GB1223493A - Guanidines - Google Patents

Guanidines

Info

Publication number
GB1223493A
GB1223493A GB3907470A GB3907470A GB1223493A GB 1223493 A GB1223493 A GB 1223493A GB 3907470 A GB3907470 A GB 3907470A GB 3907470 A GB3907470 A GB 3907470A GB 1223493 A GB1223493 A GB 1223493A
Authority
GB
United Kingdom
Prior art keywords
hno
chloro
reacting
acid addition
aminoguanidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3907470A
Inventor
William Fausset Bruce
Thomas Baum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Priority to GB3907470A priority Critical patent/GB1223493A/en
Publication of GB1223493A publication Critical patent/GB1223493A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,223,493. Aminoguanidine derivative. AMERICAN HOME PRODUCTS CORP. 11 Oct., 1968, No. 39074/70. Divided out of 1,223,491. Addition to 1,223,491. Heading C2C. The invention comprises 2-chloro-6-fluorobenzylideneaminoguanidine (I), its acid addition salts (e.g. with HCl, HBr, H 2 SO 4 , HNO 3 , H 3 PO 4 , or with lactic, fumaric, tartaric, citric, formic, acetic, glycolic, succinic, gluconic, glutaric, maleic or trifluoroacetic acids), and processes for making it by (a) reacting 2-chloro-6-fluorobenzaldehyde (II) with aminoguanidine or its acid addition salt, (b) heating II-thiosemicarbazone with NH 3 , and (c) reacting II-hydrazone with CNNH 2 . The preparation of I-HNO 3 salt by method (a) is exemplified. Pharmaceutical and veterinary compositions comprise I, which has hypotensive and antihypertensive activity, in conventional forms for oral or parenteral administration.
GB3907470A 1968-10-11 1968-10-11 Guanidines Expired GB1223493A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3907470A GB1223493A (en) 1968-10-11 1968-10-11 Guanidines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3907470A GB1223493A (en) 1968-10-11 1968-10-11 Guanidines

Publications (1)

Publication Number Publication Date
GB1223493A true GB1223493A (en) 1971-02-24

Family

ID=10407489

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3907470A Expired GB1223493A (en) 1968-10-11 1968-10-11 Guanidines

Country Status (1)

Country Link
GB (1) GB1223493A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8148429B2 (en) 2000-08-07 2012-04-03 Anamar Ab Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8148429B2 (en) 2000-08-07 2012-04-03 Anamar Ab Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
US8309609B2 (en) 2000-08-07 2012-11-13 Anamar Ab Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
US8410174B2 (en) 2000-08-07 2013-04-02 Anamar Ab Method for treating arthritis
US9227927B2 (en) 2000-08-07 2016-01-05 Anamar Ab Method of treating inflammation

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