JP2004525899A5 - - Google Patents
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- Publication number
- JP2004525899A5 JP2004525899A5 JP2002565579A JP2002565579A JP2004525899A5 JP 2004525899 A5 JP2004525899 A5 JP 2004525899A5 JP 2002565579 A JP2002565579 A JP 2002565579A JP 2002565579 A JP2002565579 A JP 2002565579A JP 2004525899 A5 JP2004525899 A5 JP 2004525899A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitors
- compound
- compounds
- rapamycin
- coagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 6
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- 229940123413 Angiotensin II antagonist Drugs 0.000 claims 1
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 1
- 229940122361 Bisphosphonate Drugs 0.000 claims 1
- 102400000967 Bradykinin Human genes 0.000 claims 1
- 101800004538 Bradykinin Proteins 0.000 claims 1
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 claims 1
- 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 claims 1
- 102400000932 Gonadoliberin-1 Human genes 0.000 claims 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 1
- 102100024025 Heparanase Human genes 0.000 claims 1
- 101500026183 Homo sapiens Gonadoliberin-1 Proteins 0.000 claims 1
- 101710181812 Methionine aminopeptidase Proteins 0.000 claims 1
- 102000029749 Microtubule Human genes 0.000 claims 1
- 108091022875 Microtubule Proteins 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 claims 1
- 239000000317 Topoisomerase II Inhibitor Substances 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 1
- 230000002280 anti-androgenic effect Effects 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 230000009949 anti-apoptotic pathway Effects 0.000 claims 1
- 229940046836 anti-estrogen Drugs 0.000 claims 1
- 230000001833 anti-estrogenic effect Effects 0.000 claims 1
- 239000000051 antiandrogen Substances 0.000 claims 1
- 239000002814 antineoplastic antimetabolite Substances 0.000 claims 1
- 229940045985 antineoplastic platinum compound Drugs 0.000 claims 1
- 239000003886 aromatase inhibitor Substances 0.000 claims 1
- 150000004663 bisphosphonates Chemical class 0.000 claims 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 1
- 230000009400 cancer invasion Effects 0.000 claims 1
- 230000000711 cancerogenic effect Effects 0.000 claims 1
- 231100000315 carcinogenic Toxicity 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 230000002074 deregulated effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 239000000328 estrogen antagonist Substances 0.000 claims 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 claims 1
- 229960001442 gonadorelin Drugs 0.000 claims 1
- 239000002474 gonadorelin antagonist Substances 0.000 claims 1
- 108010037536 heparanase Proteins 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 239000000367 immunologic factor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 claims 1
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000004688 microtubule Anatomy 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 150000003058 platinum compounds Chemical class 0.000 claims 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000003277 telomerase inhibitor Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 230000034512 ubiquitination Effects 0.000 claims 1
- 238000010798 ubiquitination Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0104072A GB0104072D0 (en) | 2001-02-19 | 2001-02-19 | Organic compounds |
| GB0124957A GB0124957D0 (en) | 2001-10-17 | 2001-10-17 | Organic compounds |
| PCT/EP2002/001714 WO2002066019A2 (en) | 2001-02-19 | 2002-02-18 | Cancer treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007204409A Division JP2007284454A (ja) | 2001-02-19 | 2007-08-06 | 癌の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525899A JP2004525899A (ja) | 2004-08-26 |
| JP2004525899A5 true JP2004525899A5 (enExample) | 2005-06-09 |
Family
ID=26245731
Family Applications (14)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002565579A Pending JP2004525899A (ja) | 2001-02-19 | 2002-02-18 | 癌の処置 |
| JP2007204409A Pending JP2007284454A (ja) | 2001-02-19 | 2007-08-06 | 癌の処置 |
| JP2012101519A Expired - Lifetime JP5775022B2 (ja) | 2001-02-19 | 2012-04-26 | 癌の処置 |
| JP2014095034A Expired - Lifetime JP5873128B2 (ja) | 2001-02-19 | 2014-05-02 | 癌の処置 |
| JP2014114297A Expired - Lifetime JP5879391B2 (ja) | 2001-02-19 | 2014-06-02 | 癌の処置 |
| JP2014114296A Withdrawn JP2014208657A (ja) | 2001-02-19 | 2014-06-02 | 癌の処置 |
| JP2015079430A Expired - Lifetime JP6333766B2 (ja) | 2001-02-19 | 2015-04-08 | 癌の処置 |
| JP2016149701A Expired - Lifetime JP6310970B2 (ja) | 2001-02-19 | 2016-07-29 | 癌の処置 |
| JP2017001065A Expired - Lifetime JP6383814B2 (ja) | 2001-02-19 | 2017-01-06 | 癌の処置 |
| JP2018021353A Expired - Lifetime JP6349475B2 (ja) | 2001-02-19 | 2018-02-08 | 癌の処置 |
| JP2018021352A Expired - Lifetime JP6349474B2 (ja) | 2001-02-19 | 2018-02-08 | 癌の処置 |
| JP2018021354A Expired - Lifetime JP6349476B2 (ja) | 2001-02-19 | 2018-02-08 | 癌の処置 |
| JP2018129096A Withdrawn JP2018168188A (ja) | 2001-02-19 | 2018-07-06 | 癌の処置 |
| JP2020091227A Expired - Lifetime JP6904640B2 (ja) | 2001-02-19 | 2020-05-26 | 癌の処置 |
Family Applications After (13)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007204409A Pending JP2007284454A (ja) | 2001-02-19 | 2007-08-06 | 癌の処置 |
| JP2012101519A Expired - Lifetime JP5775022B2 (ja) | 2001-02-19 | 2012-04-26 | 癌の処置 |
| JP2014095034A Expired - Lifetime JP5873128B2 (ja) | 2001-02-19 | 2014-05-02 | 癌の処置 |
| JP2014114297A Expired - Lifetime JP5879391B2 (ja) | 2001-02-19 | 2014-06-02 | 癌の処置 |
| JP2014114296A Withdrawn JP2014208657A (ja) | 2001-02-19 | 2014-06-02 | 癌の処置 |
| JP2015079430A Expired - Lifetime JP6333766B2 (ja) | 2001-02-19 | 2015-04-08 | 癌の処置 |
| JP2016149701A Expired - Lifetime JP6310970B2 (ja) | 2001-02-19 | 2016-07-29 | 癌の処置 |
| JP2017001065A Expired - Lifetime JP6383814B2 (ja) | 2001-02-19 | 2017-01-06 | 癌の処置 |
| JP2018021353A Expired - Lifetime JP6349475B2 (ja) | 2001-02-19 | 2018-02-08 | 癌の処置 |
| JP2018021352A Expired - Lifetime JP6349474B2 (ja) | 2001-02-19 | 2018-02-08 | 癌の処置 |
| JP2018021354A Expired - Lifetime JP6349476B2 (ja) | 2001-02-19 | 2018-02-08 | 癌の処置 |
| JP2018129096A Withdrawn JP2018168188A (ja) | 2001-02-19 | 2018-07-06 | 癌の処置 |
| JP2020091227A Expired - Lifetime JP6904640B2 (ja) | 2001-02-19 | 2020-05-26 | 癌の処置 |
Country Status (27)
| Country | Link |
|---|---|
| US (10) | US8410131B2 (enExample) |
| EP (11) | EP3143995B2 (enExample) |
| JP (14) | JP2004525899A (enExample) |
| KR (3) | KR20070102762A (enExample) |
| CN (5) | CN104083365A (enExample) |
| AU (1) | AU2002250968C1 (enExample) |
| BR (1) | BR0207378A (enExample) |
| CA (3) | CA2438504C (enExample) |
| CY (11) | CY1116616T1 (enExample) |
| CZ (5) | CZ303611B6 (enExample) |
| DK (6) | DK2269604T3 (enExample) |
| ES (8) | ES2744377T3 (enExample) |
| HK (2) | HK1250336B (enExample) |
| HU (1) | HUP0303271A3 (enExample) |
| IL (13) | IL157425A0 (enExample) |
| LT (9) | LT2269604T (enExample) |
| LU (3) | LU92880I2 (enExample) |
| MX (3) | MX368013B (enExample) |
| NO (14) | NO333105B1 (enExample) |
| NZ (1) | NZ527692A (enExample) |
| PL (5) | PL409579A1 (enExample) |
| PT (7) | PT2269604T (enExample) |
| RU (8) | RU2322981C2 (enExample) |
| SI (6) | SI3351246T1 (enExample) |
| SK (5) | SK288546B6 (enExample) |
| TW (2) | TWI334350B (enExample) |
| WO (1) | WO2002066019A2 (enExample) |
Families Citing this family (72)
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|---|---|---|---|---|
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| CA2359244C (en) | 1999-01-13 | 2013-10-08 | Bayer Corporation | .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| SI3351246T1 (sl) * | 2001-02-19 | 2019-08-30 | Novartis Pharma Ag | Derivat rapamicina za zdravljenje trdnega tumorja, povezanega z deregulirano angiogenezo |
| HUP0400006A2 (hu) * | 2001-06-01 | 2004-04-28 | Wyeth | Antineopláziás kombinációs készítmények |
| EP2324825A1 (en) | 2002-02-11 | 2011-05-25 | Bayer Healthcare LLC | Aryl ureas with angiogenesis inhibiting activity |
| US8383605B2 (en) | 2002-07-30 | 2013-02-26 | Aeterna Zentaris Gmbh | Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals |
| DK1545553T3 (da) * | 2002-07-30 | 2011-09-12 | Aeterna Zentaris Gmbh | Anvendelse af alkylphosphocholiner i kombination med antitumormedikamenter |
| US7846141B2 (en) | 2002-09-03 | 2010-12-07 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
| AU2003264822A1 (en) * | 2002-10-11 | 2004-05-04 | Dana-Farber Cancer Institute Inc | Epothilone derivatives for the treatment of multiple myeloma |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| ES2288694T3 (es) | 2003-05-20 | 2008-01-16 | Bayer Pharmaceuticals Corporation | Diaril ureas para enfermedades mediadas por el receptor del factor de crecimiento derivado de plaquetas. |
| UA84156C2 (ru) | 2003-07-23 | 2008-09-25 | Байер Фармасьютикалс Корпорейшн | Фторозамещённая омега-карбоксиарилдифенилмочевина для лечения и профилактики болезней и состояний |
| AU2004274026A1 (en) | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
| RU2385944C2 (ru) * | 2004-02-23 | 2010-04-10 | Новартис Аг | Биомаркер |
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| JP2008530127A (ja) | 2005-02-09 | 2008-08-07 | マクサイト， インコーポレイテッド | 眼の処置のための処方物 |
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| AU2006315512B2 (en) | 2005-11-14 | 2012-11-01 | Ariad Pharmaceuticals, Inc. | Administration of an mTOR inhibitor to treat patients with cancer |
| PL2275103T3 (pl) * | 2005-11-21 | 2014-09-30 | Novartis Ag | Inhibitory mTOR w leczeniu nowotworów neuroendokrynnych |
| US20100305150A1 (en) | 2006-02-02 | 2010-12-02 | Novartis Ag | Tuberous sclerosis treatment |
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| AU2007230964B2 (en) | 2006-03-23 | 2012-07-19 | Santen Pharmaceutical Co., Ltd. | Formulations and methods for vascular permeability-related diseases or conditions |
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| CA2661024A1 (en) * | 2006-08-28 | 2008-03-06 | The Regents Of The University Of California | Small molecule potentiator of hormonal therapy for breast cancer |
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| PT2481409T (pt) * | 2007-03-07 | 2018-10-18 | Abraxis Bioscience Llc | Nanopartícula que compreende rapamicina e albumina como agente anticancerígeno |
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| RU2015143729A (ru) | 2013-03-15 | 2017-04-21 | СМИТ ЭНД НЕФЬЮ ПиЭлСи | Раневая повязка и способ лечения |
| US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
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| EP3548894B1 (en) | 2016-12-02 | 2021-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for diagnosing renal cell carcinoma |
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