|
ES2165768B1
(es)
|
1999-07-14 |
2003-04-01 |
Almirall Prodesfarma Sa |
Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
IL153707A0
(en)
|
2000-06-27 |
2003-07-06 |
S A L V A T Lab Sa |
Carbamates derived from arylalkylamines
|
|
AU2002228015B2
(en)
|
2000-12-22 |
2007-08-23 |
Almirall, S.A. |
Quinuclidine carbamate derivatives and their use as M3 antagonists
|
|
CA2433128C
(en)
|
2000-12-28 |
2010-05-25 |
Almirall Prodesfarma Ag |
Novel quinuclidine derivatives and medicinal compositions containing the same
|
|
CA2470567A1
(en)
|
2001-12-14 |
2003-06-26 |
Targacept, Inc. |
Methods and compositions for treatment of central nervous system disorders
|
|
EA006505B1
(ru)
*
|
2001-12-20 |
2005-12-29 |
Лабораториос С.А.Л.В.А.Т.,С.А. |
Производные карбамата 1-алкил-1-азониабицикло[2.2.2]октана и их применение в качестве антагонистов мускаринового рецептора
|
|
ES2203327B1
(es)
*
|
2002-06-21 |
2005-06-16 |
Almirall Prodesfarma, S.A. |
Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
ES2204295B1
(es)
*
|
2002-07-02 |
2005-08-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de quinuclidina-amida.
|
|
CN1668585A
(zh)
*
|
2002-07-08 |
2005-09-14 |
兰贝克赛实验室有限公司 |
用作蝇蕈碱受体拮抗剂的3,6－二取代氮杂双环[3.1.0]己烷衍生物
|
|
TWI295669B
(en)
|
2002-10-30 |
2008-04-11 |
Theravance Inc |
Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
|
|
PE20040950A1
(es)
|
2003-02-14 |
2005-01-01 |
Theravance Inc |
DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
|
|
WO2004089898A1
(en)
|
2003-04-09 |
2004-10-21 |
Ranbaxy Laboratories Limited |
Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
|
|
BRPI0409302A
(pt)
|
2003-04-11 |
2006-04-11 |
Ranbaxy Lab Ltd |
derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos
|
|
TW200519106A
(en)
|
2003-05-02 |
2005-06-16 |
Novartis Ag |
Organic compounds
|
|
US7358244B2
(en)
|
2003-05-28 |
2008-04-15 |
Theravance, Inc. |
Azabicycloalkane compounds
|
|
EP1644356A1
(en)
|
2003-07-11 |
2006-04-12 |
Theravance, Inc. |
Substituted 4-amino-1-benzylpiperidine compounds
|
|
CN100569760C
(zh)
|
2003-11-21 |
2009-12-16 |
施万制药 |
具有β2肾上腺素能受体激动剂和毒蕈碱性受体拮抗剂活性的化合物
|
|
GB0401334D0
(en)
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
|
JP2007528416A
(ja)
|
2004-03-11 |
2007-10-11 |
セラヴァンス， インコーポレーテッド |
ムスカリンレセプターアンタゴニストとしての有用なビフェニル化合物
|
|
US7501442B2
(en)
|
2004-03-11 |
2009-03-10 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
TW200538095A
(en)
|
2004-03-11 |
2005-12-01 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
WO2005087739A1
(en)
|
2004-03-11 |
2005-09-22 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
TWI341836B
(en)
|
2004-03-11 |
2011-05-11 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7262205B2
(en)
|
2004-03-11 |
2007-08-28 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
EP1723115A1
(en)
|
2004-03-11 |
2006-11-22 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
JP2007528412A
(ja)
|
2004-03-11 |
2007-10-11 |
セラヴァンス， インコーポレーテッド |
ムスカリンレセプターアンタゴニストとして有用なビフェニル化合物
|
|
GB0411056D0
(en)
|
2004-05-18 |
2004-06-23 |
Novartis Ag |
Organic compounds
|
|
ES2246170B1
(es)
*
|
2004-07-29 |
2007-04-01 |
Almirall Prodesfarma, S.A. |
Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
|
|
GT200500281A
(es)
|
2004-10-22 |
2006-04-24 |
Novartis Ag |
Compuestos organicos.
|
|
GB0424284D0
(en)
|
2004-11-02 |
2004-12-01 |
Novartis Ag |
Organic compounds
|
|
GB0426164D0
(en)
|
2004-11-29 |
2004-12-29 |
Novartis Ag |
Organic compounds
|
|
WO2006099032A1
(en)
|
2005-03-10 |
2006-09-21 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
TW200714587A
(en)
|
2005-03-10 |
2007-04-16 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
JP2008537931A
(ja)
|
2005-03-10 |
2008-10-02 |
セラヴァンス， インコーポレーテッド |
ムスカリン性レセプターアンタゴニストとして有用なビフェニル化合物
|
|
US7659403B2
(en)
|
2005-03-10 |
2010-02-09 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7642355B2
(en)
|
2005-03-10 |
2010-01-05 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
GB0507577D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
US7728144B2
(en)
|
2005-06-13 |
2010-06-01 |
Theravance, Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
ATE482959T1
(de)
|
2005-08-22 |
2010-10-15 |
Targacept Inc |
Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung
|
|
JP5006330B2
(ja)
|
2005-10-21 |
2012-08-22 |
ノバルティス アーゲー |
Ｉｌ１３に対するヒト抗体および治療的使用
|
|
EP1968980A1
(en)
*
|
2005-12-30 |
2008-09-17 |
Ranbaxy Laboratories, Ltd. |
Muscarinic receptor antagonists
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
GB0602778D0
(en)
|
2006-02-10 |
2006-03-22 |
Glaxo Group Ltd |
Novel compound
|
|
HRP20120494T1
(hr)
|
2006-04-21 |
2012-08-31 |
Novartis Ag |
Derivati purina za uporabu kao agonista adenozin a2a receptora
|
|
ES2298049B1
(es)
|
2006-07-21 |
2009-10-20 |
Laboratorios Almirall S.A. |
Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
|
|
EP1882691A1
(en)
|
2006-07-26 |
2008-01-30 |
CHIESI FARMACEUTICI S.p.A. |
Quinuclidine derivatives as M3 antagonists
|
|
KR20090073121A
(ko)
|
2006-09-29 |
2009-07-02 |
노파르티스 아게 |
Ｐｉ3ｋ 지질 키나제 억제제로서의 피라졸로피리미딘
|
|
TW200825084A
(en)
*
|
2006-11-14 |
2008-06-16 |
Astrazeneca Ab |
New compounds 521
|
|
CA2673803A1
(en)
|
2007-01-10 |
2008-07-17 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|
|
JP5293192B2
(ja)
*
|
2007-02-09 |
2013-09-18 |
アステラス製薬株式会社 |
アザ架橋環化合物
|
|
US20090010923A1
(en)
*
|
2007-04-24 |
2009-01-08 |
University Of Maryland, Baltimore |
Treatment of cancer with anti-muscarinic receptor agents
|
|
ES2361595T3
(es)
|
2007-05-07 |
2011-06-20 |
Novartis Ag |
Compuestos orgánicos.
|
|
SA08290475B1
(ar)
|
2007-08-02 |
2013-06-22 |
Targacept Inc |
(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
|
|
CN101883771A
(zh)
|
2007-10-01 |
2010-11-10 |
科门蒂斯公司 |
作为α7-烟碱乙酰胆碱受体配体用于治疗阿尔茨海默氏病的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物
|
|
EP2065385A1
(en)
*
|
2007-11-28 |
2009-06-03 |
Laboratorios SALVAT, S.A. |
Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester
|
|
KR101578235B1
(ko)
|
2007-12-10 |
2015-12-16 |
노파르티스 아게 |
유기 화합물
|
|
WO2009087224A1
(en)
|
2008-01-11 |
2009-07-16 |
Novartis Ag |
Pyrimidines as kinase inhibitors
|
|
EP2080507A1
(en)
*
|
2008-01-15 |
2009-07-22 |
CHIESI FARMACEUTICI S.p.A. |
Pharmaceutical formulations comprising an anticholinergic drug
|
|
EP2633868A1
(en)
|
2008-02-13 |
2013-09-04 |
Targacept, Inc. |
Combination of alpha 7 nicotinic agonists and antipsychotics
|
|
US20100055045A1
(en)
|
2008-02-26 |
2010-03-04 |
William Gerhart |
Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
|
|
NZ587561A
(en)
|
2008-02-26 |
2012-10-26 |
Elevation Pharmaceuticals Inc |
Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations (an muscarinic antagnoist)
|
|
EP2100599A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
EP2100598A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
US8268834B2
(en)
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
AU2009256645A1
(en)
|
2008-06-10 |
2009-12-17 |
Novartis Ag |
Pyrazine derivatives as epithelial sodium channel blockers
|
|
EP2154136A1
(en)
|
2008-08-08 |
2010-02-17 |
CHIESI FARMACEUTICI S.p.A. |
Quinuclidine carbonate derivatives and medicinal compositions thereof
|
|
WO2010045633A2
(en)
*
|
2008-10-17 |
2010-04-22 |
National Jewish Health |
Measurement and analysis of leukotrienes
|
|
EP2206712A1
(en)
*
|
2008-12-23 |
2010-07-14 |
CHIESI FARMACEUTICI S.p.A. |
"Alkaloid aminoester derivatives and medicinal composition thereof"
|
|
TW201031664A
(en)
|
2009-01-26 |
2010-09-01 |
Targacept Inc |
Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
|
|
TW201031406A
(en)
|
2009-01-29 |
2010-09-01 |
Novartis Ag |
Substituted benzimidazoles for the treatment of astrocytomas
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
EA201200260A1
(ru)
|
2009-08-12 |
2012-09-28 |
Новартис Аг |
Гетероциклические гидразоны и их применение для лечения рака и воспаления
|
|
CN102573846B
(zh)
|
2009-08-17 |
2015-10-07 |
因特利凯公司 |
杂环化合物及其用途
|
|
MX2012002179A
(es)
|
2009-08-20 |
2012-03-16 |
Novartis Ag |
Compuestos heterociclicos de oxima.
|
|
AU2010310449A1
(en)
|
2009-10-22 |
2012-05-03 |
Vertex Pharmaceuticals Incorporated |
Compositions for treatment of cystic fibrosis and other chronic diseases
|
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
|
KR20130087405A
(ko)
*
|
2010-06-22 |
2013-08-06 |
키에시 파르마슈티시 엣스. 피. 에이. |
알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
|
|
KR20130087406A
(ko)
|
2010-06-22 |
2013-08-06 |
키에시 파르마슈티시 엣스. 피. 에이. |
알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
|
|
KR20130111968A
(ko)
*
|
2010-06-22 |
2013-10-11 |
키에시 파르마슈티시 엣스. 피. 에이. |
알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
|
|
NZ604983A
(en)
|
2010-06-22 |
2014-07-25 |
Chiesi Farma Spa |
Dry powder formulation comprising an antimuscarinic drug
|
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
US8372845B2
(en)
|
2010-09-17 |
2013-02-12 |
Novartis Ag |
Pyrazine derivatives as enac blockers
|
|
EP2643295B1
(en)
*
|
2010-11-26 |
2016-04-13 |
Chiesi Farmaceutici S.p.A. |
Glycine derivatives and their use as muscarinic receptor antagonists
|
|
KR101928505B1
(ko)
*
|
2011-01-28 |
2018-12-12 |
에스케이바이오팜 주식회사 |
피리돈 유도체 및 이를 포함하는 약학적 조성물
|
|
US20130324526A1
(en)
|
2011-02-10 |
2013-12-05 |
Novartis Ag |
[1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
|
US20120220557A1
(en)
|
2011-02-17 |
2012-08-30 |
Chiesi Farmaceutici S.P.A. |
Liquid propellant-free formulation comprising an antimuscarinic drug
|
|
US9127000B2
(en)
|
2011-02-23 |
2015-09-08 |
Intellikine, LLC. |
Heterocyclic compounds and uses thereof
|
|
JP5959541B2
(ja)
|
2011-02-25 |
2016-08-02 |
ノバルティス アーゲー |
Ｔｒｋ阻害剤としてのピラゾロ［１，５−ａ］ピリジン
|
|
LT3673906T
(lt)
*
|
2011-03-18 |
2025-08-11 |
Genzyme Corporation |
Gliukozilceramido sintazės inhibitoriai
|
|
EP2510928A1
(en)
|
2011-04-15 |
2012-10-17 |
Almirall, S.A. |
Aclidinium for use in improving the quality of sleep in respiratory patients
|
|
BR112013025682A2
(pt)
*
|
2011-04-29 |
2017-01-03 |
Chiesi Farm Spa |
Compostos, composição farmacêutica, uso de um composto, combinação e dispositivo
|
|
UY34305A
(es)
|
2011-09-01 |
2013-04-30 |
Novartis Ag |
Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
|
|
EP2755976B1
(en)
|
2011-09-15 |
2018-07-18 |
Novartis AG |
6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors
|
|
EP2755967B1
(en)
|
2011-09-16 |
2015-10-21 |
Novartis AG |
Heterocyclic compounds for the treatment of cystic fibrosis
|
|
US9056867B2
(en)
|
2011-09-16 |
2015-06-16 |
Novartis Ag |
N-substituted heterocyclyl carboxamides
|
|
WO2013038373A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
WO2013038378A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
WO2013038381A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine/pyrazine amide derivatives
|
|
CA2856803A1
(en)
|
2011-11-23 |
2013-05-30 |
Intellikine, Llc |
Enhanced treatment regimens using mtor inhibitors
|
|
BR112014013179A2
(pt)
|
2011-12-30 |
2017-06-13 |
Chiesi Farm Spa |
compostos, combinação de um composto, composição farmacêutica e usos de um composto
|
|
US8809340B2
(en)
|
2012-03-19 |
2014-08-19 |
Novartis Ag |
Crystalline form
|
|
ES2894830T3
(es)
|
2012-04-03 |
2022-02-16 |
Novartis Ag |
Productos combinados con inhibidores de tirosina·cinasa y su uso
|
|
JOP20130273B1
(ar)
|
2012-09-11 |
2021-08-17 |
Genzyme Corp |
مثبطات انزيم (سينثاز) غلوكوسيل سيراميد
|
|
US9073921B2
(en)
|
2013-03-01 |
2015-07-07 |
Novartis Ag |
Salt forms of bicyclic heterocyclic derivatives
|
|
CN105246482A
(zh)
|
2013-03-15 |
2016-01-13 |
因特利凯有限责任公司 |
激酶抑制剂的组合及其用途
|
|
TW201605450A
(zh)
|
2013-12-03 |
2016-02-16 |
諾華公司 |
Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
|
|
EP3134397A1
(en)
|
2014-04-24 |
2017-03-01 |
Novartis AG |
Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
EA201692140A1
(ru)
|
2014-04-24 |
2017-04-28 |
Новартис Аг |
Производные аминопиридина в качестве ингибиторов фосфатидилинозитол 3-киназы
|
|
JP6404944B2
(ja)
|
2014-04-24 |
2018-10-17 |
ノバルティス アーゲー |
ホスファチジルイノシトール３−キナーゼ阻害薬としてのピラジン誘導体
|
|
JP2017524736A
(ja)
|
2014-07-11 |
2017-08-31 |
アルファーマゲン，エルエルシー |
アルファ７−ニコチン性アセチルコリン受容体活性を調節するためのキヌクリジン化合物
|
|
WO2016011658A1
(en)
|
2014-07-25 |
2016-01-28 |
Novartis Ag |
Combination therapy
|
|
KR20170036037A
(ko)
|
2014-07-31 |
2017-03-31 |
노파르티스 아게 |
조합 요법
|
|
US9724340B2
(en)
|
2015-07-31 |
2017-08-08 |
Attenua, Inc. |
Antitussive compositions and methods
|
|
EP3980121A1
(en)
|
2019-06-10 |
2022-04-13 |
Novartis AG |
Pyridine and pyrazine derivative for the treatment of cf, copd, and bronchiectasis
|
|
CN114341132A
(zh)
|
2019-08-28 |
2022-04-12 |
诺华股份有限公司 |
经取代的1,3-苯基杂芳基衍生物及其在治疗疾病中的用途
|
|
TW202140550A
(zh)
|
2020-01-29 |
2021-11-01 |
瑞士商諾華公司 |
使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法
|
|
IL295255A
(en)
|
2020-02-03 |
2022-10-01 |
Genzyme Corp |
Methods for treating neurological symptoms associated with lysosomal storage diseases
|
|
MX2023001014A
(es)
|
2020-07-24 |
2023-03-01 |
Genzyme Corp |
Composiciones farmaceuticas que comprenden venglustat.
|