|
US20050032690A1
(en)
*
|
1997-09-10 |
2005-02-10 |
Rojkjaer Lisa Payne |
Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia
|
|
US7786070B2
(en)
|
1997-09-10 |
2010-08-31 |
Novo Nordisk Healthcare A/G |
Subcutaneous administration of coagulation factor VII
|
|
US6747003B1
(en)
*
|
1997-10-23 |
2004-06-08 |
Regents Of The University Of Minnesota |
Modified vitamin K-dependent polypeptides
|
|
US7247708B2
(en)
*
|
1997-10-23 |
2007-07-24 |
Regents Of The University Of Minnesota |
Modified vitamin K-dependent polypeptides
|
|
ATE370961T1
(de)
|
1998-05-06 |
2007-09-15 |
Genentech Inc |
Reinigung von antikörpern durch ionenaustauschchromatographie
|
|
WO2001058935A2
(en)
*
|
2000-02-11 |
2001-08-16 |
Maxygen Aps |
FACTOR VII OR VIIa-LIKE MOLECULES
|
|
US7812132B2
(en)
|
2000-04-28 |
2010-10-12 |
Regents Of The University Of Minnesota |
Modified vitamin K-dependent polypeptides
|
|
US7220837B1
(en)
|
2000-04-28 |
2007-05-22 |
Regents Of The University Of Minnesota |
Modified vitamin K-dependent polypeptides
|
|
US20030211094A1
(en)
*
|
2001-06-26 |
2003-11-13 |
Nelsestuen Gary L. |
High molecular weight derivatives of vitamin k-dependent polypeptides
|
|
US20030040480A1
(en)
*
|
2001-07-20 |
2003-02-27 |
Rasmus Rojkjaer |
Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides
|
|
EP1434857B1
(en)
|
2001-10-02 |
2007-08-01 |
Novo Nordisk Health Care AG |
Method for production of recombinant proteins in eukaryote cells
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
KR20040065278A
(ko)
*
|
2001-12-21 |
2004-07-21 |
노보 노르디스크 에이/에스 |
변경된 인자 ⅶ 폴리펩티드의 액체 조성물
|
|
JP2005530683A
(ja)
|
2001-12-21 |
2005-10-13 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
第vii因子ポリペプチドの液体組成物
|
|
DE60334983D1
(de)
*
|
2002-04-30 |
2010-12-30 |
Bayer Healthcare Llc |
Faktor vii oder faktor viia polypeptidvarianten
|
|
US20040009918A1
(en)
*
|
2002-05-03 |
2004-01-15 |
Hanne Nedergaard |
Stabilised solid compositions of modified factor VII
|
|
CN101912601B
(zh)
|
2002-06-21 |
2012-08-29 |
诺和诺德医疗保健公司 |
因子vii多肽的稳定化固体组合物
|
|
ES2363205T3
(es)
*
|
2002-06-21 |
2011-07-26 |
Novo Nordisk Health Care Ag |
Glicoformas del factor vii pegilado.
|
|
JP4472526B2
(ja)
*
|
2002-09-30 |
2010-06-02 |
バイエル ヘルスケア エルエルシー |
凝血活性が増加した第VII因子または第VIIa因子変種
|
|
EP3103869A1
(en)
*
|
2003-03-18 |
2016-12-14 |
Novo Nordisk Health Care AG |
Method for the production of factor vii polypeptides
|
|
CA2518327A1
(en)
*
|
2003-03-18 |
2004-09-30 |
Novo Nordisk Health Care Ag |
Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides
|
|
EP2085470B1
(en)
*
|
2003-03-20 |
2012-05-16 |
Bayer HealthCare LLC |
FVII or FVIIa variants
|
|
US7897734B2
(en)
*
|
2003-03-26 |
2011-03-01 |
Novo Nordisk Healthcare Ag |
Method for the production of proteins
|
|
CA2522345A1
(en)
|
2003-04-09 |
2004-11-18 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
KR20060015574A
(ko)
*
|
2003-05-23 |
2006-02-17 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
용액 중 단백질 안정화
|
|
JP4915918B2
(ja)
*
|
2003-06-19 |
2012-04-11 |
バイエル ヘルスケア エルエルシー |
第VII因子または第VIIa因子のGlaドメイン変種
|
|
ES2382157T3
(es)
*
|
2003-06-25 |
2012-06-05 |
Novo Nordisk Health Care Ag |
Composición líquida de polipépttidos del factor VII
|
|
US7687478B2
(en)
*
|
2003-06-30 |
2010-03-30 |
Otsuka Chemical Co., Ltd. |
Disialoundecasaccharide chain asparagine/fatty acid amide and medical drug containing the same
|
|
JP5306597B2
(ja)
*
|
2003-07-01 |
2013-10-02 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
第vii因子ポリペプチドの液体水性薬学的組成物
|
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
|
EP1656158B1
(en)
|
2003-08-14 |
2016-03-09 |
Novo Nordisk Health Care AG |
Liquid, aqueous pharmaceutical composition of factor vii polypeptides
|
|
CN101870729A
(zh)
|
2003-09-09 |
2010-10-27 |
诺和诺德医疗保健公司 |
凝固因子ⅶ多肽
|
|
ATE455174T1
(de)
|
2003-09-23 |
2010-01-15 |
Univ North Carolina |
Zellen, die vitamin-k-reduktase und vitamin-k- abhängiges protein coexprimieren und deren anwendung zur verbesserung der produktivität von diesem vitamin-k-abhängigen protein
|
|
US7645602B2
(en)
|
2003-09-23 |
2010-01-12 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for producing vitamin K dependent proteins
|
|
ES2565077T3
(es)
|
2003-10-10 |
2016-03-31 |
Novo Nordisk Health Care Ag |
Método para producción en gran escala de un polipéptido en células eucariotas
|
|
GB0324044D0
(en)
|
2003-10-14 |
2003-11-19 |
Astrazeneca Ab |
Protein
|
|
EP2272951B1
(en)
*
|
2003-10-14 |
2014-07-23 |
Baxter International Inc. |
Vitamin k epoxide recycling polypeptide vkorc1, a therapeutic target of coumarin and their derivatives
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
AU2004294403A1
(en)
|
2003-12-01 |
2005-06-16 |
Novo Nordisk Health Care Ag |
Nanofiltration of factor VII solutions to remove virus
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
EP2311437A1
(en)
*
|
2003-12-19 |
2011-04-20 |
Novo Nordisk Health Care AG |
Stabilised compositions of factor VII polypeptides
|
|
WO2005068620A1
(en)
*
|
2004-01-07 |
2005-07-28 |
Novo Nordisk Health Care Ag |
Method for the production of recombinant proteins
|
|
CA2565414A1
(en)
|
2004-05-04 |
2005-11-24 |
Novo Nordisk Health Care Ag |
O-linked glycoforms of polypeptides and method to manufacture them
|
|
RU2396347C2
(ru)
*
|
2004-08-17 |
2010-08-10 |
Ксл Бехринг Гмбх |
Модифицированные витамин к-зависимые полипептиды
|
|
CN102718859A
(zh)
*
|
2004-09-29 |
2012-10-10 |
诺和诺德医疗保健公司 |
通过分级洗脱从阴离子交换材料中纯化批量凝血因子vii多肽
|
|
EP1814573B1
(en)
|
2004-10-29 |
2016-03-09 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
EP1831363A1
(en)
*
|
2004-12-21 |
2007-09-12 |
Novo Nordisk Health Care AG |
Expression of gamma-carboxylated polypeptides in gamma-carboxylation deficient host systems
|
|
EP1831242B1
(en)
*
|
2004-12-23 |
2012-09-26 |
Novo Nordisk Health Care AG |
Reduction of the content of protein contaminants in compositions comprising a vitamin k-dependent protein of interest
|
|
CA2593682C
(en)
|
2005-01-10 |
2016-03-22 |
Neose Technologies, Inc. |
Glycopegylated granulocyte colony stimulating factor
|
|
JP5523674B2
(ja)
*
|
2005-02-11 |
2014-06-18 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
植物タンパク質加水分解産物を含有する血清フリーの細胞培養液におけるポリペプチドの生産
|
|
KR101310532B1
(ko)
|
2005-02-28 |
2013-09-23 |
박스터 헬쓰케어 에스에이 |
비타민 k 의존성 단백질 발현의 개선을 위한 비타민 k에폭사이드 환원효소 소단위 1의 재조합 동시발현
|
|
CA2601574C
(en)
|
2005-03-15 |
2014-12-02 |
University Of North Carolina At Chapel Hill |
Methods and compositions for producing active vitamin k-dependent proteins
|
|
US9187546B2
(en)
|
2005-04-08 |
2015-11-17 |
Novo Nordisk A/S |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
|
KR101599062B1
(ko)
*
|
2005-04-13 |
2016-03-02 |
아스트라제네카 아베 |
감마 카르복실화를 필요로 하는 단백질 생산용 벡터를 포함하는 숙주 세포
|
|
US20080255026A1
(en)
|
2005-05-25 |
2008-10-16 |
Glycopegylated Factor 1X |
Glycopegylated Factor Ix
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
US20090048440A1
(en)
|
2005-11-03 |
2009-02-19 |
Neose Technologies, Inc. |
Nucleotide Sugar Purification Using Membranes
|
|
ES2503365T5
(es)
*
|
2005-12-21 |
2017-10-31 |
Cnj Holdings, Inc |
Método para producir proteínas dependientes de vitamina K biológicamente activas por métodos recombinantes
|
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
|
DK2004214T3
(da)
|
2006-03-16 |
2013-02-18 |
Stellaris Pharmaceuticals Aps |
Lokalbehandling med faktor VII
|
|
ATE474917T1
(de)
*
|
2006-04-11 |
2010-08-15 |
Csl Behring Gmbh |
Verfahren zur erhöhung der in-vivo-gewinnung therapeutischer polypeptide
|
|
FR2901707B1
(fr)
|
2006-05-31 |
2017-09-29 |
Lab Francais Du Fractionnement |
Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
|
|
WO2008009635A2
(en)
*
|
2006-07-17 |
2008-01-24 |
Novo Nordisk Health Care Ag |
Factor viia analogues with increased activity for treating thrombocytopenia
|
|
CN101516388B
(zh)
|
2006-07-21 |
2012-10-31 |
诺和诺德公司 |
通过o-联糖基化序列的肽的糖基化
|
|
FR2904558B1
(fr)
*
|
2006-08-01 |
2008-10-17 |
Lab Francais Du Fractionnement |
"composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
WO2008056816A1
(fr)
*
|
2006-11-07 |
2008-05-15 |
Kyoto University |
Support de suspension pour une molécule d'acide nucléique linéaire, procédé d'extension d'une molécule d'acide nucléique linéaire et spécimen de molécule d'acide nucléique linéaire
|
|
DK2101821T3
(da)
*
|
2006-12-15 |
2014-10-06 |
Baxter Healthcare Sa |
Faktor VIIA-(poly)sialinsyre-konjugat med forlænget halveringstid in vivo
|
|
WO2008077616A1
(en)
|
2006-12-22 |
2008-07-03 |
Csl Behring Gmbh |
Modified coagulation factors with prolonged in vivo half-life
|
|
JP5558106B2
(ja)
*
|
2007-01-03 |
2014-07-23 |
ノボ ノルディスク ヘルス ケア アーゲー |
凝固第vii因子関連ポリペプチドの皮下投与
|
|
EP2144923B1
(en)
|
2007-04-03 |
2013-02-13 |
BioGeneriX AG |
Methods of treatment using glycopegylated g-csf
|
|
RU2571931C2
(ru)
*
|
2007-04-13 |
2015-12-27 |
Каталист Биосайенсис, Инк. |
Полипептиды на основе модифицированного фактора vii и их применение
|
|
AU2014202989B2
(en)
*
|
2007-04-26 |
2016-07-07 |
Aptevo Biotherapeutics Llc |
Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same
|
|
AU2008245524A1
(en)
*
|
2007-04-26 |
2008-11-06 |
Cnj Holdings, Inc. |
Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
|
|
AU2016238889B2
(en)
*
|
2007-04-26 |
2019-06-27 |
Aptevo Biotherapeutics Llc |
Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
|
|
WO2008154639A2
(en)
|
2007-06-12 |
2008-12-18 |
Neose Technologies, Inc. |
Improved process for the production of nucleotide sugars
|
|
US8206967B2
(en)
|
2007-07-06 |
2012-06-26 |
Medimmune Limited |
Method for production of recombinant human thrombin
|
|
EP2014299A1
(en)
*
|
2007-07-11 |
2009-01-14 |
Novo Nordisk A/S |
Subcutaneous administration of coagulation factor VII
|
|
EP2244814B1
(en)
|
2007-12-28 |
2021-06-02 |
Takeda Pharmaceutical Company Limited |
Recombinant vwf formulations
|
|
US11197916B2
(en)
|
2007-12-28 |
2021-12-14 |
Takeda Pharmaceutical Company Limited |
Lyophilized recombinant VWF formulations
|
|
US20130189239A1
(en)
|
2008-02-27 |
2013-07-25 |
Novo Nordisk A/S |
Conjugated Factor VIII Molecules
|
|
TWI465247B
(zh)
|
2008-04-11 |
2014-12-21 |
Catalyst Biosciences Inc |
經修飾的因子vii多肽和其用途
|
|
EP2349314B1
(en)
|
2008-10-21 |
2013-02-27 |
Baxter International Inc. |
Lyophilized recombinant vwf formulations
|
|
PT2356247E
(pt)
|
2008-11-12 |
2015-10-26 |
Baxalta Inc |
Método de produção de fator vii isento de soro e de insulina
|
|
JP5027106B2
(ja)
*
|
2008-12-25 |
2012-09-19 |
一般財団法人阪大微生物病研究会 |
日本脳炎ウイルス抗原
|
|
EP3081233B1
(en)
|
2009-07-27 |
2020-12-23 |
Baxalta GmbH |
Glycopolysialylation of proteins other than blood coagulation proteins
|
|
BR112012001814A8
(pt)
|
2009-07-27 |
2018-02-06 |
Baxalta GmbH |
Conjugados de proteína de coagulação sanguínea
|
|
US8809501B2
(en)
|
2009-07-27 |
2014-08-19 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
RU2744370C2
(ru)
|
2009-07-27 |
2021-03-05 |
Баксалта Инкорпорейтед |
Конъюгаты белков свертывания крови
|
|
US8642737B2
(en)
|
2010-07-26 |
2014-02-04 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
US8580554B2
(en)
|
2009-07-31 |
2013-11-12 |
Baxter International Inc. |
Method of producing a polypeptide or virus of interest in a continuous cell culture
|
|
WO2011053738A1
(en)
*
|
2009-10-30 |
2011-05-05 |
Inspiration Biopharmaceuticals, Inc. |
Method of producing recombinant vitamin k dependent proteins
|
|
US20110136682A1
(en)
*
|
2009-12-04 |
2011-06-09 |
Momenta Pharmaceuticals, Inc. |
Antennary fucosylation in glycoproteins from cho cells
|
|
FR2954349A1
(fr)
|
2009-12-22 |
2011-06-24 |
Agronomique Inst Nat Rech |
Sulfatase modifiant selectivement les glycosaminoglycanes
|
|
WO2012075138A1
(en)
*
|
2010-11-30 |
2012-06-07 |
Progenetics Llc |
Method of producing biologically active vitamin k dependent proteins in transgenic animals
|
|
US9631002B2
(en)
|
2010-12-21 |
2017-04-25 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for producing active vitamin K-dependent proteins
|
|
ES2800983T3
(es)
|
2010-12-22 |
2021-01-07 |
Baxalta GmbH |
Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína
|
|
WO2012149197A2
(en)
|
2011-04-27 |
2012-11-01 |
Abbott Laboratories |
Methods for controlling the galactosylation profile of recombinantly-expressed proteins
|
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
|
US9150645B2
(en)
|
2012-04-20 |
2015-10-06 |
Abbvie, Inc. |
Cell culture methods to reduce acidic species
|
|
US9181572B2
(en)
|
2012-04-20 |
2015-11-10 |
Abbvie, Inc. |
Methods to modulate lysine variant distribution
|
|
US9512214B2
(en)
|
2012-09-02 |
2016-12-06 |
Abbvie, Inc. |
Methods to control protein heterogeneity
|
|
WO2014057069A1
(en)
|
2012-10-10 |
2014-04-17 |
Novo Nordisk Health Care Ag |
Liquid pharmaceutical composition of factor vii polypeptide
|
|
SG11201507230PA
(en)
|
2013-03-12 |
2015-10-29 |
Abbvie Inc |
Human antibodies that bind human tnf-alpha and methods of preparing the same
|
|
WO2014151878A2
(en)
|
2013-03-14 |
2014-09-25 |
Abbvie Inc. |
Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
|
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
|
FR3006591B1
(fr)
|
2013-06-11 |
2016-05-06 |
Lab Francais Du Fractionnement |
Composition de facteur vii presentant un point isoelectrique substantiellement homogene
|
|
US9598667B2
(en)
|
2013-10-04 |
2017-03-21 |
Abbvie Inc. |
Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
|
|
US9085618B2
(en)
|
2013-10-18 |
2015-07-21 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same
|
|
US9181337B2
(en)
|
2013-10-18 |
2015-11-10 |
Abbvie, Inc. |
Modulated lysine variant species compositions and methods for producing and using the same
|
|
US20150139988A1
(en)
|
2013-11-15 |
2015-05-21 |
Abbvie, Inc. |
Glycoengineered binding protein compositions
|
|
NZ724826A
(en)
*
|
2014-04-16 |
2022-07-29 |
Cmc Biologics As |
A high cell density fill and draw fermentation process
|
|
KR102391259B1
(ko)
|
2014-06-04 |
2022-04-26 |
암젠 인크 |
포유류 세포 배양물을 회수하는 방법
|
|
US9714302B2
(en)
|
2014-10-10 |
2017-07-25 |
W. R. Grace & Co.—Conn. |
Process for preparing spherical polymerization catalyst components for use in olefin polymerizations
|
|
FR3034669B1
(fr)
|
2015-04-07 |
2020-02-14 |
Laboratoire Francais Du Fractionnement Et Des Biotechnologies |
Nouvelle utilisation du facteur von willebrand
|
|
BR102015012334A2
(pt)
|
2015-05-27 |
2016-11-29 |
Fundação Hemoct De Ribeirão Preto Fundherp |
processo de produção do fator vii de coagulação sanguínea e fator vii de coagulação sanguínea
|
|
WO2017025566A1
(en)
*
|
2015-08-10 |
2017-02-16 |
Glycotope Gmbh |
Improved recombinant factor vii
|
|
AU2016363789B2
(en)
*
|
2015-12-02 |
2022-06-02 |
CSL Behring Lengnau AG |
Improved media for the expression of recombinant vitamin K-dependent proteins
|
|
EP3488858A1
(en)
|
2017-11-27 |
2019-05-29 |
Laboratoire Français du Fractionnement et des Biotechnologies |
A von willebrand factor composition for use in treating a pathology mediated by angiogenesis
|
|
EP3833381B1
(en)
|
2019-08-15 |
2022-08-03 |
Catalyst Biosciences, Inc. |
Modified factor vii polypeptides for subcutaneous administration
|
|
CN117434281B
(zh)
*
|
2023-10-18 |
2026-01-06 |
上海太阳生物技术有限公司 |
组合物、检测试剂、检测试剂盒以及在制备检测凝血因子x活性中的应用
|