ATE194168T1 - Varianten in den leltin domäne von selektin - Google Patents

Varianten in den leltin domäne von selektin

Info

Publication number
ATE194168T1
ATE194168T1 AT93910869T AT93910869T ATE194168T1 AT E194168 T1 ATE194168 T1 AT E194168T1 AT 93910869 T AT93910869 T AT 93910869T AT 93910869 T AT93910869 T AT 93910869T AT E194168 T1 ATE194168 T1 AT E194168T1
Authority
AT
Austria
Prior art keywords
variants
selectin
domain
selektin
leltin
Prior art date
Application number
AT93910869T
Other languages
English (en)
Inventor
David V Erbe
Laurence A Lasky
Leonard G Presta
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE194168T1 publication Critical patent/ATE194168T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Non-Volatile Memory (AREA)
  • Semiconductor Memories (AREA)
AT93910869T 1992-04-30 1993-04-28 Varianten in den leltin domäne von selektin ATE194168T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87903692A 1992-04-30 1992-04-30
US95670192A 1992-10-01 1992-10-01
PCT/US1993/003987 WO1993022436A1 (en) 1992-04-30 1993-04-28 Lectin domain variants of selectin

Publications (1)

Publication Number Publication Date
ATE194168T1 true ATE194168T1 (de) 2000-07-15

Family

ID=27128518

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93910869T ATE194168T1 (de) 1992-04-30 1993-04-28 Varianten in den leltin domäne von selektin

Country Status (12)

Country Link
US (1) US5593882A (de)
EP (1) EP0639224B1 (de)
JP (2) JPH07506253A (de)
AT (1) ATE194168T1 (de)
AU (1) AU674317B2 (de)
CA (1) CA2134756C (de)
DE (1) DE69328928T2 (de)
DK (1) DK0639224T3 (de)
ES (1) ES2152251T3 (de)
GR (1) GR3034447T3 (de)
PT (1) PT639224E (de)
WO (1) WO1993022436A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE240395T1 (de) 1994-03-29 2003-05-15 Celltech Therapeutics Ltd Antikörper gegen e-selektin
US6127524A (en) * 1996-10-18 2000-10-03 Dade Behring Inc. Binding molecules and computer-based methods of increasing the binding affinity thereof
JP2004509069A (ja) * 2000-05-19 2004-03-25 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Ｐ−セレクチン、ｐ−およびｅ−セレクチン複合体の結晶構造、ならびにそれらの用途
US7897575B2 (en) * 2000-05-24 2011-03-01 The United States Of America As Represented By The Department Of Health And Human Services Treatment and prevention of vascular dementia
EP1842551A1 (de) * 2000-05-24 2007-10-10 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services E-selectin zur behandlung oder vorbeugung von schlaganfall
EP2284270A3 (de) 2000-12-13 2012-07-25 Anaphore, Inc. Verfahren zur Identifizierung und Isolierung von bindenden Polypeptiden aus kombinatorischen Bibliotheken von Proteinen mit der Gerüststruktur von lectinähnlichen Domänen vom C-typ
AU2156802A (en) 2000-12-13 2002-06-24 Borean Pharma As Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains
DE60235348D1 (de) * 2001-02-20 2010-04-01 Summit Glycores Corp Lectine zur analyse von zuckerketten und verfahren zu ihrer verwendung
US20040116333A1 (en) * 2001-08-03 2004-06-17 Rong-Hwa Lin Modulators of P-selectin glycoprotein ligand 1
AU2002359815A1 (en) * 2001-12-19 2003-07-09 Immunex Corporation C-type lectin polypeptide, polynucleotide and methods of making and use thereof
US20070244043A1 (en) * 2005-03-10 2007-10-18 Novavax, Inc. Recombinant E-selectin made in insect cells
US8945565B2 (en) 2006-12-01 2015-02-03 Selexys Pharmaceuticals Corporation Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies
PT2662091T (pt) 2006-12-01 2018-12-03 Novartis Ag Anticorpos anti-p-selectina e métodos para os utilizar no tratamento de doenças inflamatórias
JP2010538655A (ja) * 2007-09-12 2010-12-16 アナフォア インコーポレイテッド 自己免疫疾患についてのｈｓｐ７０に基づく治療
WO2011043835A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that bind il-23r
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
CA2822610C (en) * 2010-12-21 2019-09-03 Selexys Pharmaceuticals Corporation Use of anti-p-selectin antibodies
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
AU2018244030B2 (en) * 2017-03-29 2021-10-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Purification of an agent of interest

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081034A (en) * 1988-11-14 1992-01-14 Brigham & Women's Hospital Cloned genes which encode elam-1
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
DE69133120T2 (de) * 1990-07-17 2003-05-15 Univ Oklahoma Norman Board Of GMP-140 Ligand

Also Published As

Publication number Publication date
EP0639224B1 (de) 2000-06-28
PT639224E (pt) 2000-12-29
DK0639224T3 (da) 2000-10-30
GR3034447T3 (en) 2000-12-29
CA2134756C (en) 2010-04-20
WO1993022436A1 (en) 1993-11-11
JP3749529B2 (ja) 2006-03-01
EP0639224A1 (de) 1995-02-22
DE69328928T2 (de) 2000-11-30
JPH07506253A (ja) 1995-07-13
CA2134756A1 (en) 1993-11-11
AU4220893A (en) 1993-11-29
JP2004049234A (ja) 2004-02-19
US5593882A (en) 1997-01-14
ES2152251T3 (es) 2001-02-01
DE69328928D1 (de) 2000-08-03
AU674317B2 (en) 1996-12-19

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UEP Publication of translation of european patent specification