JP2004531510A - ベンジリデンアミノグアニジンの、メラノコルチンレセプターリガンドとしての使用方法 - Google Patents
ベンジリデンアミノグアニジンの、メラノコルチンレセプターリガンドとしての使用方法 Download PDFInfo
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- JP2004531510A JP2004531510A JP2002578935A JP2002578935A JP2004531510A JP 2004531510 A JP2004531510 A JP 2004531510A JP 2002578935 A JP2002578935 A JP 2002578935A JP 2002578935 A JP2002578935 A JP 2002578935A JP 2004531510 A JP2004531510 A JP 2004531510A
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- msh
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- hydrogen
- melanocortin
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Reproductive Health (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0108631.3A GB0108631D0 (en) | 2001-04-05 | 2001-04-05 | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| PCT/GB2002/001589 WO2002080896A1 (en) | 2001-04-05 | 2002-04-05 | Uses of benzylideneamino guanidines as ligands to the melanocortiin receptors |
Publications (1)
| Publication Number | Publication Date |
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| JP2004531510A true JP2004531510A (ja) | 2004-10-14 |
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| JP2002579418A Withdrawn JP2004531516A (ja) | 2001-04-05 | 2002-04-05 | 新規ベンジリデンアミノグアニジンおよびそれらのメラノコルチンレセプターリガンドとしての使用方法 |
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| JP2002579418A Withdrawn JP2004531516A (ja) | 2001-04-05 | 2002-04-05 | 新規ベンジリデンアミノグアニジンおよびそれらのメラノコルチンレセプターリガンドとしての使用方法 |
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| US (2) | US20040106682A1 (https=) |
| EP (2) | EP1383740A2 (https=) |
| JP (2) | JP2004531510A (https=) |
| KR (2) | KR20030088056A (https=) |
| BR (2) | BR0208657A (https=) |
| CA (2) | CA2443057A1 (https=) |
| GB (1) | GB0108631D0 (https=) |
| IL (2) | IL158247A0 (https=) |
| MX (2) | MXPA03008972A (https=) |
| WO (2) | WO2002080896A1 (https=) |
| ZA (1) | ZA200307453B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513258A (ja) * | 2006-12-14 | 2010-04-30 | アキュア ファーマ エービー | メラノコルチン受容体リガンドとしての新規アミノグアニジン |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| GB0119172D0 (en) * | 2001-08-06 | 2001-09-26 | Melacure Therapeutics Ab | Phenyl pyrrole derivatives |
| DE602004025758D1 (de) | 2003-01-23 | 2010-04-15 | Kuraray Co | Polyvinylacetal und dessen Verwendung |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2045250A1 (en) * | 2007-09-26 | 2009-04-08 | Action Pharma A/S | Ring-substituted phenyl pyrrole aminoguanidine derivatives |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| JP5514831B2 (ja) | 2008-11-17 | 2014-06-04 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病の治療のための置換二環式アミン |
| WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| CA2768577A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| EP2563764B1 (en) | 2010-04-26 | 2015-02-25 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
| US9365539B2 (en) | 2010-05-11 | 2016-06-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
| US9006268B2 (en) | 2010-06-11 | 2015-04-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| BR112013021236B1 (pt) | 2011-02-25 | 2021-05-25 | Merck Sharp & Dohme Corp | composto derivado de benzimidazol, e, composição |
| US9527875B2 (en) | 2012-08-02 | 2016-12-27 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| SI3004138T1 (sl) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Limited | Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| ES2812800T3 (es) * | 2014-07-02 | 2021-03-18 | Inflectis Bioscience | Nuevos usos terapéuticos de derivados de la bencilidenguanidina para el tratamiento de proteopatías |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| US20180230105A1 (en) | 2017-01-13 | 2018-08-16 | Regents Of The University Of Minnesota | Therapeutic compounds |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US2584784A (en) * | 1949-05-21 | 1952-02-05 | Du Pont | Salts of 1-salicylalaminoguanidine |
| DE1165013B (de) * | 1960-08-09 | 1964-03-12 | Vismara Francesco Spa | Verfahren zur Herstellung von Guanylhydrazonen |
| GB1223491A (en) * | 1967-10-13 | 1971-02-24 | American Home Prod | Guanidines |
| US3592935A (en) * | 1969-12-11 | 1971-07-13 | Sandoz Ag | Substituted benzylidene hydrazines as anti-inflammatory agents |
| US3982020A (en) * | 1970-03-17 | 1976-09-21 | Sandoz, Inc. | Substituted benzylidene hydrazines for treating hyperglycemia, obesity and inflammation |
| US4060640A (en) * | 1970-04-29 | 1977-11-29 | Shell Oil Company | Therapeutic agents |
| US3816531A (en) * | 1970-07-01 | 1974-06-11 | American Home Prod | (2,6-disubstituted benzylidene)amino guanidines and related compounds |
| US3896232A (en) * | 1973-01-11 | 1975-07-22 | Sandoz Ag | Substituted benzylidene hydrazines as anti-migraine syndrome agents |
| US3941825A (en) * | 1973-07-27 | 1976-03-02 | American Cyanamid Company | Substituted aminobenzylideneamino guanidine compounds |
| US4006250A (en) * | 1975-08-25 | 1977-02-01 | American Home Products Corporation | Systemic treatment of psoriasis |
| JPH06510760A (ja) * | 1991-08-27 | 1994-12-01 | ジ・アップジョン・カンパニー | 代謝障害および代謝の治療法 |
| US5599984A (en) * | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| SE9604348D0 (sv) * | 1996-11-26 | 1996-11-26 | Wapharm Ab | Användning av hydroxyguanidiner |
| WO2001013921A1 (en) * | 1999-08-23 | 2001-03-01 | Ockert David M | Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms |
| AU7802700A (en) * | 1999-10-06 | 2001-05-10 | Melacure Therapeutics Ab | Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase |
| GB0019357D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0019359D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
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- 2002-04-05 JP JP2002578935A patent/JP2004531510A/ja not_active Withdrawn
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- 2002-04-05 KR KR10-2003-7012904A patent/KR20030092045A/ko not_active Withdrawn
- 2002-04-05 MX MXPA03008972A patent/MXPA03008972A/es unknown
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- 2002-04-05 IL IL15824802A patent/IL158248A0/xx unknown
- 2002-04-05 EP EP02707026A patent/EP1383740A2/en not_active Withdrawn
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513258A (ja) * | 2006-12-14 | 2010-04-30 | アキュア ファーマ エービー | メラノコルチン受容体リガンドとしての新規アミノグアニジン |
Also Published As
| Publication number | Publication date |
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| ZA200307453B (en) | 2004-09-27 |
| JP2004531516A (ja) | 2004-10-14 |
| MXPA03008973A (es) | 2004-02-12 |
| EP1372625A1 (en) | 2004-01-02 |
| IL158248A0 (en) | 2004-05-12 |
| IL158247A0 (en) | 2004-05-12 |
| CA2443099A1 (en) | 2002-10-17 |
| US20040106682A1 (en) | 2004-06-03 |
| BR0208657A (pt) | 2004-03-02 |
| KR20030092045A (ko) | 2003-12-03 |
| US20040106683A1 (en) | 2004-06-03 |
| KR20030088056A (ko) | 2003-11-15 |
| WO2002081430A2 (en) | 2002-10-17 |
| EP1383740A2 (en) | 2004-01-28 |
| CA2443057A1 (en) | 2002-10-17 |
| GB0108631D0 (en) | 2001-05-30 |
| WO2002081430A3 (en) | 2003-08-14 |
| WO2002080896A1 (en) | 2002-10-17 |
| MXPA03008972A (es) | 2004-02-12 |
| BR0208658A (pt) | 2004-03-02 |
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