JP2004515245A5 - - Google Patents
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- Publication number
- JP2004515245A5 JP2004515245A5 JP2002549720A JP2002549720A JP2004515245A5 JP 2004515245 A5 JP2004515245 A5 JP 2004515245A5 JP 2002549720 A JP2002549720 A JP 2002549720A JP 2002549720 A JP2002549720 A JP 2002549720A JP 2004515245 A5 JP2004515245 A5 JP 2004515245A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tag
- loop
- dna
- coli
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 4
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001872 | 2000-12-13 | ||
| US27209801P | 2001-02-28 | 2001-02-28 | |
| PCT/DK2001/000825 WO2002048189A2 (en) | 2000-12-13 | 2001-12-13 | Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004515245A JP2004515245A (ja) | 2004-05-27 |
| JP2004515245A5 true JP2004515245A5 (enExample) | 2010-04-08 |
| JP4493271B2 JP4493271B2 (ja) | 2010-06-30 |
Family
ID=26068925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002549720A Expired - Fee Related JP4493271B2 (ja) | 2000-12-13 | 2001-12-13 | Ｃ型レクチン様ドメインの骨格構造を有する蛋白質のコンビナトリアルライブラリ |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8017559B2 (enExample) |
| EP (2) | EP2105503B1 (enExample) |
| JP (1) | JP4493271B2 (enExample) |
| KR (1) | KR100865602B1 (enExample) |
| CN (1) | CN100580084C (enExample) |
| AT (1) | ATE431851T1 (enExample) |
| AU (2) | AU2002221568B2 (enExample) |
| BR (1) | BR0116138A (enExample) |
| CA (1) | CA2430953A1 (enExample) |
| DE (1) | DE60138764D1 (enExample) |
| DK (1) | DK1341912T3 (enExample) |
| NO (1) | NO20032663L (enExample) |
| NZ (1) | NZ526312A (enExample) |
| WO (1) | WO2002048189A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2430953A1 (en) | 2000-12-13 | 2002-06-20 | Borean Pharma A/S | Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains |
| WO2004005335A2 (en) * | 2002-07-05 | 2004-01-15 | Borean Pharma A/S | Multimerised growth hormone fusion proteins |
| AU2003254952A1 (en) | 2002-08-20 | 2004-03-11 | Summit Glycoresearch Corporation | Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells |
| WO2004039841A2 (en) | 2002-10-29 | 2004-05-13 | Borean Pharma A/S | Trimeric binding proteins for trimeric cytokines |
| DK1680507T3 (da) * | 2003-11-06 | 2011-10-10 | Danisco Us Inc | Bakterieekspression af proteaseinhibitorer og varianter deraf |
| US20100028995A1 (en) * | 2004-02-23 | 2010-02-04 | Anaphore, Inc. | Tetranectin Trimerizing Polypeptides |
| EP1824878A1 (en) * | 2004-11-22 | 2007-08-29 | Borean Pharma A/S | Tnf antagonists |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| EP2195333A1 (en) * | 2007-09-12 | 2010-06-16 | Anaphore, Inc. | Hsp70-based treatment for autoimmune diseases |
| US20110027267A1 (en) * | 2007-11-09 | 2011-02-03 | Anaphore, Inc. | Fusion Proteins of Mannose Binding Lectins for Treatment of Disease |
| AR071874A1 (es) | 2008-05-22 | 2010-07-21 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
| AU2009296246B2 (en) | 2008-09-26 | 2015-07-30 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| US20130295106A1 (en) * | 2008-09-26 | 2013-11-07 | Oncomed Pharmaceuticals, Inc. | Frizzled-Binding Agents And Uses Thereof |
| AU2009303304A1 (en) | 2008-10-10 | 2010-04-15 | Anaphore, Inc. | Polypeptides that bind TRAIL-RI and TRAIL-R2 |
| US20110086806A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that Bind IL-23R |
| CA2776954A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Combinatorial libraries based on c-type lectin domain |
| WO2011043835A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that bind il-23r |
| WO2011074941A1 (en) * | 2009-12-15 | 2011-06-23 | Universiti Malaya | A method of high throughput screening of inhibitors that inhibit interaction of an attachment protein to cell receptors using recombinant phage display |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| JP2013530929A (ja) | 2010-04-01 | 2013-08-01 | オンコメッド ファーマシューティカルズ インコーポレイテッド | ｆｒｉｚｚｌｅｄ結合剤およびその使用 |
| KR101294982B1 (ko) * | 2011-12-09 | 2013-08-08 | 경북대학교 산학협력단 | 단백질 골격모듈을 포함하는 융합 폴리펩타이드 및 이를 이용한 목적 단백질에 특이적인 펩타이드 라이브러리 스크리닝 방법 |
| KR102101210B1 (ko) * | 2012-03-02 | 2020-04-16 | 고쿠리츠켄큐카이하츠호진 카가쿠기쥬츠신코키코 | 기능성 핵산 분자의 구축법, 및 상기 방법에 사용하는 핵산 조합물 |
| US9266959B2 (en) | 2012-10-23 | 2016-02-23 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using frizzled-binding agents |
| CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| WO2014139182A1 (en) | 2013-03-15 | 2014-09-18 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
| GB201311031D0 (en) * | 2013-06-20 | 2013-08-07 | Queen Mary & Westfield College | Method |
| ES2969960T3 (es) | 2014-10-01 | 2024-05-23 | Medimmune Llc | Método para conjugar un polipéptido |
| AR111963A1 (es) | 2017-05-26 | 2019-09-04 | Univ California | Método y moléculas |
| CN113372428B (zh) * | 2021-05-21 | 2022-07-08 | 广东食品药品职业学院 | 文昌鱼C型凝集素BjCTL4基因及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE194168T1 (de) | 1992-04-30 | 2000-07-15 | Genentech Inc | Varianten in den leltin domäne von selektin |
| US5679548A (en) * | 1993-02-02 | 1997-10-21 | The Scripps Research Institute | Methods for producing polypeptide metal binding sites and compositions thereof |
| KR100310739B1 (ko) | 1993-02-04 | 2002-05-30 | 알란 스코브 | 단백질재생을위한개선된방법 |
| US6025485A (en) * | 1997-02-14 | 2000-02-15 | Arcaris, Inc. | Methods and compositions for peptide libraries displayed on light-emitting scaffolds |
| AU736707B2 (en) | 1997-06-11 | 2001-08-02 | Anaphore, Inc. | Trimerising module |
| EP0947582A1 (en) * | 1998-03-31 | 1999-10-06 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| US6180343B1 (en) * | 1998-10-08 | 2001-01-30 | Rigel Pharmaceuticals, Inc. | Green fluorescent protein fusions with random peptides |
| CA2430953A1 (en) | 2000-12-13 | 2002-06-20 | Borean Pharma A/S | Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains |
-
2001
- 2001-12-13 CA CA002430953A patent/CA2430953A1/en not_active Abandoned
- 2001-12-13 NZ NZ526312A patent/NZ526312A/en not_active IP Right Cessation
- 2001-12-13 EP EP09160663A patent/EP2105503B1/en not_active Expired - Lifetime
- 2001-12-13 KR KR1020037007858A patent/KR100865602B1/ko not_active Expired - Fee Related
- 2001-12-13 DK DK01270552T patent/DK1341912T3/da active
- 2001-12-13 AU AU2002221568A patent/AU2002221568B2/en not_active Ceased
- 2001-12-13 DE DE60138764T patent/DE60138764D1/de not_active Expired - Lifetime
- 2001-12-13 CN CN01821632A patent/CN100580084C/zh not_active Expired - Fee Related
- 2001-12-13 AT AT01270552T patent/ATE431851T1/de not_active IP Right Cessation
- 2001-12-13 WO PCT/DK2001/000825 patent/WO2002048189A2/en not_active Ceased
- 2001-12-13 BR BR0116138-5A patent/BR0116138A/pt not_active IP Right Cessation
- 2001-12-13 EP EP01270552A patent/EP1341912B1/en not_active Expired - Lifetime
- 2001-12-13 JP JP2002549720A patent/JP4493271B2/ja not_active Expired - Fee Related
- 2001-12-13 AU AU2156802A patent/AU2156802A/xx active Pending
-
2003
- 2003-06-12 NO NO20032663A patent/NO20032663L/no not_active Application Discontinuation
-
2006
- 2006-12-04 US US11/633,040 patent/US8017559B2/en not_active Expired - Fee Related
-
2011
- 2011-06-08 US US13/156,138 patent/US20120094873A1/en not_active Abandoned
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