JP2005500393A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005500393A5 JP2005500393A5 JP2003522304A JP2003522304A JP2005500393A5 JP 2005500393 A5 JP2005500393 A5 JP 2005500393A5 JP 2003522304 A JP2003522304 A JP 2003522304A JP 2003522304 A JP2003522304 A JP 2003522304A JP 2005500393 A5 JP2005500393 A5 JP 2005500393A5
- Authority
- JP
- Japan
- Prior art keywords
- plant
- protein
- chromatin
- use according
- protein components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000196324 Embryophyta Species 0.000 claims description 49
- 235000004252 protein component Nutrition 0.000 claims description 38
- 108010077544 Chromatin Proteins 0.000 claims description 32
- 210000003483 chromatin Anatomy 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 14
- 241000894006 Bacteria Species 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000003242 anti bacterial agent Substances 0.000 claims description 7
- 240000005979 Hordeum vulgare Species 0.000 claims description 6
- 235000007340 Hordeum vulgare Nutrition 0.000 claims description 6
- 235000021307 Triticum Nutrition 0.000 claims description 5
- 239000004599 antimicrobial Substances 0.000 claims description 5
- 108010034791 Heterochromatin Proteins 0.000 claims description 3
- 241000186805 Listeria innocua Species 0.000 claims description 3
- 241000209056 Secale Species 0.000 claims description 3
- 235000007238 Secale cereale Nutrition 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 239000008139 complexing agent Substances 0.000 claims description 3
- 238000010494 dissociation reaction Methods 0.000 claims description 3
- 210000004458 heterochromatin Anatomy 0.000 claims description 3
- 235000007319 Avena orientalis Nutrition 0.000 claims description 2
- 244000075850 Avena orientalis Species 0.000 claims description 2
- 240000008620 Fagopyrum esculentum Species 0.000 claims description 2
- 235000009419 Fagopyrum esculentum Nutrition 0.000 claims description 2
- 241000192125 Firmicutes Species 0.000 claims description 2
- 235000010469 Glycine max Nutrition 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims description 2
- 235000007164 Oryza sativa Nutrition 0.000 claims description 2
- 241000589516 Pseudomonas Species 0.000 claims description 2
- 240000008042 Zea mays Species 0.000 claims description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 235000005822 corn Nutrition 0.000 claims description 2
- 230000029087 digestion Effects 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 239000005022 packaging material Substances 0.000 claims description 2
- 238000009928 pasteurization Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000009372 pisciculture Methods 0.000 claims description 2
- 238000004321 preservation Methods 0.000 claims description 2
- 235000009566 rice Nutrition 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 208000035143 Bacterial infection Diseases 0.000 claims 6
- 208000022362 bacterial infectious disease Diseases 0.000 claims 6
- 230000002159 abnormal effect Effects 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 208000023433 Abnormality of the ear Diseases 0.000 claims 1
- 208000030560 Abnormality of the skin Diseases 0.000 claims 1
- PQKBPHSEKWERTG-UHFFFAOYSA-N Fenoxaprop ethyl Chemical compound C1=CC(OC(C)C(=O)OCC)=CC=C1OC1=NC2=CC=C(Cl)C=C2O1 PQKBPHSEKWERTG-UHFFFAOYSA-N 0.000 claims 1
- 241000589540 Pseudomonas fluorescens Species 0.000 claims 1
- 244000062793 Sorghum vulgare Species 0.000 claims 1
- 244000098338 Triticum aestivum Species 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 239000003674 animal food additive Substances 0.000 claims 1
- 244000052616 bacterial pathogen Species 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 235000013373 food additive Nutrition 0.000 claims 1
- 239000002778 food additive Substances 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 235000019713 millet Nutrition 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 31
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 25
- 235000018102 proteins Nutrition 0.000 description 23
- 102000004169 proteins and genes Human genes 0.000 description 23
- 108090000623 proteins and genes Proteins 0.000 description 23
- 239000011780 sodium chloride Substances 0.000 description 17
- 239000000463 material Substances 0.000 description 16
- 239000011159 matrix material Substances 0.000 description 15
- 238000000746 purification Methods 0.000 description 13
- 238000000926 separation method Methods 0.000 description 13
- 230000002209 hydrophobic effect Effects 0.000 description 11
- 230000000845 anti-microbial effect Effects 0.000 description 10
- 238000000605 extraction Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 239000007858 starting material Substances 0.000 description 10
- 239000002585 base Substances 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- 230000000813 microbial effect Effects 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 238000002955 isolation Methods 0.000 description 6
- 108010033040 Histones Proteins 0.000 description 5
- 102000006947 Histones Human genes 0.000 description 5
- -1 amino Chemical group 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 108700042778 Antimicrobial Peptides Proteins 0.000 description 4
- 102000044503 Antimicrobial Peptides Human genes 0.000 description 4
- 241000209140 Triticum Species 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000005194 fractionation Methods 0.000 description 4
- 239000008363 phosphate buffer Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 241000972773 Aulopiformes Species 0.000 description 2
- 108010002069 Defensins Proteins 0.000 description 2
- 102000000541 Defensins Human genes 0.000 description 2
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000206602 Eukaryota Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 240000006394 Sorghum bicolor Species 0.000 description 2
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000021736 acetylation Effects 0.000 description 2
- 238000006640 acetylation reaction Methods 0.000 description 2
- 241001148470 aerobic bacillus Species 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 230000035784 germination Effects 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 239000012678 infectious agent Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 239000004325 lysozyme Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 235000019515 salmon Nutrition 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 description 1
- 101710197241 Accessory gland-specific peptide 70A Proteins 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 241000219194 Arabidopsis Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 239000012619 Butyl Sepharose® Substances 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 108050004290 Cecropin Proteins 0.000 description 1
- 229940123150 Chelating agent Drugs 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000252203 Clupea harengus Species 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical group CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 108010026389 Gramicidin Proteins 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- 241000186781 Listeria Species 0.000 description 1
- 108060003100 Magainin Proteins 0.000 description 1
- 108010036176 Melitten Proteins 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 description 1
- 241000244206 Nematoda Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 102000003867 Phospholipid Transfer Proteins Human genes 0.000 description 1
- 108090000216 Phospholipid Transfer Proteins Proteins 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 108010064851 Plant Proteins Proteins 0.000 description 1
- 108010007568 Protamines Proteins 0.000 description 1
- 102000007327 Protamines Human genes 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000269435 Rana <genus> Species 0.000 description 1
- 241000270934 Rana catesbeiana Species 0.000 description 1
- 102000002278 Ribosomal Proteins Human genes 0.000 description 1
- 108010000605 Ribosomal Proteins Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 241000746181 Therates Species 0.000 description 1
- 235000009430 Thespesia populnea Nutrition 0.000 description 1
- 241000135164 Timea Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 241000397921 Turbellaria Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000012870 ammonium sulfate precipitation Methods 0.000 description 1
- 238000012435 analytical chromatography Methods 0.000 description 1
- 235000019730 animal feed additive Nutrition 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000001557 animal structure Anatomy 0.000 description 1
- 238000011482 antibacterial activity assay Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000739 chaotic effect Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000882 contact lens solution Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 229960004905 gramicidin Drugs 0.000 description 1
- ZWCXYZRRTRDGQE-SORVKSEFSA-N gramicidina Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 ZWCXYZRRTRDGQE-SORVKSEFSA-N 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 210000003783 haploid cell Anatomy 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 235000019514 herring Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940030980 inova Drugs 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 239000013586 microbial product Substances 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000004309 nisin Substances 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 108010062940 pexiganan Proteins 0.000 description 1
- KGZGFSNZWHMDGZ-KAYYGGFYSA-N pexiganan Chemical compound C([C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=CC=C1 KGZGFSNZWHMDGZ-KAYYGGFYSA-N 0.000 description 1
- 229950001731 pexiganan Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 230000003032 phytopathogenic effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229940048914 protamine Drugs 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 150000003682 vanadium compounds Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102864-6 | 2001-08-29 | ||
| SE0102864A SE0102864D0 (sv) | 2001-08-29 | 2001-08-29 | Antimicrorobial agent |
| PCT/SE2002/001538 WO2003017769A1 (en) | 2001-08-29 | 2002-08-28 | Antimicrobial agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005500393A JP2005500393A (ja) | 2005-01-06 |
| JP2005500393A5 true JP2005500393A5 (https=) | 2012-02-23 |
| JP4938215B2 JP4938215B2 (ja) | 2012-05-23 |
Family
ID=20285157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003522304A Expired - Fee Related JP4938215B2 (ja) | 2001-08-29 | 2002-08-28 | 抗菌剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8080258B2 (https=) |
| EP (1) | EP1420646B1 (https=) |
| JP (1) | JP4938215B2 (https=) |
| CN (1) | CN100356853C (https=) |
| AT (1) | ATE330474T1 (https=) |
| AU (1) | AU2002324408B2 (https=) |
| BR (1) | BR0212260A (https=) |
| CA (1) | CA2457488C (https=) |
| CY (1) | CY1105224T1 (https=) |
| DE (1) | DE60212647T2 (https=) |
| ES (1) | ES2268069T3 (https=) |
| PT (1) | PT1420646E (https=) |
| RU (1) | RU2303357C2 (https=) |
| SE (1) | SE0102864D0 (https=) |
| WO (1) | WO2003017769A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2651239A1 (en) * | 2006-05-05 | 2007-11-15 | Svenska Miljoebolaget Svv Ab | Virus susceptibility by plant nucleosomes |
| RU2347811C1 (ru) * | 2007-08-09 | 2009-02-27 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pET-KSI-Buf2, КОДИРУЮЩАЯ ГИБРИДНЫЙ БЕЛОК, СОДЕРЖАЩИЙ АНТИМИКРОБНЫЙ ПЕПТИД БУФОРИН-2, ШТАММ Escherichia coli BL21(DE3)/pET-KSI-Buf2 - ПРОДУЦЕНТ УКАЗАННОГО БЕЛКА И СПОСОБ ПОЛУЧЕНИЯ АНТИМИКРОБНОГО ПЕПТИДА БУФОРИНА-2 |
| UA104899C2 (uk) * | 2009-08-06 | 2014-03-25 | Анітокс Корпорейшн | Консервант для води та корму |
| SE535754C2 (sv) * | 2010-09-01 | 2012-12-04 | Ulf Sven Erik Rothman | Förfarande för isolering av katjoniska nukleoproteiner |
| AU2011315525B2 (en) * | 2010-10-12 | 2016-05-12 | Consumo Em Verde - Biotecnologia Das Plantas, S.A. | Antimicrobial protein |
| PT105332A (pt) * | 2010-10-12 | 2012-04-12 | Cev Biotecnologia Das Plantas S A | Agentes para utilização com antimicrobianos |
| KR20140097253A (ko) | 2011-11-30 | 2014-08-06 | 아니톡스 코포레이션 | 알데히드, 유기산 및 유기산 에스테르의 항미생물성 혼합물 |
| EP3287782B1 (en) * | 2013-03-15 | 2020-04-22 | The Procter & Gamble Company | A noninvasive method for measuring antimicrobial peptides from skin as an objective measurement of natural protection from microbes |
| RU2562119C2 (ru) * | 2013-07-10 | 2015-09-10 | Федеральное государственное бюджетное учреждение науки Санкт-Петербургский научно-исследовательский центр экологической безопасности Российской академии наук (НИЦЭБ РАН) | Штамм streptomyces flavogriseus - продуцент антибиотического комплекса, содержащего гексаеновый антибиотик подгруппы медиоцидина и неполиеновый антибиотик гетероциклической структуры |
| AU2017240064B8 (en) | 2016-03-31 | 2021-11-11 | Gojo Industries, Inc. | Antimicrobial peptide stimulating sanitizing composition |
| WO2017173240A1 (en) | 2016-03-31 | 2017-10-05 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
| EP3436041B1 (en) | 2016-03-31 | 2023-05-24 | Gojo Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
| RU2662767C2 (ru) * | 2016-05-11 | 2018-07-30 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ижевская государственная сельскохозяйственная академия" | Энерго-протеиновая кормовая добавка на основе семян рапса и зерна проса |
| JP2020500860A (ja) | 2016-11-23 | 2020-01-16 | ゴジョ・インダストリーズ・インコーポレイテッド | プロバイオティック／プレバイオティックな有効成分を含む消毒薬組成物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1568445A (en) * | 1925-01-27 | 1926-01-05 | Charles F Diller | Plant spray |
| SU843915A1 (ru) * | 1979-12-17 | 1981-07-07 | Научно-Производственное Объеди-Нение "Биохимреактив" | Способ получени суммарного гистонаиз жиВОТНОгО СыРь |
| US4665158A (en) * | 1984-06-13 | 1987-05-12 | Battelle Memorial Institute | Method for hydrolyzing protein materials |
| JPS6130526A (ja) * | 1984-07-23 | 1986-02-12 | ダ−ナ−フア−ベル キヤンサ− インス テイテユ−ト | リンパ球増殖因子 |
| SU1319352A1 (ru) * | 1985-01-07 | 1995-09-10 | Ленинградский государственный университет им.А.А.Жданова | Способ очистки препарата гистона н4 из ткани тимуса |
| DE3689927T3 (de) * | 1985-10-04 | 1998-10-22 | South African Inventions | Reagens und Verfahren. |
| JPS63179899A (ja) * | 1987-01-21 | 1988-07-23 | Daicel Chem Ind Ltd | 蛋白質ｐｈｉ及びその製造法 |
| DE3722044A1 (de) * | 1987-07-03 | 1989-01-12 | Hoechst Ag | Mittel zur inaktivierung von sporen sowie verfahren zur verlaengerung der haltbarkeit von produkten, stoffen oder erzeugnissen, die durch bakteriellen sporenbefall verderblich sind |
| US5573801A (en) * | 1989-02-21 | 1996-11-12 | Viskase Corporation | Surface treatment of foodstuffs with antimicrobial compositions |
| US5698200A (en) * | 1996-08-14 | 1997-12-16 | Lockheed Martin Idaho Technologies Company | Antimicrobial product and process |
| GB9714564D0 (en) * | 1997-07-10 | 1997-09-17 | Zeneca Ltd | Composition |
| US6350738B1 (en) * | 1998-03-06 | 2002-02-26 | Brigham Young University | Steroid derived antibiotics |
| US6086885A (en) * | 1998-04-09 | 2000-07-11 | Kemin Industries, Inc. | Anti-bacterial protein extracts from seeds of marigold and paprika |
| JP2000007699A (ja) * | 1998-04-23 | 2000-01-11 | Agriculture Forestry & Fisheries Technical Inf Soc | ウズラのｈ１ヒストン及びその遺伝子 |
| US6306632B1 (en) * | 1998-07-14 | 2001-10-23 | E. I. Du Pont De Nemours & Company | Chromatin associated proteins |
| US6565854B2 (en) * | 1998-08-13 | 2003-05-20 | Philadelphia Health And Education Corporation | Antimicrobial histone H1 compositions, kits, and methods of use thereof |
-
2001
- 2001-08-29 SE SE0102864A patent/SE0102864D0/xx unknown
-
2002
- 2002-08-28 DE DE2002612647 patent/DE60212647T2/de not_active Expired - Lifetime
- 2002-08-28 BR BR0212260A patent/BR0212260A/pt not_active Application Discontinuation
- 2002-08-28 AU AU2002324408A patent/AU2002324408B2/en not_active Ceased
- 2002-08-28 ES ES02759048T patent/ES2268069T3/es not_active Expired - Lifetime
- 2002-08-28 PT PT02759048T patent/PT1420646E/pt unknown
- 2002-08-28 RU RU2004109154A patent/RU2303357C2/ru not_active IP Right Cessation
- 2002-08-28 AT AT02759048T patent/ATE330474T1/de not_active IP Right Cessation
- 2002-08-28 EP EP02759048A patent/EP1420646B1/en not_active Expired - Lifetime
- 2002-08-28 WO PCT/SE2002/001538 patent/WO2003017769A1/en not_active Ceased
- 2002-08-28 JP JP2003522304A patent/JP4938215B2/ja not_active Expired - Fee Related
- 2002-08-28 CA CA 2457488 patent/CA2457488C/en not_active Expired - Fee Related
- 2002-08-28 CN CNB028193768A patent/CN100356853C/zh not_active Expired - Fee Related
- 2002-08-29 US US10/231,400 patent/US8080258B2/en not_active Expired - Lifetime
-
2006
- 2006-09-20 CY CY20061101351T patent/CY1105224T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4938215B2 (ja) | 抗菌剤 | |
| JP2005500393A5 (https=) | ||
| TWI684642B (zh) | 一種產細菌素之類芽孢桿菌及其應用 | |
| KR20110123791A (ko) | 생물학 분자의 부위 활성화된 착물화 방법 및 물질 | |
| JPH09509175A (ja) | 広域スペクトル抗菌化合物と使用方法 | |
| EP3039968B1 (en) | Method of producing feed additive containing surfactin | |
| AU2002324408A1 (en) | Antimicrobial agent | |
| Mohan et al. | Preservatives from food—For food: Pea protein hydrolysate as a novel bio‐preservative against Escherichia coli O157: H7 on a lettuce leaf | |
| CN117886889A (zh) | 一种抗菌肽ai18及其应用 | |
| CN110257269A (zh) | 一种产细菌素的类芽孢杆菌及其应用 | |
| CN104761617B (zh) | 一种鹰嘴豆多肽部位的制备方法及其应用 | |
| CN108719595A (zh) | 一种可替代饲用抗生素且可作为诱食剂的组合物 | |
| CN117530369A (zh) | 一种易吸收的饲料添加剂及其制备方法 | |
| US20160193284A1 (en) | Use of a bacterium isolated from the genus pseudoalteromonas, cyclolipopeptides and uses thereof | |
| DE69132498T2 (de) | Antimikrobielle zusammensetzung | |
| CN103109925A (zh) | 纯天然果蔬种植除菌杀虫保鲜剂 | |
| Liu et al. | Antibacterial activity, cytotoxicity and mechanisms of action of cathelicidin peptides against enteric pathogens in weaning piglets | |
| CN111658759A (zh) | 一种抗菌肽在体外抑制大肠杆菌中的应用 | |
| KR100454228B1 (ko) | 양식어류용 사료첨가제 | |
| CN117751948A (zh) | 一种复合消毒剂及其制备方法与应用 | |
| DE69736828T2 (de) | Antimikrobielles protein | |
| CN113563444B (zh) | 一种多肽、应用及含有该多肽的虾养殖饲料和药物 | |
| CN105707646A (zh) | 一种植物源天然防腐剂及其在海鲜调味料中的应用 | |
| CN109678934A (zh) | 具有选择性抗铜绿假单胞菌活性的灭菌肽及其活性优化修饰物 | |
| Vahinalahaja et al. | Chemical and toxicological research on extracts from the leaves of Pittosporum senacia Poir.(Pittosporaceae), a medicinal plant endemic to Madagascar |