JP2004531516A5 - - Google Patents

Info

Publication number

JP2004531516A5

JP2004531516A5 JP2002579418A JP2002579418A JP2004531516A5 JP 2004531516 A5 JP2004531516 A5 JP 2004531516A5 JP 2002579418 A JP2002579418 A JP 2002579418A JP 2002579418 A JP2002579418 A JP 2002579418A JP 2004531516 A5 JP2004531516 A5 JP 2004531516A5

Authority

JP

Japan

Prior art keywords

guanidine

compound

patient

hydrogen

compound according

Prior art date

2002-04-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 150000001875 compounds Chemical class 0.000 claims 20
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
• 229910052739 hydrogen Inorganic materials 0.000 claims 8
• 239000001257 hydrogen Substances 0.000 claims 8
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
• -1 hydroxy, methyl Chemical group 0.000 claims 6
• 238000001727 in vivo Methods 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 5
• 208000035475 disorder Diseases 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 5
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
• 230000001575 pathological effect Effects 0.000 claims 5
• 208000030814 Eating disease Diseases 0.000 claims 4
• 208000019454 Feeding and Eating disease Diseases 0.000 claims 4
• 102400000740 Melanocyte-stimulating hormone alpha Human genes 0.000 claims 4
• 101710200814 Melanotropin alpha Proteins 0.000 claims 4
• 230000009471 action Effects 0.000 claims 4
• 238000002405 diagnostic procedure Methods 0.000 claims 4
• 235000014632 disordered eating Nutrition 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 125000001153 fluoro group Chemical group F* 0.000 claims 4
• 239000002955 immunomodulating agent Substances 0.000 claims 4
• 229940121354 immunomodulator Drugs 0.000 claims 4
• 230000002584 immunomodulator Effects 0.000 claims 4
• 230000036407 pain Effects 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 230000005995 skin dysfunction Effects 0.000 claims 4
• 208000011117 substance-related disease Diseases 0.000 claims 4
• WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 claims 4
• 102000004378 Melanocortin Receptors Human genes 0.000 claims 3
• 108090000950 Melanocortin Receptors Proteins 0.000 claims 3
• 201000001880 Sexual dysfunction Diseases 0.000 claims 3
• 125000001246 bromo group Chemical group Br* 0.000 claims 3
• 229910052736 halogen Inorganic materials 0.000 claims 3
• 150000002367 halogens Chemical class 0.000 claims 3
• 231100000872 sexual dysfunction Toxicity 0.000 claims 3
• 206010013654 Drug abuse Diseases 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 2
• 108010008364 Melanocortins Proteins 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 125000001309 chloro group Chemical group Cl* 0.000 claims 2
• 238000003745 diagnosis Methods 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 125000002346 iodo group Chemical group I* 0.000 claims 2
• 239000002865 melanocortin Substances 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 210000005036 nerve Anatomy 0.000 claims 2
• 201000009032 substance abuse Diseases 0.000 claims 2
• 231100000736 substance abuse Toxicity 0.000 claims 2
• OQUDJZCQJGQDKZ-UHFFFAOYSA-N 2-[(4-bromo-2-iodophenyl)methylideneamino]guanidine Chemical compound NC(=N)NN=CC1=CC=C(Br)C=C1I OQUDJZCQJGQDKZ-UHFFFAOYSA-N 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000002574 poison Substances 0.000 claims 1
• 231100000614 poison Toxicity 0.000 claims 1
• 230000002285 radioactive effect Effects 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 230000036299 sexual function Effects 0.000 claims 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1