ES2269097T3 - Utilizacion de derivados de piridazino-4,5-(b)-indol-1-acetamida para la preparacion de medicamentos destinados a enfermedades asociadas a la disfuncion de los receptores de tipo periferico de las benzodiazepinas. - Google Patents
Utilizacion de derivados de piridazino-4,5-(b)-indol-1-acetamida para la preparacion de medicamentos destinados a enfermedades asociadas a la disfuncion de los receptores de tipo periferico de las benzodiazepinas. Download PDFInfo
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- ES2269097T3 ES2269097T3 ES00900637T ES00900637T ES2269097T3 ES 2269097 T3 ES2269097 T3 ES 2269097T3 ES 00900637 T ES00900637 T ES 00900637T ES 00900637 T ES00900637 T ES 00900637T ES 2269097 T3 ES2269097 T3 ES 2269097T3
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 238000007911 parenteral administration Methods 0.000 description 1
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- 229940067157 phenylhydrazine Drugs 0.000 description 1
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- 229960003415 propylparaben Drugs 0.000 description 1
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- 238000011002 quantification Methods 0.000 description 1
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- 208000012802 recumbency Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
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- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
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- 230000006641 stabilisation Effects 0.000 description 1
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- 230000004083 survival effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000009424 thromboembolic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9900806A FR2788696B1 (fr) | 1999-01-26 | 1999-01-26 | Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central |
| FR9900806 | 1999-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2269097T3 true ES2269097T3 (es) | 2007-04-01 |
Family
ID=9541212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00900637T Expired - Lifetime ES2269097T3 (es) | 1999-01-26 | 2000-01-21 | Utilizacion de derivados de piridazino-4,5-(b)-indol-1-acetamida para la preparacion de medicamentos destinados a enfermedades asociadas a la disfuncion de los receptores de tipo periferico de las benzodiazepinas. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6395729B1 (https=) |
| EP (1) | EP1148881B1 (https=) |
| JP (1) | JP4688295B2 (https=) |
| KR (1) | KR100694752B1 (https=) |
| CN (1) | CN100577167C (https=) |
| AR (1) | AR022413A1 (https=) |
| AT (1) | ATE335487T1 (https=) |
| AU (1) | AU764445B2 (https=) |
| BG (1) | BG65152B1 (https=) |
| BR (1) | BR0007718A (https=) |
| CA (1) | CA2360754C (https=) |
| CO (1) | CO5160242A1 (https=) |
| CY (1) | CY1106257T1 (https=) |
| CZ (1) | CZ294283B6 (https=) |
| DE (1) | DE60029929T2 (https=) |
| DK (1) | DK1148881T3 (https=) |
| EE (1) | EE04905B1 (https=) |
| ES (1) | ES2269097T3 (https=) |
| FR (1) | FR2788696B1 (https=) |
| HK (1) | HK1040905B (https=) |
| HU (1) | HU228670B1 (https=) |
| IL (2) | IL144181A0 (https=) |
| NO (1) | NO321997B1 (https=) |
| NZ (1) | NZ512981A (https=) |
| PL (1) | PL193420B1 (https=) |
| PT (1) | PT1148881E (https=) |
| RU (1) | RU2243764C2 (https=) |
| SK (1) | SK285707B6 (https=) |
| TR (1) | TR200102134T2 (https=) |
| TW (1) | TW541177B (https=) |
| UA (1) | UA70349C2 (https=) |
| WO (1) | WO2000044384A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329493A (zh) * | 1998-12-02 | 2002-01-02 | 辉瑞产品公司 | 恢复p53家族蛋白质的构象稳定性的方法和组合物 |
| FR2811897A1 (fr) * | 2000-07-24 | 2002-01-25 | Sanofi Synthelabo | UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES |
| FR2838124B1 (fr) | 2002-04-03 | 2004-05-28 | Sanofi Synthelabo | Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique |
| FR2876715B1 (fr) | 2004-10-19 | 2006-12-15 | Profiles Du Ct Sa | Embout de protection pour ecran de glissiere de securite routiere |
| GT200600005A (es) * | 2005-01-12 | 2006-08-16 | Un derivado de 2-(aminocarbonilo ciclico)-indolina y una composicion farmaceutica que lo contiene | |
| CN101252914B (zh) * | 2005-05-05 | 2013-03-27 | 塞诺菲-安万特美国有限责任公司 | 稳定的纳米粒制剂 |
| BRPI0615259A2 (pt) * | 2005-08-29 | 2011-05-17 | Sanofi Aventis Us Llc | forma cristalina de um derivado de piridazino[4,5-b] indol |
| CN101272767B (zh) * | 2005-08-29 | 2012-08-29 | 赛诺菲-安万特美国有限责任公司 | 7-氯-N,N,5-三甲基-4-氧-3-苯基-3,5-二氢-4H-哒嗪并[4,5-b]吲哚-1-乙酰胺的无定形固体分散体 |
| CN1946120B (zh) * | 2006-10-20 | 2010-05-12 | 华为技术有限公司 | 实现话单关联的方法及系统 |
| FR2918563B1 (fr) | 2007-07-12 | 2009-12-04 | Oreal | Composition photoprotectrice fluide aqueuse a base d'un polymere polyamide a terminaison amide tertiaire. |
| FR2931064B1 (fr) | 2008-05-14 | 2010-08-13 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un derive de pyrrolidinone; procede de photostabilisation du derive de dibenzoylmethane |
| CA2734448A1 (en) * | 2008-08-18 | 2010-02-25 | Sanofi-Aventis U.S. Llc | Process for preparing polymorph of 7-chloro-n, n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4h-pyridazin0[4,5-b]indole-1-acetamide |
| GB0818738D0 (en) * | 2008-10-13 | 2008-11-19 | Ge Healthcare Ltd | Imaging neuroflammation |
| FR2936706B1 (fr) | 2008-10-08 | 2010-12-17 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un compose dithiolane ; procede de photostabilisation du derive de dibenzoylmethane |
| EP2181717A1 (en) * | 2008-10-28 | 2010-05-05 | Sanofi-Aventis | Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels |
| WO2011073279A2 (fr) | 2009-12-18 | 2011-06-23 | L'oreal | Procédé de traitement cosmétique impliquant un composé apte à condenser in situ |
| FR2960773B1 (fr) | 2010-06-03 | 2015-12-11 | Oreal | Procedes de traitement cosmetique utilisant un revetement a base d'un polymere polyamide-polyether |
| WO2019113248A1 (en) * | 2017-12-07 | 2019-06-13 | The Regents Of The University Of California | Anti-upar antibody-drug conjugates and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3121137A1 (de) * | 1981-05-27 | 1982-12-16 | Hoechst Ag, 6000 Frankfurt | Neue pyridazino(4,5-b)indole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und deren herstellung" |
| GB9411955D0 (en) * | 1994-06-15 | 1994-08-03 | Merck Sharp & Dohme | Therapeutic agents |
| FR2754262B1 (fr) * | 1996-10-08 | 1998-10-30 | Synthelabo | Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique |
| US6069267A (en) * | 1997-07-29 | 2000-05-30 | E. I. Du Pont De Nemours And Company | Selective synthesis of organodiphosphite compounds |
| FR2766823B1 (fr) * | 1997-07-30 | 1999-10-08 | Synthelabo | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique |
| FR2788776B1 (fr) * | 1999-01-26 | 2001-02-23 | Synthelabo | Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique |
-
1999
- 1999-01-26 FR FR9900806A patent/FR2788696B1/fr not_active Expired - Fee Related
-
2000
- 2000-01-21 IL IL14418100A patent/IL144181A0/xx active IP Right Grant
- 2000-01-21 EE EEP200100388A patent/EE04905B1/xx not_active IP Right Cessation
- 2000-01-21 TR TR2001/02134T patent/TR200102134T2/xx unknown
- 2000-01-21 DK DK00900637T patent/DK1148881T3/da active
- 2000-01-21 JP JP2000595687A patent/JP4688295B2/ja not_active Expired - Fee Related
- 2000-01-21 NZ NZ512981A patent/NZ512981A/xx not_active IP Right Cessation
- 2000-01-21 CZ CZ20012681A patent/CZ294283B6/cs not_active IP Right Cessation
- 2000-01-21 CA CA002360754A patent/CA2360754C/en not_active Expired - Fee Related
- 2000-01-21 CN CN00805273A patent/CN100577167C/zh not_active Expired - Fee Related
- 2000-01-21 HK HK02100510.9A patent/HK1040905B/zh not_active IP Right Cessation
- 2000-01-21 US US09/889,983 patent/US6395729B1/en not_active Expired - Lifetime
- 2000-01-21 EP EP00900637A patent/EP1148881B1/fr not_active Expired - Lifetime
- 2000-01-21 PT PT00900637T patent/PT1148881E/pt unknown
- 2000-01-21 SK SK1050-2001A patent/SK285707B6/sk not_active IP Right Cessation
- 2000-01-21 RU RU2001121160/15A patent/RU2243764C2/ru not_active IP Right Cessation
- 2000-01-21 ES ES00900637T patent/ES2269097T3/es not_active Expired - Lifetime
- 2000-01-21 UA UA2001074907A patent/UA70349C2/uk unknown
- 2000-01-21 WO PCT/FR2000/000135 patent/WO2000044384A1/fr not_active Ceased
- 2000-01-21 DE DE60029929T patent/DE60029929T2/de not_active Expired - Lifetime
- 2000-01-21 HU HU0201280A patent/HU228670B1/hu not_active IP Right Cessation
- 2000-01-21 PL PL00349364A patent/PL193420B1/pl not_active IP Right Cessation
- 2000-01-21 BR BR0007718-6A patent/BR0007718A/pt not_active Application Discontinuation
- 2000-01-21 KR KR1020017009272A patent/KR100694752B1/ko not_active Expired - Fee Related
- 2000-01-21 AU AU30579/00A patent/AU764445B2/en not_active Ceased
- 2000-01-21 AT AT00900637T patent/ATE335487T1/de active
- 2000-01-25 TW TW089101179A patent/TW541177B/zh not_active IP Right Cessation
- 2000-01-25 AR ARP000100305A patent/AR022413A1/es not_active Application Discontinuation
- 2000-01-25 CO CO00003866A patent/CO5160242A1/es unknown
-
2001
- 2001-07-05 IL IL144181A patent/IL144181A/en not_active IP Right Cessation
- 2001-07-24 NO NO20013645A patent/NO321997B1/no not_active IP Right Cessation
- 2001-07-24 BG BG105728A patent/BG65152B1/bg unknown
-
2006
- 2006-11-08 CY CY20061101607T patent/CY1106257T1/el unknown
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