JP2004534523A5 - - Google Patents
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- JP2004534523A5 JP2004534523A5 JP2002573813A JP2002573813A JP2004534523A5 JP 2004534523 A5 JP2004534523 A5 JP 2004534523A5 JP 2002573813 A JP2002573813 A JP 2002573813A JP 2002573813 A JP2002573813 A JP 2002573813A JP 2004534523 A5 JP2004534523 A5 JP 2004534523A5
- Authority
- JP
- Japan
- Prior art keywords
- variant
- amino acid
- variant according
- substitution
- glycosylation site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000004988 N-glycosylation Effects 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 9
- 102220519361 Coatomer subunit alpha_C17S_mutation Human genes 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 5
- 102000003996 Interferon-beta Human genes 0.000 claims 4
- 108090000467 Interferon-beta Proteins 0.000 claims 4
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 4
- 230000013595 glycosylation Effects 0.000 claims 4
- 238000006206 glycosylation reaction Methods 0.000 claims 4
- 229960001388 interferon-beta Drugs 0.000 claims 4
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 101001054334 Homo sapiens Interferon beta Proteins 0.000 claims 2
- 102220580583 NEDD4-binding protein 2-like 1_K33R_mutation Human genes 0.000 claims 2
- 102220480920 Nicotinate phosphoribosyltransferase_K45R_mutation Human genes 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102220067563 rs200327756 Human genes 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102220594474 Annexin-2 receptor_L88T_mutation Human genes 0.000 claims 1
- 102220627590 Coagulation factor IX_K45N_mutation Human genes 0.000 claims 1
- 102220476665 Dynein axonemal assembly factor 10_S75T_mutation Human genes 0.000 claims 1
- 102220480985 Nicotinate phosphoribosyltransferase_Q51N_mutation Human genes 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 102220486979 Sodium-dependent phosphate transport protein 1_S76N_mutation Human genes 0.000 claims 1
- 102220603542 TYRO protein tyrosine kinase-binding protein_R27N_mutation Human genes 0.000 claims 1
- 102220472118 Transmembrane protein_Q48N_mutation Human genes 0.000 claims 1
- 102220487674 Uridine diphosphate glucose pyrophosphatase NUDT22_K19N_mutation Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102220209765 rs1057523510 Human genes 0.000 claims 1
- 102220035366 rs281865432 Human genes 0.000 claims 1
- 102220010923 rs371877084 Human genes 0.000 claims 1
- 102200080720 rs4077515 Human genes 0.000 claims 1
- 102220104696 rs879253900 Human genes 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100323 | 2001-02-27 | ||
| DKPA200100333 | 2001-03-01 | ||
| DKPA200101040 | 2001-06-29 | ||
| DKPA200101277 | 2001-08-30 | ||
| DKPA200101954 | 2001-12-21 | ||
| DKPA200200257 | 2002-02-19 | ||
| PCT/DK2002/000128 WO2002074806A2 (en) | 2001-02-27 | 2002-02-26 | New interferon beta-like molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004534523A JP2004534523A (ja) | 2004-11-18 |
| JP2004534523A5 true JP2004534523A5 (https=) | 2005-12-22 |
Family
ID=27545246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573813A Pending JP2004534523A (ja) | 2001-02-27 | 2002-02-26 | 新規なインターフェロンβ様分子 |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP1366075B1 (https=) |
| JP (1) | JP2004534523A (https=) |
| AT (1) | ATE432288T1 (https=) |
| BR (1) | BR0207576A (https=) |
| CA (1) | CA2469846A1 (https=) |
| CZ (1) | CZ20032526A3 (https=) |
| DE (1) | DE60232434D1 (https=) |
| HU (1) | HUP0303251A2 (https=) |
| IL (1) | IL156059A0 (https=) |
| IS (1) | IS6927A (https=) |
| MX (1) | MXPA03007619A (https=) |
| NO (1) | NO20033781L (https=) |
| PL (1) | PL367154A1 (https=) |
| RU (1) | RU2003128955A (https=) |
| SK (1) | SK11882003A3 (https=) |
| WO (1) | WO2002074806A2 (https=) |
| YU (1) | YU48703A (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2411007T3 (es) | 2001-10-10 | 2013-07-04 | Novo Nordisk A/S | Remodelación y glicoconjugación de péptidos |
| US7265085B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycoconjugation methods and proteins/peptides produced by the methods |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US7439043B2 (en) | 2001-10-10 | 2008-10-21 | Neose Technologies, Inc. | Galactosyl nucleotide sugars |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
| US7226903B2 (en) | 2001-10-10 | 2007-06-05 | Neose Technologies, Inc. | Interferon beta: remodeling and glycoconjugation of interferon beta |
| US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
| US7179617B2 (en) | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US7297511B2 (en) | 2001-10-10 | 2007-11-20 | Neose Technologies, Inc. | Interferon alpha: remodeling and glycoconjugation of interferon alpha |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7696163B2 (en) | 2001-10-10 | 2010-04-13 | Novo Nordisk A/S | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7399613B2 (en) | 2001-10-10 | 2008-07-15 | Neose Technologies, Inc. | Sialic acid nucleotide sugars |
| US7473680B2 (en) | 2001-11-28 | 2009-01-06 | Neose Technologies, Inc. | Remodeling and glycoconjugation of peptides |
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| JP5207590B2 (ja) * | 2002-12-26 | 2013-06-12 | マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド | 増強された生物学的能力を有するインターフェロン−βのポリマー結合体 |
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| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
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| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| JP2007523630A (ja) | 2003-05-09 | 2007-08-23 | ネオス テクノロジーズ インコーポレイテッド | ヒト成長ホルモングリコシル化突然変異体の組成と調合法 |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US7842661B2 (en) | 2003-11-24 | 2010-11-30 | Novo Nordisk A/S | Glycopegylated erythropoietin formulations |
| EP1694347B1 (en) | 2003-11-24 | 2013-11-20 | BioGeneriX AG | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| CN1913917B (zh) * | 2003-12-31 | 2012-02-01 | 正统逻辑公司 | 凝血酶肽衍生物的药物组合物 |
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| KR20070008645A (ko) | 2004-05-04 | 2007-01-17 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 폴리펩티드의 ｏ-연결된 단백당형 및 그들의 제조 방법 |
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| WO2006031811A2 (en) | 2004-09-10 | 2006-03-23 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
| WO2006050247A2 (en) | 2004-10-29 | 2006-05-11 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| EP2975135A1 (en) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glycopegylated factor IX |
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| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
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| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| EP2049144B8 (en) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylation of peptides via o-linked glycosylation sequences |
| CN101506232A (zh) * | 2006-08-08 | 2009-08-12 | 诺瓦提斯公司 | 具有增强的生物活性的重组干扰素-β |
| EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES |
| HRP20130382T1 (hr) | 2007-04-03 | 2013-05-31 | Biogenerix Ag | Postupci lijeäśenja pomoä†u glikopegiliranog g-csf |
| CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
| US7625555B2 (en) | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
| US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
| PL2257311T3 (pl) | 2008-02-27 | 2014-09-30 | Novo Nordisk As | Koniugaty cząsteczek czynnika VIII |
| DK2762489T3 (en) | 2011-10-01 | 2018-07-02 | Glytech Inc | GLYCOSYLED POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME |
| WO2014049588A1 (en) * | 2012-09-27 | 2014-04-03 | University College Dublin, National University Of Ireland, Dublin | A method for treatment of pulmonary fibrosis and diagnosis or prognosis of an aggressive pulmonary fibrosis phenotype |
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| US9579628B2 (en) | 2015-04-15 | 2017-02-28 | Air Products And Chemicals, Inc. | Perforated adsorbent particles |
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-
2002
- 2002-02-26 WO PCT/DK2002/000128 patent/WO2002074806A2/en not_active Ceased
- 2002-02-26 YU YU48703A patent/YU48703A/sh unknown
- 2002-02-26 JP JP2002573813A patent/JP2004534523A/ja active Pending
- 2002-02-26 CZ CZ20032526A patent/CZ20032526A3/cs unknown
- 2002-02-26 BR BR0207576-8A patent/BR0207576A/pt not_active Application Discontinuation
- 2002-02-26 AT AT02702228T patent/ATE432288T1/de not_active IP Right Cessation
- 2002-02-26 DE DE60232434T patent/DE60232434D1/de not_active Expired - Lifetime
- 2002-02-26 SK SK1188-2003A patent/SK11882003A3/sk unknown
- 2002-02-26 RU RU2003128955/13A patent/RU2003128955A/ru not_active Application Discontinuation
- 2002-02-26 PL PL02367154A patent/PL367154A1/xx unknown
- 2002-02-26 EP EP02702228A patent/EP1366075B1/en not_active Expired - Lifetime
- 2002-02-26 MX MXPA03007619A patent/MXPA03007619A/es unknown
- 2002-02-26 CA CA002469846A patent/CA2469846A1/en not_active Abandoned
- 2002-02-26 HU HU0303251A patent/HUP0303251A2/hu unknown
- 2002-02-26 IL IL15605902A patent/IL156059A0/xx unknown
- 2002-02-26 EP EP09075066A patent/EP2080771A3/en not_active Withdrawn
-
2003
- 2003-08-26 IS IS6927A patent/IS6927A/is unknown
- 2003-08-26 NO NO20033781A patent/NO20033781L/no not_active Application Discontinuation
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