CA2430953A1 - Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains - Google Patents
Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains Download PDFInfo
- Publication number
- CA2430953A1 CA2430953A1 CA002430953A CA2430953A CA2430953A1 CA 2430953 A1 CA2430953 A1 CA 2430953A1 CA 002430953 A CA002430953 A CA 002430953A CA 2430953 A CA2430953 A CA 2430953A CA 2430953 A1 CA2430953 A1 CA 2430953A1
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- CA
- Canada
- Prior art keywords
- amino acid
- ctld
- beta
- seq
- tetranectin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4726—Lectins
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
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| DKPA200001872 | 2000-12-13 | ||
| DKPA200001872 | 2000-12-13 | ||
| US27209801P | 2001-02-28 | 2001-02-28 | |
| US60/272,098 | 2001-02-28 | ||
| PCT/DK2001/000825 WO2002048189A2 (en) | 2000-12-13 | 2001-12-13 | Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains |
Publications (1)
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|---|---|
| CA2430953A1 true CA2430953A1 (en) | 2002-06-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002430953A Abandoned CA2430953A1 (en) | 2000-12-13 | 2001-12-13 | Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains |
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| Country | Link |
|---|---|
| US (2) | US8017559B2 (enExample) |
| EP (2) | EP2105503B1 (enExample) |
| JP (1) | JP4493271B2 (enExample) |
| KR (1) | KR100865602B1 (enExample) |
| CN (1) | CN100580084C (enExample) |
| AT (1) | ATE431851T1 (enExample) |
| AU (2) | AU2002221568B2 (enExample) |
| BR (1) | BR0116138A (enExample) |
| CA (1) | CA2430953A1 (enExample) |
| DE (1) | DE60138764D1 (enExample) |
| DK (1) | DK1341912T3 (enExample) |
| NO (1) | NO20032663L (enExample) |
| NZ (1) | NZ526312A (enExample) |
| WO (1) | WO2002048189A2 (enExample) |
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| CA2430953A1 (en) | 2000-12-13 | 2002-06-20 | Borean Pharma A/S | Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains |
| WO2004005335A2 (en) * | 2002-07-05 | 2004-01-15 | Borean Pharma A/S | Multimerised growth hormone fusion proteins |
| AU2003254952A1 (en) | 2002-08-20 | 2004-03-11 | Summit Glycoresearch Corporation | Use of lectin library for distinguishing glycoproteins or cells, diagnosing serum or cells, or fractionating glycoproteins or cells |
| WO2004039841A2 (en) | 2002-10-29 | 2004-05-13 | Borean Pharma A/S | Trimeric binding proteins for trimeric cytokines |
| DK1680507T3 (da) * | 2003-11-06 | 2011-10-10 | Danisco Us Inc | Bakterieekspression af proteaseinhibitorer og varianter deraf |
| US20100028995A1 (en) * | 2004-02-23 | 2010-02-04 | Anaphore, Inc. | Tetranectin Trimerizing Polypeptides |
| EP1824878A1 (en) * | 2004-11-22 | 2007-08-29 | Borean Pharma A/S | Tnf antagonists |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| AU2007325838B2 (en) | 2006-11-22 | 2013-09-19 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| EP2195333A1 (en) * | 2007-09-12 | 2010-06-16 | Anaphore, Inc. | Hsp70-based treatment for autoimmune diseases |
| US20110027267A1 (en) * | 2007-11-09 | 2011-02-03 | Anaphore, Inc. | Fusion Proteins of Mannose Binding Lectins for Treatment of Disease |
| AR071874A1 (es) | 2008-05-22 | 2010-07-21 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
| AU2009296246B2 (en) | 2008-09-26 | 2015-07-30 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| US20130295106A1 (en) * | 2008-09-26 | 2013-11-07 | Oncomed Pharmaceuticals, Inc. | Frizzled-Binding Agents And Uses Thereof |
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| US20110086806A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that Bind IL-23R |
| CA2776954A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Combinatorial libraries based on c-type lectin domain |
| WO2011043835A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that bind il-23r |
| WO2011074941A1 (en) * | 2009-12-15 | 2011-06-23 | Universiti Malaya | A method of high throughput screening of inhibitors that inhibit interaction of an attachment protein to cell receptors using recombinant phage display |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| JP2013530929A (ja) | 2010-04-01 | 2013-08-01 | オンコメッド ファーマシューティカルズ インコーポレイテッド | ｆｒｉｚｚｌｅｄ結合剤およびその使用 |
| KR101294982B1 (ko) * | 2011-12-09 | 2013-08-08 | 경북대학교 산학협력단 | 단백질 골격모듈을 포함하는 융합 폴리펩타이드 및 이를 이용한 목적 단백질에 특이적인 펩타이드 라이브러리 스크리닝 방법 |
| KR102101210B1 (ko) * | 2012-03-02 | 2020-04-16 | 고쿠리츠켄큐카이하츠호진 카가쿠기쥬츠신코키코 | 기능성 핵산 분자의 구축법, 및 상기 방법에 사용하는 핵산 조합물 |
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| CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| WO2014139182A1 (en) | 2013-03-15 | 2014-09-18 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
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| ATE194168T1 (de) | 1992-04-30 | 2000-07-15 | Genentech Inc | Varianten in den leltin domäne von selektin |
| US5679548A (en) * | 1993-02-02 | 1997-10-21 | The Scripps Research Institute | Methods for producing polypeptide metal binding sites and compositions thereof |
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| US6025485A (en) * | 1997-02-14 | 2000-02-15 | Arcaris, Inc. | Methods and compositions for peptide libraries displayed on light-emitting scaffolds |
| AU736707B2 (en) | 1997-06-11 | 2001-08-02 | Anaphore, Inc. | Trimerising module |
| EP0947582A1 (en) * | 1998-03-31 | 1999-10-06 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| US6180343B1 (en) * | 1998-10-08 | 2001-01-30 | Rigel Pharmaceuticals, Inc. | Green fluorescent protein fusions with random peptides |
| CA2430953A1 (en) | 2000-12-13 | 2002-06-20 | Borean Pharma A/S | Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains |
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2001
- 2001-12-13 CA CA002430953A patent/CA2430953A1/en not_active Abandoned
- 2001-12-13 NZ NZ526312A patent/NZ526312A/en not_active IP Right Cessation
- 2001-12-13 EP EP09160663A patent/EP2105503B1/en not_active Expired - Lifetime
- 2001-12-13 KR KR1020037007858A patent/KR100865602B1/ko not_active Expired - Fee Related
- 2001-12-13 DK DK01270552T patent/DK1341912T3/da active
- 2001-12-13 AU AU2002221568A patent/AU2002221568B2/en not_active Ceased
- 2001-12-13 DE DE60138764T patent/DE60138764D1/de not_active Expired - Lifetime
- 2001-12-13 CN CN01821632A patent/CN100580084C/zh not_active Expired - Fee Related
- 2001-12-13 AT AT01270552T patent/ATE431851T1/de not_active IP Right Cessation
- 2001-12-13 WO PCT/DK2001/000825 patent/WO2002048189A2/en not_active Ceased
- 2001-12-13 BR BR0116138-5A patent/BR0116138A/pt not_active IP Right Cessation
- 2001-12-13 EP EP01270552A patent/EP1341912B1/en not_active Expired - Lifetime
- 2001-12-13 JP JP2002549720A patent/JP4493271B2/ja not_active Expired - Fee Related
- 2001-12-13 AU AU2156802A patent/AU2156802A/xx active Pending
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2003
- 2003-06-12 NO NO20032663A patent/NO20032663L/no not_active Application Discontinuation
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2006
- 2006-12-04 US US11/633,040 patent/US8017559B2/en not_active Expired - Fee Related
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- 2011-06-08 US US13/156,138 patent/US20120094873A1/en not_active Abandoned
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| BR0116138A (pt) | 2003-09-23 |
| NZ526312A (en) | 2004-11-26 |
| DE60138764D1 (de) | 2009-07-02 |
| US20120094873A1 (en) | 2012-04-19 |
| JP4493271B2 (ja) | 2010-06-30 |
| ATE431851T1 (de) | 2009-06-15 |
| WO2002048189A3 (en) | 2003-01-09 |
| EP1341912A2 (en) | 2003-09-10 |
| AU2156802A (en) | 2002-06-24 |
| KR20040018316A (ko) | 2004-03-03 |
| EP2105503A3 (en) | 2011-03-02 |
| CN1484698A (zh) | 2004-03-24 |
| EP1341912B1 (en) | 2009-05-20 |
| US8017559B2 (en) | 2011-09-13 |
| AU2002221568B2 (en) | 2005-06-02 |
| WO2002048189A2 (en) | 2002-06-20 |
| NO20032663D0 (no) | 2003-06-12 |
| JP2004515245A (ja) | 2004-05-27 |
| CN100580084C (zh) | 2010-01-13 |
| EP2105503A2 (en) | 2009-09-30 |
| US20070275393A1 (en) | 2007-11-29 |
| DK1341912T3 (da) | 2009-09-21 |
| KR100865602B1 (ko) | 2008-10-27 |
| NO20032663L (no) | 2003-07-17 |
| EP2105503B1 (en) | 2012-09-19 |
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