JP2002535370A5 - - Google Patents
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- Publication number
- JP2002535370A5 JP2002535370A5 JP2000595687A JP2000595687A JP2002535370A5 JP 2002535370 A5 JP2002535370 A5 JP 2002535370A5 JP 2000595687 A JP2000595687 A JP 2000595687A JP 2000595687 A JP2000595687 A JP 2000595687A JP 2002535370 A5 JP2002535370 A5 JP 2002535370A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- disorder
- pharmaceutical composition
- composition according
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 22
- 201000010099 disease Diseases 0.000 description 12
- 208000035475 disorder Diseases 0.000 description 10
- 239000008194 pharmaceutical composition Substances 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 4
- 102000004300 GABA-A Receptors Human genes 0.000 description 2
- 108090000839 GABA-A Receptors Proteins 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 208000037765 diseases and disorders Diseases 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000002757 morpholinyl group Chemical group 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 210000001428 peripheral nervous system Anatomy 0.000 description 2
- 125000003386 piperidinyl group Chemical group 0.000 description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 2
- 0 **1C=CC(N(*2=O)N=C(CC(*)=O)c3c2[n](*)c2c3CCC(*)=C2)=CC=C1 Chemical compound **1C=CC(N(*2=O)N=C(CC(*)=O)c3c2[n](*)c2c3CCC(*)=C2)=CC=C1 0.000 description 1
- IUUZMSMGSOUFTO-UHFFFAOYSA-N 2-indol-1-ylacetamide Chemical group C1=CC=C2N(CC(=O)N)C=CC2=C1 IUUZMSMGSOUFTO-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9900806A FR2788696B1 (fr) | 1999-01-26 | 1999-01-26 | Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central |
| FR99/00806 | 1999-01-26 | ||
| PCT/FR2000/000135 WO2000044384A1 (fr) | 1999-01-26 | 2000-01-21 | UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AUX MALADIES LIEES AU DYSFONCTIONNEMENT DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002535370A JP2002535370A (ja) | 2002-10-22 |
| JP2002535370A5 true JP2002535370A5 (https=) | 2007-03-15 |
| JP4688295B2 JP4688295B2 (ja) | 2011-05-25 |
Family
ID=9541212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000595687A Expired - Fee Related JP4688295B2 (ja) | 1999-01-26 | 2000-01-21 | 末梢型ベンゾジアゼピン受容体の機能不全に関連した疾患治療用薬剤の製造用のピリダジノ［４，５−ｂ］インドール−１−アセトアミド誘導体の使用 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6395729B1 (https=) |
| EP (1) | EP1148881B1 (https=) |
| JP (1) | JP4688295B2 (https=) |
| KR (1) | KR100694752B1 (https=) |
| CN (1) | CN100577167C (https=) |
| AR (1) | AR022413A1 (https=) |
| AT (1) | ATE335487T1 (https=) |
| AU (1) | AU764445B2 (https=) |
| BG (1) | BG65152B1 (https=) |
| BR (1) | BR0007718A (https=) |
| CA (1) | CA2360754C (https=) |
| CO (1) | CO5160242A1 (https=) |
| CY (1) | CY1106257T1 (https=) |
| CZ (1) | CZ294283B6 (https=) |
| DE (1) | DE60029929T2 (https=) |
| DK (1) | DK1148881T3 (https=) |
| EE (1) | EE04905B1 (https=) |
| ES (1) | ES2269097T3 (https=) |
| FR (1) | FR2788696B1 (https=) |
| HK (1) | HK1040905B (https=) |
| HU (1) | HU228670B1 (https=) |
| IL (2) | IL144181A0 (https=) |
| NO (1) | NO321997B1 (https=) |
| NZ (1) | NZ512981A (https=) |
| PL (1) | PL193420B1 (https=) |
| PT (1) | PT1148881E (https=) |
| RU (1) | RU2243764C2 (https=) |
| SK (1) | SK285707B6 (https=) |
| TR (1) | TR200102134T2 (https=) |
| TW (1) | TW541177B (https=) |
| UA (1) | UA70349C2 (https=) |
| WO (1) | WO2000044384A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329493A (zh) * | 1998-12-02 | 2002-01-02 | 辉瑞产品公司 | 恢复p53家族蛋白质的构象稳定性的方法和组合物 |
| FR2811897A1 (fr) * | 2000-07-24 | 2002-01-25 | Sanofi Synthelabo | UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES |
| FR2838124B1 (fr) | 2002-04-03 | 2004-05-28 | Sanofi Synthelabo | Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique |
| FR2876715B1 (fr) | 2004-10-19 | 2006-12-15 | Profiles Du Ct Sa | Embout de protection pour ecran de glissiere de securite routiere |
| GT200600005A (es) * | 2005-01-12 | 2006-08-16 | Un derivado de 2-(aminocarbonilo ciclico)-indolina y una composicion farmaceutica que lo contiene | |
| CN101252914B (zh) * | 2005-05-05 | 2013-03-27 | 塞诺菲-安万特美国有限责任公司 | 稳定的纳米粒制剂 |
| BRPI0615259A2 (pt) * | 2005-08-29 | 2011-05-17 | Sanofi Aventis Us Llc | forma cristalina de um derivado de piridazino[4,5-b] indol |
| CN101272767B (zh) * | 2005-08-29 | 2012-08-29 | 赛诺菲-安万特美国有限责任公司 | 7-氯-N,N,5-三甲基-4-氧-3-苯基-3,5-二氢-4H-哒嗪并[4,5-b]吲哚-1-乙酰胺的无定形固体分散体 |
| CN1946120B (zh) * | 2006-10-20 | 2010-05-12 | 华为技术有限公司 | 实现话单关联的方法及系统 |
| FR2918563B1 (fr) | 2007-07-12 | 2009-12-04 | Oreal | Composition photoprotectrice fluide aqueuse a base d'un polymere polyamide a terminaison amide tertiaire. |
| FR2931064B1 (fr) | 2008-05-14 | 2010-08-13 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un derive de pyrrolidinone; procede de photostabilisation du derive de dibenzoylmethane |
| CA2734448A1 (en) * | 2008-08-18 | 2010-02-25 | Sanofi-Aventis U.S. Llc | Process for preparing polymorph of 7-chloro-n, n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4h-pyridazin0[4,5-b]indole-1-acetamide |
| GB0818738D0 (en) * | 2008-10-13 | 2008-11-19 | Ge Healthcare Ltd | Imaging neuroflammation |
| FR2936706B1 (fr) | 2008-10-08 | 2010-12-17 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un compose dithiolane ; procede de photostabilisation du derive de dibenzoylmethane |
| EP2181717A1 (en) * | 2008-10-28 | 2010-05-05 | Sanofi-Aventis | Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels |
| WO2011073279A2 (fr) | 2009-12-18 | 2011-06-23 | L'oreal | Procédé de traitement cosmétique impliquant un composé apte à condenser in situ |
| FR2960773B1 (fr) | 2010-06-03 | 2015-12-11 | Oreal | Procedes de traitement cosmetique utilisant un revetement a base d'un polymere polyamide-polyether |
| WO2019113248A1 (en) * | 2017-12-07 | 2019-06-13 | The Regents Of The University Of California | Anti-upar antibody-drug conjugates and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3121137A1 (de) * | 1981-05-27 | 1982-12-16 | Hoechst Ag, 6000 Frankfurt | Neue pyridazino(4,5-b)indole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und deren herstellung" |
| GB9411955D0 (en) * | 1994-06-15 | 1994-08-03 | Merck Sharp & Dohme | Therapeutic agents |
| FR2754262B1 (fr) * | 1996-10-08 | 1998-10-30 | Synthelabo | Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique |
| US6069267A (en) * | 1997-07-29 | 2000-05-30 | E. I. Du Pont De Nemours And Company | Selective synthesis of organodiphosphite compounds |
| FR2766823B1 (fr) * | 1997-07-30 | 1999-10-08 | Synthelabo | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique |
| FR2788776B1 (fr) * | 1999-01-26 | 2001-02-23 | Synthelabo | Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique |
-
1999
- 1999-01-26 FR FR9900806A patent/FR2788696B1/fr not_active Expired - Fee Related
-
2000
- 2000-01-21 IL IL14418100A patent/IL144181A0/xx active IP Right Grant
- 2000-01-21 EE EEP200100388A patent/EE04905B1/xx not_active IP Right Cessation
- 2000-01-21 TR TR2001/02134T patent/TR200102134T2/xx unknown
- 2000-01-21 DK DK00900637T patent/DK1148881T3/da active
- 2000-01-21 JP JP2000595687A patent/JP4688295B2/ja not_active Expired - Fee Related
- 2000-01-21 NZ NZ512981A patent/NZ512981A/xx not_active IP Right Cessation
- 2000-01-21 CZ CZ20012681A patent/CZ294283B6/cs not_active IP Right Cessation
- 2000-01-21 CA CA002360754A patent/CA2360754C/en not_active Expired - Fee Related
- 2000-01-21 CN CN00805273A patent/CN100577167C/zh not_active Expired - Fee Related
- 2000-01-21 HK HK02100510.9A patent/HK1040905B/zh not_active IP Right Cessation
- 2000-01-21 US US09/889,983 patent/US6395729B1/en not_active Expired - Lifetime
- 2000-01-21 EP EP00900637A patent/EP1148881B1/fr not_active Expired - Lifetime
- 2000-01-21 PT PT00900637T patent/PT1148881E/pt unknown
- 2000-01-21 SK SK1050-2001A patent/SK285707B6/sk not_active IP Right Cessation
- 2000-01-21 RU RU2001121160/15A patent/RU2243764C2/ru not_active IP Right Cessation
- 2000-01-21 ES ES00900637T patent/ES2269097T3/es not_active Expired - Lifetime
- 2000-01-21 UA UA2001074907A patent/UA70349C2/uk unknown
- 2000-01-21 WO PCT/FR2000/000135 patent/WO2000044384A1/fr not_active Ceased
- 2000-01-21 DE DE60029929T patent/DE60029929T2/de not_active Expired - Lifetime
- 2000-01-21 HU HU0201280A patent/HU228670B1/hu not_active IP Right Cessation
- 2000-01-21 PL PL00349364A patent/PL193420B1/pl not_active IP Right Cessation
- 2000-01-21 BR BR0007718-6A patent/BR0007718A/pt not_active Application Discontinuation
- 2000-01-21 KR KR1020017009272A patent/KR100694752B1/ko not_active Expired - Fee Related
- 2000-01-21 AU AU30579/00A patent/AU764445B2/en not_active Ceased
- 2000-01-21 AT AT00900637T patent/ATE335487T1/de active
- 2000-01-25 TW TW089101179A patent/TW541177B/zh not_active IP Right Cessation
- 2000-01-25 AR ARP000100305A patent/AR022413A1/es not_active Application Discontinuation
- 2000-01-25 CO CO00003866A patent/CO5160242A1/es unknown
-
2001
- 2001-07-05 IL IL144181A patent/IL144181A/en not_active IP Right Cessation
- 2001-07-24 NO NO20013645A patent/NO321997B1/no not_active IP Right Cessation
- 2001-07-24 BG BG105728A patent/BG65152B1/bg unknown
-
2006
- 2006-11-08 CY CY20061101607T patent/CY1106257T1/el unknown
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