TR200102134T2 - Periferal-tipteki benzodiazepin reseptörlerinin disfonksiyonu ile bağlantılı hastalıkları tedavi etmek için ilaçların hazırlanması için, piridazino[4,5-b]indol-1-asetamid türevlerinin kullanımı - Google Patents
Periferal-tipteki benzodiazepin reseptörlerinin disfonksiyonu ile bağlantılı hastalıkları tedavi etmek için ilaçların hazırlanması için, piridazino[4,5-b]indol-1-asetamid türevlerinin kullanımıInfo
- Publication number
- TR200102134T2 TR200102134T2 TR2001/02134T TR200102134T TR200102134T2 TR 200102134 T2 TR200102134 T2 TR 200102134T2 TR 2001/02134 T TR2001/02134 T TR 2001/02134T TR 200102134 T TR200102134 T TR 200102134T TR 200102134 T2 TR200102134 T2 TR 200102134T2
- Authority
- TR
- Turkey
- Prior art keywords
- peripheral
- pyridazino
- indole
- dysfunction
- drugs
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- JVOHISHEWPRTIM-UHFFFAOYSA-N 2-(5h-pyridazino[4,5-b]indol-1-yl)acetamide Chemical class N1C2=CC=CC=C2C2=C1C=NN=C2CC(=O)N JVOHISHEWPRTIM-UHFFFAOYSA-N 0.000 title 1
- 102100031274 Translocator protein Human genes 0.000 title 1
- 101710166801 Translocator protein Proteins 0.000 title 1
- 230000004064 dysfunction Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9900806A FR2788696B1 (fr) | 1999-01-26 | 1999-01-26 | Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200102134T2 true TR200102134T2 (tr) | 2003-03-21 |
Family
ID=9541212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/02134T TR200102134T2 (tr) | 1999-01-26 | 2000-01-21 | Periferal-tipteki benzodiazepin reseptörlerinin disfonksiyonu ile bağlantılı hastalıkları tedavi etmek için ilaçların hazırlanması için, piridazino[4,5-b]indol-1-asetamid türevlerinin kullanımı |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6395729B1 (https=) |
| EP (1) | EP1148881B1 (https=) |
| JP (1) | JP4688295B2 (https=) |
| KR (1) | KR100694752B1 (https=) |
| CN (1) | CN100577167C (https=) |
| AR (1) | AR022413A1 (https=) |
| AT (1) | ATE335487T1 (https=) |
| AU (1) | AU764445B2 (https=) |
| BG (1) | BG65152B1 (https=) |
| BR (1) | BR0007718A (https=) |
| CA (1) | CA2360754C (https=) |
| CO (1) | CO5160242A1 (https=) |
| CY (1) | CY1106257T1 (https=) |
| CZ (1) | CZ294283B6 (https=) |
| DE (1) | DE60029929T2 (https=) |
| DK (1) | DK1148881T3 (https=) |
| EE (1) | EE04905B1 (https=) |
| ES (1) | ES2269097T3 (https=) |
| FR (1) | FR2788696B1 (https=) |
| HK (1) | HK1040905B (https=) |
| HU (1) | HU228670B1 (https=) |
| IL (2) | IL144181A0 (https=) |
| NO (1) | NO321997B1 (https=) |
| NZ (1) | NZ512981A (https=) |
| PL (1) | PL193420B1 (https=) |
| PT (1) | PT1148881E (https=) |
| RU (1) | RU2243764C2 (https=) |
| SK (1) | SK285707B6 (https=) |
| TR (1) | TR200102134T2 (https=) |
| TW (1) | TW541177B (https=) |
| UA (1) | UA70349C2 (https=) |
| WO (1) | WO2000044384A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329493A (zh) * | 1998-12-02 | 2002-01-02 | 辉瑞产品公司 | 恢复p53家族蛋白质的构象稳定性的方法和组合物 |
| FR2811897A1 (fr) * | 2000-07-24 | 2002-01-25 | Sanofi Synthelabo | UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES |
| FR2838124B1 (fr) | 2002-04-03 | 2004-05-28 | Sanofi Synthelabo | Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique |
| FR2876715B1 (fr) | 2004-10-19 | 2006-12-15 | Profiles Du Ct Sa | Embout de protection pour ecran de glissiere de securite routiere |
| GT200600005A (es) * | 2005-01-12 | 2006-08-16 | Un derivado de 2-(aminocarbonilo ciclico)-indolina y una composicion farmaceutica que lo contiene | |
| CN101252914B (zh) * | 2005-05-05 | 2013-03-27 | 塞诺菲-安万特美国有限责任公司 | 稳定的纳米粒制剂 |
| BRPI0615259A2 (pt) * | 2005-08-29 | 2011-05-17 | Sanofi Aventis Us Llc | forma cristalina de um derivado de piridazino[4,5-b] indol |
| CN101272767B (zh) * | 2005-08-29 | 2012-08-29 | 赛诺菲-安万特美国有限责任公司 | 7-氯-N,N,5-三甲基-4-氧-3-苯基-3,5-二氢-4H-哒嗪并[4,5-b]吲哚-1-乙酰胺的无定形固体分散体 |
| CN1946120B (zh) * | 2006-10-20 | 2010-05-12 | 华为技术有限公司 | 实现话单关联的方法及系统 |
| FR2918563B1 (fr) | 2007-07-12 | 2009-12-04 | Oreal | Composition photoprotectrice fluide aqueuse a base d'un polymere polyamide a terminaison amide tertiaire. |
| FR2931064B1 (fr) | 2008-05-14 | 2010-08-13 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un derive de pyrrolidinone; procede de photostabilisation du derive de dibenzoylmethane |
| CA2734448A1 (en) * | 2008-08-18 | 2010-02-25 | Sanofi-Aventis U.S. Llc | Process for preparing polymorph of 7-chloro-n, n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4h-pyridazin0[4,5-b]indole-1-acetamide |
| GB0818738D0 (en) * | 2008-10-13 | 2008-11-19 | Ge Healthcare Ltd | Imaging neuroflammation |
| FR2936706B1 (fr) | 2008-10-08 | 2010-12-17 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un compose dithiolane ; procede de photostabilisation du derive de dibenzoylmethane |
| EP2181717A1 (en) * | 2008-10-28 | 2010-05-05 | Sanofi-Aventis | Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels |
| WO2011073279A2 (fr) | 2009-12-18 | 2011-06-23 | L'oreal | Procédé de traitement cosmétique impliquant un composé apte à condenser in situ |
| FR2960773B1 (fr) | 2010-06-03 | 2015-12-11 | Oreal | Procedes de traitement cosmetique utilisant un revetement a base d'un polymere polyamide-polyether |
| WO2019113248A1 (en) * | 2017-12-07 | 2019-06-13 | The Regents Of The University Of California | Anti-upar antibody-drug conjugates and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3121137A1 (de) * | 1981-05-27 | 1982-12-16 | Hoechst Ag, 6000 Frankfurt | Neue pyridazino(4,5-b)indole, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und deren herstellung" |
| GB9411955D0 (en) * | 1994-06-15 | 1994-08-03 | Merck Sharp & Dohme | Therapeutic agents |
| FR2754262B1 (fr) * | 1996-10-08 | 1998-10-30 | Synthelabo | Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique |
| US6069267A (en) * | 1997-07-29 | 2000-05-30 | E. I. Du Pont De Nemours And Company | Selective synthesis of organodiphosphite compounds |
| FR2766823B1 (fr) * | 1997-07-30 | 1999-10-08 | Synthelabo | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique |
| FR2788776B1 (fr) * | 1999-01-26 | 2001-02-23 | Synthelabo | Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique |
-
1999
- 1999-01-26 FR FR9900806A patent/FR2788696B1/fr not_active Expired - Fee Related
-
2000
- 2000-01-21 IL IL14418100A patent/IL144181A0/xx active IP Right Grant
- 2000-01-21 EE EEP200100388A patent/EE04905B1/xx not_active IP Right Cessation
- 2000-01-21 TR TR2001/02134T patent/TR200102134T2/xx unknown
- 2000-01-21 DK DK00900637T patent/DK1148881T3/da active
- 2000-01-21 JP JP2000595687A patent/JP4688295B2/ja not_active Expired - Fee Related
- 2000-01-21 NZ NZ512981A patent/NZ512981A/xx not_active IP Right Cessation
- 2000-01-21 CZ CZ20012681A patent/CZ294283B6/cs not_active IP Right Cessation
- 2000-01-21 CA CA002360754A patent/CA2360754C/en not_active Expired - Fee Related
- 2000-01-21 CN CN00805273A patent/CN100577167C/zh not_active Expired - Fee Related
- 2000-01-21 HK HK02100510.9A patent/HK1040905B/zh not_active IP Right Cessation
- 2000-01-21 US US09/889,983 patent/US6395729B1/en not_active Expired - Lifetime
- 2000-01-21 EP EP00900637A patent/EP1148881B1/fr not_active Expired - Lifetime
- 2000-01-21 PT PT00900637T patent/PT1148881E/pt unknown
- 2000-01-21 SK SK1050-2001A patent/SK285707B6/sk not_active IP Right Cessation
- 2000-01-21 RU RU2001121160/15A patent/RU2243764C2/ru not_active IP Right Cessation
- 2000-01-21 ES ES00900637T patent/ES2269097T3/es not_active Expired - Lifetime
- 2000-01-21 UA UA2001074907A patent/UA70349C2/uk unknown
- 2000-01-21 WO PCT/FR2000/000135 patent/WO2000044384A1/fr not_active Ceased
- 2000-01-21 DE DE60029929T patent/DE60029929T2/de not_active Expired - Lifetime
- 2000-01-21 HU HU0201280A patent/HU228670B1/hu not_active IP Right Cessation
- 2000-01-21 PL PL00349364A patent/PL193420B1/pl not_active IP Right Cessation
- 2000-01-21 BR BR0007718-6A patent/BR0007718A/pt not_active Application Discontinuation
- 2000-01-21 KR KR1020017009272A patent/KR100694752B1/ko not_active Expired - Fee Related
- 2000-01-21 AU AU30579/00A patent/AU764445B2/en not_active Ceased
- 2000-01-21 AT AT00900637T patent/ATE335487T1/de active
- 2000-01-25 TW TW089101179A patent/TW541177B/zh not_active IP Right Cessation
- 2000-01-25 AR ARP000100305A patent/AR022413A1/es not_active Application Discontinuation
- 2000-01-25 CO CO00003866A patent/CO5160242A1/es unknown
-
2001
- 2001-07-05 IL IL144181A patent/IL144181A/en not_active IP Right Cessation
- 2001-07-24 NO NO20013645A patent/NO321997B1/no not_active IP Right Cessation
- 2001-07-24 BG BG105728A patent/BG65152B1/bg unknown
-
2006
- 2006-11-08 CY CY20061101607T patent/CY1106257T1/el unknown
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