EA199900794A1 - Cash (гомолог каспазы) с "гибель-эффекторным" доменом, модуляторы функций fas-рецепторов - Google Patents

Cash (гомолог каспазы) с "гибель-эффекторным" доменом, модуляторы функций fas-рецепторов

Info

Publication number
EA199900794A1
EA199900794A1 EA199900794A EA199900794A EA199900794A1 EA 199900794 A1 EA199900794 A1 EA 199900794A1 EA 199900794 A EA199900794 A EA 199900794A EA 199900794 A EA199900794 A EA 199900794A EA 199900794 A1 EA199900794 A1 EA 199900794A1
Authority
EA
Eurasian Patent Office
Prior art keywords
caspaze
homologist
cash
effector
modulators
Prior art date
Application number
EA199900794A
Other languages
English (en)
Other versions
EA003269B1 (ru
Inventor
Дэвид Валлах
Юра Гольцев
Андрей Коваленко
Евгений Варфоломеев
Вадим Бродянский
Original Assignee
Йеда Рисерч Энд Дивелопмент Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12036797A external-priority patent/IL120367A0/xx
Application filed by Йеда Рисерч Энд Дивелопмент Ко., Лтд. filed Critical Йеда Рисерч Энд Дивелопмент Ко., Лтд.
Publication of EA199900794A1 publication Critical patent/EA199900794A1/ru
Publication of EA003269B1 publication Critical patent/EA003269B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Раскрыты белки, способные модулировать или опосредовать функции MORT-1. Также раскрыты последовательности ДНК, кодирующие эти белки, и получение таких рекомбинантных белков, а также пути их использования.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900794A 1997-03-03 1998-02-26 Cash (гомолог каспазы) с "гибель-эффекторным" доменом, модуляторы функций fas-рецепторов EA003269B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL12036797A IL120367A0 (en) 1997-03-03 1997-03-03 Modulators of the function of FAS receptors and other proteins
IL12075997A IL120759A0 (en) 1997-03-03 1997-05-01 Modulators of the function of fas receptors and other proteins
PCT/IL1998/000098 WO1998039435A1 (en) 1997-03-03 1998-02-26 Cash (caspase homologue) with death effector domain, modulators of the function of fas receptors

Publications (2)

Publication Number Publication Date
EA199900794A1 true EA199900794A1 (ru) 2000-04-24
EA003269B1 EA003269B1 (ru) 2003-02-27

Family

ID=26323378

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900794A EA003269B1 (ru) 1997-03-03 1998-02-26 Cash (гомолог каспазы) с "гибель-эффекторным" доменом, модуляторы функций fas-рецепторов

Country Status (19)

Country Link
US (1) US7419804B2 (ru)
EP (1) EP0977842A1 (ru)
JP (1) JP2002500508A (ru)
KR (1) KR100544776B1 (ru)
CN (1) CN1148446C (ru)
AU (1) AU740223B2 (ru)
BG (1) BG64799B1 (ru)
BR (1) BR9808173A (ru)
CA (1) CA2281484A1 (ru)
EA (1) EA003269B1 (ru)
EE (1) EE9900384A (ru)
HK (1) HK1024508A1 (ru)
HU (1) HUP0000913A3 (ru)
IL (3) IL120759A0 (ru)
NO (1) NO994250L (ru)
NZ (1) NZ337143A (ru)
PL (1) PL193394B1 (ru)
SK (1) SK117599A3 (ru)
WO (1) WO1998039435A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713434C1 (de) * 1997-04-01 1998-09-24 Deutsches Krebsforsch Protein zur Inhibierung von Apoptose
DE19713393C2 (de) * 1997-04-01 2002-12-05 Apotech Res & Dev Ltd Flip-Gen und Flip-Protein
WO2000003023A1 (en) * 1998-07-08 2000-01-20 Merck Frosst Canada & Co. Usurpin, a mammalian ded-caspase homologue that precludes caspase-8 recruitment and activation by the cd-95 (fas, apo-1) receptor complex
AU2222000A (en) * 1998-12-31 2000-07-31 St. Jude Children's Research Hospital A tumor suppressor protein involved in death signaling, and diagnostics, therapeutics, and screening based on this protein
US7052834B1 (en) 1998-12-31 2006-05-30 St. Jude Children's Research Hospital Tumor suppressor protein involved in death signaling, and diagnostics, therapeutics, and screening based on this protein
US20020174450A1 (en) * 2000-12-11 2002-11-21 Allen Keith D. Transgenic mice containing cash gene disruptions
CN110988354A (zh) * 2019-11-15 2020-04-10 同济大学 一种分泌蛋白Caspase1在早期心梗诊断试剂中的应用
CN116426678B (zh) * 2023-03-27 2024-03-22 中国热带农业科学院三亚研究院 与番木瓜果肉果糖含量相关的snp分子标记及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
EP0841399A3 (en) * 1996-11-12 1998-07-08 Smithkline Beecham Corporation Mammalian fin-1 nucleic acid (a caspase) and protein sequences and uses therefor
JP2001511011A (ja) 1997-01-21 2001-08-07 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド 腫瘍壊死因子レセプター−１誘導性アポトーシスおよびｃｄ−９５誘導性アポトーシスの新規なインヒビターである、ｉ−ｆｌｉｃｅ
US6242569B1 (en) * 1997-02-05 2001-06-05 Tularik, Inc. Regulators of apoptosis
DE19713393C2 (de) 1997-04-01 2002-12-05 Apotech Res & Dev Ltd Flip-Gen und Flip-Protein
US6207458B1 (en) * 1998-05-07 2001-03-27 University Of Washigton/Stowers Insitute For Medical Research Proteins capable of regulating NF-κB JNK and apoptosis pathways and methods of using the same

Also Published As

Publication number Publication date
AU740223B2 (en) 2001-11-01
AU6112698A (en) 1998-09-22
US20060216788A1 (en) 2006-09-28
BG64799B1 (bg) 2006-04-28
PL335448A1 (en) 2000-04-25
US7419804B2 (en) 2008-09-02
SK117599A3 (en) 2000-05-16
NO994250D0 (no) 1999-09-02
EP0977842A1 (en) 2000-02-09
IL131247A (en) 2007-08-19
CN1148446C (zh) 2004-05-05
JP2002500508A (ja) 2002-01-08
HUP0000913A2 (hu) 2000-06-28
EE9900384A (et) 2000-04-17
IL131247A0 (en) 2001-01-28
BR9808173A (pt) 2000-05-16
NZ337143A (en) 2001-12-21
NO994250L (no) 1999-11-02
PL193394B1 (pl) 2007-02-28
IL120759A0 (en) 1997-09-30
HK1024508A1 (en) 2000-10-13
EA003269B1 (ru) 2003-02-27
WO1998039435A1 (en) 1998-09-11
CA2281484A1 (en) 1998-09-11
HUP0000913A3 (en) 2001-11-28
KR20000075721A (ko) 2000-12-26
KR100544776B1 (ko) 2006-01-23
CN1249780A (zh) 2000-04-05
BG103693A (en) 2000-05-31

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU