|
US7786070B2
(en)
|
1997-09-10 |
2010-08-31 |
Novo Nordisk Healthcare A/G |
Subcutaneous administration of coagulation factor VII
|
|
US20050032690A1
(en)
*
|
1997-09-10 |
2005-02-10 |
Rojkjaer Lisa Payne |
Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia
|
|
US6747003B1
(en)
|
1997-10-23 |
2004-06-08 |
Regents Of The University Of Minnesota |
Modified vitamin K-dependent polypeptides
|
|
US7247708B2
(en)
|
1997-10-23 |
2007-07-24 |
Regents Of The University Of Minnesota |
Modified vitamin K-dependent polypeptides
|
|
BRPI9910332B8
(pt)
|
1998-05-06 |
2021-05-25 |
Genentech Inc |
método para purificação de um polipeptídio a partir de uma composição
|
|
EP1982732A3
(en)
|
2000-02-11 |
2011-06-08 |
Bayer HealthCare LLC |
Factor VII or VIIA-like conjugates
|
|
US7812132B2
(en)
|
2000-04-28 |
2010-10-12 |
Regents Of The University Of Minnesota |
Modified vitamin K-dependent polypeptides
|
|
US7220837B1
(en)
|
2000-04-28 |
2007-05-22 |
Regents Of The University Of Minnesota |
Modified vitamin K-dependent polypeptides
|
|
US20030211094A1
(en)
*
|
2001-06-26 |
2003-11-13 |
Nelsestuen Gary L. |
High molecular weight derivatives of vitamin k-dependent polypeptides
|
|
US20030040480A1
(en)
*
|
2001-07-20 |
2003-02-27 |
Rasmus Rojkjaer |
Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides
|
|
HUP0402158A2
(hu)
|
2001-10-02 |
2005-01-28 |
Novo Nordisk Health Care Ag |
Rekombináns fehérjék előállítási eljárása eukarióta sejtekben
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
KR20040065278A
(ko)
*
|
2001-12-21 |
2004-07-21 |
노보 노르디스크 에이/에스 |
변경된 인자 ⅶ 폴리펩티드의 액체 조성물
|
|
RU2357751C2
(ru)
|
2001-12-21 |
2009-06-10 |
Ново Нордиск Хелт Кэр Аг |
Жидкая композиция полипептидов фактора vii
|
|
US7700733B2
(en)
*
|
2002-04-30 |
2010-04-20 |
Bayer Healthcare Llc |
Factor VII or VIIa polypeptide variants
|
|
US20040009918A1
(en)
*
|
2002-05-03 |
2004-01-15 |
Hanne Nedergaard |
Stabilised solid compositions of modified factor VII
|
|
BR0311978A
(pt)
*
|
2002-06-21 |
2005-03-22 |
Novo Nordisk Healthcare Ag |
Preparação, método para preparar a mesma, formulação farmacêutica, métodos para tratar de uma sìndrome responsiva ao fator vii, para prevenir hemorragias indesejáveis, para prevenir coagulação sanguìnea indesejável e para prevenir as reações mediadas pelo fator tecidual, e, uso de uma preparação
|
|
BRPI0311959B8
(pt)
|
2002-06-21 |
2021-05-25 |
Novo Nordisk Healthcare Ag |
composição, métodos para preparar um polipeptídeo estável do fator vii, e para tratar uma síndrome responsiva do fator vii, e, uso do polipeptídeo do fator vii
|
|
EP1549677B1
(en)
*
|
2002-09-30 |
2011-04-13 |
Bayer HealthCare LLC |
FVII OR FVIIa VARIANTS HAVING INCREASED CLOTTING ACTIVITY
|
|
AU2004222625A1
(en)
*
|
2003-03-18 |
2004-09-30 |
Novo Nordisk Health Care Ag |
Liquid, aqueous, pharmaceutical compositions of factor VII polypeptides
|
|
AU2004221758B2
(en)
*
|
2003-03-18 |
2010-07-22 |
Novo Nordisk Health Care Ag |
Method for the production of GLA-residue containing serine proteases
|
|
DK2085470T3
(da)
|
2003-03-20 |
2012-08-06 |
Bayer Healthcare Llc |
FVII- eller FVIIa-varianter
|
|
US7897734B2
(en)
*
|
2003-03-26 |
2011-03-01 |
Novo Nordisk Healthcare Ag |
Method for the production of proteins
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
WO2006127896A2
(en)
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated factor ix
|
|
NZ542586A
(en)
|
2003-04-09 |
2009-11-27 |
Biogenerix Ag |
Method of forming a covalent conjugate between a G-CSF peptide and PEG
|
|
RU2364609C2
(ru)
*
|
2003-05-23 |
2009-08-20 |
Ново Нордиск Хелт Кэр Аг |
Стабилизация белка в растворе
|
|
DK1644504T3
(da)
*
|
2003-06-19 |
2010-05-25 |
Bayer Healthcare Llc |
Faktor VII- eller -VIIA-Gla-domænevarianter
|
|
WO2004112828A1
(en)
*
|
2003-06-25 |
2004-12-29 |
Novo Nordisk Health Care Ag |
Liquid composition of factor vii polypeptides
|
|
US7687478B2
(en)
*
|
2003-06-30 |
2010-03-30 |
Otsuka Chemical Co., Ltd. |
Disialoundecasaccharide chain asparagine/fatty acid amide and medical drug containing the same
|
|
ATE446768T1
(de)
*
|
2003-07-01 |
2009-11-15 |
Novo Nordisk Healthcare Ag |
Flüssige wässrige pharmazeutische zusammnesetzung von factor vii polypeptiden
|
|
US9005625B2
(en)
|
2003-07-25 |
2015-04-14 |
Novo Nordisk A/S |
Antibody toxin conjugates
|
|
AU2004264282B2
(en)
|
2003-08-14 |
2010-10-14 |
Novo Nordisk Health Care Ag |
Liquid, aqueous pharmaceutical composition of Factor VII polypeptides
|
|
EP2392655A3
(en)
|
2003-09-09 |
2012-02-29 |
Novo Nordisk Health Care AG |
Coagulation factor VII polypeptides
|
|
PT2380985E
(pt)
|
2003-09-23 |
2014-03-26 |
Univ North Carolina |
Células que expressam a vitamina k epóxido reductase e sua utilização
|
|
JP4740138B2
(ja)
|
2003-10-10 |
2011-08-03 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
真核生物細胞におけるポリペプチドの大規模生産方法及びそれに適した培養容器
|
|
GB0324044D0
(en)
|
2003-10-14 |
2003-11-19 |
Astrazeneca Ab |
Protein
|
|
DK2189523T3
(da)
|
2003-10-14 |
2012-03-12 |
Baxter Int |
VKORC1 (vitamin K-epoxid-tilbageføringspolypeptid), et terapeutisk mål for coumarin og dets derivater
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
CN106916802B
(zh)
|
2003-12-01 |
2022-03-25 |
诺和诺德医疗保健公司 |
液体因子vii组合物的病毒过滤
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
KR20150138427A
(ko)
*
|
2003-12-19 |
2015-12-09 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
인자 vii 폴리펩티드의 안정화된 조성물
|
|
WO2005068620A1
(en)
*
|
2004-01-07 |
2005-07-28 |
Novo Nordisk Health Care Ag |
Method for the production of recombinant proteins
|
|
KR20070008645A
(ko)
|
2004-05-04 |
2007-01-17 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
폴리펩티드의 o-연결된 단백당형 및 그들의 제조 방법
|
|
BRPI0514396A2
(pt)
*
|
2004-08-17 |
2009-05-12 |
Csl Behring Gmbh |
polipeptìdeos dependentes de vitamina k modificada
|
|
JP2008514216A
(ja)
*
|
2004-09-29 |
2008-05-08 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
Desgla−vii因子ポリペプチド構造の除去による、vii因子ポリペプチドの原体の精製
|
|
EP3061461A1
(en)
|
2004-10-29 |
2016-08-31 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
EP1831363A1
(en)
*
|
2004-12-21 |
2007-09-12 |
Novo Nordisk Health Care AG |
Expression of gamma-carboxylated polypeptides in gamma-carboxylation deficient host systems
|
|
JP2008525381A
(ja)
*
|
2004-12-23 |
2008-07-17 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
関心のあるビタミンk依存性タンパク質を含んでなる組成物中におけるタンパク質混入物の量の減少
|
|
US9029331B2
(en)
|
2005-01-10 |
2015-05-12 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
ES2380485T3
(es)
|
2005-02-11 |
2012-05-14 |
Novo Nordisk Health Care Ag |
Producción de un polipéptido en un lÃquido de cultivo sin suero con hidrolizado de proteÃnas vegetales
|
|
PT1853700E
(pt)
|
2005-02-28 |
2013-01-14 |
Baxter Int |
Co-expressão recombinante da subunidade 1 da vitamina k epóxido redutase para melhorar a expressão de proteína dependente de vitamina
|
|
CA2601574C
(en)
|
2005-03-15 |
2014-12-02 |
University Of North Carolina At Chapel Hill |
Methods and compositions for producing active vitamin k-dependent proteins
|
|
EP1871795A4
(en)
|
2005-04-08 |
2010-03-31 |
Biogenerix Ag |
COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE
|
|
WO2006110083A1
(en)
|
2005-04-13 |
2006-10-19 |
Astrazeneca Ab |
A host cell comprising a vector for production of proteins requiring gamma-carboxylation
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
|
PL1969127T5
(pl)
*
|
2005-12-21 |
2018-02-28 |
Cnj Holdings, Inc |
Metoda wytwarzania biologicznie czynnych białek zależnych od witaminy K metodami rekombinacji
|
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
|
EP2004214B1
(en)
|
2006-03-16 |
2012-11-07 |
STELLARIS PHARMACEUTICALS Aps |
Local treatment with factor vii
|
|
DE602007007923D1
(de)
*
|
2006-04-11 |
2010-09-02 |
Csl Behring Gmbh |
Verfahren zur erhöhung der in-vivo-gewinnung therapeutischer polypeptide
|
|
FR2901707B1
(fr)
*
|
2006-05-31 |
2017-09-29 |
Lab Francais Du Fractionnement |
Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
|
|
WO2008009635A2
(en)
*
|
2006-07-17 |
2008-01-24 |
Novo Nordisk Health Care Ag |
Factor viia analogues with increased activity for treating thrombocytopenia
|
|
US20080242607A1
(en)
|
2006-07-21 |
2008-10-02 |
Neose Technologies, Inc. |
Glycosylation of peptides via o-linked glycosylation sequences
|
|
FR2904558B1
(fr)
*
|
2006-08-01 |
2008-10-17 |
Lab Francais Du Fractionnement |
"composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
WO2008056816A1
(fr)
*
|
2006-11-07 |
2008-05-15 |
Kyoto University |
Support de suspension pour une molécule d'acide nucléique linéaire, procédé d'extension d'une molécule d'acide nucléique linéaire et spécimen de molécule d'acide nucléique linéaire
|
|
AU2007333049B2
(en)
*
|
2006-12-15 |
2014-02-20 |
Takeda Pharmaceutical Company Limited |
Factor VIIa-(poly)sialic acid conjugate having prolonged in vivo half-life
|
|
CA2673459C
(en)
|
2006-12-22 |
2016-09-13 |
Stefan Schulte |
Modified coagulation factors with prolonged in vivo half-life
|
|
WO2008081024A1
(en)
*
|
2007-01-03 |
2008-07-10 |
Novo Nordisk Health Care Ag |
Subcutaneous administration of coagulation factor viia-related popypeptdes
|
|
CN101796063B
(zh)
|
2007-04-03 |
2017-03-22 |
拉蒂奥法姆有限责任公司 |
使用糖聚乙二醇化g‑csf的治疗方法
|
|
EP2481797A1
(en)
*
|
2007-04-13 |
2012-08-01 |
Catalyst Biosciences, Inc. |
Modified factor VII polypeptides and uses thereof
|
|
AU2014202989B2
(en)
*
|
2007-04-26 |
2016-07-07 |
Aptevo Biotherapeutics Llc |
Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same
|
|
AU2016238889B2
(en)
*
|
2007-04-26 |
2019-06-27 |
Aptevo Biotherapeutics Llc |
Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
|
|
CA2683423C
(en)
*
|
2007-04-26 |
2020-10-27 |
Inspiration Biopharmaceuticals, Inc. |
Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same
|
|
US9493499B2
(en)
|
2007-06-12 |
2016-11-15 |
Novo Nordisk A/S |
Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
|
|
US8206967B2
(en)
|
2007-07-06 |
2012-06-26 |
Medimmune Limited |
Method for production of recombinant human thrombin
|
|
EP2014299A1
(en)
*
|
2007-07-11 |
2009-01-14 |
Novo Nordisk A/S |
Subcutaneous administration of coagulation factor VII
|
|
US11197916B2
(en)
|
2007-12-28 |
2021-12-14 |
Takeda Pharmaceutical Company Limited |
Lyophilized recombinant VWF formulations
|
|
WO2009086400A2
(en)
|
2007-12-28 |
2009-07-09 |
Baxter International Inc. |
Recombinant vwf formulations
|
|
DK2257311T3
(da)
|
2008-02-27 |
2014-06-30 |
Novo Nordisk As |
Konjugerede Faktor VIII-Molekyler
|
|
TWI465247B
(zh)
|
2008-04-11 |
2014-12-21 |
Catalyst Biosciences Inc |
經修飾的因子vii多肽和其用途
|
|
DK2349314T3
(da)
|
2008-10-21 |
2013-05-27 |
Baxter Int |
Lyofiliserede præparater af rekombinant VWF
|
|
HUE026210T2
(en)
*
|
2008-11-12 |
2016-05-30 |
Baxalta Inc |
Procedure for serum-free, insulin-free VII. factor
|
|
JP5027106B2
(ja)
*
|
2008-12-25 |
2012-09-19 |
一般財団法人阪大微生物病研究会 |
日本脳炎ウイルス抗原
|
|
US8642737B2
(en)
|
2010-07-26 |
2014-02-04 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
WO2011012850A2
(en)
|
2009-07-27 |
2011-02-03 |
Lipoxen Technologies Limited |
Glycopolysialylation of non-blood coagulation proteins
|
|
US8637640B2
(en)
|
2009-07-27 |
2014-01-28 |
Baxter International Inc. |
Blood coagulation protein conjugates
|
|
US8809501B2
(en)
|
2009-07-27 |
2014-08-19 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
RU2744370C2
(ru)
|
2009-07-27 |
2021-03-05 |
Баксалта Инкорпорейтед |
Конъюгаты белков свертывания крови
|
|
US8580554B2
(en)
|
2009-07-31 |
2013-11-12 |
Baxter International Inc. |
Method of producing a polypeptide or virus of interest in a continuous cell culture
|
|
EP2494040B1
(en)
*
|
2009-10-30 |
2018-08-29 |
Aptevo BioTherapeutics LLC |
Method of producing recombinant vitamin k dependent proteins
|
|
WO2011069056A2
(en)
*
|
2009-12-04 |
2011-06-09 |
Momenta Pharmaceuticals, Inc. |
Antennary fucosylation in glycoproteins from cho cells
|
|
FR2954349A1
(fr)
|
2009-12-22 |
2011-06-24 |
Agronomique Inst Nat Rech |
Sulfatase modifiant selectivement les glycosaminoglycanes
|
|
WO2012075138A1
(en)
*
|
2010-11-30 |
2012-06-07 |
Progenetics Llc |
Method of producing biologically active vitamin k dependent proteins in transgenic animals
|
|
EP2655607A4
(en)
|
2010-12-21 |
2014-05-14 |
Univ North Carolina |
METHOD AND COMPOSITIONS FOR PRODUCING ACTIVE VITAMIN K-DEPENDENT PROTEINS
|
|
PL2654794T3
(pl)
|
2010-12-22 |
2020-07-27 |
Baxalta GmbH |
Materiały i sposoby sprzęgania rozpuszczalnej w wodzie pochodnej kwasu tłuszczowego z białkiem
|
|
US9062106B2
(en)
|
2011-04-27 |
2015-06-23 |
Abbvie Inc. |
Methods for controlling the galactosylation profile of recombinantly-expressed proteins
|
|
WO2013158279A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Protein purification methods to reduce acidic species
|
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
|
WO2013158273A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Methods to modulate c-terminal lysine variant distribution
|
|
US9512214B2
(en)
|
2012-09-02 |
2016-12-06 |
Abbvie, Inc. |
Methods to control protein heterogeneity
|
|
EP2906236A1
(en)
|
2012-10-10 |
2015-08-19 |
Novo Nordisk Health Care AG |
Liquid pharmaceutical composition of factor vii polypeptide
|
|
SG11201507230PA
(en)
|
2013-03-12 |
2015-10-29 |
Abbvie Inc |
Human antibodies that bind human tnf-alpha and methods of preparing the same
|
|
WO2014151878A2
(en)
|
2013-03-14 |
2014-09-25 |
Abbvie Inc. |
Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
|
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
|
FR3006591B1
(fr)
|
2013-06-11 |
2016-05-06 |
Lab Francais Du Fractionnement |
Composition de facteur vii presentant un point isoelectrique substantiellement homogene
|
|
EP3052640A2
(en)
|
2013-10-04 |
2016-08-10 |
AbbVie Inc. |
Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
|
|
US9181337B2
(en)
|
2013-10-18 |
2015-11-10 |
Abbvie, Inc. |
Modulated lysine variant species compositions and methods for producing and using the same
|
|
US9085618B2
(en)
|
2013-10-18 |
2015-07-21 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same
|
|
WO2015073884A2
(en)
|
2013-11-15 |
2015-05-21 |
Abbvie, Inc. |
Glycoengineered binding protein compositions
|
|
WO2015158696A1
(en)
*
|
2014-04-16 |
2015-10-22 |
Cmc Biologics A/S |
A high cell density fill and draw fermentation process
|
|
SG10202113019XA
(en)
|
2014-06-04 |
2021-12-30 |
Amgen Inc |
Methods for harvesting mammalian cell cultures
|
|
US9714302B2
(en)
|
2014-10-10 |
2017-07-25 |
W. R. Grace & Co.—Conn. |
Process for preparing spherical polymerization catalyst components for use in olefin polymerizations
|
|
FR3034669B1
(fr)
|
2015-04-07 |
2020-02-14 |
Laboratoire Francais Du Fractionnement Et Des Biotechnologies |
Nouvelle utilisation du facteur von willebrand
|
|
BR102015012334A2
(pt)
|
2015-05-27 |
2016-11-29 |
Fundação Hemoct De Ribeirão Preto Fundherp |
processo de produção do fator vii de coagulação sanguínea e fator vii de coagulação sanguínea
|
|
WO2017025566A1
(en)
*
|
2015-08-10 |
2017-02-16 |
Glycotope Gmbh |
Improved recombinant factor vii
|
|
ES2803773T3
(es)
*
|
2015-12-02 |
2021-01-29 |
CSL Behring Lengnau AG |
Medios mejorados para la expresión de proteínas recombinantes dependientes de vitamina k
|
|
EP3488858A1
(en)
|
2017-11-27 |
2019-05-29 |
Laboratoire Français du Fractionnement et des Biotechnologies |
A von willebrand factor composition for use in treating a pathology mediated by angiogenesis
|
|
WO2021030787A1
(en)
|
2019-08-15 |
2021-02-18 |
Catalyst Biosciences, Inc. |
Modified factor vii polypeptides for subcutaneous administration and on-demand treatment
|
|
CN117434281B
(zh)
*
|
2023-10-18 |
2026-01-06 |
上海太阳生物技术有限公司 |
组合物、检测试剂、检测试剂盒以及在制备检测凝血因子x活性中的应用
|