JP2004505912A5 - - Google Patents

Download PDF

Info

Publication number
JP2004505912A5
JP2004505912A5 JP2002517052A JP2002517052A JP2004505912A5 JP 2004505912 A5 JP2004505912 A5 JP 2004505912A5 JP 2002517052 A JP2002517052 A JP 2002517052A JP 2002517052 A JP2002517052 A JP 2002517052A JP 2004505912 A5 JP2004505912 A5 JP 2004505912A5
Authority
JP
Japan
Prior art keywords
guanidine
nitrobenzylideneamino
composition according
guanidine acetate
acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002517052A
Other languages
English (en)
Japanese (ja)
Other versions
JP5654190B2 (ja
JP2004505912A (ja
Filing date
Publication date
Priority claimed from GB0019357A external-priority patent/GB0019357D0/en
Application filed filed Critical
Publication of JP2004505912A publication Critical patent/JP2004505912A/ja
Publication of JP2004505912A5 publication Critical patent/JP2004505912A5/ja
Application granted granted Critical
Publication of JP5654190B2 publication Critical patent/JP5654190B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2002517052A 2000-08-07 2001-08-07 ベンジリデンアミノグアニジンおよびヒドロキシグアニジンのメラノコルチン受容体リガンドとしての使用 Expired - Fee Related JP5654190B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0019357.3 2000-08-07
GB0019357A GB0019357D0 (en) 2000-08-07 2000-08-07 Novel phenyl guanidines
PCT/GB2001/003534 WO2002011715A2 (en) 2000-08-07 2001-08-07 The use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011148414A Division JP5683396B2 (ja) 2000-08-07 2011-07-04 ベンジリデンアミノグアニジンおよびヒドロキシグアニジンのメラノコルチン受容体リガンドとしての使用

Publications (3)

Publication Number Publication Date
JP2004505912A JP2004505912A (ja) 2004-02-26
JP2004505912A5 true JP2004505912A5 (https=) 2007-08-30
JP5654190B2 JP5654190B2 (ja) 2015-01-14

Family

ID=9897134

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002517052A Expired - Fee Related JP5654190B2 (ja) 2000-08-07 2001-08-07 ベンジリデンアミノグアニジンおよびヒドロキシグアニジンのメラノコルチン受容体リガンドとしての使用
JP2011148414A Expired - Fee Related JP5683396B2 (ja) 2000-08-07 2011-07-04 ベンジリデンアミノグアニジンおよびヒドロキシグアニジンのメラノコルチン受容体リガンドとしての使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011148414A Expired - Fee Related JP5683396B2 (ja) 2000-08-07 2011-07-04 ベンジリデンアミノグアニジンおよびヒドロキシグアニジンのメラノコルチン受容体リガンドとしての使用

Country Status (12)

Country Link
US (6) US20040024060A1 (https=)
EP (1) EP1313461A2 (https=)
JP (2) JP5654190B2 (https=)
KR (1) KR100929363B1 (https=)
AU (1) AU2001276522A1 (https=)
BR (1) BR0113053A (https=)
CA (1) CA2417098A1 (https=)
GB (1) GB0019357D0 (https=)
IL (2) IL154272A0 (https=)
MX (1) MXPA03001072A (https=)
WO (1) WO2002011715A2 (https=)
ZA (1) ZA200300829B (https=)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000613A2 (en) * 2000-06-27 2002-01-03 Axxima Pharmaceuticals Ag Inhibitors of hepatitis b virus infection
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
GB0108631D0 (en) * 2001-04-05 2001-05-30 Melacure Therapeutics Ab Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
GB0119172D0 (en) 2001-08-06 2001-09-26 Melacure Therapeutics Ab Phenyl pyrrole derivatives
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US6967219B2 (en) * 2001-10-12 2005-11-22 Cornell Research Foundation, Inc. Reversing or preventing premature vascular senescence
US20070004743A1 (en) * 2002-02-25 2007-01-04 Xiao Linda L Intranasal administration of mc4-r agonists
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ATE547404T1 (de) 2003-09-22 2012-03-15 Msd Kk Piperidinderivate
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
BRPI0610580B8 (pt) 2005-05-30 2021-05-25 Banyu Pharma Co Ltd composto derivado de piperidina
JPWO2007018248A1 (ja) 2005-08-10 2009-02-19 萬有製薬株式会社 ピリドン化合物
WO2007024004A1 (ja) 2005-08-24 2007-03-01 Banyu Pharmaceutical Co., Ltd. フェニルピリドン誘導体
WO2007029847A1 (ja) 2005-09-07 2007-03-15 Banyu Pharmaceutical Co., Ltd. 二環性芳香族置換ピリドン誘導体
EP1940842B1 (en) 2005-09-29 2012-05-30 Merck Sharp & Dohme Corp. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
JP2009512715A (ja) 2005-10-21 2009-03-26 ノバルティス アクチエンゲゼルシャフト レニン阻害剤と抗異脂肪血症剤および/または抗肥満症剤の組み合わせ
EP1944301A4 (en) 2005-10-27 2012-01-04 Msd Kk NEW BENZOXATHIIN DERIVATIVES
ES2381205T3 (es) 2005-11-10 2012-05-24 Msd K.K. Derivado espiro aza-sustituido
NZ573457A (en) 2006-06-09 2011-06-30 Action Pharma As Phenyl pyrrole aminoguanidine derivatives
US8173629B2 (en) 2006-09-22 2012-05-08 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
US20090247560A1 (en) 2006-09-28 2009-10-01 Banyu Pharmaceutical Co., Ltd. Diaryl ketimine derivative
GB0623381D0 (en) * 2006-11-23 2007-01-03 Acure Pharma Ab Use of a compound as VEGF inhibitor
GB0624987D0 (en) 2006-12-14 2007-01-24 Acure Pharma Ab Novel aminoguanidines as melanocortin receptor ligands
ES2405655T3 (es) 2006-12-26 2013-05-31 Lantheus Medical Imaging, Inc. N-[3-bromo-4-(3-[18F]fluoropropoxi)-bencil]-guanidina para la formación de imágenes de la inervación cardíaca
JP5319518B2 (ja) 2007-04-02 2013-10-16 Msd株式会社 インドールジオン誘導体
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8442179B2 (en) * 2007-10-19 2013-05-14 The Boeing Company Method and apparatus for tagging and identifying a target
WO2009111037A2 (en) * 2008-03-04 2009-09-11 Indigene Pharmaceuticals Inc. Compositions and methods for treating nos-associated diseases
EP2264026A4 (en) 2008-03-06 2012-03-28 Msd Kk ALKYLAMINOPYRIDINDERIVATE
WO2009119726A1 (ja) 2008-03-28 2009-10-01 萬有製薬株式会社 メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体
JPWO2009154132A1 (ja) 2008-06-19 2011-12-01 Msd株式会社 スピロジアミン−ジアリールケトオキシム誘導体
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2319841A1 (en) 2008-07-30 2011-05-11 Msd K.K. (5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative
EP2348857B1 (en) 2008-10-22 2016-02-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US20110243940A1 (en) 2008-12-16 2011-10-06 Schering Corporation Bicyclic pyranone derivatives and methods of use thereof
EP2379547A1 (en) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
EP2411812B1 (en) * 2009-03-24 2013-10-02 AnaMar AB Metabolic profiles
WO2011012868A1 (en) 2009-07-31 2011-02-03 Anamar Ab Compounds for treatment of inflammation
DK3323810T3 (da) 2010-02-08 2022-03-28 Lantheus Medical Imaging Inc Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler
JP2013520502A (ja) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
ES2763815T3 (es) 2010-05-11 2020-06-01 Lantheus Medical Imaging Inc Composiciones, métodos y sistemas para la síntesis y uso de agentes de formación de imágenes
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
SG192941A1 (en) 2011-02-25 2013-09-30 Merck Sharp & Dohme Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
CN108484449A (zh) * 2011-09-09 2018-09-04 蓝瑟斯医学影像公司 用于合成和使用显像剂的组合物、方法和系统
RU2015106909A (ru) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. Антидиабетические трициклические соединения
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
GB201300435D0 (en) * 2013-01-10 2013-02-27 Medical Res Council Benzylideneguanidine Derivatives and Therapeutic Use for the Treatment of Protein Misfolding Diseases
KR20150118158A (ko) 2013-02-22 2015-10-21 머크 샤프 앤드 돔 코포레이션 항당뇨병 비시클릭 화합물
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
RU2712452C2 (ru) * 2014-07-02 2020-01-29 Инфлектис Байосайенс Новое терапевтическое применение производных бензилиденгуанидина для лечения протеинопатий
KR20170027737A (ko) * 2014-07-02 2017-03-10 인플렉티스 바이오사이언스 O-알킬-벤질리덴구아니딘 유도체 및 미스폴딩된 단백질의 축적 관련 장애의 치료를 위한 치료 용도
KR102431436B1 (ko) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
MX379437B (es) * 2015-04-08 2025-03-10 Res & Innovation Uk Derivados de hidrazina-bencilo sustituidos, como inhibidores de ppp1r15a y ppp1r15b, y el uso de los mismos para el tratamiento de trastorno de proteostasis.
WO2018069532A1 (en) 2016-10-14 2018-04-19 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
EP3558298B1 (en) 2016-12-20 2026-03-11 Merck Sharp & Dohme LLC Antidiabetic spirochroman compounds
US20180230105A1 (en) 2017-01-13 2018-08-16 Regents Of The University Of Minnesota Therapeutic compounds
CN108066763A (zh) * 2017-12-21 2018-05-25 陈敏 Pcsk9抑制剂在制备治疗t细胞介导的炎症免疫性疾病药中的应用
US20210177814A1 (en) * 2018-05-09 2021-06-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of guanabenz or derivates thereof for the treatment of type i ifn-dependent pathologies
AR117122A1 (es) 2018-11-20 2021-07-14 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
LT3773558T (lt) 2019-05-10 2022-09-12 Synact Pharma Aps Kompleksinis artrito gydymas
EP4359076B1 (en) 2021-06-21 2025-08-06 SynAct Pharma ApS Phenyl pyrrole aminoguanidine salts and formulations
US20240293343A1 (en) 2023-02-13 2024-09-05 Inflectis Bioscience Benzylideneaminoguanidine derivatives as NR2B-selective NMDA receptor antagonists and their therapeutic applications

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2584784A (en) * 1949-05-21 1952-02-05 Du Pont Salts of 1-salicylalaminoguanidine
GB892117A (en) 1958-06-20 1962-03-21 May & Baker Ltd Phenanthridine salts and their preparation
GB923398A (en) 1960-08-09 1963-04-10 Vismara Francesco Spa Diphenyl mono-and bis-formyl guanylhydrazones
DE1165013B (de) 1960-08-09 1964-03-12 Vismara Francesco Spa Verfahren zur Herstellung von Guanylhydrazonen
GB1019120A (en) 1964-03-18 1966-02-02 Shell Int Research Novel hydrazine compounds and compositions containing them
GB1204631A (en) 1967-10-12 1970-09-09 Shell Int Research Pharmacologically active benzylideneamino guanidines and their use
GB1223492A (en) 1967-10-13 1971-02-24 American Home Prod Guanidines
CH500953A (de) 1967-11-13 1970-12-31 Sandoz Ag Verfahren zur Herstellung von neuen N-Benzyliden-N'-amidinohydrazinen
US3591636A (en) * 1968-09-16 1971-07-06 Sandoz Ag Substituted benzylideneamino guanidines
GB1223493A (en) 1968-10-11 1971-02-24 American Home Prod Guanidines
US3592852A (en) * 1968-12-16 1971-07-13 Sandoz Ag Substituted benzylideneamino guanidine
DE2015321A1 (en) 1969-04-04 1970-10-08 Sandoz Ag, Basel (Schweiz) Novel guanidine derivs
FR2036989A1 (en) * 1969-04-28 1970-12-31 Anvar Amidino hydrazone antivirals
US3541218A (en) * 1969-06-18 1970-11-17 Lilly Co Eli Omicron-fluorobenzylaminoguanidine for diabetes
US3592935A (en) * 1969-12-11 1971-07-13 Sandoz Ag Substituted benzylidene hydrazines as anti-inflammatory agents
US3982020A (en) * 1970-03-17 1976-09-21 Sandoz, Inc. Substituted benzylidene hydrazines for treating hyperglycemia, obesity and inflammation
US3975533A (en) * 1970-04-29 1976-08-17 Shell Oil Company Therapeutic agents
US4060640A (en) * 1970-04-29 1977-11-29 Shell Oil Company Therapeutic agents
JPS4842969B1 (https=) 1970-12-30 1973-12-15
BE791536A (fr) 1971-11-19 1973-05-17 Merck & Co Inc Nouvelles 1,3-diamino guanidines substituees
US3896232A (en) * 1973-01-11 1975-07-22 Sandoz Ag Substituted benzylidene hydrazines as anti-migraine syndrome agents
US3941825A (en) * 1973-07-27 1976-03-02 American Cyanamid Company Substituted aminobenzylideneamino guanidine compounds
US4006249A (en) * 1975-08-06 1977-02-01 American Home Products Corporation Systemic treatment of psoriasis
US4006250A (en) * 1975-08-25 1977-02-01 American Home Products Corporation Systemic treatment of psoriasis
FR2324294A1 (fr) 1975-09-22 1977-04-15 Roussel Uclaf Nouveau medicament hypotenseur a action retardee, ainsi que le procede de preparation de ce nouveau medicament
GB1550401A (en) * 1976-01-07 1979-08-15 Hexachimie Hydrazine derivatives their preparation and their use
DE2620369C3 (de) * 1976-05-08 1979-01-04 Bayer Ag, 5090 Leverkusen Verfahren zur Wiedergewinnung von (l-S)-2-Oxo-bornansulfonat-(10)
US4312886A (en) * 1978-07-20 1982-01-26 American Home Products Corporation Prevention of gastric ulcers and depression of gastric secretion by administration of guanabenz
JPS5562017A (en) 1978-11-01 1980-05-10 Teijin Ltd Anti-inflammatory agent comprising guanidine derivative
US5958933A (en) * 1982-11-23 1999-09-28 Naftchi; N. Eric Neurologically active compounds and compounds with multiple activities
US4983604A (en) 1987-11-13 1991-01-08 The Rockefeller University Inhibitors of nonenzymatic cross-linking
ZA853488B (en) 1984-05-10 1986-12-30 American Home Prod Transdermal dosage form
DE3428342A1 (de) * 1984-08-01 1986-02-13 Boehringer Ingelheim Vetmedica GmbH, 6507 Ingelheim Futtermittelzusatz zur verbesserung des wachstums bei landwirtschaftlichen nutztieren
US6413962B1 (en) * 1988-05-02 2002-07-02 N. Eric Naftchi Guanidino compounds effective as anesthetics
DK0520032T3 (da) 1990-03-16 1999-06-14 Beth Israel Hospital Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel
CA2104873C (en) 1991-02-26 2000-05-23 James N. Campbell Compositions and methods of treatment of sympathetically maintained pain
HUT64023A (en) 1991-03-22 1993-11-29 Sandoz Ag Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds
AU664710B2 (en) * 1991-08-27 1995-11-30 Upjohn Company, The A method for treatment of metabolic disorders
US5696128A (en) 1994-07-07 1997-12-09 The Board Of Supervisors Of Louisiana University And Agricultural And Mechanical College Method of regulating immune function
US5750545A (en) * 1993-07-23 1998-05-12 The Green Cross Corporation Triazole derivative and pharmaceutical use thereof
US5599984A (en) * 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
EP0711553A1 (en) 1994-08-09 1996-05-15 Mario Cagnoni Use of the Melatonin in the traetment of the articular symptoms of trheumatoid arthritis
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
WO1996018607A1 (en) * 1994-12-12 1996-06-20 Chugai Seiyaku Kabushiki Kaisha Aniline derivative having the effect of inhibiting nitrogen monoxide synthase
US5602277A (en) 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
US5958934A (en) 1996-05-23 1999-09-28 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives and uses thereof
SE9604348D0 (sv) * 1996-11-26 1996-11-26 Wapharm Ab Användning av hydroxyguanidiner
WO1999021571A1 (en) 1997-10-27 1999-05-06 Trega Biosciences, Inc. Melanocortin receptor ligands and methods of using same
AU3166299A (en) 1998-04-09 1999-11-01 Eisai Co. Ltd. Arginine peptide analogs useful as fibroblast growth factor antagonists
EP1076649A4 (en) 1998-04-28 2010-06-02 Trega Biosciences Inc ISOQUINOLINE-BASED COMPOUNDS IN PLACE OF MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USE
WO1999064002A1 (en) 1998-06-11 1999-12-16 Merck & Co., Inc. Spiropiperidine derivatives as melanocortin receptor agonists
WO2000009115A1 (en) 1998-08-14 2000-02-24 Smithkline Beecham Corporation Grp receptor ligands
GB9827500D0 (en) 1998-12-14 1999-02-10 Wapharm Ab Compounds for control of eating, growth and body weight
US6544541B1 (en) * 1999-06-02 2003-04-08 Cardiovascular Solutions, Inc. Devices and compounds for treating arterial restenosis
WO2001005401A1 (en) 1999-07-16 2001-01-25 Trega Biosciences, Inc. Melanocortin receptor-3 ligands to treat sexual dysfunction
US6503950B1 (en) 1999-08-23 2003-01-07 David M. Ockert Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms
WO2001025192A1 (en) * 1999-10-06 2001-04-12 Melacure Therapeutics Ab Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase
GB0019357D0 (en) * 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
GB0019359D0 (en) * 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel guanidines
GB0108631D0 (en) 2001-04-05 2001-05-30 Melacure Therapeutics Ab Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
GB0119172D0 (en) * 2001-08-06 2001-09-26 Melacure Therapeutics Ab Phenyl pyrrole derivatives
US7060711B2 (en) 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
GB0622826D0 (en) * 2006-11-15 2006-12-27 Acurepharma Ab Novel amides acting on the adenosine receptors
GB0624987D0 (en) * 2006-12-14 2007-01-24 Acure Pharma Ab Novel aminoguanidines as melanocortin receptor ligands

Similar Documents

Publication Publication Date Title
JP2004505912A5 (https=)
JP2004505947A5 (https=)
EP1797878A3 (en) Benzothiazole derivatives
TR200001795T2 (tr) 1-İkameli-1-Aminometil-sikloalkan türevleri (=Gabapentin analogları), bunların hazırlanması ve nörolojik bozuklukların tedavisinde kullanımı.
JP2005516967A5 (https=)
CA2349142A1 (en) Compositions and methods for stimulating gastrointestinal motility
BR0213358A (pt) Uso de flibanserina
DK1404331T3 (da) Sustained release-formuleringer af oxymorphon
JP2005525345A5 (https=)
JP2004531516A5 (https=)
JP2010523477A5 (https=)
JP2004500426A5 (https=)
JP2010507593A5 (https=)
JP2002535370A5 (https=)
JP2002518502A5 (https=)
JPH10147529A5 (https=)
RU2004136999A (ru) Способы лечения болевых расстройств желудочно-кишечной и мочеполовой систем, использующие венлфаксин и его производные
EP1431286A3 (en) Prodigiosin derivatives for treating cancer or viral diseases
CA2389032A1 (en) Preventive or therapeutic agents for inflammatory diseases of intestine
MY133512A (en) Non-steroidal il-5 inhibitors, processes and intermediates for their preparation and pharmaceutical compositions comprising said inhibitors
BR9504230A (pt) Composto composiçao farmacêutica método para o tratamento ou prevençao de uma doença e utilizaçao de um composto
JP2006510659A5 (https=)
AU2003232805A8 (en) Pharmaceutical active substance combination and the use thereof
JP2003505513A5 (https=)
JP2003246730A5 (https=)