherent culture Methods 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004114 suspension culture Methods 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 241000712891 Arenavirus Species 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000701157 Canine mastadenovirus A Species 0.000 claims 1
- 208000037404 Central European encephalitis Diseases 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000710831 Flavivirus Species 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000711386 Mumps virus Species 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010037742 Rabies Diseases 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000710799 Rubella virus Species 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 claims 1
- 208000004006 Tick-borne encephalitis Diseases 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 241001492478 dsDNA viruses, no RNA stage Species 0.000 claims 1
- 241001493065 dsRNA viruses Species 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012533 medium component Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 241001147420 ssDNA viruses Species 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 238000005199 ultracentrifugation Methods 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10144903A DE10144903A1 (de) | 2001-09-12 | 2001-09-12 | Vermehrung von Viren in Zellkultur |
| PCT/EP2002/010207 WO2003023025A1 (de) | 2001-09-12 | 2002-09-11 | Vermehrung von viren in zellkultur |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010145663A Division JP2010246559A (ja) | 2001-09-12 | 2010-06-25 | 細胞培養物中のウイルス増殖 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005502357A JP2005502357A (ja) | 2005-01-27 |
| JP2005502357A5 true JP2005502357A5 (cg-RX-API-DMAC10.html) | 2006-01-05 |
Family
ID=7698761
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527090A Pending JP2005502357A (ja) | 2001-09-12 | 2002-09-11 | 細胞培養物中のウイルス増殖 |
| JP2010145663A Pending JP2010246559A (ja) | 2001-09-12 | 2010-06-25 | 細胞培養物中のウイルス増殖 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010145663A Pending JP2010246559A (ja) | 2001-09-12 | 2010-06-25 | 細胞培養物中のウイルス増殖 |
Country Status (16)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005245943A1 (en) * | 2004-05-20 | 2005-12-01 | Id Biomedical Corporation | Process for the production of an influenza vaccine |
| RS51665B (sr) | 2004-09-09 | 2011-10-31 | Novartis Vaccines And Diagnostics Gmbh. | Smanjenje potencijalnih jatrogenih rizika povezanih sa vakcinama protiv gripa |
| ATE494906T1 (de) | 2005-11-01 | 2011-01-15 | Novartis Vaccines & Diagnostic | Von zellen stammende virale impfstoffe mit geringen mengen an rest-zell-dna |
| WO2007052055A1 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| ES2377884T3 (es) | 2005-11-04 | 2012-04-02 | Novartis Vaccines And Diagnostics S.R.L. | Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores |
| NZ594482A (en) | 2005-11-04 | 2012-11-30 | Novartis Vaccines & Diagnostic | Influenza vaccines with reduced amount of oil-in-water emulsion as adjuvant |
| CA2628424A1 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted influenza vaccines including cytokine-inducing agents |
| KR20080069232A (ko) | 2005-11-04 | 2008-07-25 | 노바티스 백신즈 앤드 다이아그노스틱스 에스.알.엘. | 스플리트 인플루엔자 백신에 대한 보조제로서 유리 수성상계면활성제를 갖는 에멀젼 |
| WO2007110776A1 (en) | 2006-03-24 | 2007-10-04 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Storage of influenza vaccines without refrigeration |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| NZ575271A (en) * | 2006-09-11 | 2011-09-30 | Novartis Ag | Making influenza virus vaccines without using eggs |
| AU2007347716B2 (en) | 2006-09-15 | 2013-06-20 | Medimmune, Llc | MDCK cell lines supporting viral growth to high titers and bioreactor process using the same |
| PT2185191E (pt) | 2007-06-27 | 2012-11-27 | Novartis Ag | Vacinas contra a gripe com baixo teor de aditivos |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| CN102216450B (zh) | 2008-09-24 | 2014-05-14 | 米迪缪尼有限公司 | 培养细胞、增殖和纯化病毒的方法 |
| KR20110074563A (ko) | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
| EP2361304A2 (en) | 2008-11-05 | 2011-08-31 | GlaxoSmithKline Biologicals S.A. | Novel method |
| DE102010018462A1 (de) | 2009-04-27 | 2011-04-07 | Novartis Ag | Impfstoffe zum Schutz gegen Influenza |
| KR20120083480A (ko) * | 2009-10-20 | 2012-07-25 | 노파르티스 아게 | 바이러스 구제를 위한 개선된 역유전학 방법 |
| SG184833A1 (en) | 2010-04-14 | 2012-11-29 | Emd Millipore Corp | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| JP6072677B2 (ja) | 2010-05-06 | 2017-02-01 | ノバルティス アーゲー | 微生物の不活化のための有機ペルオキシド化合物 |
| JP5876036B2 (ja) | 2010-05-21 | 2016-03-02 | ノバルティス アーゲー | インフルエンザウイルス再集合方法 |
| PL2575872T3 (pl) | 2010-06-01 | 2021-02-22 | Seqirus UK Limited | Zatężanie antygenów szczepionkowych grypy bez liofilizacji |
| CA2801151A1 (en) | 2010-06-01 | 2011-12-08 | Novartis Ag | Concentration of vaccine antigens with lyophilization |
| CA2808965C (en) | 2010-08-20 | 2020-01-07 | Theraject, Inc. | Soluble needle arrays for delivery of influenza vaccines |
| AU2012217170B2 (en) * | 2011-02-17 | 2016-07-28 | Boehringer Ingelheim Vetmedica Gmbh | Commercial scale process for production of PRRSV |
| EP2686423A4 (en) | 2011-03-14 | 2015-01-28 | Nat Res Council Canada | Method of viral production in cells |
| GB201216121D0 (en) | 2012-09-10 | 2012-10-24 | Novartis Ag | Sample quantification by disc centrifugation |
| CN104159608A (zh) | 2012-03-06 | 2014-11-19 | 克鲁塞尔荷兰公司 | 针对流感的改善的疫苗接种 |
| US20150210986A1 (en) * | 2012-08-24 | 2015-07-30 | Ge Healthcare Bio-Sciences Corp. | Virus purification and formulation process |
| KR101370512B1 (ko) | 2013-06-07 | 2014-03-06 | 재단법인 목암생명공학연구소 | 무단백 배지에서 부유 배양되는 mdck 유래 세포주 및 상기 세포주를 이용하여 바이러스를 증식시키는 방법 |
| KR20180035807A (ko) | 2015-06-26 | 2018-04-06 | 세퀴러스 유케이 리미티드 | 항원적으로 매치된 인플루엔자 백신 |
| AU2016290603B2 (en) | 2015-07-07 | 2022-06-02 | Seqirus UK Limited | Influenza potency assays |
| CN105561317B (zh) * | 2015-12-22 | 2018-03-20 | 肇庆大华农生物药品有限公司 | 重组伪狂犬病病毒疫苗耐热冻干保护剂及其制备方法 |
| CN108239619A (zh) * | 2016-12-23 | 2018-07-03 | 甘肃健顺生物科技有限公司 | 悬浮mdck细胞相关疫苗生产的二阶培养工艺技术 |
| CN108570445A (zh) * | 2017-11-09 | 2018-09-25 | 甘肃健顺生物科技有限公司 | Pk15细胞驯化悬浮方法和二阶病毒生产工艺 |
| CN108570444A (zh) * | 2017-11-09 | 2018-09-25 | 甘肃健顺生物科技有限公司 | St细胞驯化悬浮方法和二阶病毒生产工艺 |
| CN108570454A (zh) * | 2017-11-09 | 2018-09-25 | 甘肃健顺生物科技有限公司 | Mdbk驯化悬浮方法和二阶病毒生产工艺 |
| EP4061930A1 (en) | 2019-11-18 | 2022-09-28 | Seqirus Pty Ltd | Method for producing reassortant influenza viruses |
| KR102444684B1 (ko) * | 2020-04-29 | 2022-09-16 | 에스케이바이오사이언스(주) | 일회용 배양 공정 시스템을 이용한 인플루엔자 바이러스 생산 방법 |
| CN115927755A (zh) * | 2022-11-22 | 2023-04-07 | 辽宁成大生物股份有限公司 | 一种微量水痘-带状疱疹病毒的检测方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| EP0878541A4 (en) * | 1996-10-18 | 2001-10-17 | Univ Osaka Res Found | ROTAVIRUS ANTIGENS, VACCINALS AND MEDICATIONS AGAINST INFECTION BY ROTAVIRUS, AND METHOD FOR THEIR PRODUCTION |
| GB9915413D0 (en) * | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Propagation method |
| CA2401117C (en) * | 2000-03-03 | 2010-06-29 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell |
-
2001
- 2001-09-12 DE DE10144903A patent/DE10144903A1/de not_active Ceased
-
2002
- 2002-09-11 JP JP2003527090A patent/JP2005502357A/ja active Pending
- 2002-09-11 NZ NZ532203A patent/NZ532203A/en not_active IP Right Cessation
- 2002-09-11 CA CA002456561A patent/CA2456561A1/en not_active Abandoned
- 2002-09-11 BR BR0212469-6A patent/BR0212469A/pt not_active IP Right Cessation
- 2002-09-11 ES ES02777068T patent/ES2345606T3/es not_active Expired - Lifetime
- 2002-09-11 AU AU2002338666A patent/AU2002338666B2/en not_active Ceased
- 2002-09-11 SI SI200230909T patent/SI1427817T1/sl unknown
- 2002-09-11 WO PCT/EP2002/010207 patent/WO2003023025A1/de not_active Ceased
- 2002-09-11 PT PT02777068T patent/PT1427817E/pt unknown
- 2002-09-11 US US10/487,709 patent/US20050118698A1/en not_active Abandoned
- 2002-09-11 KR KR1020047003711A patent/KR100968141B1/ko not_active Expired - Lifetime
- 2002-09-11 AT AT02777068T patent/ATE466932T1/de active
- 2002-09-11 DE DE50214416T patent/DE50214416D1/de not_active Expired - Lifetime
- 2002-09-11 DK DK02777068.4T patent/DK1427817T3/da active
- 2002-09-11 EP EP02777068A patent/EP1427817B1/de not_active Expired - Lifetime
-
2010
- 2010-06-25 JP JP2010145663A patent/JP2010246559A/ja active Pending
- 2010-07-30 CY CY20101100718T patent/CY1110716T1/el unknown
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