JP2004528349A - 副腎皮質刺激ホルモン放出因子(crf)のアンタゴニストとしての縮合ピリミジン類 - Google Patents
副腎皮質刺激ホルモン放出因子(crf)のアンタゴニストとしての縮合ピリミジン類 Download PDFInfo
- Publication number
- JP2004528349A JP2004528349A JP2002585397A JP2002585397A JP2004528349A JP 2004528349 A JP2004528349 A JP 2004528349A JP 2002585397 A JP2002585397 A JP 2002585397A JP 2002585397 A JP2002585397 A JP 2002585397A JP 2004528349 A JP2004528349 A JP 2004528349A
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- Japan
- Prior art keywords
- methyl
- dihydro
- pyrrolo
- dichlorophenyl
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 *c1nc(N*)c(CCN2*)c2n1 Chemical compound *c1nc(N*)c(CCN2*)c2n1 0.000 description 5
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0110570A GB0110570D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0110569A GB0110569D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0110567A GB0110567D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0117401A GB0117401D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
| GB0117420A GB0117420D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
| GB0117399A GB0117399D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
| GB0203201A GB0203201D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
| GB0206834A GB0206834D0 (en) | 2002-03-22 | 2002-03-22 | Chemical compounds |
| PCT/GB2002/002029 WO2002088095A1 (en) | 2001-04-30 | 2002-04-30 | Fused pyrimidines as antagonists of the corticotropin releasing factor (crf) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528349A true JP2004528349A (ja) | 2004-09-16 |
| JP2004528349A5 JP2004528349A5 (https=) | 2005-12-22 |
Family
ID=27571152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002585397A Pending JP2004528349A (ja) | 2001-04-30 | 2002-04-30 | 副腎皮質刺激ホルモン放出因子(crf)のアンタゴニストとしての縮合ピリミジン類 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7279474B2 (https=) |
| EP (1) | EP1383747B1 (https=) |
| JP (1) | JP2004528349A (https=) |
| KR (1) | KR20040015206A (https=) |
| CN (1) | CN1649848A (https=) |
| AR (1) | AR033295A1 (https=) |
| AT (1) | ATE386727T1 (https=) |
| AU (1) | AU2002253357B2 (https=) |
| BR (1) | BR0209267A (https=) |
| CA (1) | CA2446514A1 (https=) |
| CZ (1) | CZ20032946A3 (https=) |
| DE (1) | DE60225127T2 (https=) |
| ES (1) | ES2301633T3 (https=) |
| HU (1) | HUP0304054A2 (https=) |
| IL (1) | IL158062A0 (https=) |
| MX (1) | MXPA03009938A (https=) |
| NO (1) | NO20034836L (https=) |
| PL (1) | PL366934A1 (https=) |
| WO (1) | WO2002088095A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013209381A (ja) * | 2006-07-06 | 2013-10-10 | Array Biopharma Inc | Aktプロテインキナーゼ阻害剤としてのシクロペンタ[d]ピリミジン |
| US8872330B2 (en) | 2006-08-04 | 2014-10-28 | Osram Opto Semiconductors Gmbh | Thin-film semiconductor component and component assembly |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462622B2 (en) * | 2001-06-12 | 2008-12-09 | Glaxo Group Limited | Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists |
| GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| DE602004005960T2 (de) * | 2003-01-16 | 2008-01-17 | Sb Pharmco Puerto Rico Inc. | Heteroaryl-substituierte pyrrolä2, 3- büpyridin-derivate als crf-rezeptor-antagonisten |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
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Also Published As
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| US20040176400A1 (en) | 2004-09-09 |
| ATE386727T1 (de) | 2008-03-15 |
| MXPA03009938A (es) | 2005-09-07 |
| PL366934A1 (en) | 2005-02-07 |
| IL158062A0 (en) | 2004-03-28 |
| CZ20032946A3 (en) | 2004-05-12 |
| ES2301633T3 (es) | 2008-07-01 |
| NO20034836D0 (no) | 2003-10-29 |
| DE60225127T2 (de) | 2009-02-19 |
| HUP0304054A2 (hu) | 2004-04-28 |
| US7279474B2 (en) | 2007-10-09 |
| CA2446514A1 (en) | 2002-11-07 |
| DE60225127D1 (en) | 2008-04-03 |
| EP1383747A1 (en) | 2004-01-28 |
| AU2002253357B2 (en) | 2006-08-24 |
| CN1649848A (zh) | 2005-08-03 |
| AR033295A1 (es) | 2003-12-10 |
| EP1383747B1 (en) | 2008-02-20 |
| WO2002088095A1 (en) | 2002-11-07 |
| BR0209267A (pt) | 2004-06-15 |
| NO20034836L (no) | 2003-10-29 |
| KR20040015206A (ko) | 2004-02-18 |
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