KR20030088056A - 신규의 벤질리덴아미노 구아니딘 및 이들의 멜라노코르틴수용체에 대한 리간드로서의 사용방법 - Google Patents
신규의 벤질리덴아미노 구아니딘 및 이들의 멜라노코르틴수용체에 대한 리간드로서의 사용방법 Download PDFInfo
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- KR20030088056A KR20030088056A KR10-2003-7012903A KR20037012903A KR20030088056A KR 20030088056 A KR20030088056 A KR 20030088056A KR 20037012903 A KR20037012903 A KR 20037012903A KR 20030088056 A KR20030088056 A KR 20030088056A
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- guanidine
- compound
- compound according
- hydrogen
- nitro
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0108631.3 | 2001-04-05 | ||
| GBGB0108631.3A GB0108631D0 (en) | 2001-04-05 | 2001-04-05 | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| PCT/GB2002/001593 WO2002081430A2 (en) | 2001-04-05 | 2002-04-05 | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20030088056A true KR20030088056A (ko) | 2003-11-15 |
Family
ID=9912357
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2003-7012903A Withdrawn KR20030088056A (ko) | 2001-04-05 | 2002-04-05 | 신규의 벤질리덴아미노 구아니딘 및 이들의 멜라노코르틴수용체에 대한 리간드로서의 사용방법 |
| KR10-2003-7012904A Withdrawn KR20030092045A (ko) | 2001-04-05 | 2002-04-05 | 벤질리덴아미노 구아니딘의 멜라노코르틴 수용체에 대한리간드로서의 사용방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2003-7012904A Withdrawn KR20030092045A (ko) | 2001-04-05 | 2002-04-05 | 벤질리덴아미노 구아니딘의 멜라노코르틴 수용체에 대한리간드로서의 사용방법 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20040106682A1 (https=) |
| EP (2) | EP1372625A1 (https=) |
| JP (2) | JP2004531510A (https=) |
| KR (2) | KR20030088056A (https=) |
| BR (2) | BR0208658A (https=) |
| CA (2) | CA2443099A1 (https=) |
| GB (1) | GB0108631D0 (https=) |
| IL (2) | IL158247A0 (https=) |
| MX (2) | MXPA03008972A (https=) |
| WO (2) | WO2002081430A2 (https=) |
| ZA (1) | ZA200307453B (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| GB0119172D0 (en) * | 2001-08-06 | 2001-09-26 | Melacure Therapeutics Ab | Phenyl pyrrole derivatives |
| DE602004025758D1 (de) | 2003-01-23 | 2010-04-15 | Kuraray Co | Polyvinylacetal und dessen Verwendung |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| GB0624987D0 (en) * | 2006-12-14 | 2007-01-24 | Acure Pharma Ab | Novel aminoguanidines as melanocortin receptor ligands |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| EP2045250A1 (en) * | 2007-09-26 | 2009-04-08 | Action Pharma A/S | Ring-substituted phenyl pyrrole aminoguanidine derivatives |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2348857B1 (en) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| EP2358200A4 (en) | 2008-11-17 | 2012-05-16 | Merck Sharp & Dohme | SUBSTITUTED BICYCLIC AMINES FOR THE TREATMENT OF DIABETES |
| CA2768577A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| WO2011137024A1 (en) | 2010-04-26 | 2011-11-03 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
| EP2568812B1 (en) | 2010-05-11 | 2016-10-26 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
| WO2011156246A1 (en) | 2010-06-11 | 2011-12-15 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| SG192941A1 (en) | 2011-02-25 | 2013-09-30 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| RU2015106909A (ru) | 2012-08-02 | 2016-09-27 | Мерк Шарп И Доум Корп. | Антидиабетические трициклические соединения |
| KR20150118158A (ko) | 2013-02-22 | 2015-10-21 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병 비시클릭 화합물 |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| RU2712452C2 (ru) * | 2014-07-02 | 2020-01-29 | Инфлектис Байосайенс | Новое терапевтическое применение производных бензилиденгуанидина для лечения протеинопатий |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298B1 (en) | 2016-12-20 | 2026-03-11 | Merck Sharp & Dohme LLC | Antidiabetic spirochroman compounds |
| US20180230105A1 (en) | 2017-01-13 | 2018-08-16 | Regents Of The University Of Minnesota | Therapeutic compounds |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2584784A (en) * | 1949-05-21 | 1952-02-05 | Du Pont | Salts of 1-salicylalaminoguanidine |
| DE1165013B (de) * | 1960-08-09 | 1964-03-12 | Vismara Francesco Spa | Verfahren zur Herstellung von Guanylhydrazonen |
| GB1223492A (en) * | 1967-10-13 | 1971-02-24 | American Home Prod | Guanidines |
| US3592935A (en) * | 1969-12-11 | 1971-07-13 | Sandoz Ag | Substituted benzylidene hydrazines as anti-inflammatory agents |
| US3982020A (en) * | 1970-03-17 | 1976-09-21 | Sandoz, Inc. | Substituted benzylidene hydrazines for treating hyperglycemia, obesity and inflammation |
| US4060640A (en) * | 1970-04-29 | 1977-11-29 | Shell Oil Company | Therapeutic agents |
| US3816531A (en) * | 1970-07-01 | 1974-06-11 | American Home Prod | (2,6-disubstituted benzylidene)amino guanidines and related compounds |
| US3896232A (en) * | 1973-01-11 | 1975-07-22 | Sandoz Ag | Substituted benzylidene hydrazines as anti-migraine syndrome agents |
| US3941825A (en) * | 1973-07-27 | 1976-03-02 | American Cyanamid Company | Substituted aminobenzylideneamino guanidine compounds |
| US4006250A (en) * | 1975-08-25 | 1977-02-01 | American Home Products Corporation | Systemic treatment of psoriasis |
| AU664710B2 (en) * | 1991-08-27 | 1995-11-30 | Upjohn Company, The | A method for treatment of metabolic disorders |
| US5599984A (en) * | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| SE9604348D0 (sv) * | 1996-11-26 | 1996-11-26 | Wapharm Ab | Användning av hydroxyguanidiner |
| US6503950B1 (en) * | 1999-08-23 | 2003-01-07 | David M. Ockert | Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms |
| WO2001025192A1 (en) * | 1999-10-06 | 2001-04-12 | Melacure Therapeutics Ab | Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase |
| GB0019357D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0019359D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
-
2001
- 2001-04-05 GB GBGB0108631.3A patent/GB0108631D0/en not_active Ceased
-
2002
- 2002-04-05 BR BR0208658-1A patent/BR0208658A/pt not_active Application Discontinuation
- 2002-04-05 US US10/472,767 patent/US20040106682A1/en not_active Abandoned
- 2002-04-05 WO PCT/GB2002/001593 patent/WO2002081430A2/en not_active Ceased
- 2002-04-05 IL IL15824702A patent/IL158247A0/xx unknown
- 2002-04-05 MX MXPA03008972A patent/MXPA03008972A/es unknown
- 2002-04-05 CA CA002443099A patent/CA2443099A1/en not_active Abandoned
- 2002-04-05 JP JP2002578935A patent/JP2004531510A/ja not_active Withdrawn
- 2002-04-05 EP EP02707025A patent/EP1372625A1/en not_active Withdrawn
- 2002-04-05 IL IL15824802A patent/IL158248A0/xx unknown
- 2002-04-05 WO PCT/GB2002/001589 patent/WO2002080896A1/en not_active Ceased
- 2002-04-05 EP EP02707026A patent/EP1383740A2/en not_active Withdrawn
- 2002-04-05 KR KR10-2003-7012903A patent/KR20030088056A/ko not_active Withdrawn
- 2002-04-05 JP JP2002579418A patent/JP2004531516A/ja not_active Withdrawn
- 2002-04-05 US US10/472,768 patent/US20040106683A1/en not_active Abandoned
- 2002-04-05 MX MXPA03008973A patent/MXPA03008973A/es unknown
- 2002-04-05 CA CA002443057A patent/CA2443057A1/en not_active Abandoned
- 2002-04-05 BR BR0208657-3A patent/BR0208657A/pt not_active Application Discontinuation
- 2002-04-05 KR KR10-2003-7012904A patent/KR20030092045A/ko not_active Withdrawn
-
2003
- 2003-09-25 ZA ZA200307453A patent/ZA200307453B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL158248A0 (en) | 2004-05-12 |
| CA2443099A1 (en) | 2002-10-17 |
| BR0208657A (pt) | 2004-03-02 |
| JP2004531510A (ja) | 2004-10-14 |
| CA2443057A1 (en) | 2002-10-17 |
| US20040106683A1 (en) | 2004-06-03 |
| IL158247A0 (en) | 2004-05-12 |
| ZA200307453B (en) | 2004-09-27 |
| MXPA03008972A (es) | 2004-02-12 |
| KR20030092045A (ko) | 2003-12-03 |
| US20040106682A1 (en) | 2004-06-03 |
| EP1383740A2 (en) | 2004-01-28 |
| JP2004531516A (ja) | 2004-10-14 |
| MXPA03008973A (es) | 2004-02-12 |
| GB0108631D0 (en) | 2001-05-30 |
| BR0208658A (pt) | 2004-03-02 |
| EP1372625A1 (en) | 2004-01-02 |
| WO2002080896A1 (en) | 2002-10-17 |
| WO2002081430A3 (en) | 2003-08-14 |
| WO2002081430A2 (en) | 2002-10-17 |
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Legal Events
| Date | Code | Title | Description |
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| PA0105 | International application |
Patent event date: 20031001 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |