CN1649848A - 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 - Google Patents
作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 Download PDFInfo
- Publication number
- CN1649848A CN1649848A CNA028107462A CN02810746A CN1649848A CN 1649848 A CN1649848 A CN 1649848A CN A028107462 A CNA028107462 A CN A028107462A CN 02810746 A CN02810746 A CN 02810746A CN 1649848 A CN1649848 A CN 1649848A
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- Prior art keywords
- methyl
- dihydro
- pyrrolo
- compound
- pyrimidine
- Prior art date
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
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Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0110567A GB0110567D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0110570A GB0110570D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0110569A GB0110569D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0110569.1 | 2001-04-30 | ||
| GB0110570.9 | 2001-04-30 | ||
| GB0110567.5 | 2001-04-30 | ||
| GB0117420.0 | 2001-07-17 | ||
| GB0117401.0 | 2001-07-17 | ||
| GB0117399A GB0117399D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
| GB0117401A GB0117401D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
| GB0117399.6 | 2001-07-17 | ||
| GB0117420A GB0117420D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
| GB0203201.9 | 2002-02-11 | ||
| GB0203201A GB0203201D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
| GB0206834A GB0206834D0 (en) | 2002-03-22 | 2002-03-22 | Chemical compounds |
| GB0206834.4 | 2002-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1649848A true CN1649848A (zh) | 2005-08-03 |
Family
ID=27571152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA028107462A Pending CN1649848A (zh) | 2001-04-30 | 2002-04-30 | 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7279474B2 (https=) |
| EP (1) | EP1383747B1 (https=) |
| JP (1) | JP2004528349A (https=) |
| KR (1) | KR20040015206A (https=) |
| CN (1) | CN1649848A (https=) |
| AR (1) | AR033295A1 (https=) |
| AT (1) | ATE386727T1 (https=) |
| AU (1) | AU2002253357B2 (https=) |
| BR (1) | BR0209267A (https=) |
| CA (1) | CA2446514A1 (https=) |
| CZ (1) | CZ20032946A3 (https=) |
| DE (1) | DE60225127T2 (https=) |
| ES (1) | ES2301633T3 (https=) |
| HU (1) | HUP0304054A2 (https=) |
| IL (1) | IL158062A0 (https=) |
| MX (1) | MXPA03009938A (https=) |
| NO (1) | NO20034836L (https=) |
| PL (1) | PL366934A1 (https=) |
| WO (1) | WO2002088095A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104193745A (zh) * | 2014-07-30 | 2014-12-10 | 天津市斯芬克司药物研发有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462622B2 (en) * | 2001-06-12 | 2008-12-09 | Glaxo Group Limited | Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists |
| GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| DE602004005960T2 (de) * | 2003-01-16 | 2008-01-17 | Sb Pharmco Puerto Rico Inc. | Heteroaryl-substituierte pyrrolä2, 3- büpyridin-derivate als crf-rezeptor-antagonisten |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| EP1622910A1 (en) | 2003-05-05 | 2006-02-08 | F. Hoffmann-La Roche Ag | Fused pyrimidine derivatives with crf activity |
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- 2002-04-30 EP EP02722478A patent/EP1383747B1/en not_active Expired - Lifetime
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- 2002-04-30 CN CNA028107462A patent/CN1649848A/zh active Pending
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- 2002-04-30 AU AU2002253357A patent/AU2002253357B2/en not_active Ceased
- 2002-04-30 WO PCT/GB2002/002029 patent/WO2002088095A1/en not_active Ceased
- 2002-04-30 JP JP2002585397A patent/JP2004528349A/ja active Pending
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104193745A (zh) * | 2014-07-30 | 2014-12-10 | 天津市斯芬克司药物研发有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
| CN104193745B (zh) * | 2014-07-30 | 2016-09-28 | 斯芬克司药物研发(天津)股份有限公司 | 一种咪唑并嘧啶羧酸类化合物及其制备方法 |
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| US20040176400A1 (en) | 2004-09-09 |
| JP2004528349A (ja) | 2004-09-16 |
| ATE386727T1 (de) | 2008-03-15 |
| MXPA03009938A (es) | 2005-09-07 |
| PL366934A1 (en) | 2005-02-07 |
| IL158062A0 (en) | 2004-03-28 |
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| HUP0304054A2 (hu) | 2004-04-28 |
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| DE60225127D1 (en) | 2008-04-03 |
| EP1383747A1 (en) | 2004-01-28 |
| AU2002253357B2 (en) | 2006-08-24 |
| AR033295A1 (es) | 2003-12-10 |
| EP1383747B1 (en) | 2008-02-20 |
| WO2002088095A1 (en) | 2002-11-07 |
| BR0209267A (pt) | 2004-06-15 |
| NO20034836L (no) | 2003-10-29 |
| KR20040015206A (ko) | 2004-02-18 |
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