BR0116138A - Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c - Google Patents

Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c

Info

Publication number
BR0116138A
BR0116138A BR0116138-5A BR0116138A BR0116138A BR 0116138 A BR0116138 A BR 0116138A BR 0116138 A BR0116138 A BR 0116138A BR 0116138 A BR0116138 A BR 0116138A
Authority
BR
Brazil
Prior art keywords
ctlds
libraries
tetranectin
domains
protein
Prior art date
Application number
BR0116138-5A
Other languages
English (en)
Inventor
Michael Etzerodt
Thor Las Holtet
Niels Jonas Heilskov Graversen
Hans Christian Thogersen
Original Assignee
Borean Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Borean Pharma As filed Critical Borean Pharma As
Publication of BR0116138A publication Critical patent/BR0116138A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"BIBLIOTECAS COMBINATORIAIS DE PROTEìNAS TENDO A ESTRUTURA DE ANDAIME DE DOMìNIOS TIPO LECTINA TIPO C". Uma nova família de bibliotecas de proteína compreendendo CTLDS (<UM>C<MV>-<UM>t<MV>ype <UM>L<MV>ectin-<UM>L<MV>ike <UM>D<MV>omains) nas quais regiões de alça de polipeptídeo internas revestindo os sítios de ligação de ligando nos CTLDs foram substituídas com conjuntos de segmentos de polipeptídeo completamente ou parcialmente aleatorizados. Os CTLDs de tetranectina foram escolhidos como estrutura para a modalidade preferida da invenção; e vetores de fagomídeo versátil úteis na geração e manipulação de bibliotecas de CTLD de tetranectina humana e de murino são descritos como parte desta invenção. Os CTLDs de tetranectina em forma monomérica bem como trimérica são eficientemente exibidos como fusões de gene III em forma totalmente funcional pelo vetor de exibição de fago fd recombinante. Os derivados de CTLD com afinidade para novos ligandos podem facilmente ser isolados de bibliotecas de vetores exibindo CTLDS, nos quais regiões de alça foram aleatorizadas, empregando-se um ou mais ciclos de enriquecimento por avaliação ou seleção seguida por amplificação da subpopulação enriquecida em cada ciclo. A eficiência com a qual produtos de proteína contendo CTLDs com novas propriedades de ligação podem ser produzidos, por exemplo, por expressão bacteriana em redobramento in vitro, em formatos mono-, tri ou multiméricos fornece importantes vantagens em termos de simplicidade, custo e eficiência de geração, produção e aplicações diagnósticas ou terapêuticas em comparação com derivados de anticorpo recombinante.
BR0116138-5A 2000-12-13 2001-12-13 Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c BR0116138A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001872 2000-12-13
US27209801P 2001-02-28 2001-02-28
PCT/DK2001/000825 WO2002048189A2 (en) 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains

Publications (1)

Publication Number Publication Date
BR0116138A true BR0116138A (pt) 2003-09-23

Family

ID=26068925

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116138-5A BR0116138A (pt) 2000-12-13 2001-12-13 Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c

Country Status (14)

Country Link
US (2) US8017559B2 (pt)
EP (2) EP2105503B1 (pt)
JP (1) JP4493271B2 (pt)
KR (1) KR100865602B1 (pt)
CN (1) CN100580084C (pt)
AT (1) ATE431851T1 (pt)
AU (2) AU2156802A (pt)
BR (1) BR0116138A (pt)
CA (1) CA2430953A1 (pt)
DE (1) DE60138764D1 (pt)
DK (1) DK1341912T3 (pt)
NO (1) NO20032663L (pt)
NZ (1) NZ526312A (pt)
WO (1) WO2002048189A2 (pt)

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AU2156802A (en) 2000-12-13 2002-06-24 Borean Pharma As Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains
WO2004005335A2 (en) * 2002-07-05 2004-01-15 Borean Pharma A/S Multimerised growth hormone fusion proteins
AU2003254952A1 (en) 2002-08-20 2004-03-11 Summit Glycoresearch Corporation Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells
CN101899106A (zh) 2002-10-29 2010-12-01 阿纳福公司 三聚细胞因子的三聚结合蛋白
EP1692160B1 (en) 2003-11-06 2010-10-27 Danisco US Inc. Fgf-5 binding and supported peptides
US20100028995A1 (en) * 2004-02-23 2010-02-04 Anaphore, Inc. Tetranectin Trimerizing Polypeptides
AU2005306168A1 (en) 2004-11-22 2006-05-26 Anaphore, Inc. TNF antagonists
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP2727936B1 (en) 2006-11-22 2016-09-07 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
WO2009036349A1 (en) * 2007-09-12 2009-03-19 Anaphore, Inc. Hsp70-based treatment for autoimmune diseases
EP2225269A2 (en) * 2007-11-09 2010-09-08 Anaphore, Inc. Fusion proteins of mannose binding lectins for treatment of disease
AR071874A1 (es) 2008-05-22 2010-07-21 Bristol Myers Squibb Co Proteinas de dominio de armazon basadas en fibronectina multivalentes
US20130295106A1 (en) * 2008-09-26 2013-11-07 Oncomed Pharmaceuticals, Inc. Frizzled-Binding Agents And Uses Thereof
WO2010037041A2 (en) 2008-09-26 2010-04-01 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
AU2009303304A1 (en) 2008-10-10 2010-04-15 Anaphore, Inc. Polypeptides that bind TRAIL-RI and TRAIL-R2
WO2011043834A1 (en) * 2009-10-09 2011-04-14 Anphore, Inc Combinatorial libraries based on c-type lectin domain
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
CN102686606A (zh) * 2009-10-09 2012-09-19 阿纳福公司 结合il-23r的多肽
WO2011074941A1 (en) * 2009-12-15 2011-06-23 Universiti Malaya A method of high throughput screening of inhibitors that inhibit interaction of an attachment protein to cell receptors using recombinant phage display
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
JP2013530929A (ja) 2010-04-01 2013-08-01 オンコメッド ファーマシューティカルズ インコーポレイテッド ｆｒｉｚｚｌｅｄ結合剤およびその使用
KR101294982B1 (ko) * 2011-12-09 2013-08-08 경북대학교 산학협력단 단백질 골격모듈을 포함하는 융합 폴리펩타이드 및 이를 이용한 목적 단백질에 특이적인 펩타이드 라이브러리 스크리닝 방법
CN104169422B (zh) * 2012-03-02 2017-04-26 国立研究开发法人科学技术振兴机构 功能性核酸分子的构建方法和该方法中使用的核酸组合物
CA2887711A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
EP2950885B1 (en) 2013-02-04 2018-11-21 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US20160039877A1 (en) 2013-03-15 2016-02-11 Shenzhen Hightide Biopharmaceutical, Ltd. Compositions and methods of using islet neogenesis peptides and analogs thereof
GB201311031D0 (en) * 2013-06-20 2013-08-07 Queen Mary & Westfield College Method
CN106922129B (zh) 2014-10-01 2024-02-20 免疫医疗有限责任公司 轭合多肽的方法
AR111963A1 (es) 2017-05-26 2019-09-04 Univ California Método y moléculas
CN113372428B (zh) * 2021-05-21 2022-07-08 广东食品药品职业学院 文昌鱼C型凝集素BjCTL4基因及其应用

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US5679548A (en) * 1993-02-02 1997-10-21 The Scripps Research Institute Methods for producing polypeptide metal binding sites and compositions thereof
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Also Published As

Publication number Publication date
EP2105503A3 (en) 2011-03-02
US20120094873A1 (en) 2012-04-19
US20070275393A1 (en) 2007-11-29
NZ526312A (en) 2004-11-26
CN1484698A (zh) 2004-03-24
CN100580084C (zh) 2010-01-13
WO2002048189A2 (en) 2002-06-20
AU2156802A (en) 2002-06-24
EP1341912B1 (en) 2009-05-20
CA2430953A1 (en) 2002-06-20
DE60138764D1 (de) 2009-07-02
NO20032663D0 (no) 2003-06-12
JP2004515245A (ja) 2004-05-27
WO2002048189A3 (en) 2003-01-09
EP2105503B1 (en) 2012-09-19
KR100865602B1 (ko) 2008-10-27
EP2105503A2 (en) 2009-09-30
EP1341912A2 (en) 2003-09-10
DK1341912T3 (da) 2009-09-21
ATE431851T1 (de) 2009-06-15
KR20040018316A (ko) 2004-03-03
US8017559B2 (en) 2011-09-13
JP4493271B2 (ja) 2010-06-30
NO20032663L (no) 2003-07-17
AU2002221568B2 (en) 2005-06-02

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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