GB0108631D0 - Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors - Google Patents

Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors

Info

Publication number
GB0108631D0
GB0108631D0 GBGB0108631.3A GB0108631A GB0108631D0 GB 0108631 D0 GB0108631 D0 GB 0108631D0 GB 0108631 A GB0108631 A GB 0108631A GB 0108631 D0 GB0108631 D0 GB 0108631D0
Authority
GB
United Kingdom
Prior art keywords
ligands
novel
melanocortin receptors
benzylideneamino
guanidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0108631.3A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melacure Therapeutics AB
Original Assignee
Melacure Therapeutics AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melacure Therapeutics AB filed Critical Melacure Therapeutics AB
Priority to GBGB0108631.3A priority Critical patent/GB0108631D0/en
Publication of GB0108631D0 publication Critical patent/GB0108631D0/en
Priority to KR10-2003-7012904A priority patent/KR20030092045A/ko
Priority to US10/472,767 priority patent/US20040106682A1/en
Priority to KR10-2003-7012903A priority patent/KR20030088056A/ko
Priority to MXPA03008973A priority patent/MXPA03008973A/es
Priority to EP02707025A priority patent/EP1372625A1/en
Priority to JP2002578935A priority patent/JP2004531510A/ja
Priority to CA002443057A priority patent/CA2443057A1/en
Priority to BR0208658-1A priority patent/BR0208658A/pt
Priority to MXPA03008972A priority patent/MXPA03008972A/es
Priority to IL15824702A priority patent/IL158247A0/xx
Priority to JP2002579418A priority patent/JP2004531516A/ja
Priority to PCT/GB2002/001593 priority patent/WO2002081430A2/en
Priority to IL15824802A priority patent/IL158248A0/xx
Priority to PCT/GB2002/001589 priority patent/WO2002080896A1/en
Priority to BR0208657-3A priority patent/BR0208657A/pt
Priority to US10/472,768 priority patent/US20040106683A1/en
Priority to CA002443099A priority patent/CA2443099A1/en
Priority to EP02707026A priority patent/EP1383740A2/en
Priority to ZA200307453A priority patent/ZA200307453B/xx
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB0108631.3A 2001-04-05 2001-04-05 Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors Ceased GB0108631D0 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GBGB0108631.3A GB0108631D0 (en) 2001-04-05 2001-04-05 Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
EP02707026A EP1383740A2 (en) 2001-04-05 2002-04-05 Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
BR0208658-1A BR0208658A (pt) 2001-04-05 2002-04-05 Benzilidenoamino guanidinas e seus usos como ligandos aos receptores de melanocortina
IL15824702A IL158247A0 (en) 2001-04-05 2002-04-05 Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
KR10-2003-7012903A KR20030088056A (ko) 2001-04-05 2002-04-05 신규의 벤질리덴아미노 구아니딘 및 이들의 멜라노코르틴수용체에 대한 리간드로서의 사용방법
MXPA03008973A MXPA03008973A (es) 2001-04-05 2002-04-05 Uso de bencilidenaminoguanidinas como ligandos para receptores de melanocortina.
EP02707025A EP1372625A1 (en) 2001-04-05 2002-04-05 Uses of benzylideneamino guanidines as ligands to the melanocortiin receptors
JP2002578935A JP2004531510A (ja) 2001-04-05 2002-04-05 ベンジリデンアミノグアニジンの、メラノコルチンレセプターリガンドとしての使用方法
CA002443057A CA2443057A1 (en) 2001-04-05 2002-04-05 Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
KR10-2003-7012904A KR20030092045A (ko) 2001-04-05 2002-04-05 벤질리덴아미노 구아니딘의 멜라노코르틴 수용체에 대한리간드로서의 사용방법
MXPA03008972A MXPA03008972A (es) 2001-04-05 2002-04-05 Bencilidenaminoguanidinas novedosas y sus usos como ligandos para receptores de melanocortina.
US10/472,767 US20040106682A1 (en) 2001-04-05 2002-04-05 Novel benzylideneamino guanidines and their uses as ligands to the melnocortin receptors
JP2002579418A JP2004531516A (ja) 2001-04-05 2002-04-05 新規ベンジリデンアミノグアニジンおよびそれらのメラノコルチンレセプターリガンドとしての使用方法
PCT/GB2002/001593 WO2002081430A2 (en) 2001-04-05 2002-04-05 Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
IL15824802A IL158248A0 (en) 2001-04-05 2002-04-05 Uses of benzylideneamino guanidines as ligands to the melanocortiin receptors
PCT/GB2002/001589 WO2002080896A1 (en) 2001-04-05 2002-04-05 Uses of benzylideneamino guanidines as ligands to the melanocortiin receptors
BR0208657-3A BR0208657A (pt) 2001-04-05 2002-04-05 Usos de benzilideno amino guanidinas como ligantes para os receptores de melanocortina
US10/472,768 US20040106683A1 (en) 2001-04-05 2002-04-05 Uses of benzylideneamino guanidines as ligands to the melnocortin receptors
CA002443099A CA2443099A1 (en) 2001-04-05 2002-04-05 Uses of benzylideneamino guanidines as ligands to the melanocortiin receptors
ZA200307453A ZA200307453B (en) 2001-04-05 2003-09-25 Uses of benzylideneamino guanidines as ligands to the melanocortin receptors.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0108631.3A GB0108631D0 (en) 2001-04-05 2001-04-05 Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors

Publications (1)

Publication Number Publication Date
GB0108631D0 true GB0108631D0 (en) 2001-05-30

Family

ID=9912357

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0108631.3A Ceased GB0108631D0 (en) 2001-04-05 2001-04-05 Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors

Country Status (11)

Country Link
US (2) US20040106682A1 (https=)
EP (2) EP1383740A2 (https=)
JP (2) JP2004531510A (https=)
KR (2) KR20030088056A (https=)
BR (2) BR0208657A (https=)
CA (2) CA2443057A1 (https=)
GB (1) GB0108631D0 (https=)
IL (2) IL158247A0 (https=)
MX (2) MXPA03008972A (https=)
WO (2) WO2002080896A1 (https=)
ZA (1) ZA200307453B (https=)

Families Citing this family (35)

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GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
GB0108631D0 (en) * 2001-04-05 2001-05-30 Melacure Therapeutics Ab Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
GB0119172D0 (en) * 2001-08-06 2001-09-26 Melacure Therapeutics Ab Phenyl pyrrole derivatives
DE602004025758D1 (de) 2003-01-23 2010-04-15 Kuraray Co Polyvinylacetal und dessen Verwendung
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
GB0624987D0 (en) * 2006-12-14 2007-01-24 Acure Pharma Ab Novel aminoguanidines as melanocortin receptor ligands
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2045250A1 (en) * 2007-09-26 2009-04-08 Action Pharma A/S Ring-substituted phenyl pyrrole aminoguanidine derivatives
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010047982A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
JP5557845B2 (ja) 2008-10-31 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
JP5514831B2 (ja) 2008-11-17 2014-06-04 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病の治療のための置換二環式アミン
WO2011011506A1 (en) 2009-07-23 2011-01-27 Schering Corporation Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
CA2768577A1 (en) 2009-07-23 2011-01-27 Schering Corporation Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
EP2563764B1 (en) 2010-04-26 2015-02-25 Merck Sharp & Dohme Corp. Novel spiropiperidine prolylcarboxypeptidase inhibitors
US9365539B2 (en) 2010-05-11 2016-06-14 Merck Sharp & Dohme Corp. Prolylcarboxypeptidase inhibitors
US9006268B2 (en) 2010-06-11 2015-04-14 Merck Sharp & Dohme Corp. Prolylcarboxypeptidase inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
BR112013021236B1 (pt) 2011-02-25 2021-05-25 Merck Sharp & Dohme Corp composto derivado de benzimidazol, e, composição
US9527875B2 (en) 2012-08-02 2016-12-27 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
RU2015140066A (ru) 2013-02-22 2017-03-30 Мерк Шарп И Доум Корп. Противодиабетические бициклические соединения
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
ES2812800T3 (es) * 2014-07-02 2021-03-18 Inflectis Bioscience Nuevos usos terapéuticos de derivados de la bencilidenguanidina para el tratamiento de proteopatías
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
US20180230105A1 (en) 2017-01-13 2018-08-16 Regents Of The University Of Minnesota Therapeutic compounds

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DE1165013B (de) * 1960-08-09 1964-03-12 Vismara Francesco Spa Verfahren zur Herstellung von Guanylhydrazonen
GB1223491A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3592935A (en) * 1969-12-11 1971-07-13 Sandoz Ag Substituted benzylidene hydrazines as anti-inflammatory agents
US3982020A (en) * 1970-03-17 1976-09-21 Sandoz, Inc. Substituted benzylidene hydrazines for treating hyperglycemia, obesity and inflammation
US4060640A (en) * 1970-04-29 1977-11-29 Shell Oil Company Therapeutic agents
US3816531A (en) * 1970-07-01 1974-06-11 American Home Prod (2,6-disubstituted benzylidene)amino guanidines and related compounds
US3896232A (en) * 1973-01-11 1975-07-22 Sandoz Ag Substituted benzylidene hydrazines as anti-migraine syndrome agents
US3941825A (en) * 1973-07-27 1976-03-02 American Cyanamid Company Substituted aminobenzylideneamino guanidine compounds
US4006250A (en) * 1975-08-25 1977-02-01 American Home Products Corporation Systemic treatment of psoriasis
JPH06510760A (ja) * 1991-08-27 1994-12-01 ジ・アップジョン・カンパニー 代謝障害および代謝の治療法
US5599984A (en) * 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
SE9604348D0 (sv) * 1996-11-26 1996-11-26 Wapharm Ab Användning av hydroxyguanidiner
WO2001013921A1 (en) * 1999-08-23 2001-03-01 Ockert David M Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms
AU7802700A (en) * 1999-10-06 2001-05-10 Melacure Therapeutics Ab Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase
GB0019357D0 (en) * 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
GB0019359D0 (en) * 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel guanidines
GB0108631D0 (en) * 2001-04-05 2001-05-30 Melacure Therapeutics Ab Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors

Also Published As

Publication number Publication date
ZA200307453B (en) 2004-09-27
JP2004531516A (ja) 2004-10-14
MXPA03008973A (es) 2004-02-12
EP1372625A1 (en) 2004-01-02
JP2004531510A (ja) 2004-10-14
IL158248A0 (en) 2004-05-12
IL158247A0 (en) 2004-05-12
CA2443099A1 (en) 2002-10-17
US20040106682A1 (en) 2004-06-03
BR0208657A (pt) 2004-03-02
KR20030092045A (ko) 2003-12-03
US20040106683A1 (en) 2004-06-03
KR20030088056A (ko) 2003-11-15
WO2002081430A2 (en) 2002-10-17
EP1383740A2 (en) 2004-01-28
CA2443057A1 (en) 2002-10-17
WO2002081430A3 (en) 2003-08-14
WO2002080896A1 (en) 2002-10-17
MXPA03008972A (es) 2004-02-12
BR0208658A (pt) 2004-03-02

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