DK0520032T3 - Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel - Google Patents

Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel

Info

Publication number
DK0520032T3
DK0520032T3 DK91907118T DK91907118T DK0520032T3 DK 0520032 T3 DK0520032 T3 DK 0520032T3 DK 91907118 T DK91907118 T DK 91907118T DK 91907118 T DK91907118 T DK 91907118T DK 0520032 T3 DK0520032 T3 DK 0520032T3
Authority
DK
Denmark
Prior art keywords
spiperone
mammal
immunosuppressive
inflammatory agent
neuroleptic
Prior art date
Application number
DK91907118T
Other languages
English (en)
Inventor
J Sharpe Richard
A Arndt Kenneth
J Galli Stephen
Original Assignee
Beth Israel Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital filed Critical Beth Israel Hospital
Application granted granted Critical
Publication of DK0520032T3 publication Critical patent/DK0520032T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
DK91907118T 1990-03-16 1991-03-13 Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel DK0520032T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49474090A 1990-03-16 1990-03-16
PCT/US1991/001684 WO1991013622A1 (en) 1990-03-16 1991-03-13 Use of spiperone as an immunosuppressant and anti-inflammatory agent

Publications (1)

Publication Number Publication Date
DK0520032T3 true DK0520032T3 (da) 1999-06-14

Family

ID=23965760

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91907118T DK0520032T3 (da) 1990-03-16 1991-03-13 Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel

Country Status (13)

Country Link
US (1) US5290783A (da)
EP (1) EP0520032B1 (da)
JP (1) JPH078792B2 (da)
AT (1) ATE171067T1 (da)
CA (1) CA2077907C (da)
DE (1) DE69130216T2 (da)
DK (1) DK0520032T3 (da)
ES (1) ES2121779T3 (da)
IE (1) IE910882A1 (da)
NZ (1) NZ237422A (da)
PT (1) PT97057A (da)
WO (1) WO1991013622A1 (da)
ZA (1) ZA911932B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5574041A (en) * 1990-03-16 1996-11-12 Beth Israel Hospital Association Use of spiperone derivatives as immunosuppressant agents
EP0661972A1 (en) * 1991-12-27 1995-07-12 Beth Israel Hospital Use of spiperone or spiperone derivatives as immunosuppressant agents
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
EP0690715B1 (en) * 1993-03-26 2003-05-28 Beth Israel Hospital Association Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
US7226966B2 (en) 2001-08-03 2007-06-05 Nanogram Corporation Structures incorporating polymer-inorganic particle blends
AU3809999A (en) * 1998-05-18 1999-12-06 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2004019921A2 (en) * 2002-08-29 2004-03-11 University Of Southampton Use of apoptosis inducing agents in the preparation of a medicament for the treatment of liver diseases
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
CA2663377A1 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
CA2760945A1 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120190751A1 (en) * 2009-07-31 2012-07-26 Ana-Mar Ab Compounds for treatments of inflammation
US8895962B2 (en) 2010-06-29 2014-11-25 Nanogram Corporation Silicon/germanium nanoparticle inks, laser pyrolysis reactors for the synthesis of nanoparticles and associated methods
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161644A (en) * 1962-06-22 1964-12-15 Res Lab Dr C Janssen N V 1-benzyl-4-substituted piperidines
US3155670A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3155669A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3238216A (en) * 1963-06-20 1966-03-01 Res Lab Dr C Janssen N V Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
BE792906A (fr) * 1971-12-18 1973-06-18 Sumitomo Chemical Co Aryl-cetones et leur preparation
US3996363A (en) * 1975-06-13 1976-12-07 E. R. Squibb & Sons, Inc. 2-[(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)alkyl]-1H-benz[de]isoquinolin-1,3(2H)-diones
EP0056995B1 (en) * 1981-01-23 1986-03-26 The Wellcome Foundation Limited Chemical complex
US4874766A (en) * 1986-09-22 1989-10-17 Janssen Pharmaceutica N.V. Method of promoting wound-healing
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
JPH01308274A (ja) * 1987-12-14 1989-12-12 Kyowa Hakko Kogyo Co Ltd 三環式化合物
DE69025943T2 (de) * 1989-08-21 1996-09-19 Beth Israel Hospital Verwendung von Spiperone-derivate zur Immunosuppression

Also Published As

Publication number Publication date
NZ237422A (en) 1997-06-24
JPH05506855A (ja) 1993-10-07
ZA911932B (en) 1991-12-24
DE69130216T2 (de) 1999-03-25
ES2121779T3 (es) 1998-12-16
CA2077907A1 (en) 1991-09-17
EP0520032B1 (en) 1998-09-16
DE69130216D1 (de) 1998-10-22
JPH078792B2 (ja) 1995-02-01
EP0520032A1 (en) 1992-12-30
ATE171067T1 (de) 1998-10-15
CA2077907C (en) 1998-06-09
IE910882A1 (en) 1991-09-25
EP0520032A4 (en) 1993-02-24
WO1991013622A1 (en) 1991-09-19
PT97057A (pt) 1991-12-31
US5290783A (en) 1994-03-01

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