JP2005270108A5 - - Google Patents

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Publication number
JP2005270108A5
JP2005270108A5 JP2005120409A JP2005120409A JP2005270108A5 JP 2005270108 A5 JP2005270108 A5 JP 2005270108A5 JP 2005120409 A JP2005120409 A JP 2005120409A JP 2005120409 A JP2005120409 A JP 2005120409A JP 2005270108 A5 JP2005270108 A5 JP 2005270108A5
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JP
Japan
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strand
nucleic acid
target strand
primer
target
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JP2005120409A
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Japanese (ja)
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JP4675141B2 (ja
JP2005270108A (ja
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Priority claimed from US09/104,067 external-priority patent/US6743605B1/en
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Publication of JP4675141B2 publication Critical patent/JP4675141B2/ja
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JP2005120409A 1998-06-24 2005-04-18 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法 Expired - Lifetime JP4675141B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/104,067 US6743605B1 (en) 1998-06-24 1998-06-24 Linear amplification of specific nucleic acid sequences

Related Parent Applications (1)

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JP2003428482A Division JP4493330B2 (ja) 1998-06-24 2003-12-24 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法

Publications (3)

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JP2005270108A JP2005270108A (ja) 2005-10-06
JP2005270108A5 true JP2005270108A5 (cg-RX-API-DMAC7.html) 2008-05-08
JP4675141B2 JP4675141B2 (ja) 2011-04-20

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JP11179056A Withdrawn JP2000037194A (ja) 1998-06-24 1999-06-24 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法
JP2003428482A Expired - Lifetime JP4493330B2 (ja) 1998-06-24 2003-12-24 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法
JP2005120409A Expired - Lifetime JP4675141B2 (ja) 1998-06-24 2005-04-18 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法

Family Applications Before (2)

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JP11179056A Withdrawn JP2000037194A (ja) 1998-06-24 1999-06-24 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法
JP2003428482A Expired - Lifetime JP4493330B2 (ja) 1998-06-24 2003-12-24 核酸を増幅するため、核酸配列のための終結後標識プロセス、および減少した熱力学安定性を有する核酸を生成するための新規の方法

Country Status (6)

Country Link
US (11) US6743605B1 (cg-RX-API-DMAC7.html)
EP (1) EP0971039B1 (cg-RX-API-DMAC7.html)
JP (3) JP2000037194A (cg-RX-API-DMAC7.html)
CA (1) CA2273064C (cg-RX-API-DMAC7.html)
DE (1) DE69943292D1 (cg-RX-API-DMAC7.html)
IL (1) IL130477A (cg-RX-API-DMAC7.html)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
GB9812768D0 (en) * 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6743605B1 (en) 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US8445664B2 (en) 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
JP3974441B2 (ja) * 1998-11-09 2007-09-12 栄研化学株式会社 核酸の合成方法
WO2000028082A1 (fr) 1998-11-09 2000-05-18 Eiken Kagaku Kabushiki Kaisha Procede de synthese d'acide nucleique
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
AU1057801A (en) 1999-11-08 2001-06-06 Eiken Kagaku Kabushiki Kaisha Method of detecting variation or polymorphism
JP4721603B2 (ja) * 1999-11-08 2011-07-13 栄研化学株式会社 変異および/または多型の検出方法
EP1275715B1 (en) 2000-04-07 2015-07-15 Eiken Kagaku Kabushiki Kaisha Method for amplifyingand detecting a nucleic acid by using double-stranded nucleic acid as template
JP2001309785A (ja) * 2000-05-01 2001-11-06 Eiken Chem Co Ltd 遺伝子配列間の相違検出方法
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
DE60141087D1 (de) 2000-06-26 2010-03-04 Nugen Technologies Inc Methoden und zusammensetzungen zur auf transkription basierenden vervielfältigung von nukleinsäuren
ATE437225T1 (de) 2000-09-19 2009-08-15 Eiken Chemical Verfahren zur polynukleotidsynthese
CA2430329A1 (en) 2000-12-13 2002-06-20 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
CN1289690C (zh) 2001-03-09 2006-12-13 纽亘技术公司 Rna序列扩增的方法和组合物
US7094536B2 (en) 2001-03-09 2006-08-22 Nugen Technologies, Inc. Methods and compositions for amplification of RNA sequences
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US9777312B2 (en) 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
JP2005052002A (ja) * 2001-07-06 2005-03-03 Wakunaga Pharmaceut Co Ltd 非環状核酸断片の増幅方法
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
EP1453979B1 (en) 2001-11-19 2012-01-04 Affymetrix, Inc. Multiplex pcr
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US6815167B2 (en) 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
EP2292801B1 (en) 2002-06-14 2018-08-08 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus
GB0218215D0 (en) * 2002-08-06 2002-09-11 Tepnel Medical Ltd Amplification of nucleic acids
EP1564301A4 (en) * 2002-10-29 2007-07-11 Riken PROCESS FOR NUCLEIC ACID AMPLIFICATION
JP2006523465A (ja) * 2003-04-14 2006-10-19 ニューゲン テクノロジーズ, インコーポレイテッド ランダムにプライミングされる複合プライマーを用いる大規模増幅
TW200525026A (en) 2003-12-25 2005-08-01 Riken Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
US7575863B2 (en) * 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
CA2476030A1 (en) * 2004-06-09 2005-12-09 Wilsun Xu A power signaling based technique for detecting islanding conditions in electric power distribution systems
US8124334B2 (en) * 2004-07-06 2012-02-28 Enzo Biochem, Inc. Selective detection of oncogenic HPV
ATE494392T1 (de) * 2004-09-21 2011-01-15 Life Technologies Corp Zweifarbige echtzeit/endpunkt-quantifizierung von mikro-rnas (mirnas)
EP1696040A1 (en) * 2005-02-28 2006-08-30 Eurofins Viralliance, Inc. Method of genotyping and phenotyping hepatitis B viruses resistant to antiviral molecules
EP1871897B1 (en) 2005-04-12 2010-09-29 Olink AB Methods for production of oligonucleotides
CN101238221B (zh) * 2005-04-12 2011-11-16 Novia公司名下的现场Rcp公司 新型环形探针及其在鉴定生物分子中的用途
KR101392106B1 (ko) 2005-05-09 2014-05-07 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
ATE550441T1 (de) * 2005-09-06 2012-04-15 Gen Probe Inc Verfahren, zusammensetzungen und kits zur isothermischen amplifikation von nukleinsäuren
EP1929046B1 (en) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
EP3263117A1 (en) * 2005-11-28 2018-01-03 Imaginot Pty Ltd. Oral therapeutic compound delivery system
JP4580875B2 (ja) * 2006-01-20 2010-11-17 株式会社東芝 核酸検出法のためのプライマーの設計方法
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US7833716B2 (en) 2006-06-06 2010-11-16 Gen-Probe Incorporated Tagged oligonucleotides and their use in nucleic acid amplification methods
US7501254B2 (en) 2006-07-20 2009-03-10 Ghc Technologies, Inc. Methods and compositions for amplification and capture of nucleic acid sequences
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
AU2008206221A1 (en) * 2007-01-17 2008-07-24 Meridian Bioscience, Inc. Stable reagents and kits useful in loop-mediated isothermal amplification (LAMP)
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
BR122020017678B1 (pt) 2007-10-02 2021-08-03 Labrador Diagnostics Llc Sistema para detecção automática de um analito em uma amostra de fluido corporal
US8420323B2 (en) * 2007-11-14 2013-04-16 Fujifilm Corporation Nucleic acid amplification method
US20090162845A1 (en) * 2007-12-20 2009-06-25 Elazar Rabbani Affinity tag nucleic acid and protein compositions, and processes for using same
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
GB0820927D0 (en) 2008-11-14 2008-12-24 Isis Innovation Method
BRPI1007214A8 (pt) 2009-01-30 2022-12-20 Oxford Nanopore Tech Ltd Adaptador para sequenciar ácidos nucleicos, par de adaptadores, kit, construto de ácido nucleico, e, métodos para preparar um adaptador, um construto de ácido nucleico, e um construto de dequência, e para sequenciar ácido nucleico de fita dupla.
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
WO2010114842A1 (en) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
EP2272980A1 (en) * 2009-07-09 2011-01-12 Bioesplora SRL Molecular probes for target nucleic acid detection and quantification
US9416409B2 (en) 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
CN105740641A (zh) 2009-10-19 2016-07-06 提拉诺斯公司 集成的健康数据采集和分析系统
JP2013511285A (ja) 2009-11-23 2013-04-04 スイフト・バイオサイエンシズ・インコーポレイテツド 一本鎖標的分子を伸長させるデバイス
MX2013008339A (es) 2011-01-21 2014-02-11 Theranos Inc Sistemas y metodos para maximizacion de uso de muestras.
CA2843136C (en) 2011-07-25 2020-12-29 Oxford Nanopore Technologies Limited Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
US9109226B2 (en) * 2011-09-01 2015-08-18 New England Biolabs, Inc. Synthetic nucleic acids for polymerization reactions
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
US9970061B2 (en) 2011-12-27 2018-05-15 Ibis Biosciences, Inc. Bioagent detection oligonucleotides
WO2013101783A2 (en) 2011-12-30 2013-07-04 Bio-Rad Laboratories, Inc. Methods and compositions for performing nucleic acid amplification reactions
CN108611398A (zh) 2012-01-13 2018-10-02 Data生物有限公司 通过新一代测序进行基因分型
CN112646019B (zh) 2012-04-10 2022-08-16 牛津纳米孔科技公开有限公司 突变胞溶素孔
WO2014013259A1 (en) 2012-07-19 2014-01-23 Oxford Nanopore Technologies Limited Ssb method
FI3511424T3 (fi) 2012-08-03 2023-11-22 Univ Washington Through Its Center For Commercialization Koostumuksia ja menetelmiä nanohuokosten sekvensoinnin parantamiseksi
WO2014110127A1 (en) 2013-01-08 2014-07-17 Enzo Biochem, Inc. Diagnosis and treatment of viral diseases
US9617607B2 (en) 2013-01-08 2017-04-11 Enzo Biochem, Inc. Diagnosis and treatment of viral diseases
CN105209634B (zh) 2013-03-08 2020-05-12 牛津纳米孔技术公司 酶停滞方法
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
EP2970960B1 (en) 2013-03-15 2019-03-13 Theranos IP Company, LLC Nucleic acid amplification
AU2014233150A1 (en) 2013-03-15 2015-09-17 Theranos Ip Company, Llc Nucleic acid amplification
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
CA2906824C (en) 2013-03-15 2023-10-03 Theranos, Inc. Nucleic acid amplification
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
SG11201601611WA (en) 2013-09-06 2016-04-28 Theranos Inc Systems and methods for detecting infectious diseases
AU2015208919B9 (en) 2014-01-22 2021-04-01 Oxford Nanopore Technologies Limited Method for attaching one or more polynucleotide binding proteins to a target polynucleotide
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
WO2015166275A1 (en) 2014-05-02 2015-11-05 Oxford Nanopore Technologies Limited Mutant pores
WO2015187849A2 (en) 2014-06-04 2015-12-10 Lucigen Corporation Sample collection and analysis devices
EP3169793B1 (en) 2014-07-16 2022-07-06 Tangen Biosciences Inc. Isothermal methods for amplifying nucleic acid samples
KR20250130441A (ko) 2014-09-01 2025-09-01 브이아이비 브이지더블유 돌연변이체 csgg 포어
EP3194590A4 (en) * 2014-09-17 2018-05-09 Theranos, Inc. Hybrid multi-step nucleic acid amplification
WO2016055778A1 (en) 2014-10-07 2016-04-14 Oxford Nanopore Technologies Limited Mutant pores
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
WO2016073353A1 (en) 2014-11-03 2016-05-12 Tangen Biosciences, Inc. Apparatus and method for cell, spore, or virus capture and disruption
GB201502809D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Mutant pore
GB201502810D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Method
US11169138B2 (en) 2015-04-14 2021-11-09 Katholieke Universiteit Leuven Nanopores with internal protein adaptors
JP7237586B2 (ja) 2015-12-08 2023-03-13 カトリック ユニヴェルシテット ルーヴェン カーユー ルーヴェン リサーチ アンド ディベロップメント 修飾ナノポア、それを含む組成物およびその使用
WO2017142825A2 (en) * 2016-02-18 2017-08-24 Merck Sharp & Dohme Corp. N3-substituted iminopyrimidinones as antimalarial agents
WO2017149318A1 (en) 2016-03-02 2017-09-08 Oxford Nanopore Technologies Limited Mutant pores
EP4122949B1 (en) 2016-04-06 2024-06-05 Oxford Nanopore Technologies plc Mutant pore
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
PL3469365T3 (pl) 2016-06-09 2023-04-03 The Regents Of The University Of California Zatężanie biomarkera i amplifikacja sygnału do zastosowania w testach immunologicznych na bazie papieru
US10822648B1 (en) 2016-07-29 2020-11-03 Labrador Diagnostics Llc Hybrid multi-step nucleic acid amplification
KR102349259B1 (ko) 2017-01-04 2022-01-07 엠쥐아이 테크 컴퍼니 엘티디. 친화성 시약을 이용한 핵산 시퀀싱
GB201707122D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Pore
EP3642363B1 (en) * 2017-06-20 2025-12-24 Bio-Rad Laboratories, Inc. Mda using bead oligonucleotide
CN117106037B (zh) 2017-06-30 2025-07-25 弗拉芒区生物技术研究所 新颖蛋白孔
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE265429C (cg-RX-API-DMAC7.html) 1911-12-15 1913-10-10
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US5260433A (en) 1982-06-23 1993-11-09 Enzo Diagnostics, Inc. Saccharide specific binding system labeled nucleotides
US5241060A (en) 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US5171534A (en) 1984-01-16 1992-12-15 California Institute Of Technology Automated DNA sequencing technique
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US5230781A (en) 1984-03-29 1993-07-27 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes
US5360523A (en) 1984-03-29 1994-11-01 Li-Cor, Inc. DNA sequencing
US5346603A (en) 1984-03-29 1994-09-13 The Board Of Regents Of The University Of Nebraska DNA sequencing
US4729947A (en) 1984-03-29 1988-03-08 The Board Of Regents Of The University Of Nebraska DNA sequencing
US4749647A (en) * 1984-06-22 1988-06-07 Genetic Systems Corporation Polymerization-induced separation assay using recognition pairs
GB8421967D0 (en) * 1984-08-30 1984-10-03 Hickory Springs Mfg Co Polyurethane foams
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5093232A (en) 1985-12-11 1992-03-03 Chiron Corporation Nucleic acid probes
JP3293820B2 (ja) 1985-12-13 2002-06-17 エンゾ− バイオケム インコ−ポレイテツド 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
CA1340806C (en) 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5032570A (en) 1987-08-04 1991-07-16 Hitachi Metals, Ltd. Method for producing ceramic superconducting material using intermediate products
DD265429A1 (de) * 1987-09-30 1989-03-01 Adl Inst Phytopathologie Verfahren zur nichtradioaktiven markierung von polynukleotiden
CA1323293C (en) 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
US5260428A (en) * 1988-07-11 1993-11-09 Boehringer Mannheim Gmbh Agent for the detection of substances with hydrolase activity
US5508178A (en) 1989-01-19 1996-04-16 Rose; Samuel Nucleic acid amplification using single primer
US5503975A (en) * 1989-03-01 1996-04-02 City Of Hope Mechanism based inhibitors of DNA methyltransferase
JPH0750041Y2 (ja) 1990-01-17 1995-11-15 大同特殊鋼株式会社 連続鋳造設備におけるタンディッシュ交換装置
WO1992000989A1 (en) 1990-07-10 1992-01-23 Imperial Chemical Industries Plc Non-isotopic nucleic acid labelling method
US5439793A (en) 1990-07-19 1995-08-08 Syntex (U.S.A.) Inc. Method for producing a polynucleotide having an intramolecularly base-paired structure
US5595891A (en) 1990-07-19 1997-01-21 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5518900A (en) * 1993-01-15 1996-05-21 Molecular Tool, Inc. Method for generating single-stranded DNA molecules
US5569582A (en) 1991-07-15 1996-10-29 Institute Of Molecular Biology & Technology Rapid amplification and detection of nucleic acids
US5714323A (en) 1991-08-30 1998-02-03 The University Of Medecine And Dentistry Of New Jersey Over expression of single-stranded molecules
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5612199A (en) 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
JPH07500734A (ja) * 1991-10-31 1995-01-26 ユニヴァーシティ オブ ピッツバーグ オリゴヌクレオチドプローブのポリマーを用いる核酸配列の検出方法
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
ZA929351B (en) * 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
FR2687679B1 (fr) 1992-02-05 1994-10-28 Centre Nat Rech Scient Oligothionucleotides.
US5462854A (en) 1993-04-19 1995-10-31 Beckman Instruments, Inc. Inverse linkage oligonucleotides for chemical and enzymatic processes
US5470723A (en) 1993-05-05 1995-11-28 Becton, Dickinson And Company Detection of mycobacteria by multiplex nucleic acid amplification
WO1995002690A1 (en) 1993-07-13 1995-01-26 Abbott Laboratories Nucleotide sequences and process for amplifying and detection of hepatitis b virus
CA2105364A1 (en) * 1993-09-01 1995-03-02 Eric T. Kool Stem-loop oligonucleotides containing parallel and antiparallel binding domains
DE4331670A1 (de) * 1993-09-17 1995-03-23 Hoechst Ag Neue Antisense-Oligonucleotide gegen HSV-1 sowie deren Herstellung
US5470184A (en) * 1994-01-14 1995-11-28 Chandler; Charles W. Screw hole plug
US5462584A (en) * 1994-03-21 1995-10-31 Gas Research Institute Process for dehydrating natural gas
FR2721945B1 (fr) 1994-07-04 1996-10-18 David Fabrice Accroissement genique, un procede d'amplicication genique isotherme et ses applications
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
US5665545A (en) * 1994-11-28 1997-09-09 Akzo Nobel N.V. Terminal repeat amplification method
US5798276A (en) * 1995-06-07 1998-08-25 Molecular Probes, Inc. Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
AT402203B (de) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
WO1997004131A1 (en) * 1995-07-21 1997-02-06 Forsyth Dental Infirmary For Children Single primer amplification of polynucleotide hairpins
US6114150A (en) * 1995-11-29 2000-09-05 Yale University Amplification of nucleic acids
GB9609441D0 (en) 1996-05-04 1996-07-10 Zeneca Ltd Process
US5821356A (en) 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides
JPH10312826A (ja) 1997-03-10 1998-11-24 Sanyo Electric Co Ltd 非水電解質電池及びその充電方法
EP0973788A1 (en) 1997-04-02 2000-01-26 Amersham Pharmacia Biotech UK Limited Tricyclic base analogues
GB9717061D0 (en) 1997-08-13 1997-10-15 Tepnel Medical Ltd Amplification of nucleic acids
US6087099A (en) * 1997-09-08 2000-07-11 Myriad Genetics, Inc. Method for sequencing both strands of a double stranded DNA in a single sequencing reaction
US6124120A (en) 1997-10-08 2000-09-26 Yale University Multiple displacement amplification
GB9810865D0 (en) * 1998-05-20 1998-07-22 Zeneca Ltd Nucleic acid sequence identification
US5991238A (en) 1998-06-09 1999-11-23 Western Atlas International, Inc. Weighted backus filter method of combining dual sensor traces
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
WO2000028082A1 (fr) 1998-11-09 2000-05-18 Eiken Kagaku Kabushiki Kaisha Procede de synthese d'acide nucleique
US6114123A (en) * 1999-06-14 2000-09-05 Incyte Pharmaceuticals, Inc. Lipocalin family protein
AU1057801A (en) 1999-11-08 2001-06-06 Eiken Kagaku Kabushiki Kaisha Method of detecting variation or polymorphism
RU2252964C2 (ru) 1999-11-08 2005-05-27 Эйкен Кагаку Кабусики Кайся Способ и набор для синтеза нуклеиновой кислоты, имеющей нуклеотидную последовательность, где в одной цепи попеременно связаны комплементарные нуклеотидные последовательности

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