|
ATE381542T1
(de)
*
|
2001-08-13 |
2008-01-15 |
Phenex Pharmaceuticals Ag |
Nr1h4-kern-rezeptor-bindende verbindungen
|
|
US6953787B2
(en)
|
2002-04-12 |
2005-10-11 |
Arena Pharmaceuticals, Inc. |
5HT2C receptor modulators
|
|
CN100484933C
(zh)
|
2002-06-19 |
2009-05-06 |
比奥维特罗姆股份公开公司 |
新的吡嗪化合物及其在制备用于治疗与5-羟色胺相关的疾病的药物中的用途
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
TW200504033A
(en)
*
|
2002-10-23 |
2005-02-01 |
Procter & Gamble |
Melanocortin receptor ligands
|
|
KR100547109B1
(ko)
*
|
2002-11-14 |
2006-01-26 |
삼성전자주식회사 |
자외선 흡수 치환기를 포함한 기능성 첨가제 및 이를포함하는잉크 조성물
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
CL2004000826A1
(es)
|
2003-04-25 |
2005-03-04 |
Pfizer |
Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
|
|
CN1805938B
(zh)
|
2003-06-17 |
2010-06-16 |
艾尼纳制药公司 |
用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
|
|
HUE028976T2
(en)
|
2003-06-17 |
2017-02-28 |
Arena Pharm Inc |
8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
|
|
EP1644347A1
(en)
*
|
2003-06-20 |
2006-04-12 |
Arena Pharmaceuticals, Inc. |
N-PHENYL-PIPERAZINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT sb 2C /sb RECEPTOR ASSOCIATED DISEASES
|
|
AU2004274309B2
(en)
|
2003-09-22 |
2010-04-08 |
Msd K.K. |
Novel piperidine derivative
|
|
US20080125403A1
(en)
|
2004-04-02 |
2008-05-29 |
Merck & Co., Inc. |
Method of Treating Men with Metabolic and Anthropometric Disorders
|
|
EP1586560A1
(en)
*
|
2004-04-13 |
2005-10-19 |
Cephalon, Inc. |
Thio-substituted arylmethanesulfinyl derivatives
|
|
US7297817B2
(en)
*
|
2004-04-13 |
2007-11-20 |
Cephalon France |
Thio-substituted arylmethanesulfinyl derivatives
|
|
EP2248524A3
(en)
|
2004-08-25 |
2011-03-09 |
Takeda Pharmaceutical Company Limited |
Preventives/remedies for stress urinary incontinence and method of screening the same
|
|
EP2286840A3
(en)
|
2004-11-01 |
2013-09-04 |
Amylin Pharmaceuticals, LLC |
Treatment of obesity and related diseases
|
|
GT200500317A
(es)
*
|
2004-11-05 |
2006-10-27 |
|
Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
|
|
WO2006062110A1
(ja)
*
|
2004-12-06 |
2006-06-15 |
Banyu Pharmaceutical Co., Ltd. |
ピペラジン誘導体
|
|
CA2594987A1
(en)
*
|
2004-12-14 |
2006-06-22 |
Shionogi & Co., Ltd. |
Therapeutic agent for constipation
|
|
SI1838677T1
(sl)
|
2004-12-21 |
2010-01-29 |
Arena Pharm Inc |
Kristalne oblike (R)-8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepin hidroklorida
|
|
US7737155B2
(en)
|
2005-05-17 |
2010-06-15 |
Schering Corporation |
Nitrogen-containing heterocyclic compounds and methods of use thereof
|
|
CA2609388C
(en)
|
2005-05-30 |
2013-08-06 |
Banyu Pharmaceutical Co., Ltd. |
Novel piperidine derivative
|
|
AR054849A1
(es)
*
|
2005-07-26 |
2007-07-18 |
Wyeth Corp |
Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
|
|
JPWO2007018248A1
(ja)
|
2005-08-10 |
2009-02-19 |
萬有製薬株式会社 |
ピリドン化合物
|
|
BRPI0614649A2
(pt)
|
2005-08-11 |
2011-04-12 |
Amylin Pharmaceuticals Inc |
polipeptìdeos hìbridos com propriedades selecionáveis
|
|
EP2330124B1
(en)
|
2005-08-11 |
2015-02-25 |
Amylin Pharmaceuticals, LLC |
Hybrid polypeptides with selectable properties
|
|
EP1921065B1
(en)
|
2005-08-24 |
2010-10-20 |
Banyu Pharmaceutical Co., Ltd. |
Phenylpyridone derivative
|
|
WO2007029847A1
(ja)
|
2005-09-07 |
2007-03-15 |
Banyu Pharmaceutical Co., Ltd. |
二環性芳香族置換ピリドン誘導体
|
|
BRPI0616463A2
(pt)
|
2005-09-29 |
2011-06-21 |
Merck & Co Inc |
composto, composição farmacêutica, e, uso de um composto
|
|
WO2007048027A2
(en)
|
2005-10-21 |
2007-04-26 |
Novartis Ag |
Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
|
|
AU2006307046A1
(en)
|
2005-10-27 |
2007-05-03 |
Msd K.K. |
Novel benzoxathiin derivative
|
|
US8158791B2
(en)
|
2005-11-10 |
2012-04-17 |
Msd K.K. |
Aza-substituted spiro derivatives
|
|
TW200734334A
(en)
*
|
2006-01-13 |
2007-09-16 |
Wyeth Corp |
Treatment of substance abuse
|
|
KR20080105104A
(ko)
*
|
2006-03-24 |
2008-12-03 |
와이어쓰 |
우울증 치료를 위한 신규한 치료학적 병용제
|
|
EP2471779A1
(en)
|
2006-04-03 |
2012-07-04 |
Arena Pharmaceuticals, Inc. |
Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
|
|
EP2742936A1
(en)
|
2006-05-16 |
2014-06-18 |
Takeda Pharmaceutical Company Limited |
Fused heterocyclic compound and use thereof
|
|
JP5489333B2
(ja)
|
2006-09-22 |
2014-05-14 |
メルク・シャープ・アンド・ドーム・コーポレーション |
脂肪酸合成阻害剤を用いた治療の方法
|
|
AU2007301126A1
(en)
|
2006-09-28 |
2008-04-03 |
Banyu Pharmaceutical Co., Ltd. |
Diaryl ketimine derivative
|
|
US8299241B2
(en)
|
2006-12-05 |
2012-10-30 |
Arena Pharmaceuticals, Inc. |
Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
|
|
CA2675638C
(en)
|
2007-01-16 |
2015-11-24 |
Ipintl, Llc |
Composition comprising serotonin for treating metabolic syndrome
|
|
CA2682727C
(en)
|
2007-04-02 |
2016-03-22 |
Banyu Pharmaceutical Co., Ltd. |
Indoledione derivative
|
|
ES2379848T3
(es)
|
2007-05-14 |
2012-05-04 |
Sk Biopharmaceuticals Co., Ltd. |
Compuesto arilpiperazina arilalcanoil carbomoiloxi novedoso, composiciones farmacéuticas que comprenden el compuesto y método para tratar el dolor, ansiedad y depresión al administrar el compuesto
|
|
EP2527360B1
(en)
|
2007-06-04 |
2015-10-28 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
CL2008002777A1
(es)
*
|
2007-09-21 |
2010-01-22 |
Wyeth Corp |
Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
|
|
EP2789338A3
(en)
|
2007-11-15 |
2015-01-14 |
Takeda Pharmaceutical Company Limited |
Condensed pyridine derivate and use thereof
|
|
CN102015668A
(zh)
|
2007-12-05 |
2011-04-13 |
阿斯利康(瑞典)有限公司 |
用作瘦蛋白受体调节剂的哌嗪衍生物及其用途
|
|
CN102015591B
(zh)
|
2008-03-04 |
2014-01-29 |
艾尼纳制药公司 |
制备与5-ht2c激动剂(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
|
|
US20110015181A1
(en)
|
2008-03-06 |
2011-01-20 |
Makoto Ando |
Alkylaminopyridine derivative
|
|
EP2272841A1
(en)
|
2008-03-28 |
2011-01-12 |
Banyu Pharmaceutical Co., Ltd. |
Diarylmethylamide derivative having antagonistic activity on melanin-concentrating hormone receptor
|
|
CA2666036C
(en)
|
2008-05-16 |
2017-09-12 |
Chien-Hung Chen |
Novel compositions and methods for treating hyperproliferative diseases
|
|
JP2011522006A
(ja)
*
|
2008-06-04 |
2011-07-28 |
アストラゼネカ アクチボラグ |
新規化合物v
|
|
EP2810951B1
(en)
|
2008-06-04 |
2017-03-15 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
AU2009261248A1
(en)
|
2008-06-19 |
2009-12-23 |
Banyu Pharmaceutical Co., Ltd. |
Spirodiamine-diarylketoxime derivative
|
|
EP3241839B1
(en)
|
2008-07-16 |
2019-09-04 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
|
WO2010013595A1
(ja)
|
2008-07-30 |
2010-02-04 |
萬有製薬株式会社 |
5員-5員又は5員-6員縮環シクロアルキルアミン誘導体
|
|
WO2010047982A1
(en)
|
2008-10-22 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
JP5635991B2
(ja)
|
2008-10-30 |
2014-12-03 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
イソニコチンアミドオレキシン受容体アンタゴニスト
|
|
JP5557845B2
(ja)
|
2008-10-31 |
2014-07-23 |
メルク・シャープ・アンド・ドーム・コーポレーション |
糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
|
|
WO2010075069A1
(en)
|
2008-12-16 |
2010-07-01 |
Schering Corporation |
Bicyclic pyranone derivatives as nicotinic acid receptor agonists
|
|
US20110245209A1
(en)
|
2008-12-16 |
2011-10-06 |
Schering Corporation |
Pyridopyrimidine derivatives and methods of use thereof
|
|
US8952197B2
(en)
|
2009-06-18 |
2015-02-10 |
Arena Pharmaceuticals, Inc. |
Processes for the preparation of 5-HT2C receptor agonists
|
|
JPWO2011071136A1
(ja)
|
2009-12-11 |
2013-04-22 |
アステラス製薬株式会社 |
線維筋痛症治療剤
|
|
US8895596B2
(en)
|
2010-02-25 |
2014-11-25 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
KR20130112848A
(ko)
|
2010-06-02 |
2013-10-14 |
아레나 파마슈티칼스, 인크. |
5-ht2c 수용체 아고니스트의 제조 방법
|
|
KR20140091458A
(ko)
|
2010-09-01 |
2014-07-21 |
아레나 파마슈티칼스, 인크. |
신장 손상을 갖는 개체에 대한 로카세린의 투여
|
|
KR20130138770A
(ko)
|
2010-09-01 |
2013-12-19 |
아레나 파마슈티칼스, 인크. |
광학적으로 활성 산을 갖는 로르카세린의 염
|
|
EP3485878A1
(en)
|
2010-09-01 |
2019-05-22 |
Arena Pharmaceuticals, Inc. |
Modified-release dosage forms of 5-ht2c agonists useful for weight management
|
|
JP2013536859A
(ja)
|
2010-09-01 |
2013-09-26 |
アリーナ ファーマシューティカルズ, インコーポレイテッド |
5−ht2cアゴニストの非吸湿性塩
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
RU2013114767A
(ru)
*
|
2010-09-29 |
2014-11-10 |
СК Биофармасьютикалз Ко., Лтд. |
Новые производные метилциклогексана и его применение
|
|
BR112013021236B1
(pt)
|
2011-02-25 |
2021-05-25 |
Merck Sharp & Dohme Corp |
composto derivado de benzimidazol, e, composição
|
|
ES2664873T3
(es)
|
2011-03-01 |
2018-04-23 |
Synergy Pharmaceuticals Inc. |
Proceso de preparación de agonistas de guanilato ciclasa C
|
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
|
US9527875B2
(en)
|
2012-08-02 |
2016-12-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
WO2014058441A1
(en)
|
2012-10-09 |
2014-04-17 |
Arena Pharmaceuticals, Inc. |
Method of weight management
|
|
WO2014139388A1
(en)
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
CA2905435A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Compositions useful for the treatment of gastrointestinal disorders
|
|
CA2905438A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
|
CN103265498A
(zh)
*
|
2013-05-14 |
2013-08-28 |
广州科瑞生物技术有限公司 |
反式2,6-二甲基哌嗪的新工艺
|
|
SI3004138T1
(sl)
|
2013-06-05 |
2024-07-31 |
Bausch Health Ireland Limited |
Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
|
|
WO2015066344A1
(en)
|
2013-11-01 |
2015-05-07 |
Arena Pharmaceuticals, Inc. |
5-ht2c receptor agonists and compositions and methods of use
|
|
KR102431436B1
(ko)
|
2014-08-29 |
2022-08-10 |
테스 파마 에스.알.엘. |
α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
|
|
AR109950A1
(es)
|
2016-10-14 |
2019-02-06 |
Tes Pharma S R L |
INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
|
|
EP3733204A4
(en)
|
2017-12-27 |
2021-09-15 |
Takeda Pharmaceutical Company Limited |
THERAPEUTIC AGENT FOR URINARY INCONTINENCE OF STRESS AND FECAL INCONTINENCE
|
|
AR117122A1
(es)
|
2018-11-20 |
2021-07-14 |
Tes Pharma S R L |
INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
|
|
WO2020167701A1
(en)
|
2019-02-13 |
2020-08-20 |
Merck Sharp & Dohme Corp. |
Pyrrolidine orexin receptor agonists
|
|
US11098029B2
(en)
|
2019-02-13 |
2021-08-24 |
Merck Sharp & Dohme Corp. |
5-alkyl pyrrolidine orexin receptor agonists
|
|
US12312332B2
(en)
|
2019-08-08 |
2025-05-27 |
Merck Sharp & Dohme Llc |
Heteroaryl pyrrolidine and piperidine orexin receptor agonists
|
|
CN111646949B
(zh)
*
|
2020-06-12 |
2021-03-30 |
上海馨远医药科技有限公司 |
一种2,6-二甲基哌嗪二盐酸盐的制备方法
|
|
BR112023002957A2
(pt)
|
2020-08-18 |
2023-04-04 |
Merck Sharp & Dohme Llc |
Composto, composição farmacêutica, e, métodos para tratar narcolepsia e para tratar hipersonia em um sujeito mamífero
|