ES2152251T3 - Variantes del dominio lectina de la selectina. - Google Patents

Variantes del dominio lectina de la selectina.

Info

Publication number
ES2152251T3
ES2152251T3 ES93910869T ES93910869T ES2152251T3 ES 2152251 T3 ES2152251 T3 ES 2152251T3 ES 93910869 T ES93910869 T ES 93910869T ES 93910869 T ES93910869 T ES 93910869T ES 2152251 T3 ES2152251 T3 ES 2152251T3
Authority
ES
Spain
Prior art keywords
variants
lectin domain
selectin
selectine
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93910869T
Other languages
English (en)
Inventor
David V Erbe
Laurence A Lasky
Leonard G Presta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2152251T3 publication Critical patent/ES2152251T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Non-Volatile Memory (AREA)
  • Semiconductor Memories (AREA)

Abstract

LA INVENCION SE REFIERE A VARIANTES DE LA SELECTINA QUE TIENEN UNA ALTERACION DEL AMINOACIDO EN LA ZONA O ZONAS DE UNA SECUENCIA DE AMINOACIDO DEL DOMINIO DE LA LECTINA DE LA SELECTINA DENTRO DE UNA REGION DEFINIDA POR ZONAS DE UNION RECONOCIDAS POR ANTICUERPOS MONOCLONALES BLOQUEANTES A LA SELECTINA CORRESPONDIENTE INALTERADA EN EL DOMINIO DE LA LECTINA. DENTRO DEL CAMPO DE LA INVENCION TAMBIEN SE ENCUENTRAN SECUENCIAS NUCLEOTIDAS QUE CODIFICAN TALES VARIANTES, VECTORES DE EXPRESION QUE CONTIENEN TALES SECUENCIAS NUCLEOTIDAS Y CELULAS ANFITRIONAS TRANSFORMADAS CON TALES VECTORES DE EXPRESION.
ES93910869T 1992-04-30 1993-04-28 Variantes del dominio lectina de la selectina. Expired - Lifetime ES2152251T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87903692A 1992-04-30 1992-04-30
US95670192A 1992-10-01 1992-10-01

Publications (1)

Publication Number Publication Date
ES2152251T3 true ES2152251T3 (es) 2001-02-01

Family

ID=27128518

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93910869T Expired - Lifetime ES2152251T3 (es) 1992-04-30 1993-04-28 Variantes del dominio lectina de la selectina.

Country Status (12)

Country Link
US (1) US5593882A (es)
EP (1) EP0639224B1 (es)
JP (2) JPH07506253A (es)
AT (1) ATE194168T1 (es)
AU (1) AU674317B2 (es)
CA (1) CA2134756C (es)
DE (1) DE69328928T2 (es)
DK (1) DK0639224T3 (es)
ES (1) ES2152251T3 (es)
GR (1) GR3034447T3 (es)
PT (1) PT639224E (es)
WO (1) WO1993022436A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204007B1 (en) 1994-03-29 2001-03-20 Celltech Therapeutics Limited Antibodies against E-selectin
US6127524A (en) * 1996-10-18 2000-10-03 Dade Behring Inc. Binding molecules and computer-based methods of increasing the binding affinity thereof
US20040096894A1 (en) * 2000-05-19 2004-05-20 Somers William Stuart Crystal structures of P- selectin, P- and E-selectin complexes, and uses thereof
EP1842551A1 (en) * 2000-05-24 2007-10-10 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services E-selectin for treating or preventing stroke
US7897575B2 (en) * 2000-05-24 2011-03-01 The United States Of America As Represented By The Department Of Health And Human Services Treatment and prevention of vascular dementia
EP2105503B1 (en) 2000-12-13 2012-09-19 Anaphore, Inc. Method for the identification and isolation of binding polypeptides from combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains
EP2284270A3 (en) 2000-12-13 2012-07-25 Anaphore, Inc. Method for the identification and isolation of binding polypeptides from combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains
US20040091938A1 (en) * 2001-02-20 2004-05-13 Tatsuro Irimura Lectins for analyzing sugar chains and method of using the same
US20040116333A1 (en) * 2001-08-03 2004-06-17 Rong-Hwa Lin Modulators of P-selectin glycoprotein ligand 1
WO2003054164A2 (en) * 2001-12-19 2003-07-03 Immunex Corporation C-type lectin polypeptide, polynucleotide and methods of making and use thereof
US20070244043A1 (en) * 2005-03-10 2007-10-18 Novavax, Inc. Recombinant E-selectin made in insect cells
EP3501538A1 (en) 2006-12-01 2019-06-26 Novartis AG Anti-p-selectin antibodies and methods of using the same to treat inflammatory diseases
US8945565B2 (en) 2006-12-01 2015-02-03 Selexys Pharmaceuticals Corporation Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies
EP2195333A1 (en) * 2007-09-12 2010-06-16 Anaphore, Inc. Hsp70-based treatment for autoimmune diseases
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
JP2013507124A (ja) * 2009-10-09 2013-03-04 アナフォア インコーポレイテッド Ｉｌ−２３ｒを結合するポリペプチド
PL2654781T3 (pl) * 2010-12-21 2018-09-28 Novartis Ag Przeciwciała anty-p-selektynowe i sposoby ich zastosowania i identyfikacji
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2018178991A1 (en) * 2017-03-29 2018-10-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Purification of an agent of interest

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081034A (en) * 1988-11-14 1992-01-14 Brigham & Women's Hospital Cloned genes which encode elam-1
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
DK0714912T3 (da) * 1990-07-17 2003-02-03 Univ Oklahoma Funktionelt aktive selektin-deriverede peptider og ligander for GMP-140

Also Published As

Publication number Publication date
GR3034447T3 (en) 2000-12-29
CA2134756A1 (en) 1993-11-11
JPH07506253A (ja) 1995-07-13
AU674317B2 (en) 1996-12-19
EP0639224A1 (en) 1995-02-22
AU4220893A (en) 1993-11-29
DK0639224T3 (da) 2000-10-30
DE69328928D1 (de) 2000-08-03
PT639224E (pt) 2000-12-29
US5593882A (en) 1997-01-14
ATE194168T1 (de) 2000-07-15
JP3749529B2 (ja) 2006-03-01
JP2004049234A (ja) 2004-02-19
WO1993022436A1 (en) 1993-11-11
CA2134756C (en) 2010-04-20
DE69328928T2 (de) 2000-11-30
EP0639224B1 (en) 2000-06-28

Similar Documents

Publication Publication Date Title
ES2152251T3 (es) Variantes del dominio lectina de la selectina.
ATE215601T1 (de) Rezeptoren der steroid/thyroid superfamilie von rezeptoren
AU7261994A (en) Hydrazino-type radionuclide chelators having an n3s configuration
BR0011849A (pt) Anticorpos enxertados lm609 melhorados
TR199900267T2 (xx) GnRH-L�kotoksin kimeralar�.
CY1109978T1 (el) Αντιγονικα πεπτιδια εξαγομενα απο τελομεραση
DK0737207T3 (da) Inhibitorer for humant plasmin afledt af Kunitz-domæner
ATE178053T1 (de) N2s2-chelatoren des hydrazino-typs
PT726955E (pt) Proteinas quimericas compreendendo polipeptidos borrelia: suas utilizacoes
DE69434384D1 (de) Metalkomplexbildner
ATE171212T1 (de) Corticotropin freisetzende rezeptoren des faktor 2
MXPA00002111A (es) Biomoleculas que contienen un peptido elastomerico.
FR2710074B1 (fr) Gène GRB3-3, ses variants et leurs utilisations.
ATE466874T1 (de) Mit scytovirin der domäne 1 verwandte polypeptide
DE60139959D1 (de) Nukleinsäureadjuvantien
DE69619808T2 (de) Chimäre msp und daf proteine mit einem telloberflächenlokalisierendem domän
DK1279677T3 (da) GD3-mimetiske peptider
DE69840326D1 (de) Steigerung der immunantwort unter verwendung von zielgerichteten molekülen
NO962827D0 (no) Monoklonale antistoffer mot antigener uttrykt av hematopoietider facilitatoriske celler
PT773999E (pt) Receptor orfao or-1 pertencente a familia de receptores nucleares
DK0938555T3 (da) Konstruktioner og komplekser af cyclin E
SE0101519D0 (sv) Nucleic ACID
KR950005895U (ko) P.c 세그먼트의 쉬스관 마구리 정착마개

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 639224

Country of ref document: ES