ATE431851T1 - Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur - Google Patents

Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur

Info

Publication number
ATE431851T1
ATE431851T1 AT01270552T AT01270552T ATE431851T1 AT E431851 T1 ATE431851 T1 AT E431851T1 AT 01270552 T AT01270552 T AT 01270552T AT 01270552 T AT01270552 T AT 01270552T AT E431851 T1 ATE431851 T1 AT E431851T1
Authority
AT
Austria
Prior art keywords
ctlds
libraries
tetranectin
type lectin
combinatory
Prior art date
Application number
AT01270552T
Other languages
English (en)
Inventor
Michael Etzerodt
Thor HOLTET
Niels Graversen
Hans Thogersen
Original Assignee
Anaphore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anaphore Inc filed Critical Anaphore Inc
Application granted granted Critical
Publication of ATE431851T1 publication Critical patent/ATE431851T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01270552T 2000-12-13 2001-12-13 Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur ATE431851T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001872 2000-12-13
US27209801P 2001-02-28 2001-02-28
PCT/DK2001/000825 WO2002048189A2 (en) 2000-12-13 2001-12-13 Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains

Publications (1)

Publication Number Publication Date
ATE431851T1 true ATE431851T1 (de) 2009-06-15

Family

ID=26068925

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01270552T ATE431851T1 (de) 2000-12-13 2001-12-13 Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c- typ lectin-ähnlichen domäne als gerüststruktur

Country Status (14)

Country Link
US (2) US8017559B2 (de)
EP (2) EP2105503B1 (de)
JP (1) JP4493271B2 (de)
KR (1) KR100865602B1 (de)
CN (1) CN100580084C (de)
AT (1) ATE431851T1 (de)
AU (2) AU2156802A (de)
BR (1) BR0116138A (de)
CA (1) CA2430953A1 (de)
DE (1) DE60138764D1 (de)
DK (1) DK1341912T3 (de)
NO (1) NO20032663L (de)
NZ (1) NZ526312A (de)
WO (1) WO2002048189A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0116138A (pt) 2000-12-13 2003-09-23 Borean Pharma As Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c
AU2003239777A1 (en) * 2002-07-05 2004-01-23 Borean Pharma A/S Multimerised growth hormone fusion proteins
AU2003254952A1 (en) 2002-08-20 2004-03-11 Summit Glycoresearch Corporation Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells
EP2311867A1 (de) 2002-10-29 2011-04-20 Anaphore, Inc. Trimeres Bindungsprotein für trimeres Zytokin
ATE486087T1 (de) * 2003-11-06 2010-11-15 Danisco Us Inc Fgf-5-bindende und geträgerte peptide
US20100028995A1 (en) * 2004-02-23 2010-02-04 Anaphore, Inc. Tetranectin Trimerizing Polypeptides
WO2006053568A1 (en) 2004-11-22 2006-05-26 Borean Pharma Aps Tnf antagonists
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
US8470332B2 (en) 2006-11-22 2013-06-25 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
JP2010538655A (ja) * 2007-09-12 2010-12-16 アナフォア インコーポレイテッド 自己免疫疾患についてのｈｓｐ７０に基づく治療
AU2008323678A1 (en) * 2007-11-09 2009-05-14 Anaphore, Inc. Fusion proteins of mannose binding lectins for treatment of disease
AR071874A1 (es) 2008-05-22 2010-07-21 Bristol Myers Squibb Co Proteinas de dominio de armazon basadas en fibronectina multivalentes
US20130295106A1 (en) * 2008-09-26 2013-11-07 Oncomed Pharmaceuticals, Inc. Frizzled-Binding Agents And Uses Thereof
JP5792621B2 (ja) 2008-09-26 2015-10-14 オンコメッド ファーマシューティカルズ インコーポレイテッド ｆｒｉｚｚｌｅｄ結合剤およびその使用
JP2012504969A (ja) 2008-10-10 2012-03-01 アナフォア インコーポレイテッド Ｔｒａｉｌ−ｒ１及びｔｒａｉｌ−ｒ２に結合するポリペプチド
CA2777162A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that bind il-23r
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
CN102686727A (zh) * 2009-10-09 2012-09-19 阿纳福公司 基于c-型凝集素结构域的组合文库
WO2011074941A1 (en) * 2009-12-15 2011-06-23 Universiti Malaya A method of high throughput screening of inhibitors that inhibit interaction of an attachment protein to cell receptors using recombinant phage display
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
MX347515B (es) 2010-04-01 2017-04-28 Oncomed Pharmaceuticals Inc * Agentes que se unen al receptor encrespado y usos de los mismos.
KR101294982B1 (ko) * 2011-12-09 2013-08-08 경북대학교 산학협력단 단백질 골격모듈을 포함하는 융합 폴리펩타이드 및 이를 이용한 목적 단백질에 특이적인 펩타이드 라이브러리 스크리닝 방법
KR102101210B1 (ko) * 2012-03-02 2020-04-16 고쿠리츠켄큐카이하츠호진 카가쿠기쥬츠신코키코 기능성 핵산 분자의 구축법, 및 상기 방법에 사용하는 핵산 조합물
EP2911691B1 (de) 2012-10-23 2018-10-10 OncoMed Pharmaceuticals, Inc. Verfahren zur behandlung von neuroendokrinen tumoren mit wnt-pad-bindemitteln
WO2014121196A1 (en) 2013-02-04 2014-08-07 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US20160039877A1 (en) 2013-03-15 2016-02-11 Shenzhen Hightide Biopharmaceutical, Ltd. Compositions and methods of using islet neogenesis peptides and analogs thereof
GB201311031D0 (en) 2013-06-20 2013-08-07 Queen Mary & Westfield College Method
EP3200829B1 (de) 2014-10-01 2023-12-06 Medimmune, LLC Verfahren zum konjugieren eines polypeptids
AR111963A1 (es) 2017-05-26 2019-09-04 Univ California Método y moléculas
CN113372428B (zh) * 2021-05-21 2022-07-08 广东食品药品职业学院 文昌鱼C型凝集素BjCTL4基因及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0639224T3 (da) 1992-04-30 2000-10-30 Genentech Inc Varianter i lectindomænet af selectin
US5679548A (en) * 1993-02-02 1997-10-21 The Scripps Research Institute Methods for producing polypeptide metal binding sites and compositions thereof
NZ261571A (en) 1993-02-04 1997-03-24 Denzyme Aps Producing correctly folded proteins using multiple denaturation and renaturation cycles
US6025485A (en) * 1997-02-14 2000-02-15 Arcaris, Inc. Methods and compositions for peptide libraries displayed on light-emitting scaffolds
CA2304254C (en) * 1997-06-11 2012-05-22 Hans Christian Thogersen Trimerising module
EP0947582A1 (de) * 1998-03-31 1999-10-06 Innogenetics N.V. Eine Polypeptidstruktur zur Verwendung als Gerüst
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
BR0116138A (pt) 2000-12-13 2003-09-23 Borean Pharma As Bibliotecas combinatóriais de proteìnas tendo a estrutura de andaime de domìnios tipo lectina tipo c

Also Published As

Publication number Publication date
WO2002048189A2 (en) 2002-06-20
DK1341912T3 (da) 2009-09-21
CA2430953A1 (en) 2002-06-20
EP1341912A2 (de) 2003-09-10
AU2002221568B2 (en) 2005-06-02
WO2002048189A3 (en) 2003-01-09
US8017559B2 (en) 2011-09-13
KR100865602B1 (ko) 2008-10-27
NO20032663L (no) 2003-07-17
CN100580084C (zh) 2010-01-13
EP2105503A3 (de) 2011-03-02
DE60138764D1 (de) 2009-07-02
CN1484698A (zh) 2004-03-24
JP4493271B2 (ja) 2010-06-30
US20120094873A1 (en) 2012-04-19
NZ526312A (en) 2004-11-26
AU2156802A (en) 2002-06-24
BR0116138A (pt) 2003-09-23
NO20032663D0 (no) 2003-06-12
US20070275393A1 (en) 2007-11-29
KR20040018316A (ko) 2004-03-03
EP1341912B1 (de) 2009-05-20
EP2105503B1 (de) 2012-09-19
JP2004515245A (ja) 2004-05-27
EP2105503A2 (de) 2009-09-30

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