MXPA03001072A - El uso de bencilidenaminoguanidinas e hidroxiguanidinas como ligandos de receptor de melanocortina. - Google Patents

El uso de bencilidenaminoguanidinas e hidroxiguanidinas como ligandos de receptor de melanocortina.

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Publication number
MXPA03001072A
MXPA03001072A MXPA03001072A MXPA03001072A MXPA03001072A MX PA03001072 A MXPA03001072 A MX PA03001072A MX PA03001072 A MXPA03001072 A MX PA03001072A MX PA03001072 A MXPA03001072 A MX PA03001072A MX PA03001072 A MXPA03001072 A MX PA03001072A
Authority
MX
Mexico
Prior art keywords
benzylideneaminoguanidines
hydroxyguanidines
receptor ligands
melanocortin receptor
carbon atoms
Prior art date
Application number
MXPA03001072A
Other languages
English (en)
Inventor
Anna Skottner
Original Assignee
Melacure Therapeutics Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melacure Therapeutics Ab filed Critical Melacure Therapeutics Ab
Publication of MXPA03001072A publication Critical patent/MXPA03001072A/es

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    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

La presente invencion se refiere al uso de compuestos de formula general (I) como ligandos a los receptores de melanocortina y/o para el tratamiento de trastornos en el sistema de melanocortina: caracterizado porque X es H u OH; R1, R2, R3, R4 y R5 son los mismos o diferentes y se seleccionan a partir de hidrogeno, halogeno, alquilo que tiene de 1 a 5 atomos de carbono, grupos donadores de electron tales como alcoxi que tiene de 1 a 5 atomos de carbono o hidroxi, grupos aceptadores de electron seleccionados a partir de ciano, nitro, trifluoroalquilo o amida; alquilamino, benzoiloxi, nitroxi, fenilo o sulfo; y las sales de los mismos activas de manera farmacologica. (ver formulas).
MXPA03001072A 2000-08-07 2001-08-07 El uso de bencilidenaminoguanidinas e hidroxiguanidinas como ligandos de receptor de melanocortina. MXPA03001072A (es)

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GB0019357A GB0019357D0 (en) 2000-08-07 2000-08-07 Novel phenyl guanidines
PCT/GB2001/003534 WO2002011715A2 (en) 2000-08-07 2001-08-07 The use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands

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US8148429B2 (en) 2012-04-03
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KR100929363B1 (ko) 2009-12-02
BR0113053A (pt) 2003-07-08

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