AU2002221568B2 - Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains - Google Patents

Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains Download PDF

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Publication number
AU2002221568B2
AU2002221568B2 AU2002221568A AU2002221568A AU2002221568B2 AU 2002221568 B2 AU2002221568 B2 AU 2002221568B2 AU 2002221568 A AU2002221568 A AU 2002221568A AU 2002221568 A AU2002221568 A AU 2002221568A AU 2002221568 B2 AU2002221568 B2 AU 2002221568B2
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AU
Australia
Prior art keywords
ctld
combinatorial library
amino acid
proteins
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002221568A
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English (en)
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AU2002221568A1 (en
Inventor
Michael Etzerodt
Niels Jonas Heilskov Graversen
Thor Las Holtet
Hans Christian Thogersen
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Bird Rock Bio Inc
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Anaphore Inc
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Publication of AU2002221568A1 publication Critical patent/AU2002221568A1/en
Application granted granted Critical
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Assigned to BOREAN PHARMA APS reassignment BOREAN PHARMA APS Request for Assignment Assignors: ROCHE BIO DENMARK A/S
Assigned to ANAPHORE, INC. reassignment ANAPHORE, INC. Request for Assignment Assignors: BOREAN PHARMA APS
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2002221568A 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains Ceased AU2002221568B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200001872 2000-12-13
DKPA200001872 2000-12-13
US27209801P 2001-02-28 2001-02-28
US60/272,098 2001-02-28
PCT/DK2001/000825 WO2002048189A2 (en) 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains

Publications (2)

Publication Number Publication Date
AU2002221568A1 AU2002221568A1 (en) 2002-08-29
AU2002221568B2 true AU2002221568B2 (en) 2005-06-02

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2156802A Pending AU2156802A (en) 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains
AU2002221568A Ceased AU2002221568B2 (en) 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2156802A Pending AU2156802A (en) 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains

Country Status (14)

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US (2) US8017559B2 (enExample)
EP (2) EP1341912B1 (enExample)
JP (1) JP4493271B2 (enExample)
KR (1) KR100865602B1 (enExample)
CN (1) CN100580084C (enExample)
AT (1) ATE431851T1 (enExample)
AU (2) AU2156802A (enExample)
BR (1) BR0116138A (enExample)
CA (1) CA2430953A1 (enExample)
DE (1) DE60138764D1 (enExample)
DK (1) DK1341912T3 (enExample)
NO (1) NO20032663L (enExample)
NZ (1) NZ526312A (enExample)
WO (1) WO2002048189A2 (enExample)

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CN100580084C (zh) 2000-12-13 2010-01-13 阿纳福公司 具有c型类凝集素结构域的支架结构的蛋白质组合文库
AU2003239777A1 (en) * 2002-07-05 2004-01-23 Borean Pharma A/S Multimerised growth hormone fusion proteins
EP1548030A4 (en) * 2002-08-20 2006-10-04 Summit Glycores Corp USE OF A LECTIN IMAGE FOR THE DISTINCTION OF GLYCOPROTEINS OR CELLS, FOR THE DIAGNOSIS OF SERUM OR CELLS, OR FOR THE FRACTIONATION OF GLYCOPROTEINS OR CELLS
EP2311867A1 (en) 2002-10-29 2011-04-20 Anaphore, Inc. Trimeric binding proteins for trimeric cytokines
EP1692159B1 (en) * 2003-11-06 2010-09-29 Danisco US Inc. Tgf-beta1 binding and supported peptides
US20100028995A1 (en) * 2004-02-23 2010-02-04 Anaphore, Inc. Tetranectin Trimerizing Polypeptides
BRPI0518042A (pt) 2004-11-22 2008-10-28 Borean Pharma Aps polipeptìdeo capaz de se ligar ao fator de necrose de tumor (tnf), ácido nucléico isolado, vetor de expressão, célula hospedeira, método para preparação do referido polipeptìdeo, composição farmacêutica, método de ensaio para detecção de tnf e uso
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
JP5537946B2 (ja) 2006-11-22 2014-07-02 ブリストル−マイヤーズ スクイブ カンパニー Ｉｇｆ−ｉｒを含むチロシンキナーゼ受容体に対する改変タンパク質に基づく標的治療薬
EP2195333A1 (en) * 2007-09-12 2010-06-16 Anaphore, Inc. Hsp70-based treatment for autoimmune diseases
US20110027267A1 (en) * 2007-11-09 2011-02-03 Anaphore, Inc. Fusion Proteins of Mannose Binding Lectins for Treatment of Disease
EP2799448A1 (en) 2008-05-22 2014-11-05 Bristol-Myers Squibb Company Multivalent fibronectin based scaffold domain proteins
US20130295106A1 (en) * 2008-09-26 2013-11-07 Oncomed Pharmaceuticals, Inc. Frizzled-Binding Agents And Uses Thereof
US7982013B2 (en) 2008-09-26 2011-07-19 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
EP2379585A2 (en) 2008-10-10 2011-10-26 Anaphore, Inc. Polypeptides that bind trail-ri and trail-r2
CN102686727A (zh) * 2009-10-09 2012-09-19 阿纳福公司 基于c-型凝集素结构域的组合文库
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
US20110086770A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Combinatorial Libraries Based on C-type Lectin-like Domain
WO2011074941A1 (en) * 2009-12-15 2011-06-23 Universiti Malaya A method of high throughput screening of inhibitors that inhibit interaction of an attachment protein to cell receptors using recombinant phage display
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
AU2011235904B2 (en) 2010-04-01 2015-10-08 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
KR101294982B1 (ko) * 2011-12-09 2013-08-08 경북대학교 산학협력단 단백질 골격모듈을 포함하는 융합 폴리펩타이드 및 이를 이용한 목적 단백질에 특이적인 펩타이드 라이브러리 스크리닝 방법
US9598713B2 (en) * 2012-03-02 2017-03-21 Japanese Science And Technology Agency Method for constructing functional nucleic acid molecule, and nucleic acid combination to be used in said method
JP2015536933A (ja) 2012-10-23 2015-12-24 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法
AU2014212081A1 (en) 2013-02-04 2015-08-13 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a Wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US20160039877A1 (en) 2013-03-15 2016-02-11 Shenzhen Hightide Biopharmaceutical, Ltd. Compositions and methods of using islet neogenesis peptides and analogs thereof
GB201311031D0 (en) * 2013-06-20 2013-08-07 Queen Mary & Westfield College Method
CA2962783A1 (en) 2014-10-01 2016-04-07 Medimmune, Llc Method of conjugating a polypeptide
AR111963A1 (es) 2017-05-26 2019-09-04 Univ California Método y moléculas
CN113372428B (zh) * 2021-05-21 2022-07-08 广东食品药品职业学院 文昌鱼C型凝集素BjCTL4基因及其应用

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EP0947582A1 (en) * 1998-03-31 1999-10-06 Innogenetics N.V. A polypeptide structure for use as a scaffold

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US5679548A (en) * 1993-02-02 1997-10-21 The Scripps Research Institute Methods for producing polypeptide metal binding sites and compositions thereof
JP3695467B2 (ja) 1993-02-04 2005-09-14 ボレアン ファーマ エー／エス タンパクを再生するための改良された方法
US6025485A (en) * 1997-02-14 2000-02-15 Arcaris, Inc. Methods and compositions for peptide libraries displayed on light-emitting scaffolds
WO1998056906A1 (en) * 1997-06-11 1998-12-17 Thoegersen Hans Christian Trimerising module
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
CN100580084C (zh) 2000-12-13 2010-01-13 阿纳福公司 具有c型类凝集素结构域的支架结构的蛋白质组合文库

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Publication number Priority date Publication date Assignee Title
EP0947582A1 (en) * 1998-03-31 1999-10-06 Innogenetics N.V. A polypeptide structure for use as a scaffold

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
CN1484698A (zh) 2004-03-24
EP1341912A2 (en) 2003-09-10
JP2004515245A (ja) 2004-05-27
WO2002048189A3 (en) 2003-01-09
NZ526312A (en) 2004-11-26
NO20032663L (no) 2003-07-17
KR100865602B1 (ko) 2008-10-27
ATE431851T1 (de) 2009-06-15
AU2156802A (en) 2002-06-24
EP1341912B1 (en) 2009-05-20
US20120094873A1 (en) 2012-04-19
EP2105503A2 (en) 2009-09-30
NO20032663D0 (no) 2003-06-12
EP2105503A3 (en) 2011-03-02
US20070275393A1 (en) 2007-11-29
JP4493271B2 (ja) 2010-06-30
BR0116138A (pt) 2003-09-23
CN100580084C (zh) 2010-01-13
CA2430953A1 (en) 2002-06-20
WO2002048189A2 (en) 2002-06-20
EP2105503B1 (en) 2012-09-19
US8017559B2 (en) 2011-09-13
KR20040018316A (ko) 2004-03-03
DE60138764D1 (de) 2009-07-02
DK1341912T3 (da) 2009-09-21

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: BOREAN PHARMA APS

Free format text: FORMER OWNER WAS: ROCHE BIO DENMARK A/S

PC Assignment registered

Owner name: ANAPHORE, INC.

Free format text: FORMER OWNER WAS: BOREAN PHARMA APS

MK14 Patent ceased section 143(a) (annual fees not paid) or expired